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The map label for this gene is thiP [H]

Identifier: 225853209

GI number: 225853209

Start: 1708943

End: 1710595

Strand: Direct

Name: thiP [H]

Synonym: BMEA_A1811

Alternate gene names: 225853209

Gene position: 1708943-1710595 (Clockwise)

Preceding gene: 225853208

Following gene: 225853210

Centisome position: 80.39

GC content: 60.8

Gene sequence:

>1653_bases
ATGGCTGGCAGCCACCAGCAGATGACAGCCACACCGGCAAGACGCACATCCCTTGCATCTCCCGCGACAAAACCTGTCGC
GGGCGGTTTGGCGCTCGCCTTTCTGGCCACACTTGCCGGGGGCGCACTCCTTGCCCTTGCACTGGAAGCAGGCGGTGGCG
GTTTTGATGCTGCCGCCAATTTCGACACCTATCTCTGGCGCGTCGCCCGTTTCACCATCTGGCAGGCGGTTGCATCGAGC
CTGCTTTCGGTGCTGTTCGCCATTCCCATTGCGCGCGCGCTTTATGCGGAGGCTCGCTTTCCGGGGCGCGGCCTGATCCT
GCGCCTTTTCGCCCAGCCGCTTGCTCTGCCCGCGCTCGTCGCCGTGCTGGGTGTCACCAGTATTTATGGCCGCAATGGCC
TGATCGCCCATATTTCAGACATGCTGGGCCACCCCATGCAGCCGGACATCTACGGCATCGCCGGCATTCTGATCGCCCAT
ATTTTCTTCAACATGCCGCTTGCCGTGCGCCTTCTTCTGGCAGCCTATGAATCCATTCCCGACGATCACTGGAAGCTTGC
AGCCCAGCTTGGCATGGGAAGCCGCGCCCGTTTCCGGCTGATAGACTGGCCCGTTATCCGGCGCAGCCTTCCCGGCATGA
TCGGCCTTGTCTTCATGCTCTGCGTGACGAGTTTCACCACGGTTCTGACACTTGGCGGCGGCCCACGCGCCACCACACTG
GAAGTTGCGATCTATCAAAGCCTGCATTTCGATTTTGATCCGGCACGCGCCGTCGCGCTCACCTTCACGCAACTTGCCCT
CACTTTGTTGATCCTGCTCATCCTGCGGCTGACAGGACGCCCTTCCCAGGAAGGCTTTACCCAAACTGCAACCCCTCGGC
GCTATGGCAGCCCCCGAAAAACGGAGCGCCTTTTCAATATTATCGTTATCGCGCTCGGCTTTCTTTATGTCGCGCTGCCG
ATTGCAGGCGTCGTCGTTTCCGGCCTGACAGCCGATCTGGTGCGCCTGCTCAGCGAAAGAATTGTCTGGCACGCCATCGC
CACCAGCCTTGCGCTCGGCTTTTCTGCCGCCCTTCTCGCGGTTTTTCTGTCGCTTGCTCTTGTTGCCGCCCGCGAAGCAA
CCCGCAATGCGCGGATCGCAAATATCTTCGACACCGGCGCAAGCCTCATTCTCGTCATGCCGCCCATTGTCATCGGCGCG
GGCTGGTTTATCCTGCTGCGCCATTTCACCGATCCCTTTGTCATGGCGCCACTGATGGTCGTCACCGTCAATGCCGCAAT
GGCCATGCCCTTCGCGGTGCGGCTCTTGCGCCCCGCATGGGATACGGCGGCAAGCCGCCACAACAAGCTTTGCAGCCAGC
TTGGGATAAAGGGTTTCAACCGGTTGCGGCTCATCGACTGGCCGTCGATCCGCCGGCCCTGCGGCATGGCTTTCGCCTTT
GCCATGGCGCTTTCGCTGGGCGATCTTGGAACCATCGCACTGTTTGGCAGCGATGCGCTTGTGACACTCCCCTATCTCCT
CTTGCAGCGCATGGGCAGCTATCGCACATTCGACGCGGCCGGGCTTGCCCTCATTTTAGGTGTGCTTTGCCTCGCACTGA
TGATGATCGCCGACCGCGCCGCCGCATCGCGAAAGGAAGCATTCCTTCAATGA

Upstream 100 bases:

>100_bases
AGCCGCTTCCAGCCGCCTTCGATGCCCTGCCGAAGCCGGAGAAGACCCTGCTCATCCCTCCCTACGAAGTGGCGAAAAAC
CGCAGATTGTGGGTGAATGA

Downstream 100 bases:

>100_bases
CCGCCTCTGCCGATATCCGCCTGAGCGACGTGCGCTTCAGCTATGGCGAAACCGCGATGCATTTCGACGTGACCATCACC
GGGGGCGAAATCGCGGCCAT

Product: thiamine transporter membrane protein

Products: ADP; phosphate; thiamine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 550; Mature: 549

Protein sequence:

>550_residues
MAGSHQQMTATPARRTSLASPATKPVAGGLALAFLATLAGGALLALALEAGGGGFDAAANFDTYLWRVARFTIWQAVASS
LLSVLFAIPIARALYAEARFPGRGLILRLFAQPLALPALVAVLGVTSIYGRNGLIAHISDMLGHPMQPDIYGIAGILIAH
IFFNMPLAVRLLLAAYESIPDDHWKLAAQLGMGSRARFRLIDWPVIRRSLPGMIGLVFMLCVTSFTTVLTLGGGPRATTL
EVAIYQSLHFDFDPARAVALTFTQLALTLLILLILRLTGRPSQEGFTQTATPRRYGSPRKTERLFNIIVIALGFLYVALP
IAGVVVSGLTADLVRLLSERIVWHAIATSLALGFSAALLAVFLSLALVAAREATRNARIANIFDTGASLILVMPPIVIGA
GWFILLRHFTDPFVMAPLMVVTVNAAMAMPFAVRLLRPAWDTAASRHNKLCSQLGIKGFNRLRLIDWPSIRRPCGMAFAF
AMALSLGDLGTIALFGSDALVTLPYLLLQRMGSYRTFDAAGLALILGVLCLALMMIADRAAASRKEAFLQ

Sequences:

>Translated_550_residues
MAGSHQQMTATPARRTSLASPATKPVAGGLALAFLATLAGGALLALALEAGGGGFDAAANFDTYLWRVARFTIWQAVASS
LLSVLFAIPIARALYAEARFPGRGLILRLFAQPLALPALVAVLGVTSIYGRNGLIAHISDMLGHPMQPDIYGIAGILIAH
IFFNMPLAVRLLLAAYESIPDDHWKLAAQLGMGSRARFRLIDWPVIRRSLPGMIGLVFMLCVTSFTTVLTLGGGPRATTL
EVAIYQSLHFDFDPARAVALTFTQLALTLLILLILRLTGRPSQEGFTQTATPRRYGSPRKTERLFNIIVIALGFLYVALP
IAGVVVSGLTADLVRLLSERIVWHAIATSLALGFSAALLAVFLSLALVAAREATRNARIANIFDTGASLILVMPPIVIGA
GWFILLRHFTDPFVMAPLMVVTVNAAMAMPFAVRLLRPAWDTAASRHNKLCSQLGIKGFNRLRLIDWPSIRRPCGMAFAF
AMALSLGDLGTIALFGSDALVTLPYLLLQRMGSYRTFDAAGLALILGVLCLALMMIADRAAASRKEAFLQ
>Mature_549_residues
AGSHQQMTATPARRTSLASPATKPVAGGLALAFLATLAGGALLALALEAGGGGFDAAANFDTYLWRVARFTIWQAVASSL
LSVLFAIPIARALYAEARFPGRGLILRLFAQPLALPALVAVLGVTSIYGRNGLIAHISDMLGHPMQPDIYGIAGILIAHI
FFNMPLAVRLLLAAYESIPDDHWKLAAQLGMGSRARFRLIDWPVIRRSLPGMIGLVFMLCVTSFTTVLTLGGGPRATTLE
VAIYQSLHFDFDPARAVALTFTQLALTLLILLILRLTGRPSQEGFTQTATPRRYGSPRKTERLFNIIVIALGFLYVALPI
AGVVVSGLTADLVRLLSERIVWHAIATSLALGFSAALLAVFLSLALVAAREATRNARIANIFDTGASLILVMPPIVIGAG
WFILLRHFTDPFVMAPLMVVTVNAAMAMPFAVRLLRPAWDTAASRHNKLCSQLGIKGFNRLRLIDWPSIRRPCGMAFAFA
MALSLGDLGTIALFGSDALVTLPYLLLQRMGSYRTFDAAGLALILGVLCLALMMIADRAAASRKEAFLQ

Specific function: Part of the ABC transporter complex thiBPQ involved in thiamine import. Probably responsible for the translocation of the substrate across the membrane [H]

