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The map label for this gene is macA [H]

Identifier: 225853134

GI number: 225853134

Start: 1636574

End: 1637800

Strand: Reverse

Name: macA [H]

Synonym: BMEA_A1727

Alternate gene names: 225853134

Gene position: 1637800-1636574 (Counterclockwise)

Preceding gene: 225853135

Following gene: 225853133

Centisome position: 77.05

GC content: 59.09

Gene sequence:

>1227_bases
GTGCTTAAATCTAGTGATTCTTCTCAATTAGGCCAGCAACCGGCATCGGCCCGCAAACGCGCCAAAGGAAAGCGCCGCTG
GTGGCTCTGGCTTTCAGCCGCCGCCATCATCATCGGCGCGGGCTGGTACTTCTACGGCTCTTATAAGGCTGACGGCGAGA
AGAGCAGCTATCTTGCGGAGACTGTCACCCGTGGTGACATCGAAAACGCCATCACCGCCGTCGGCACGCTGAGCGCATTG
CGCAGCGTCAACGTTGGCGCGCAGGTTTCCGGCCAGTTGAAAAGCGTGAAGGTGGAAGTGGGCGATCACGTCAAACAAGG
CCAGCTCATTGCCGAAATCGATCCTTCACCGTTTGAAAAGAAGGTGGAGATCGCAGGCGCCCAGCTCGACAATCTGAAAG
CCCAATTGCTCAGCAAGGACGCACAACTGACGCTGAAGAAGCTCAATGCCGCGCGGCAGAAATCCCTCCTCGCCACACGC
GGCGTCTCGCAGGCGACCGTCGATCAGGCCAATGCCGATCTTTTAATGGCCGAAGCGGAGGTAAAGGCGCTCAACGCACA
AATCCGCCAGCAGGAAGCACAGCTTGCAAGCGACAAGGTCGATCTCGGCTACACCTCCATCTATAGCCCCATGGAAGGCA
CGGTCGTTGACGAGGCTGCCAAGGAAGGCGAAACGCTCAATGCCGTGCAGAGCGCACCCACCATTGTCACGGTCGCAGAC
CTGAAAGTAATGACGGTGGAAGCACAGGTTTCGGAAGCCGACATTTCCAAGCTGAAGCCGGGAATGCCTGTCTATTTCAC
GCTGCTTGGCCAGCCCGACAAGCGTTTTACCGGCACGCTTCGCCAGATCAAGCCGACACCTGCGACAGATAACAATGTCG
TTCTCTATTATGCCCTGTTCGACGTGCCGAACCCGACTGGCGAATTGATGATCGACATGAGTGCGCAGGTCTATTTCGTT
CTGGGTGAGGCGAAGGACGTGCTCGTTGTCCCCACGGCAGCCCTTACTGACAAGCAGAAAGGCGGCAAGCCGCAAGTCAC
CGTCAAGGTGGCCGACGAGAGCGGTACCCTCGTGGAGCGCCCGGTCAAGGTCGGCGTGCGCAACCGCGTGCTGGCCGAAA
TCCAGAGCGGGCTTGAGGAAGGCGATCGCGTGGTTGTCACCGCCGCCACCGGCAATGGCGCAGCGGGAGGCGAACGCGGA
CGCAGACCCAGTATGCGCTTCTTCTGA

Upstream 100 bases:

>100_bases
CTTAGACCCTACTTATGCGGTGGTGAATGCATTATCGCTTGGGGGCAAGTTTCTGGAAAACGCGCAAAGCGCGGTTTTCT
GAAGGTTCAGGGGTTTTAGG

Downstream 100 bases:

>100_bases
TGGGCACCCTCATGGCCGGCGCTCCACTCATCAGGCTTGAGGATATCTGCAAGACATTTCACAATGGCGATCTTGCGGTG
GAAGTCCTGCACGGCATTAC

Product: RND family efflux transporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 408; Mature: 408

Protein sequence:

>408_residues
MLKSSDSSQLGQQPASARKRAKGKRRWWLWLSAAAIIIGAGWYFYGSYKADGEKSSYLAETVTRGDIENAITAVGTLSAL
RSVNVGAQVSGQLKSVKVEVGDHVKQGQLIAEIDPSPFEKKVEIAGAQLDNLKAQLLSKDAQLTLKKLNAARQKSLLATR
GVSQATVDQANADLLMAEAEVKALNAQIRQQEAQLASDKVDLGYTSIYSPMEGTVVDEAAKEGETLNAVQSAPTIVTVAD
LKVMTVEAQVSEADISKLKPGMPVYFTLLGQPDKRFTGTLRQIKPTPATDNNVVLYYALFDVPNPTGELMIDMSAQVYFV
LGEAKDVLVVPTAALTDKQKGGKPQVTVKVADESGTLVERPVKVGVRNRVLAEIQSGLEEGDRVVVTAATGNGAAGGERG
RRPSMRFF

Sequences:

>Translated_408_residues
MLKSSDSSQLGQQPASARKRAKGKRRWWLWLSAAAIIIGAGWYFYGSYKADGEKSSYLAETVTRGDIENAITAVGTLSAL
RSVNVGAQVSGQLKSVKVEVGDHVKQGQLIAEIDPSPFEKKVEIAGAQLDNLKAQLLSKDAQLTLKKLNAARQKSLLATR
GVSQATVDQANADLLMAEAEVKALNAQIRQQEAQLASDKVDLGYTSIYSPMEGTVVDEAAKEGETLNAVQSAPTIVTVAD
LKVMTVEAQVSEADISKLKPGMPVYFTLLGQPDKRFTGTLRQIKPTPATDNNVVLYYALFDVPNPTGELMIDMSAQVYFV
LGEAKDVLVVPTAALTDKQKGGKPQVTVKVADESGTLVERPVKVGVRNRVLAEIQSGLEEGDRVVVTAATGNGAAGGERG
RRPSMRFF
>Mature_408_residues
MLKSSDSSQLGQQPASARKRAKGKRRWWLWLSAAAIIIGAGWYFYGSYKADGEKSSYLAETVTRGDIENAITAVGTLSAL
RSVNVGAQVSGQLKSVKVEVGDHVKQGQLIAEIDPSPFEKKVEIAGAQLDNLKAQLLSKDAQLTLKKLNAARQKSLLATR
GVSQATVDQANADLLMAEAEVKALNAQIRQQEAQLASDKVDLGYTSIYSPMEGTVVDEAAKEGETLNAVQSAPTIVTVAD
LKVMTVEAQVSEADISKLKPGMPVYFTLLGQPDKRFTGTLRQIKPTPATDNNVVLYYALFDVPNPTGELMIDMSAQVYFV
LGEAKDVLVVPTAALTDKQKGGKPQVTVKVADESGTLVERPVKVGVRNRVLAEIQSGLEEGDRVVVTAATGNGAAGGERG
RRPSMRFF

Specific function: Efflux transporter for macrolide antibiotics [H]

COG id: COG0845

COG function: function code M; Membrane-fusion protein

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI87081796, Length=373, Percent_Identity=39.9463806970509, Blast_Score=257, Evalue=7e-70,
Organism=Escherichia coli, GI1789929, Length=304, Percent_Identity=28.2894736842105, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI87082036, Length=346, Percent_Identity=28.0346820809249, Blast_Score=82, Evalue=8e-17,
Organism=Escherichia coli, GI1787013, Length=326, Percent_Identity=24.8466257668712, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1790519, Length=240, Percent_Identity=29.1666666666667, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1789665, Length=375, Percent_Identity=24, Blast_Score=66, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 43734; Mature: 43734

Theoretical pI: Translated: 9.27; Mature: 9.27

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKSSDSSQLGQQPASARKRAKGKRRWWLWLSAAAIIIGAGWYFYGSYKADGEKSSYLAE
CCCCCCCHHHCCCCHHHHHHCCCCCEEEEEEEEEEHHEECCEEEEEEEECCCCCHHHHHH
TVTRGDIENAITAVGTLSALRSVNVGAQVSGQLKSVKVEVGDHVKQGQLIAEIDPSPFEK
HHHHCCHHHHHHHHHHHHHHHHCCCCCEECCCEEEEEEEECCCCCCCCEEEECCCCCCCH
KVEIAGAQLDNLKAQLLSKDAQLTLKKLNAARQKSLLATRGVSQATVDQANADLLMAEAE
HHEECCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCEEEEHHH
VKALNAQIRQQEAQLASDKVDLGYTSIYSPMEGTVVDEAAKEGETLNAVQSAPTIVTVAD
HHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCCCCHHHHHHCCCHHHHHHCCCCEEEEEC
LKVMTVEAQVSEADISKLKPGMPVYFTLLGQPDKRFTGTLRQIKPTPATDNNVVLYYALF
EEEEEEEEECCHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHCCCCCCCCCCEEEEEEEE
DVPNPTGELMIDMSAQVYFVLGEAKDVLVVPTAALTDKQKGGKPQVTVKVADESGTLVER
ECCCCCCCEEEEECCEEEEEEECCCCEEEECCHHHCCCCCCCCCEEEEEEECCCCCEEEC
PVKVGVRNRVLAEIQSGLEEGDRVVVTAATGNGAAGGERGRRPSMRFF
HHHHCHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MLKSSDSSQLGQQPASARKRAKGKRRWWLWLSAAAIIIGAGWYFYGSYKADGEKSSYLAE
CCCCCCCHHHCCCCHHHHHHCCCCCEEEEEEEEEEHHEECCEEEEEEEECCCCCHHHHHH
TVTRGDIENAITAVGTLSALRSVNVGAQVSGQLKSVKVEVGDHVKQGQLIAEIDPSPFEK
HHHHCCHHHHHHHHHHHHHHHHCCCCCEECCCEEEEEEEECCCCCCCCEEEECCCCCCCH
KVEIAGAQLDNLKAQLLSKDAQLTLKKLNAARQKSLLATRGVSQATVDQANADLLMAEAE
HHEECCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCEEEEHHH
VKALNAQIRQQEAQLASDKVDLGYTSIYSPMEGTVVDEAAKEGETLNAVQSAPTIVTVAD
HHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCCCCHHHHHHCCCHHHHHHCCCCEEEEEC
LKVMTVEAQVSEADISKLKPGMPVYFTLLGQPDKRFTGTLRQIKPTPATDNNVVLYYALF
EEEEEEEEECCHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHCCCCCCCCCCEEEEEEEE
DVPNPTGELMIDMSAQVYFVLGEAKDVLVVPTAALTDKQKGGKPQVTVKVADESGTLVER
ECCCCCCCEEEEECCEEEEEEECCCCEEEECCHHHCCCCCCCCCEEEEEEECCCCCEEEC
PVKVGVRNRVLAEIQSGLEEGDRVVVTAATGNGAAGGERGRRPSMRFF
HHHHCHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]