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The map label for this gene is lpxC [H]

Identifier: 225852906

GI number: 225852906

Start: 1399299

End: 1400159

Strand: Reverse

Name: lpxC [H]

Synonym: BMEA_A1472

Alternate gene names: 225852906

Gene position: 1400159-1399299 (Counterclockwise)

Preceding gene: 225852907

Following gene: 225852904

Centisome position: 65.87

GC content: 55.98

Gene sequence:

>861_bases
TTGAACGCTTATCAAAAGACAATTGGTCGTGCAGTCACGCTTTCGGGCGTCGGTATTCATGGCGGTGCGCCGGCTTCTGC
CCGGTTATTGCCTGCGGATGCAGATACAGGCATCCTGTTTCAGCGTTCGGACATCAAGGACAGTGCGCCTGTGTGCGCTC
ACGTCTCGCAGATCGGTGCGACCGATCTTTGCACCTCGCTTGGTGCCAGGGAAGCCCGGATCGATACAGTCGAACATCTG
ATGGCGGCTATATCCGCGCTTGGTATCGATAATCTGGTGGTGGAAATAGAGGGGCCGGAAGTTCCCATTCTGGATGGCAC
GTCCGCCCGTTTTATCGAAGCCGTTGATAGTGTCGGCGTTGTCACGCAGGATGCGAAGCGCCGTTTCATCCGCATTTTAA
AGACTGTTCGTGTTGAAGCGGGCAATTCGTGGGGTGAATTCCGCCCTTATGACGGCACCCGCTTCGAGGTCGAGATTGAT
TTTGAATGCCCGCTGATCGGGCGGCAGAAATTTGCGCATGATGTGGATGAGGAAACTTTCCGCAAGGAGCTTTCCACGGC
GCGGACCTTCGGTTTCATGAAAGATGTGGAGCGTCTATGGGCTGCGGGCCTTGCGCTTGGAGCCTCGCTCGATAATTCGC
TTGTGATCGGCGACGACAATTCCATCGTCAATGCGGATGGCCTGCGCTTCAAGGATGAGTTCGTGCGCCACAAGACACTG
GATGCGGTTGGCGATCTGGCGCTCGCGGGCCTGCCGTTCATTGGCTGCTTCAGTTCCTATCGCGGCGGGCACCGTCTGAA
TTCAGAAGCCGTCAAGGCGCTTCTATCGGATGAAACGGCGTTTGAGATTATTGAGGCATAG

Upstream 100 bases:

>100_bases
GTGCTTATACAGGCGCTTCAATTGCAAAGTCCGGGCTGTCCGCATCCCGCCGATCAGGATGGCCTTTTATCCCTGTTATA
CTGAATAGATTGGAACTGTC

Downstream 100 bases:

>100_bases
ATTTCGGGTTCTATCCGCCTGGAAATTGTCAGTAAAAAGTTGAGTATCGGCGCGCGGCCTTAATTGAGCCGTGTTCGCCG
GTTCGCTTCATTGCTGAGTC

Product: UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase

Products: NA

Alternate protein names: UDP-3-O-acyl-GlcNAc deacetylase [H]

Number of amino acids: Translated: 286; Mature: 286

Protein sequence:

>286_residues
MNAYQKTIGRAVTLSGVGIHGGAPASARLLPADADTGILFQRSDIKDSAPVCAHVSQIGATDLCTSLGAREARIDTVEHL
MAAISALGIDNLVVEIEGPEVPILDGTSARFIEAVDSVGVVTQDAKRRFIRILKTVRVEAGNSWGEFRPYDGTRFEVEID
FECPLIGRQKFAHDVDEETFRKELSTARTFGFMKDVERLWAAGLALGASLDNSLVIGDDNSIVNADGLRFKDEFVRHKTL
DAVGDLALAGLPFIGCFSSYRGGHRLNSEAVKALLSDETAFEIIEA

Sequences:

>Translated_286_residues
MNAYQKTIGRAVTLSGVGIHGGAPASARLLPADADTGILFQRSDIKDSAPVCAHVSQIGATDLCTSLGAREARIDTVEHL
MAAISALGIDNLVVEIEGPEVPILDGTSARFIEAVDSVGVVTQDAKRRFIRILKTVRVEAGNSWGEFRPYDGTRFEVEID
FECPLIGRQKFAHDVDEETFRKELSTARTFGFMKDVERLWAAGLALGASLDNSLVIGDDNSIVNADGLRFKDEFVRHKTL
DAVGDLALAGLPFIGCFSSYRGGHRLNSEAVKALLSDETAFEIIEA
>Mature_286_residues
MNAYQKTIGRAVTLSGVGIHGGAPASARLLPADADTGILFQRSDIKDSAPVCAHVSQIGATDLCTSLGAREARIDTVEHL
MAAISALGIDNLVVEIEGPEVPILDGTSARFIEAVDSVGVVTQDAKRRFIRILKTVRVEAGNSWGEFRPYDGTRFEVEID
FECPLIGRQKFAHDVDEETFRKELSTARTFGFMKDVERLWAAGLALGASLDNSLVIGDDNSIVNADGLRFKDEFVRHKTL
DAVGDLALAGLPFIGCFSSYRGGHRLNSEAVKALLSDETAFEIIEA

Specific function: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell [H]

COG id: COG0774

COG function: function code M; UDP-3-O-acyl-N-acetylglucosamine deacetylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxC family [H]

Homologues:

Organism=Escherichia coli, GI1786285, Length=283, Percent_Identity=43.4628975265018, Blast_Score=258, Evalue=4e-70,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020568
- InterPro:   IPR004463
- InterPro:   IPR011334
- InterPro:   IPR015870 [H]

Pfam domain/function: PF03331 LpxC [H]

EC number: 3.5.1.-

Molecular weight: Translated: 30867; Mature: 30867

Theoretical pI: Translated: 4.71; Mature: 4.71

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNAYQKTIGRAVTLSGVGIHGGAPASARLLPADADTGILFQRSDIKDSAPVCAHVSQIGA
CCHHHHHHCCEEEEECCCCCCCCCCCCEEEECCCCCCEEEEECCCCCCCHHHHHHHHHCH
TDLCTSLGAREARIDTVEHLMAAISALGIDNLVVEIEGPEVPILDGTSARFIEAVDSVGV
HHHHHHCCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCEEECCCHHHHHHHHHHCCC
VTQDAKRRFIRILKTVRVEAGNSWGEFRPYDGTRFEVEIDFECPLIGRQKFAHDVDEETF
CCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEECCCCCCCCHHHHCCCCHHHH
RKELSTARTFGFMKDVERLWAAGLALGASLDNSLVIGDDNSIVNADGLRFKDEFVRHKTL
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCEECCCCCCHHHHHHHHHHH
DAVGDLALAGLPFIGCFSSYRGGHRLNSEAVKALLSDETAFEIIEA
HHHHHHHHHCCHHHHHHHHCCCCCCCCHHHHHHHHCCCHHHHHHCC
>Mature Secondary Structure
MNAYQKTIGRAVTLSGVGIHGGAPASARLLPADADTGILFQRSDIKDSAPVCAHVSQIGA
CCHHHHHHCCEEEEECCCCCCCCCCCCEEEECCCCCCEEEEECCCCCCCHHHHHHHHHCH
TDLCTSLGAREARIDTVEHLMAAISALGIDNLVVEIEGPEVPILDGTSARFIEAVDSVGV
HHHHHHCCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCEEECCCHHHHHHHHHHCCC
VTQDAKRRFIRILKTVRVEAGNSWGEFRPYDGTRFEVEIDFECPLIGRQKFAHDVDEETF
CCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEECCCCCCCCHHHHCCCCHHHH
RKELSTARTFGFMKDVERLWAAGLALGASLDNSLVIGDDNSIVNADGLRFKDEFVRHKTL
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCEECCCCCCHHHHHHHHHHH
DAVGDLALAGLPFIGCFSSYRGGHRLNSEAVKALLSDETAFEIIEA
HHHHHHHHHCCHHHHHHHHCCCCCCCCHHHHHHHHCCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on carbon-nitrogen bonds, other than peptide bonds; In linear amides [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA