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The map label for this gene is phbA [H]

Identifier: 225853220

GI number: 225853220

Start: 1720599

End: 1722113

Strand: Reverse

Name: phbA [H]

Synonym: BMEA_A1822

Alternate gene names: 225853220

Gene position: 1722113-1720599 (Counterclockwise)

Preceding gene: 225853222

Following gene: 225853219

Centisome position: 81.01

GC content: 59.74

Gene sequence:

>1515_bases
GTGTTGCGCCACATGCTTAAGGAGGAAAGAATGTCCGATCCGAAATCCATCGTCATCGCCAGTGCAGCGCGCACCGCGGT
GGGTGCCTTTAATGGCGCCTTTGCCAATGTTCCTGCTCATGAACTGGGTGCAGTGGCCATCAAGGCTGCTCTGGAGCGTG
CTGGTGTCGATGCGGCGGATGTCGATGAGGTTATTCTGGGGCAGGTGCTGACGGCAGGCGAAGGGCAGAATCCCGCCCGT
CAGGCCGCCATGGGGGCCGGTTGCCCGAAGGAAACCACCGCTTTTGCCATCAACCAGCTCTGCGGTTCCGGCCTGCGGGC
GGTTGCGCTCGGGATGCAGCAGATTGTTTCCGGCGATGCGAAGATTATCGTGGCGGGCGGGCAGGAATCCATGTCCATGG
CGCCGCATTGTGCCTATCTGCGCTCCGGCGTGAAGATGGGCGATTTCAAGATGATCGACACCATGCTGAAAGACGGCCTG
ACCGATGCTTTCCATGGCTATCACATGGGCATCACCGCTGAAAATATTGCGCGCCAATGGCAGTTGAGCCGCAGCGAGCA
GGACGAGTTCGCACTCGCCTCGCAGCACAAAGCCGAGGCCGCGCAGAAGGCAGGCCGCTTCGATGAGGAGATCGTGCCTT
TCACCGTCAAGGCCCGCAAGGGGGATGTTGTGGTTTCGGCAGATGAATATATCCGTCCGGGCACGACGATGGAGGTGCTG
GCCAAGCTGAAGCCGGCTTTTGACAAGGAAGGCACGGTGACGGCGGGCAATGCATCCGGCATCAATGACGGTGCCGCAGC
GGTTGTGCTGATGGATGCTGGCGAGGCAGCCAGGCGTGGCGTGAAGCCTCTGGCGCGCATCGTATCCTGGGCGACGGCTG
GCGTTGATCCGTCGATCATGGGAACCGGGCCGATCCCCGCAACGCGGAAGGCGCTGGAAAAGGCAGGCTGGAGCGTTGGC
GACCTTGATCTTGTTGAGGCCAATGAGGCCTTTGCAGCGCAGTCATGCGCGGTGGTGCGCGATCTGGGTCTCAATCCTGA
AATCGTCAATGTCAATGGCGGCGCAATCGCTATCGGCCATCCGATCGGCGCCTCCGGCGCCCGCGTGCTGACGACGCTGC
TCTACGAAATGGAGCGTCGCGATGCCAAGCGTGGTCTGGCGACGCTTTGTATCTCGGCGGCGGCATGGGCGTGGCCCTTT
GTGTCGAGCGGGATTGATCCGGTTTTAGAACGTCATCTGAAACCAACCGCCAATTTCGGGCGTGTGCCGGAAGAGGGGTG
TTTTTTTCCGGCAAAAGTTAACGCAGAACGGAAACATGCAGGGGAAAGCGTGCTGTTTCGGCTCCGCCCTATGGCGTGTG
ACTGCGGCCAGATACCAGATGTTGTGAGAACAAATACAGAAAATCCAGCCATCAGCGATTCGTCGCTGATTCGTTCCAGA
GTCGTTCCATATATTAACCGGGCGCTTCCGCCTCATCCCTCTCTTGGGAAGGCATCTGCCCGCATTGAAACTTAA

Upstream 100 bases:

>100_bases
GGCAATGCCCATATGAATGCTTGTCCTGGCGGGAAAAACACCTTCTCGATTTTCATGAAGGCGGCGCGGGGAGCTTGCCA
AGGCCGGTTTTTTGGTCTTT

Downstream 100 bases:

>100_bases
CAGGGGCGCTTTCGGTGCAGGTCGTATAGTGCTATCGCATTACTTCACATCCGGCTCTTGAGAGCAATTGTACCGGGAAC
CCGATTATTGGTATGAACCA

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetoacetyl-CoA thiolase [H]

Number of amino acids: Translated: 504; Mature: 504

Protein sequence:

>504_residues
MLRHMLKEERMSDPKSIVIASAARTAVGAFNGAFANVPAHELGAVAIKAALERAGVDAADVDEVILGQVLTAGEGQNPAR
QAAMGAGCPKETTAFAINQLCGSGLRAVALGMQQIVSGDAKIIVAGGQESMSMAPHCAYLRSGVKMGDFKMIDTMLKDGL
TDAFHGYHMGITAENIARQWQLSRSEQDEFALASQHKAEAAQKAGRFDEEIVPFTVKARKGDVVVSADEYIRPGTTMEVL
AKLKPAFDKEGTVTAGNASGINDGAAAVVLMDAGEAARRGVKPLARIVSWATAGVDPSIMGTGPIPATRKALEKAGWSVG
DLDLVEANEAFAAQSCAVVRDLGLNPEIVNVNGGAIAIGHPIGASGARVLTTLLYEMERRDAKRGLATLCISAAAWAWPF
VSSGIDPVLERHLKPTANFGRVPEEGCFFPAKVNAERKHAGESVLFRLRPMACDCGQIPDVVRTNTENPAISDSSLIRSR
VVPYINRALPPHPSLGKASARIET

Sequences:

>Translated_504_residues
MLRHMLKEERMSDPKSIVIASAARTAVGAFNGAFANVPAHELGAVAIKAALERAGVDAADVDEVILGQVLTAGEGQNPAR
QAAMGAGCPKETTAFAINQLCGSGLRAVALGMQQIVSGDAKIIVAGGQESMSMAPHCAYLRSGVKMGDFKMIDTMLKDGL
TDAFHGYHMGITAENIARQWQLSRSEQDEFALASQHKAEAAQKAGRFDEEIVPFTVKARKGDVVVSADEYIRPGTTMEVL
AKLKPAFDKEGTVTAGNASGINDGAAAVVLMDAGEAARRGVKPLARIVSWATAGVDPSIMGTGPIPATRKALEKAGWSVG
DLDLVEANEAFAAQSCAVVRDLGLNPEIVNVNGGAIAIGHPIGASGARVLTTLLYEMERRDAKRGLATLCISAAAWAWPF
VSSGIDPVLERHLKPTANFGRVPEEGCFFPAKVNAERKHAGESVLFRLRPMACDCGQIPDVVRTNTENPAISDSSLIRSR
VVPYINRALPPHPSLGKASARIET
>Mature_504_residues
MLRHMLKEERMSDPKSIVIASAARTAVGAFNGAFANVPAHELGAVAIKAALERAGVDAADVDEVILGQVLTAGEGQNPAR
QAAMGAGCPKETTAFAINQLCGSGLRAVALGMQQIVSGDAKIIVAGGQESMSMAPHCAYLRSGVKMGDFKMIDTMLKDGL
TDAFHGYHMGITAENIARQWQLSRSEQDEFALASQHKAEAAQKAGRFDEEIVPFTVKARKGDVVVSADEYIRPGTTMEVL
AKLKPAFDKEGTVTAGNASGINDGAAAVVLMDAGEAARRGVKPLARIVSWATAGVDPSIMGTGPIPATRKALEKAGWSVG
DLDLVEANEAFAAQSCAVVRDLGLNPEIVNVNGGAIAIGHPIGASGARVLTTLLYEMERRDAKRGLATLCISAAAWAWPF
VSSGIDPVLERHLKPTANFGRVPEEGCFFPAKVNAERKHAGESVLFRLRPMACDCGQIPDVVRTNTENPAISDSSLIRSR
VVPYINRALPPHPSLGKASARIET

Specific function: SHORT-CHAIN FATTY ACIDS METABOLISM. [C]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI148539872, Length=382, Percent_Identity=59.9476439790576, Blast_Score=463, Evalue=1e-130,
Organism=Homo sapiens, GI167614485, Length=384, Percent_Identity=45.3125, Blast_Score=323, Evalue=3e-88,
Organism=Homo sapiens, GI4557237, Length=401, Percent_Identity=42.643391521197, Blast_Score=306, Evalue=3e-83,
Organism=Homo sapiens, GI4501853, Length=397, Percent_Identity=41.0579345088161, Blast_Score=247, Evalue=2e-65,
Organism=Homo sapiens, GI4504327, Length=414, Percent_Identity=33.0917874396135, Blast_Score=178, Evalue=9e-45,
Organism=Homo sapiens, GI194353979, Length=391, Percent_Identity=28.9002557544757, Blast_Score=127, Evalue=2e-29,
Organism=Escherichia coli, GI1788554, Length=399, Percent_Identity=56.140350877193, Blast_Score=418, Evalue=1e-118,
Organism=Escherichia coli, GI87082165, Length=378, Percent_Identity=53.4391534391534, Blast_Score=401, Evalue=1e-113,
Organism=Escherichia coli, GI1787663, Length=403, Percent_Identity=43.6724565756824, Blast_Score=301, Evalue=5e-83,
Organism=Escherichia coli, GI48994986, Length=409, Percent_Identity=43.0317848410758, Blast_Score=263, Evalue=3e-71,
Organism=Escherichia coli, GI1788683, Length=408, Percent_Identity=32.843137254902, Blast_Score=192, Evalue=3e-50,
Organism=Caenorhabditis elegans, GI133906874, Length=379, Percent_Identity=46.1741424802111, Blast_Score=325, Evalue=3e-89,
Organism=Caenorhabditis elegans, GI25147385, Length=377, Percent_Identity=41.1140583554377, Blast_Score=286, Evalue=2e-77,
Organism=Caenorhabditis elegans, GI17535921, Length=384, Percent_Identity=41.6666666666667, Blast_Score=270, Evalue=1e-72,
Organism=Caenorhabditis elegans, GI17535917, Length=383, Percent_Identity=32.8981723237598, Blast_Score=182, Evalue=4e-46,
Organism=Caenorhabditis elegans, GI17551802, Length=412, Percent_Identity=31.7961165048544, Blast_Score=163, Evalue=2e-40,
Organism=Saccharomyces cerevisiae, GI6325229, Length=386, Percent_Identity=43.7823834196891, Blast_Score=291, Evalue=2e-79,
Organism=Saccharomyces cerevisiae, GI6322031, Length=402, Percent_Identity=37.3134328358209, Blast_Score=216, Evalue=8e-57,
Organism=Drosophila melanogaster, GI24655093, Length=381, Percent_Identity=58.005249343832, Blast_Score=459, Evalue=1e-129,
Organism=Drosophila melanogaster, GI17648125, Length=380, Percent_Identity=43.421052631579, Blast_Score=291, Evalue=7e-79,
Organism=Drosophila melanogaster, GI24640423, Length=378, Percent_Identity=43.6507936507937, Blast_Score=291, Evalue=1e-78,
Organism=Drosophila melanogaster, GI17137578, Length=447, Percent_Identity=31.5436241610738, Blast_Score=179, Evalue=4e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.9 [H]

Molecular weight: Translated: 53136; Mature: 53136

Theoretical pI: Translated: 7.04; Mature: 7.04

Prosite motif: PS00098 THIOLASE_1 ; PS00737 THIOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRHMLKEERMSDPKSIVIASAARTAVGAFNGAFANVPAHELGAVAIKAALERAGVDAAD
CCHHHHHHHHCCCCCCEEEEHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHH
VDEVILGQVLTAGEGQNPARQAAMGAGCPKETTAFAINQLCGSGLRAVALGMQQIVSGDA
HHHHHHHHHHHCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHCCCC
KIIVAGGQESMSMAPHCAYLRSGVKMGDFKMIDTMLKDGLTDAFHGYHMGITAENIARQW
EEEEECCCCCHHCCHHHHHHHCCCCCCHHHHHHHHHHCCCHHHHCCEECCCCHHHHHHHH
QLSRSEQDEFALASQHKAEAAQKAGRFDEEIVPFTVKARKGDVVVSADEYIRPGTTMEVL
HCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCEEEECHHHCCCCCHHHHH
AKLKPAFDKEGTVTAGNASGINDGAAAVVLMDAGEAARRGVKPLARIVSWATAGVDPSIM
HHHHHCCCCCCCEEECCCCCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHCCCCCCCC
GTGPIPATRKALEKAGWSVGDLDLVEANEAFAAQSCAVVRDLGLNPEIVNVNGGAIAIGH
CCCCCCHHHHHHHHCCCCCCCEEEEECCHHHHHHHHHHHHHCCCCCEEEEECCCEEEECC
PIGASGARVLTTLLYEMERRDAKRGLATLCISAAAWAWPFVSSGIDPVLERHLKPTANFG
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCC
RVPEEGCFFPAKVNAERKHAGESVLFRLRPMACDCGQIPDVVRTNTENPAISDSSLIRSR
CCCCCCCCCCCCCCCHHHHCCCHHEEEECCCCCCCCCCCHHHHCCCCCCCCCHHHHHHHH
VVPYINRALPPHPSLGKASARIET
HHHHHHHCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MLRHMLKEERMSDPKSIVIASAARTAVGAFNGAFANVPAHELGAVAIKAALERAGVDAAD
CCHHHHHHHHCCCCCCEEEEHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHH
VDEVILGQVLTAGEGQNPARQAAMGAGCPKETTAFAINQLCGSGLRAVALGMQQIVSGDA
HHHHHHHHHHHCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHCCCC
KIIVAGGQESMSMAPHCAYLRSGVKMGDFKMIDTMLKDGLTDAFHGYHMGITAENIARQW
EEEEECCCCCHHCCHHHHHHHCCCCCCHHHHHHHHHHCCCHHHHCCEECCCCHHHHHHHH
QLSRSEQDEFALASQHKAEAAQKAGRFDEEIVPFTVKARKGDVVVSADEYIRPGTTMEVL
HCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCEEEECHHHCCCCCHHHHH
AKLKPAFDKEGTVTAGNASGINDGAAAVVLMDAGEAARRGVKPLARIVSWATAGVDPSIM
HHHHHCCCCCCCEEECCCCCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHCCCCCCCC
GTGPIPATRKALEKAGWSVGDLDLVEANEAFAAQSCAVVRDLGLNPEIVNVNGGAIAIGH
CCCCCCHHHHHHHHCCCCCCCEEEEECCHHHHHHHHHHHHHCCCCCEEEEECCCEEEECC
PIGASGARVLTTLLYEMERRDAKRGLATLCISAAAWAWPFVSSGIDPVLERHLKPTANFG
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCC
RVPEEGCFFPAKVNAERKHAGESVLFRLRPMACDCGQIPDVVRTNTENPAISDSSLIRSR
CCCCCCCCCCCCCCCHHHHCCCHHEEEECCCCCCCCCCCHHHHCCCCCCCCCHHHHHHHH
VVPYINRALPPHPSLGKASARIET
HHHHHHHCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7582015; 11481430 [H]