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The map label for this gene is mntH

Identifier: 225852923

GI number: 225852923

Start: 1420018

End: 1421388

Strand: Direct

Name: mntH

Synonym: BMEA_A1489

Alternate gene names: 225852923

Gene position: 1420018-1421388 (Clockwise)

Preceding gene: 225852922

Following gene: 225852928

Centisome position: 66.8

GC content: 58.72

Gene sequence:

>1371_bases
ATGGTACCCCATGGATCATGTCCCTCCGGCGCTAGAGAGGTAACATTTGAAGGCTGGCGTCGCGAGCGTGGAGAAGCCTC
CATGTCCGATGTCCATCGTACCATCCGGGTCAACCGCTCTGGTTCAAAATTCCGCCGCGCGCTTTCATTTTTCGGCCCGG
GCTATCTTGTAGCCGTCGGTTATATGGATCCCGGCAACTGGGCCACCTCTCTAGCTGGCGGCTCCCGTTTCGGCTATGCA
CTGCTCTCGGTCGTGCTTCTGTCGAACCTCATGGCGGTTTTGCTGCAAGCACTTTGCACGCGGCTTGCCGTTGCCACGGG
GCGCGATCTTGCGCAGGCCTGCCGGGACGCTTATCCGCGTTTCCTCGCATGGCCGCTCTGGCTTCTGGCAGAGCTTGCCA
TCTGCGCCACCGACCTTGCGGAAGTTATCGGCACCGCCATCGGCCTCAATCTTCTGTTCGGCATTCCGCTGGAAATCGGC
GTTATCCTCACTGCCGTCGATGTGCTTCTGGTTCTCTATTTGCAAAACAAGGGATTCCGGCGCGTAGAGGCCCTCATCAT
TACCCTGCTTGGCGTCATTGCGCTCTGCTTCCTCACCCAGATCATCATGGCCCAGCCGCAATGGGGCGAGGTCATCAAGG
GTTTTGCGCCCACCACCGAGATCGTCAGCAACCCCGATATGCTATATATCGCGCTCGGCATCATCGGCGCGACCGTTATG
CCGCATAATCTCTATCTGCATTCCGGCATTGTGCAGACCCGCGACTATGGCCACACAACCGCGGAAAAGCGCGAGGCAAT
CCGCTATGCGACGCTTGATTCCACCATCGCGCTGACCTTTGCGCTCGTCATCAATGCGTCGATCCTCATCCTTGCCGCAG
CAAGCTTCCACGCGACCGGCCATACGGGTGTGGAAGATCTGGACAAGGCCCATGCCCTTTTGAATCCGCTTCTGGGTTCG
GCCATCGCCCCGGCACTCTTCGCCATTGCCCTGCTCTGCTGCGGCCTGAATTCGACCATCACCGCCACCATGGCGGGGCA
GATCGTGATGGAAGGCTTCATCGATATCCGGTTGAAGCCCTGGATACGCCGCGCCATTACGCGCTTCGTCGCCATCGTGC
CCGCCGCAATTGTGACGATCCTCTATGGTTCGCAGGGAACGACCGAACTTCTGATCCTCTCGCAAGTGGTGCTGAGCCTT
CAGCTCCCCTTTGCAGTCATCCCGCTGGTGATTTTCACGGCACAGAAGAAGAAGATGGGATCGCTGGCCGCCGCACCATG
GGTGACGTTCCTCGCAGCCATAACGGCGGCAATCATCGTGGTGCTGAACCTGAAGCTCATCTATGACTTTTTCACCGGCG
CCCCTATTTAA

Upstream 100 bases:

>100_bases
CCTTACTGCCTTATTCCGCCCCCCGCCGTTGACACCCGGCACATATCCCTTTACTTAATGCAAATAGTTTGCAACTGCAT
AAAGGATAAAGGTATTTCAT

Downstream 100 bases:

>100_bases
AGCACGTTTCCCGAAAGGGCGAAGCACCTCTATGGGAACATCCTTATAAACAAAGAAATAGAACGCCGATCTGATACTGT
CAGGTCGGCGTTTTAAATCC

Product: manganese transport protein MntH

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 456; Mature: 456

Protein sequence:

>456_residues
MVPHGSCPSGAREVTFEGWRRERGEASMSDVHRTIRVNRSGSKFRRALSFFGPGYLVAVGYMDPGNWATSLAGGSRFGYA
LLSVVLLSNLMAVLLQALCTRLAVATGRDLAQACRDAYPRFLAWPLWLLAELAICATDLAEVIGTAIGLNLLFGIPLEIG
VILTAVDVLLVLYLQNKGFRRVEALIITLLGVIALCFLTQIIMAQPQWGEVIKGFAPTTEIVSNPDMLYIALGIIGATVM
PHNLYLHSGIVQTRDYGHTTAEKREAIRYATLDSTIALTFALVINASILILAAASFHATGHTGVEDLDKAHALLNPLLGS
AIAPALFAIALLCCGLNSTITATMAGQIVMEGFIDIRLKPWIRRAITRFVAIVPAAIVTILYGSQGTTELLILSQVVLSL
QLPFAVIPLVIFTAQKKKMGSLAAAPWVTFLAAITAAIIVVLNLKLIYDFFTGAPI