COG id: COG1178

COG function: function code P; ABC-type Fe3+ transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 ABC transmembrane type-1 domains [H]

Homologues:

Organism=Escherichia coli, GI1786254, Length=462, Percent_Identity=43.0735930735931, Blast_Score=343, Evalue=2e-95,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000515
- InterPro:   IPR005947 [H]

Pfam domain/function: PF00528 BPD_transp_1 [H]

EC number: NA

Molecular weight: Translated: 59043; Mature: 58912

Theoretical pI: Translated: 11.03; Mature: 11.03

Prosite motif: PS50928 ABC_TM1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAGSHQQMTATPARRTSLASPATKPVAGGLALAFLATLAGGALLALALEAGGGGFDAAAN
CCCCCCCCCCCCHHHHCCCCCCCCCHHHHHHHHHHHHHHCHHHHHHHHHCCCCCCCCCCC
FDTYLWRVARFTIWQAVASSLLSVLFAIPIARALYAEARFPGRGLILRLFAQPLALPALV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
AVLGVTSIYGRNGLIAHISDMLGHPMQPDIYGIAGILIAHIFFNMPLAVRLLLAAYESIP
HHHHHHHHHCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCC
DDHWKLAAQLGMGSRARFRLIDWPVIRRSLPGMIGLVFMLCVTSFTTVLTLGGGPRATTL
CHHHHHHHHHCCCCCCCEEEECCHHHHHHCCHHHHHHHHHHHHHHHHHEEECCCCCCCEE
EVAIYQSLHFDFDPARAVALTFTQLALTLLILLILRLTGRPSQEGFTQTATPRRYGSPRK
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHH
TERLFNIIVIALGFLYVALPIAGVVVSGLTADLVRLLSERIVWHAIATSLALGFSAALLA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VFLSLALVAAREATRNARIANIFDTGASLILVMPPIVIGAGWFILLRHFTDPFVMAPLMV
HHHHHHHHHHHHHHCCCCEEEHHHCCCCEEEEHHHHHHHHHHHHHHHHCCCHHHHHHHHH
VTVNAAMAMPFAVRLLRPAWDTAASRHNKLCSQLGIKGFNRLRLIDWPSIRRPCGMAFAF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCHHHHHHHH
AMALSLGDLGTIALFGSDALVTLPYLLLQRMGSYRTFDAAGLALILGVLCLALMMIADRA
HHHHHHCCCCEEEEECCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
AASRKEAFLQ
HHHHHHHCCC
>Mature Secondary Structure 
AGSHQQMTATPARRTSLASPATKPVAGGLALAFLATLAGGALLALALEAGGGGFDAAAN
CCCCCCCCCCCHHHHCCCCCCCCCHHHHHHHHHHHHHHCHHHHHHHHHCCCCCCCCCCC
FDTYLWRVARFTIWQAVASSLLSVLFAIPIARALYAEARFPGRGLILRLFAQPLALPALV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
AVLGVTSIYGRNGLIAHISDMLGHPMQPDIYGIAGILIAHIFFNMPLAVRLLLAAYESIP
HHHHHHHHHCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCC
DDHWKLAAQLGMGSRARFRLIDWPVIRRSLPGMIGLVFMLCVTSFTTVLTLGGGPRATTL
CHHHHHHHHHCCCCCCCEEEECCHHHHHHCCHHHHHHHHHHHHHHHHHEEECCCCCCCEE
EVAIYQSLHFDFDPARAVALTFTQLALTLLILLILRLTGRPSQEGFTQTATPRRYGSPRK
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHH
TERLFNIIVIALGFLYVALPIAGVVVSGLTADLVRLLSERIVWHAIATSLALGFSAALLA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VFLSLALVAAREATRNARIANIFDTGASLILVMPPIVIGAGWFILLRHFTDPFVMAPLMV
HHHHHHHHHHHHHHCCCCEEEHHHCCCCEEEEHHHHHHHHHHHHHHHHCCCHHHHHHHHH
VTVNAAMAMPFAVRLLRPAWDTAASRHNKLCSQLGIKGFNRLRLIDWPSIRRPCGMAFAF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCHHHHHHHH
AMALSLGDLGTIALFGSDALVTLPYLLLQRMGSYRTFDAAGLALILGVLCLALMMIADRA
HHHHHHCCCCEEEEECCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
AASRKEAFLQ
HHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; thiamine [Periplasm]; H2O [C]

Specific reaction: ATP + thiamine [Periplasm] + H2O = ADP + phosphate + thiamine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA