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The map label for this gene is ureC [H]

Identifier: 225852841

GI number: 225852841

Start: 1338018

End: 1339739

Strand: Direct

Name: ureC [H]

Synonym: BMEA_A1405

Alternate gene names: 225852841

Gene position: 1338018-1339739 (Clockwise)

Preceding gene: 225852840

Following gene: 225852842

Centisome position: 62.94

GC content: 59.18

Gene sequence:

>1722_bases
ATGACACAGATTTCCCGCCAGCAATACGCCGACCTTTATGGCCCGACAATTGGGGACAAGATAAGGCTTGGCGACTCCGA
TCTTTACGTTGAAATCGAGAAGGATCTGCGCGCCACTTATGGCGACGAACTGCAATATGGTGGCGGAAAAACGCTGCGTG
ACGGCATGGGGTCGGAAAATTTCCTTACCCAGGAAGCAGGCTGCCTCGATCTGGTCATTACCAATGTGACTGTCATCGAC
GCCATACAGGGGGTTGTGAAGGCCGATGTCGGCATTCGCAACGGAAGGATCGTCGGCCTTGGAAAAGCAGGCAACCCTTC
CACCATGGACGGTGTGACGCGCGGCCTTGTGACCGGCGCTTCAACCGACGCCATATCGGGCGAGCACCTTATCCTCACCG
CGGGCGGCATGGATACCCATGTTCACTATATCGCGCCGCAGCAGGTGGAGGCCGCTCTCTCGAACGGCATCACCACGCTC
TGGGGCGGCGGCATCGGGCCGGTTGACGGCACAAACGGCGTGACCACGACCAACGGGCCGTGGAATCTCGAAATGATGCT
GCGCTCCATCGAGGGCCTGCCGATCAACTTTGGCATTCAGGGCAAGGGAAATTCCACCGGCATTGCACCTCTGATCGAGC
AGCTGGAAGCAGGTGCCGCCGGTTTCAAGGTCCATGAAGACTATGGCGCCACGCCGGCTACAATTCGCGCCTGCCTTTCG
GTTGCCGATGAATATGACGTGTCGGTGGCCGTCCATACGGATACGCTGAACGAATCCGGCTATGTCGAGGACACCATCGC
AGCCTTCGACGGGCGCTCCGTCCACACCTATCACAGCGAAGGCGCAGGCGGCGGTCACGCGCCGGATCTGCTGAAAATGG
TGGGCCAGAATAACATCCTGCCAAGCTCGACCAATCCGACATTGCCCTGCGGCAAGAACTCGGTCGCCGAACTCTTTGAT
ATGATTATGGTATGCCATAATCTCAATCCGAGAATCCCTTCCGACGTCGCCTTTGCCGAAAGCCGTGTCCGCGCCGAAAC
CATCGTCGCCGAAAGCGTGCTGCATGACATGGGTGCGATCTCGATGATCGGCTCGGATTCGCAGGCCATGGGCCGCATCG
GCGAAACCTACCTTCGCGCCATACAAACTGCGGACGCCATGAAAAAGGCGCGCGGTCCGCTGCCGGAGGATGCGCCCGGA
AACGACAATTTCCGCGTGCTGCGCTATATTGCGAAAGTGACCATCAATCCGGCGCTGACCGCCGGTGTCGGCGATGTAAT
CGGCTCGATAGAGTCCGGCAAATTCGCAGATCTGGTGCTTTGGGAACCGGCCTTCTTCGGCGTCAAGCCGAAGCTCGTCC
TCAAGGGCGGACTGGTGGCATGGGCCAATATGGGCGACCCGAACGCATCATTGCCGACCCCGCAGCCCATGTATTACCGC
CCCATGTTCGCAGCCTATGGTTCTGCGCTCCAGAAGACCTCCATCACCTTCGTTTCGCGCGCGGCCTACGACAAGGGTGT
CGCCGACCGCTTCGGCTTGCAGCGGCTGGTAATGCCCGTCTCCGGAACCCGCGTCATCGGCAAGGCCCACATGGTTCGCA
ACAGCTATCTGCCGAATATCGAAGTCGATCCGCAGACTTTCGCGGTCAAGGTCGATGGCGTCCACGCAACGGTGAAGCCG
CCACAGTCGATCTCGCTCAACCAGCTTTATTTCTTTAGCTGA

Upstream 100 bases:

>100_bases
CGAACGCGCTGAAAAACTTGGGTTTAAGTCGTGCAAGTCCGGTGGCAAGGACGCCAAATAGAGGCCCCAACCCTGAACAT
ATTTTTCGAGGCACAGGATA

Downstream 100 bases:

>100_bases
CGCCGGAAACTGCGGGATTTTACGGAATACATATCGAGGAGAAACATATGATTATCATCGAGGGCATTGTCGGCAATTCA
CACGATCCGCAATGGCGTGA

Product: urease subunit alpha

Products: NA

Alternate protein names: Urea amidohydrolase subunit alpha 2 [H]

Number of amino acids: Translated: 573; Mature: 572

Protein sequence:

>573_residues
MTQISRQQYADLYGPTIGDKIRLGDSDLYVEIEKDLRATYGDELQYGGGKTLRDGMGSENFLTQEAGCLDLVITNVTVID
AIQGVVKADVGIRNGRIVGLGKAGNPSTMDGVTRGLVTGASTDAISGEHLILTAGGMDTHVHYIAPQQVEAALSNGITTL
WGGGIGPVDGTNGVTTTNGPWNLEMMLRSIEGLPINFGIQGKGNSTGIAPLIEQLEAGAAGFKVHEDYGATPATIRACLS
VADEYDVSVAVHTDTLNESGYVEDTIAAFDGRSVHTYHSEGAGGGHAPDLLKMVGQNNILPSSTNPTLPCGKNSVAELFD
MIMVCHNLNPRIPSDVAFAESRVRAETIVAESVLHDMGAISMIGSDSQAMGRIGETYLRAIQTADAMKKARGPLPEDAPG
NDNFRVLRYIAKVTINPALTAGVGDVIGSIESGKFADLVLWEPAFFGVKPKLVLKGGLVAWANMGDPNASLPTPQPMYYR
PMFAAYGSALQKTSITFVSRAAYDKGVADRFGLQRLVMPVSGTRVIGKAHMVRNSYLPNIEVDPQTFAVKVDGVHATVKP
PQSISLNQLYFFS

Sequences:

>Translated_573_residues
MTQISRQQYADLYGPTIGDKIRLGDSDLYVEIEKDLRATYGDELQYGGGKTLRDGMGSENFLTQEAGCLDLVITNVTVID
AIQGVVKADVGIRNGRIVGLGKAGNPSTMDGVTRGLVTGASTDAISGEHLILTAGGMDTHVHYIAPQQVEAALSNGITTL
WGGGIGPVDGTNGVTTTNGPWNLEMMLRSIEGLPINFGIQGKGNSTGIAPLIEQLEAGAAGFKVHEDYGATPATIRACLS
VADEYDVSVAVHTDTLNESGYVEDTIAAFDGRSVHTYHSEGAGGGHAPDLLKMVGQNNILPSSTNPTLPCGKNSVAELFD
MIMVCHNLNPRIPSDVAFAESRVRAETIVAESVLHDMGAISMIGSDSQAMGRIGETYLRAIQTADAMKKARGPLPEDAPG
NDNFRVLRYIAKVTINPALTAGVGDVIGSIESGKFADLVLWEPAFFGVKPKLVLKGGLVAWANMGDPNASLPTPQPMYYR
PMFAAYGSALQKTSITFVSRAAYDKGVADRFGLQRLVMPVSGTRVIGKAHMVRNSYLPNIEVDPQTFAVKVDGVHATVKP
PQSISLNQLYFFS
>Mature_572_residues
TQISRQQYADLYGPTIGDKIRLGDSDLYVEIEKDLRATYGDELQYGGGKTLRDGMGSENFLTQEAGCLDLVITNVTVIDA
IQGVVKADVGIRNGRIVGLGKAGNPSTMDGVTRGLVTGASTDAISGEHLILTAGGMDTHVHYIAPQQVEAALSNGITTLW
GGGIGPVDGTNGVTTTNGPWNLEMMLRSIEGLPINFGIQGKGNSTGIAPLIEQLEAGAAGFKVHEDYGATPATIRACLSV
ADEYDVSVAVHTDTLNESGYVEDTIAAFDGRSVHTYHSEGAGGGHAPDLLKMVGQNNILPSSTNPTLPCGKNSVAELFDM
IMVCHNLNPRIPSDVAFAESRVRAETIVAESVLHDMGAISMIGSDSQAMGRIGETYLRAIQTADAMKKARGPLPEDAPGN
DNFRVLRYIAKVTINPALTAGVGDVIGSIESGKFADLVLWEPAFFGVKPKLVLKGGLVAWANMGDPNASLPTPQPMYYRP
MFAAYGSALQKTSITFVSRAAYDKGVADRFGLQRLVMPVSGTRVIGKAHMVRNSYLPNIEVDPQTFAVKVDGVHATVKPP
QSISLNQLYFFS