Sequences:

>Translated_456_residues
MVPHGSCPSGAREVTFEGWRRERGEASMSDVHRTIRVNRSGSKFRRALSFFGPGYLVAVGYMDPGNWATSLAGGSRFGYA
LLSVVLLSNLMAVLLQALCTRLAVATGRDLAQACRDAYPRFLAWPLWLLAELAICATDLAEVIGTAIGLNLLFGIPLEIG
VILTAVDVLLVLYLQNKGFRRVEALIITLLGVIALCFLTQIIMAQPQWGEVIKGFAPTTEIVSNPDMLYIALGIIGATVM
PHNLYLHSGIVQTRDYGHTTAEKREAIRYATLDSTIALTFALVINASILILAAASFHATGHTGVEDLDKAHALLNPLLGS
AIAPALFAIALLCCGLNSTITATMAGQIVMEGFIDIRLKPWIRRAITRFVAIVPAAIVTILYGSQGTTELLILSQVVLSL
QLPFAVIPLVIFTAQKKKMGSLAAAPWVTFLAAITAAIIVVLNLKLIYDFFTGAPI
>Mature_456_residues
MVPHGSCPSGAREVTFEGWRRERGEASMSDVHRTIRVNRSGSKFRRALSFFGPGYLVAVGYMDPGNWATSLAGGSRFGYA
LLSVVLLSNLMAVLLQALCTRLAVATGRDLAQACRDAYPRFLAWPLWLLAELAICATDLAEVIGTAIGLNLLFGIPLEIG
VILTAVDVLLVLYLQNKGFRRVEALIITLLGVIALCFLTQIIMAQPQWGEVIKGFAPTTEIVSNPDMLYIALGIIGATVM
PHNLYLHSGIVQTRDYGHTTAEKREAIRYATLDSTIALTFALVINASILILAAASFHATGHTGVEDLDKAHALLNPLLGS
AIAPALFAIALLCCGLNSTITATMAGQIVMEGFIDIRLKPWIRRAITRFVAIVPAAIVTILYGSQGTTELLILSQVVLSL
QLPFAVIPLVIFTAQKKKMGSLAAAPWVTFLAAITAAIIVVLNLKLIYDFFTGAPI

Specific function: H(+)-stimulated, highly selective, manganese uptake system

COG id: COG1914

COG function: function code P; Mn2+ and Fe2+ transporters of the NRAMP family

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Probable)

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NRAMP family

Homologues:

Organism=Homo sapiens, GI109255241, Length=438, Percent_Identity=34.9315068493151, Blast_Score=239, Evalue=3e-63,
Organism=Homo sapiens, GI295293167, Length=430, Percent_Identity=35.8139534883721, Blast_Score=228, Evalue=6e-60,
Organism=Homo sapiens, GI295293175, Length=431, Percent_Identity=35.7308584686775, Blast_Score=228, Evalue=8e-60,
Organism=Homo sapiens, GI295293173, Length=431, Percent_Identity=35.7308584686775, Blast_Score=228, Evalue=8e-60,
Organism=Homo sapiens, GI10835169, Length=431, Percent_Identity=35.7308584686775, Blast_Score=228, Evalue=8e-60,
Organism=Homo sapiens, GI295293171, Length=431, Percent_Identity=35.7308584686775, Blast_Score=228, Evalue=8e-60,
Organism=Homo sapiens, GI295293169, Length=431, Percent_Identity=35.7308584686775, Blast_Score=228, Evalue=8e-60,
Organism=Homo sapiens, GI295293178, Length=431, Percent_Identity=35.7308584686775, Blast_Score=228, Evalue=9e-60,
Organism=Escherichia coli, GI1788736, Length=414, Percent_Identity=41.0628019323672, Blast_Score=291, Evalue=5e-80,
Organism=Caenorhabditis elegans, GI193210616, Length=459, Percent_Identity=32.4618736383442, Blast_Score=228, Evalue=7e-60,
Organism=Caenorhabditis elegans, GI71999499, Length=465, Percent_Identity=32.0430107526882, Blast_Score=209, Evalue=2e-54,
Organism=Caenorhabditis elegans, GI17569473, Length=400, Percent_Identity=33, Blast_Score=209, Evalue=3e-54,
Organism=Caenorhabditis elegans, GI71993856, Length=244, Percent_Identity=33.1967213114754, Blast_Score=150, Evalue=1e-36,
Organism=Saccharomyces cerevisiae, GI6324450, Length=465, Percent_Identity=35.4838709677419, Blast_Score=276, Evalue=7e-75,
Organism=Saccharomyces cerevisiae, GI6323062, Length=398, Percent_Identity=43.21608040201, Blast_Score=274, Evalue=2e-74,
Organism=Saccharomyces cerevisiae, GI6321841, Length=406, Percent_Identity=42.8571428571429, Blast_Score=268, Evalue=1e-72,
Organism=Drosophila melanogaster, GI24648607, Length=439, Percent_Identity=33.2574031890661, Blast_Score=240, Evalue=1e-63,
Organism=Drosophila melanogaster, GI281362176, Length=439, Percent_Identity=33.2574031890661, Blast_Score=240, Evalue=1e-63,
Organism=Drosophila melanogaster, GI24648609, Length=439, Percent_Identity=33.2574031890661, Blast_Score=240, Evalue=1e-63,
Organism=Drosophila melanogaster, GI45553443, Length=433, Percent_Identity=34.4110854503464, Blast_Score=240, Evalue=2e-63,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MNTH_BRUME (P65544)

Other databases:

- EMBL:   AE008917
- PIR:   AC3323
- RefSeq:   NP_539486.1
- GeneID:   1196280
- GenomeReviews:   AE008917_GR
- KEGG:   bme:BMEI0569
- HOGENOM:   HBG312498
- OMA:   KFGYALL
- PhylomeDB:   P65544
- ProtClustDB:   PRK00701
- BioCyc:   BMEL224914:BMEI0569-MONOMER
- HAMAP:   MF_00221
- InterPro:   IPR023056
- InterPro:   IPR001046
- PANTHER:   PTHR11706
- PRINTS:   PR00447
- TIGRFAMs:   TIGR01197

Pfam domain/function: PF01566 Nramp

EC number: NA

Molecular weight: Translated: 49028; Mature: 49028

Theoretical pI: Translated: 8.65; Mature: 8.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x220023dc)-; HASH(0x22a847e8)-; HASH(0x21ef1dcc)-; HASH(0x22ad2dc8)-; HASH(0x22e296b0)-; HASH(0x22e21024)-; HASH(0x22dcb3f8)-; HASH(0x22872f88)-; HASH(0x21ee0724)-; HASH(0x22b5a63c)-; HASH(0x2282456c)-;

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVPHGSCPSGAREVTFEGWRRERGEASMSDVHRTIRVNRSGSKFRRALSFFGPGYLVAVG
CCCCCCCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHHHHHHCCCEEEEEE
YMDPGNWATSLAGGSRFGYALLSVVLLSNLMAVLLQALCTRLAVATGRDLAQACRDAYPR
ECCCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCHH
FLAWPLWLLAELAICATDLAEVIGTAIGLNLLFGIPLEIGVILTAVDVLLVLYLQNKGFR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCHH
RVEALIITLLGVIALCFLTQIIMAQPQWGEVIKGFAPTTEIVSNPDMLYIALGIIGATVM
HHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCHHHHCCCCHHHHHHHHHHHHHC
PHNLYLHSGIVQTRDYGHTTAEKREAIRYATLDSTIALTFALVINASILILAAASFHATG
CCCEEEECCCHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
HTGVEDLDKAHALLNPLLGSAIAPALFAIALLCCGLNSTITATMAGQIVMEGFIDIRLKP
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHEEECH
WIRRAITRFVAIVPAAIVTILYGSQGTTELLILSQVVLSLQLPFAVIPLVIFTAQKKKMG
HHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHC
SLAAAPWVTFLAAITAAIIVVLNLKLIYDFFTGAPI
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
>Mature Secondary Structure
MVPHGSCPSGAREVTFEGWRRERGEASMSDVHRTIRVNRSGSKFRRALSFFGPGYLVAVG
CCCCCCCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHHHHHHCCCEEEEEE
YMDPGNWATSLAGGSRFGYALLSVVLLSNLMAVLLQALCTRLAVATGRDLAQACRDAYPR
ECCCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCHH
FLAWPLWLLAELAICATDLAEVIGTAIGLNLLFGIPLEIGVILTAVDVLLVLYLQNKGFR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCHH
RVEALIITLLGVIALCFLTQIIMAQPQWGEVIKGFAPTTEIVSNPDMLYIALGIIGATVM
HHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCHHHHCCCCHHHHHHHHHHHHHC
PHNLYLHSGIVQTRDYGHTTAEKREAIRYATLDSTIALTFALVINASILILAAASFHATG
CCCEEEECCCHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
HTGVEDLDKAHALLNPLLGSAIAPALFAIALLCCGLNSTITATMAGQIVMEGFIDIRLKP
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHEEECH
WIRRAITRFVAIVPAAIVTILYGSQGTTELLILSQVVLSLQLPFAVIPLVIFTAQKKKMG
HHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHC
SLAAAPWVTFLAAITAAIIVVLNLKLIYDFFTGAPI
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11756688