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The map label for this gene is serA [H]

Identifier: 225853142

GI number: 225853142

Start: 1646962

End: 1648563

Strand: Reverse

Name: serA [H]

Synonym: BMEA_A1738

Alternate gene names: 225853142

Gene position: 1648563-1646962 (Counterclockwise)

Preceding gene: 225853143

Following gene: 225853141

Centisome position: 77.55

GC content: 57.37

Gene sequence:

>1602_bases
ATGGCACCTCGCGTTCTCGTATCCGATAAGCTTTCGCCCACTGCCGTCCAGATTTTCAAGGATCGCGGCGTGGACGTCGA
TTACCTGCCCGATCTCGGCAAGGACAAGGAAAAGCTTCTCGAAGTCATCGGCGAATATGACGGTCTGGCGATTCGTTCGG
CCACCAAGGTCACGGAAAAGCTGATCGCAGCCGCAAAGAAGCTGAAAGTCGTTGGTCGCGCCGGTATCGGCGTCGACAAT
GTCGATATTCCGGCCGCTTCGCGCCGCGGTATCATCGTCATGAATACGCCGTTCGGCAATTCGATCACCACCGCCGAACA
CGCTATTGCGCTGATGTTCGCTGTCGCCCGCCAATTGCCGGAGGCCGACACCTCCACCCGCGCTGGCAAGTGGGAAAAGA
ACCGCTTCATGGGCGTGGAAATCACCGGCAAGACGCTGGGTGTCGTTGGCTGCGGCAATATCGGCTCAATCGTCGCCACA
CGCGGCATAGGCCTGAAAATGCATGTGGTGGCTTTCGATCCGTTCCTTTCGGATGCGCGCGCGCAGGAACTGGGCGTTGA
AAAGGTCGAGCTGGATGAATTGCTGGCGCGCGCCGATTTCATCACGCTCCACACGCCGCTCATCGACAAGACCCGCAATA
TTATCAATGCGCAAACGCTGGCGAAAATGAAACCGGGTGTGCGCATTGTCAATTGCGCGCGCGGTGGCCTGATCGTGGAA
AAGGATCTGATTGCGGCGCTGAAATCCGGCCATGTGGCGGGTGCTGGCATTGACGTCTATGAAACCGAGCCTGCAACGGA
AAACGAGCTTTTTTCTCTGCCCAATGTGGTCTGCACGCCGCATCTGGGGGCATCGACTTCGGAAGCACAGGAAAATGTCG
CACTTCAGGTGGCCGAACAGATGTCGGACTATCTTGTGAAGGGCGCTGTCTCCAACGCCATCAACATGCCCTCGATCACG
GCGGAAGAAGCGCCGCGCCTGAAGCCGTTCGTGAAGCTTGCCGATGTGCTGGGCGCTTTTGTCGGTCAGGTCACGGATGA
GCCGATCCAGGAAGTGGAAGTGCTTTTCGACGGTTCCACCGCCTCGATGAATACGCGTGCACTGCTCAGTGCTGCTCTGG
CCGGTCTCATCCGTTCGCAGGTTGCCGACGTCAACATGGTTTCCGCGCCAATCATGGTGAAGGAGCGCGGCATCATCGTC
TCGGAAGTCAAGCGCGACAAGTCCGGCATTTTTGACGGCTATATCAAGCTGACGGTGAAGACCACCGTGCGCGAACGCTC
CATTGCGGGCACCTGTTTCTCCGATGGCAAGCCGCGTTTTATCCAGATCAAGGGAATCAATCTCGACGCCGAGGTCGGCC
CGCATATGCTTTATGTCACCAACAAGGACGTTCCGGGCATGATCGGCCTTCTTGGCACGATATGCGGCAAACATGATGTA
AATATTGCGAATTTCGCGCTCGGGCGCGACCATCCGGGTGGCGATGCAATCGCAATGCTTTATGTGGATGAACAGATTCC
ACAGGCAGCCCTTGACGAACTGATGGCTCAGGAGGCAATCAGGGCGGCGACACCGCTTGAGTTCAACGTCGGGGAAGTTT
GA

Upstream 100 bases:

>100_bases
GGCACGCATTTTCCCGTTTCAGTATCTCGCAATTGCATTTCCGGGCGCAAAGCCGGTTTCCACTTTTGCTGGAAATGCCT
GATTTTTGAAGGAGGCCTCC

Downstream 100 bases:

>100_bases
GAACATGGTTGAAGAGATGGCACAGCCGGAATGGCGGCGCATGCACGAGCAAGATATTGCCAGCGTGACTGCGGTTGCCA
ATGTTGTCCATCTCGATTTT

Product: D-3-phosphoglycerate dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 533; Mature: 532

Protein sequence:

>533_residues
MAPRVLVSDKLSPTAVQIFKDRGVDVDYLPDLGKDKEKLLEVIGEYDGLAIRSATKVTEKLIAAAKKLKVVGRAGIGVDN
VDIPAASRRGIIVMNTPFGNSITTAEHAIALMFAVARQLPEADTSTRAGKWEKNRFMGVEITGKTLGVVGCGNIGSIVAT
RGIGLKMHVVAFDPFLSDARAQELGVEKVELDELLARADFITLHTPLIDKTRNIINAQTLAKMKPGVRIVNCARGGLIVE
KDLIAALKSGHVAGAGIDVYETEPATENELFSLPNVVCTPHLGASTSEAQENVALQVAEQMSDYLVKGAVSNAINMPSIT
AEEAPRLKPFVKLADVLGAFVGQVTDEPIQEVEVLFDGSTASMNTRALLSAALAGLIRSQVADVNMVSAPIMVKERGIIV
SEVKRDKSGIFDGYIKLTVKTTVRERSIAGTCFSDGKPRFIQIKGINLDAEVGPHMLYVTNKDVPGMIGLLGTICGKHDV
NIANFALGRDHPGGDAIAMLYVDEQIPQAALDELMAQEAIRAATPLEFNVGEV

Sequences:

>Translated_533_residues
MAPRVLVSDKLSPTAVQIFKDRGVDVDYLPDLGKDKEKLLEVIGEYDGLAIRSATKVTEKLIAAAKKLKVVGRAGIGVDN
VDIPAASRRGIIVMNTPFGNSITTAEHAIALMFAVARQLPEADTSTRAGKWEKNRFMGVEITGKTLGVVGCGNIGSIVAT
RGIGLKMHVVAFDPFLSDARAQELGVEKVELDELLARADFITLHTPLIDKTRNIINAQTLAKMKPGVRIVNCARGGLIVE
KDLIAALKSGHVAGAGIDVYETEPATENELFSLPNVVCTPHLGASTSEAQENVALQVAEQMSDYLVKGAVSNAINMPSIT
AEEAPRLKPFVKLADVLGAFVGQVTDEPIQEVEVLFDGSTASMNTRALLSAALAGLIRSQVADVNMVSAPIMVKERGIIV
SEVKRDKSGIFDGYIKLTVKTTVRERSIAGTCFSDGKPRFIQIKGINLDAEVGPHMLYVTNKDVPGMIGLLGTICGKHDV
NIANFALGRDHPGGDAIAMLYVDEQIPQAALDELMAQEAIRAATPLEFNVGEV
>Mature_532_residues
APRVLVSDKLSPTAVQIFKDRGVDVDYLPDLGKDKEKLLEVIGEYDGLAIRSATKVTEKLIAAAKKLKVVGRAGIGVDNV
DIPAASRRGIIVMNTPFGNSITTAEHAIALMFAVARQLPEADTSTRAGKWEKNRFMGVEITGKTLGVVGCGNIGSIVATR
GIGLKMHVVAFDPFLSDARAQELGVEKVELDELLARADFITLHTPLIDKTRNIINAQTLAKMKPGVRIVNCARGGLIVEK
DLIAALKSGHVAGAGIDVYETEPATENELFSLPNVVCTPHLGASTSEAQENVALQVAEQMSDYLVKGAVSNAINMPSITA
EEAPRLKPFVKLADVLGAFVGQVTDEPIQEVEVLFDGSTASMNTRALLSAALAGLIRSQVADVNMVSAPIMVKERGIIVS
EVKRDKSGIFDGYIKLTVKTTVRERSIAGTCFSDGKPRFIQIKGINLDAEVGPHMLYVTNKDVPGMIGLLGTICGKHDVN
IANFALGRDHPGGDAIAMLYVDEQIPQAALDELMAQEAIRAATPLEFNVGEV

Specific function: Serine biosynthesis; first step. [C]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=400, Percent_Identity=42.5, Blast_Score=332, Evalue=5e-91,
Organism=Homo sapiens, GI4557497, Length=298, Percent_Identity=31.5436241610738, Blast_Score=149, Evalue=5e-36,
Organism=Homo sapiens, GI61743967, Length=308, Percent_Identity=31.1688311688312, Blast_Score=149, Evalue=6e-36,
Organism=Homo sapiens, GI145580578, Length=283, Percent_Identity=34.2756183745583, Blast_Score=146, Evalue=5e-35,
Organism=Homo sapiens, GI4557499, Length=283, Percent_Identity=34.2756183745583, Blast_Score=146, Evalue=5e-35,
Organism=Homo sapiens, GI145580575, Length=283, Percent_Identity=34.2756183745583, Blast_Score=144, Evalue=1e-34,
Organism=Homo sapiens, GI6912396, Length=251, Percent_Identity=33.0677290836653, Blast_Score=126, Evalue=4e-29,
Organism=Escherichia coli, GI1789279, Length=296, Percent_Identity=37.5, Blast_Score=191, Evalue=1e-49,
Organism=Escherichia coli, GI87082289, Length=327, Percent_Identity=31.4984709480122, Blast_Score=153, Evalue=3e-38,
Organism=Escherichia coli, GI1787645, Length=255, Percent_Identity=34.1176470588235, Blast_Score=132, Evalue=7e-32,
Organism=Escherichia coli, GI1788660, Length=267, Percent_Identity=30.7116104868914, Blast_Score=87, Evalue=3e-18,
Organism=Escherichia coli, GI87081824, Length=263, Percent_Identity=28.5171102661597, Blast_Score=85, Evalue=9e-18,
Organism=Caenorhabditis elegans, GI17532191, Length=302, Percent_Identity=46.3576158940397, Blast_Score=278, Evalue=5e-75,
Organism=Caenorhabditis elegans, GI25147481, Length=272, Percent_Identity=33.8235294117647, Blast_Score=162, Evalue=4e-40,
Organism=Saccharomyces cerevisiae, GI6322116, Length=335, Percent_Identity=34.9253731343284, Blast_Score=214, Evalue=2e-56,
Organism=Saccharomyces cerevisiae, GI6320925, Length=335, Percent_Identity=34.9253731343284, Blast_Score=212, Evalue=1e-55,
Organism=Saccharomyces cerevisiae, GI6324055, Length=294, Percent_Identity=30.952380952381, Blast_Score=139, Evalue=1e-33,
Organism=Saccharomyces cerevisiae, GI6324964, Length=284, Percent_Identity=28.5211267605634, Blast_Score=111, Evalue=3e-25,
Organism=Saccharomyces cerevisiae, GI6324980, Length=205, Percent_Identity=28.2926829268293, Blast_Score=80, Evalue=9e-16,
Organism=Saccharomyces cerevisiae, GI6325144, Length=112, Percent_Identity=40.1785714285714, Blast_Score=75, Evalue=3e-14,
Organism=Drosophila melanogaster, GI19921140, Length=302, Percent_Identity=46.3576158940397, Blast_Score=265, Evalue=8e-71,
Organism=Drosophila melanogaster, GI24646446, Length=275, Percent_Identity=33.8181818181818, Blast_Score=145, Evalue=5e-35,
Organism=Drosophila melanogaster, GI24646448, Length=275, Percent_Identity=33.8181818181818, Blast_Score=145, Evalue=5e-35,
Organism=Drosophila melanogaster, GI24646452, Length=275, Percent_Identity=33.8181818181818, Blast_Score=145, Evalue=5e-35,
Organism=Drosophila melanogaster, GI24646450, Length=275, Percent_Identity=33.8181818181818, Blast_Score=145, Evalue=5e-35,
Organism=Drosophila melanogaster, GI62472511, Length=275, Percent_Identity=33.8181818181818, Blast_Score=144, Evalue=1e-34,
Organism=Drosophila melanogaster, GI28574286, Length=293, Percent_Identity=32.0819112627986, Blast_Score=141, Evalue=1e-33,
Organism=Drosophila melanogaster, GI24585514, Length=267, Percent_Identity=32.2097378277154, Blast_Score=139, Evalue=7e-33,
Organism=Drosophila melanogaster, GI28574282, Length=267, Percent_Identity=32.2097378277154, Blast_Score=139, Evalue=7e-33,
Organism=Drosophila melanogaster, GI28574284, Length=267, Percent_Identity=32.2097378277154, Blast_Score=138, Evalue=8e-33,
Organism=Drosophila melanogaster, GI45552429, Length=267, Percent_Identity=32.2097378277154, Blast_Score=138, Evalue=1e-32,
Organism=Drosophila melanogaster, GI45551003, Length=267, Percent_Identity=32.2097378277154, Blast_Score=138, Evalue=1e-32,
Organism=Drosophila melanogaster, GI24585516, Length=307, Percent_Identity=29.6416938110749, Blast_Score=127, Evalue=1e-29,
Organism=Drosophila melanogaster, GI28571528, Length=265, Percent_Identity=32.0754716981132, Blast_Score=115, Evalue=9e-26,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 56896; Mature: 56764

Theoretical pI: Translated: 5.56; Mature: 5.56

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1 ; PS00670 D_2_HYDROXYACID_DH_2 ; PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAPRVLVSDKLSPTAVQIFKDRGVDVDYLPDLGKDKEKLLEVIGEYDGLAIRSATKVTEK
CCCCEEECCCCCCHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHCCCCCEEEHHHHHHHHH
LIAAAKKLKVVGRAGIGVDNVDIPAASRRGIIVMNTPFGNSITTAEHAIALMFAVARQLP
HHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHCC
EADTSTRAGKWEKNRFMGVEITGKTLGVVGCGNIGSIVATRGIGLKMHVVAFDPFLSDAR
CCCCCCCCCCCCCCCEEEEEECCCEEEEEECCCCHHHHHCCCCCEEEEEEEECCHHHHHH
AQELGVEKVELDELLARADFITLHTPLIDKTRNIINAQTLAKMKPGVRIVNCARGGLIVE
HHHHCCCHHHHHHHHHHHCEEEEECCHHHHHHHHHHHHHHHHCCCCCEEEEECCCCEEEH
KDLIAALKSGHVAGAGIDVYETEPATENELFSLPNVVCTPHLGASTSEAQENVALQVAEQ
HHHHHHHHCCCEECCCEEEEECCCCCCCHHHCCCCEEECCCCCCCCHHHHHHHHHHHHHH
MSDYLVKGAVSNAINMPSITAEEAPRLKPFVKLADVLGAFVGQVTDEPIQEVEVLFDGST
HHHHHHHHHHHCCCCCCCCCHHCCCCCHHHHHHHHHHHHHHHHCCCCHHHHEEEEECCCC
ASMNTRALLSAALAGLIRSQVADVNMVSAPIMVKERGIIVSEVKRDKSGIFDGYIKLTVK
CCCHHHHHHHHHHHHHHHHHHCCCEEECCCEEEECCCCCHHHHHHHHCCCCEEEEEEEEE
TTVRERSIAGTCFSDGKPRFIQIKGINLDAEVGPHMLYVTNKDVPGMIGLLGTICGKHDV
EEHHHHCCCCEECCCCCCCEEEEEECEECCCCCCEEEEEECCCCCHHHHHHHHHHCCCCC
NIANFALGRDHPGGDAIAMLYVDEQIPQAALDELMAQEAIRAATPLEFNVGEV
CCEEEECCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
APRVLVSDKLSPTAVQIFKDRGVDVDYLPDLGKDKEKLLEVIGEYDGLAIRSATKVTEK
CCCEEECCCCCCHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHCCCCCEEEHHHHHHHHH
LIAAAKKLKVVGRAGIGVDNVDIPAASRRGIIVMNTPFGNSITTAEHAIALMFAVARQLP
HHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHCC
EADTSTRAGKWEKNRFMGVEITGKTLGVVGCGNIGSIVATRGIGLKMHVVAFDPFLSDAR
CCCCCCCCCCCCCCCEEEEEECCCEEEEEECCCCHHHHHCCCCCEEEEEEEECCHHHHHH
AQELGVEKVELDELLARADFITLHTPLIDKTRNIINAQTLAKMKPGVRIVNCARGGLIVE
HHHHCCCHHHHHHHHHHHCEEEEECCHHHHHHHHHHHHHHHHCCCCCEEEEECCCCEEEH
KDLIAALKSGHVAGAGIDVYETEPATENELFSLPNVVCTPHLGASTSEAQENVALQVAEQ
HHHHHHHHCCCEECCCEEEEECCCCCCCHHHCCCCEEECCCCCCCCHHHHHHHHHHHHHH
MSDYLVKGAVSNAINMPSITAEEAPRLKPFVKLADVLGAFVGQVTDEPIQEVEVLFDGST
HHHHHHHHHHHCCCCCCCCCHHCCCCCHHHHHHHHHHHHHHHHCCCCHHHHEEEEECCCC
ASMNTRALLSAALAGLIRSQVADVNMVSAPIMVKERGIIVSEVKRDKSGIFDGYIKLTVK
CCCHHHHHHHHHHHHHHHHHHCCCEEECCCEEEECCCCCHHHHHHHHCCCCEEEEEEEEE
TTVRERSIAGTCFSDGKPRFIQIKGINLDAEVGPHMLYVTNKDVPGMIGLLGTICGKHDV
EEHHHHCCCCEECCCCCCCEEEEEECEECCCCCCEEEEEECCCCCHHHHHHHHHHCCCCC
NIANFALGRDHPGGDAIAMLYVDEQIPQAALDELMAQEAIRAATPLEFNVGEV
CCEEEECCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]