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The map label for this gene is lrp [H]

Identifier: 225852981

GI number: 225852981

Start: 1477578

End: 1478048

Strand: Direct

Name: lrp [H]

Synonym: BMEA_A1553

Alternate gene names: 225852981

Gene position: 1477578-1478048 (Clockwise)

Preceding gene: 225852980

Following gene: 225852986

Centisome position: 69.51

GC content: 59.02

Gene sequence:

>471_bases
ATGCCGATCAAGGCCGATCTGGACGAAATCGATTGGAAAATCCTTCGGGAGCTCCAGAACAACGGGCGCATCACCAATGT
CGAGCTTGCCGAGCGCGTCGGCATATCGGCTCCTCCCTGCCTGCGCCGTGTGCGCAAGCTGGAAGAAAGCGGCGTCATCC
GCGGCTATCGTGCGATTCTCAACGGCAATACGCTGGGGCAGGACCTTGTGGCATTCTGCTCGGTTGGGCTGCACCGTCAG
GCCGATGCGGATCTCAAGGCTTTCGCCGAAAAGACCAAGCAATGGCCGCTCGTTCGCCGCGCATGGATGGTTTCGGGTGA
ATCCGACTTCCTGCTCCATTGCGTTGCGCGCGATCTCAACACGTTCCAGACTTTCGTGATCGAGGAACTGACCGCCGCTC
CAAACGTGGATTCGGTACGCACAGCCCTCACCATTCGTCCCGTCAAGGACGAACCGTTGATGATCCTCTGA

Upstream 100 bases:

>100_bases
CCTATTTCTTTTGATATGAGCAAGATAGATTGCGCCGAGATGGCGCCGAATATTTCTATAATTACCCGGGAATGAAATTT
CCTTTCGCGCGGAGTTTTAC

Downstream 100 bases:

>100_bases
CCCGGATTATCTTCCTGCGAAAACCTGCTCATAAACGCTGCTGATAGCAGCCGCTTCCTTTTGGAGCGGAAAGGCTTCGC
GAACATGCGCCAGAGCATTT

Product: leucine-responsive regulatory protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 156; Mature: 155

Protein sequence:

>156_residues
MPIKADLDEIDWKILRELQNNGRITNVELAERVGISAPPCLRRVRKLEESGVIRGYRAILNGNTLGQDLVAFCSVGLHRQ
ADADLKAFAEKTKQWPLVRRAWMVSGESDFLLHCVARDLNTFQTFVIEELTAAPNVDSVRTALTIRPVKDEPLMIL

Sequences:

>Translated_156_residues
MPIKADLDEIDWKILRELQNNGRITNVELAERVGISAPPCLRRVRKLEESGVIRGYRAILNGNTLGQDLVAFCSVGLHRQ
ADADLKAFAEKTKQWPLVRRAWMVSGESDFLLHCVARDLNTFQTFVIEELTAAPNVDSVRTALTIRPVKDEPLMIL
>Mature_155_residues
PIKADLDEIDWKILRELQNNGRITNVELAERVGISAPPCLRRVRKLEESGVIRGYRAILNGNTLGQDLVAFCSVGLHRQA
DADLKAFAEKTKQWPLVRRAWMVSGESDFLLHCVARDLNTFQTFVIEELTAAPNVDSVRTALTIRPVKDEPLMIL

Specific function: Mediates a global response to leucine. Exogenous leucine affects the expression of a number of different operons; lrp mediates this effect for at least some of these operons [H]

COG id: COG1522

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH asnC-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787116, Length=151, Percent_Identity=38.4105960264901, Blast_Score=113, Evalue=6e-27,
Organism=Escherichia coli, GI87081742, Length=143, Percent_Identity=26.5734265734266, Blast_Score=73, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011008
- InterPro:   IPR000485
- InterPro:   IPR019885
- InterPro:   IPR019888
- InterPro:   IPR019887
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01037 AsnC_trans_reg [H]

EC number: NA

Molecular weight: Translated: 17581; Mature: 17449

Theoretical pI: Translated: 7.35; Mature: 7.35

Prosite motif: PS00519 HTH_ASNC_1 ; PS50956 HTH_ASNC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPIKADLDEIDWKILRELQNNGRITNVELAERVGISAPPCLRRVRKLEESGVIRGYRAIL
CCCCCCHHHHHHHHHHHHHHCCCEEEEHHHHHCCCCCCHHHHHHHHHHHCCHHHHHHHHH
NGNTLGQDLVAFCSVGLHRQADADLKAFAEKTKQWPLVRRAWMVSGESDFLLHCVARDLN
CCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCHHHHHHHHCCCCCHHHHHHHHHHHH
TFQTFVIEELTAAPNVDSVRTALTIRPVKDEPLMIL
HHHHHHHHHHHCCCCCCHHHHEEEEEECCCCCCEEC
>Mature Secondary Structure 
PIKADLDEIDWKILRELQNNGRITNVELAERVGISAPPCLRRVRKLEESGVIRGYRAIL
CCCCCHHHHHHHHHHHHHHCCCEEEEHHHHHCCCCCCHHHHHHHHHHHCCHHHHHHHHH
NGNTLGQDLVAFCSVGLHRQADADLKAFAEKTKQWPLVRRAWMVSGESDFLLHCVARDLN
CCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCHHHHHHHHCCCCCHHHHHHHHHHHH
TFQTFVIEELTAAPNVDSVRTALTIRPVKDEPLMIL
HHHHHHHHHHHCCCCCCHHHHEEEEEECCCCCCEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11157937; 11481430 [H]