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The map label for this gene is ispA [C]

Identifier: 225853224

GI number: 225853224

Start: 1724082

End: 1724996

Strand: Direct

Name: ispA [C]

Synonym: BMEA_A1827

Alternate gene names: 225853224

Gene position: 1724082-1724996 (Clockwise)

Preceding gene: 225853221

Following gene: 225853226

Centisome position: 81.11

GC content: 62.95

Gene sequence:

>915_bases
ATGGAAAAGCTGCCTGTCGATTTCACCACTCTTCTTAACCGCCGCGCCATGGAAGTAGAAGCTGCCCTTGCCGGTCTTCT
GGACGAACGCCCGCGCACCGGCGAGATTGCCCGTCCGCAGCGTCTCATCGCCGCCATGCGCCATGGCGTACTGAACGGCG
GCAAGCGCCTGCGCCCGTTTCTCGTCCTCGAAAGTGCTGCCCTTTTCGGACAGTACGGCCAGGCGGTGCTGCGCGTCGCT
GCCGCGCTGGAATGTATCCATTGCTATTCGCTGGTCCATGACGATCTGCCAGCCATGGATGATGACGATCTGCGCCGGGG
CCAGCCAACCGTGCACAAGGCCTTTGATGAGGCAGCCGCCATTCTGGCCGGTGATAGCCTGCTGACCTACGCCTTCGACA
TTATCGCATCCGATGAAACGGAACTCGACGCCACCACCCGCATAAAGCTTGTTTGCGCGCTCACGCGCGCTTCCGGCCTT
GGCGGCATGGCAGGCGGACAGGCGCTCGACCTGATGGCGGAAACCAGAAAACCGGACGAGGCAGGCATCATCACGCTTCA
AGCCATGAAGACCGGCGCGCTGATCCGCTTTGCCTGCGAGGCGGGCGCTATCATCGCTGGCGCATCGCAGGAAGACCGGG
AGCGCATGGCGGAATTCGGCTCGGCAATCGGCCTGGCCTTCCAGCTTGCCGACGATCTTCTGGACGTGACCGCCGACGCT
GGCACCATGGGCAAGGCAACCGGCAAGGATGCCGCCGCCGGAAAAGCCACGCTGGTTTCACTTCACGGCATTGACTGGAC
CCGCCAGCAGCTTTCAGGCCTCGTCGCACAGGCCGAAAGCCTGCTCGCACCCTTTGGAGAAGACGCCGAACCCCTCAAGC
AAGCGGCCCGCTTCATCGCCGAGCGGCAGAATTAA

Upstream 100 bases:

>100_bases
AAATGCGGGGAGCGGGTTTTATGACGCGGCGATGAAAAAGCCTGTGCTGGAGATTATGCCCTGTTGACCCGCTTCGCGCT
TTCGTCCATCCCATTCTTCC

Downstream 100 bases:

>100_bases
CAAGGTCTCACGACGCGATCTTACGACCAAGCCCAAAGCGGTTTTCGATATAGTCGGCAACCATCTTCTGGAAGTCCTCG
GCAATCCCCGGACCACGCAG

Product: polyprenyl synthetase

Products: NA

Alternate protein names: FPP synthase; (2E,6E)-farnesyl diphosphate synthase; Geranyltranstransferase [H]

Number of amino acids: Translated: 304; Mature: 304

Protein sequence:

>304_residues
MEKLPVDFTTLLNRRAMEVEAALAGLLDERPRTGEIARPQRLIAAMRHGVLNGGKRLRPFLVLESAALFGQYGQAVLRVA
AALECIHCYSLVHDDLPAMDDDDLRRGQPTVHKAFDEAAAILAGDSLLTYAFDIIASDETELDATTRIKLVCALTRASGL
GGMAGGQALDLMAETRKPDEAGIITLQAMKTGALIRFACEAGAIIAGASQEDRERMAEFGSAIGLAFQLADDLLDVTADA
GTMGKATGKDAAAGKATLVSLHGIDWTRQQLSGLVAQAESLLAPFGEDAEPLKQAARFIAERQN

Sequences:

>Translated_304_residues
MEKLPVDFTTLLNRRAMEVEAALAGLLDERPRTGEIARPQRLIAAMRHGVLNGGKRLRPFLVLESAALFGQYGQAVLRVA
AALECIHCYSLVHDDLPAMDDDDLRRGQPTVHKAFDEAAAILAGDSLLTYAFDIIASDETELDATTRIKLVCALTRASGL
GGMAGGQALDLMAETRKPDEAGIITLQAMKTGALIRFACEAGAIIAGASQEDRERMAEFGSAIGLAFQLADDLLDVTADA
GTMGKATGKDAAAGKATLVSLHGIDWTRQQLSGLVAQAESLLAPFGEDAEPLKQAARFIAERQN
>Mature_304_residues
MEKLPVDFTTLLNRRAMEVEAALAGLLDERPRTGEIARPQRLIAAMRHGVLNGGKRLRPFLVLESAALFGQYGQAVLRVA
AALECIHCYSLVHDDLPAMDDDDLRRGQPTVHKAFDEAAAILAGDSLLTYAFDIIASDETELDATTRIKLVCALTRASGL
GGMAGGQALDLMAETRKPDEAGIITLQAMKTGALIRFACEAGAIIAGASQEDRERMAEFGSAIGLAFQLADDLLDVTADA
GTMGKATGKDAAAGKATLVSLHGIDWTRQQLSGLVAQAESLLAPFGEDAEPLKQAARFIAERQN

Specific function: Unknown

COG id: COG0142

COG function: function code H; Geranylgeranyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FPP/GGPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI50659086, Length=212, Percent_Identity=32.5471698113208, Blast_Score=83, Evalue=3e-16,
Organism=Escherichia coli, GI1786623, Length=272, Percent_Identity=45.2205882352941, Blast_Score=179, Evalue=2e-46,
Organism=Escherichia coli, GI1789578, Length=217, Percent_Identity=35.9447004608295, Blast_Score=124, Evalue=8e-30,
Organism=Caenorhabditis elegans, GI17505681, Length=200, Percent_Identity=30.5, Blast_Score=75, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24651612, Length=213, Percent_Identity=33.8028169014084, Blast_Score=91, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000092
- InterPro:   IPR017446
- InterPro:   IPR008949 [H]

Pfam domain/function: PF00348 polyprenyl_synt [H]

EC number: =2.5.1.10 [H]

Molecular weight: Translated: 32315; Mature: 32315

Theoretical pI: Translated: 4.71; Mature: 4.71

Prosite motif: PS00723 POLYPRENYL_SYNTHET_1 ; PS00444 POLYPRENYL_SYNTHET_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKLPVDFTTLLNRRAMEVEAALAGLLDERPRTGEIARPQRLIAAMRHGVLNGGKRLRPF
CCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCHH
LVLESAALFGQYGQAVLRVAAALECIHCYSLVHDDLPAMDDDDLRRGQPTVHKAFDEAAA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCHHHHHHHHHHH
ILAGDSLLTYAFDIIASDETELDATTRIKLVCALTRASGLGGMAGGQALDLMAETRKPDE
HHCCCHHHHHHHHHHCCCCCCCCHHHHHHHEEEEHHCCCCCCCCCCHHHHHHHHCCCCCC
AGIITLQAMKTGALIRFACEAGAIIAGASQEDRERMAEFGSAIGLAFQLADDLLDVTADA
CCEEEEEEHHCCCCEEEECCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
GTMGKATGKDAAAGKATLVSLHGIDWTRQQLSGLVAQAESLLAPFGEDAEPLKQAARFIA
CCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
ERQN
HCCC
>Mature Secondary Structure
MEKLPVDFTTLLNRRAMEVEAALAGLLDERPRTGEIARPQRLIAAMRHGVLNGGKRLRPF
CCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCHH
LVLESAALFGQYGQAVLRVAAALECIHCYSLVHDDLPAMDDDDLRRGQPTVHKAFDEAAA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCHHHHHHHHHHH
ILAGDSLLTYAFDIIASDETELDATTRIKLVCALTRASGLGGMAGGQALDLMAETRKPDE
HHCCCHHHHHHHHHHCCCCCCCCHHHHHHHEEEEHHCCCCCCCCCCHHHHHHHHCCCCCC
AGIITLQAMKTGALIRFACEAGAIIAGASQEDRERMAEFGSAIGLAFQLADDLLDVTADA
CCEEEEEEHHCCCCEEEECCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
GTMGKATGKDAAAGKATLVSLHGIDWTRQQLSGLVAQAESLLAPFGEDAEPLKQAARFIA
CCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
ERQN
HCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8486607; 7918490 [H]