Specific function: Disrupting the ure2 operon has no effect on urease activity or pathogen survival in BALB/c mice when administered orally [H]

COG id: COG0804

COG function: function code E; Urea amidohydrolase (urease) alpha subunit

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 urease domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR011059
- InterPro:   IPR011612
- InterPro:   IPR005848
- InterPro:   IPR017951
- InterPro:   IPR017950 [H]

Pfam domain/function: PF01979 Amidohydro_1; PF00449 Urease_alpha [H]

EC number: =3.5.1.5 [H]

Molecular weight: Translated: 60818; Mature: 60687

Theoretical pI: Translated: 5.20; Mature: 5.20

Prosite motif: PS01120 UREASE_1 ; PS00145 UREASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQISRQQYADLYGPTIGDKIRLGDSDLYVEIEKDLRATYGDELQYGGGKTLRDGMGSEN
CCCCCHHHHHHHCCCCCCCEEEECCCCEEEEEEHHHHHHCCCCEECCCCCHHHCCCCCCC
FLTQEAGCLDLVITNVTVIDAIQGVVKADVGIRNGRIVGLGKAGNPSTMDGVTRGLVTGA
CCCCCCCEEEEEEHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCHHHHHHHHHHCCC
STDAISGEHLILTAGGMDTHVHYIAPQQVEAALSNGITTLWGGGIGPVDGTNGVTTTNGP
CCCCCCCCEEEEEECCCCCEEEEECHHHHHHHHHCCCEEECCCCCCCCCCCCCEECCCCC
WNLEMMLRSIEGLPINFGIQGKGNSTGIAPLIEQLEAGAAGFKVHEDYGATPATIRACLS
CHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHH
VADEYDVSVAVHTDTLNESGYVEDTIAAFDGRSVHTYHSEGAGGGHAPDLLKMVGQNNIL
HHCCCCEEEEEEECCCCCCCCCHHHHHHCCCCEEEEECCCCCCCCCCHHHHHHHCCCCCC
PSSTNPTLPCGKNSVAELFDMIMVCHNLNPRIPSDVAFAESRVRAETIVAESVLHDMGAI
CCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCE
SMIGSDSQAMGRIGETYLRAIQTADAMKKARGPLPEDAPGNDNFRVLRYIAKVTINPALT
EEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCHHH
AGVGDVIGSIESGKFADLVLWEPAFFGVKPKLVLKGGLVAWANMGDPNASLPTPQPMYYR
HCHHHHHHCCCCCCEEEEEEECCHHHCCCCEEEEECCEEEEECCCCCCCCCCCCCCCEEC
PMFAAYGSALQKTSITFVSRAAYDKGVADRFGLQRLVMPVSGTRVIGKAHMVRNSYLPNI
HHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCHHHEEECCCCCEEEHHHHHHHHCCCCCC
EVDPQTFAVKVDGVHATVKPPQSISLNQLYFFS
EECCCEEEEEECCEEEECCCCCCCCCCEEEEEC
>Mature Secondary Structure 
TQISRQQYADLYGPTIGDKIRLGDSDLYVEIEKDLRATYGDELQYGGGKTLRDGMGSEN
CCCCHHHHHHHCCCCCCCEEEECCCCEEEEEEHHHHHHCCCCEECCCCCHHHCCCCCCC
FLTQEAGCLDLVITNVTVIDAIQGVVKADVGIRNGRIVGLGKAGNPSTMDGVTRGLVTGA
CCCCCCCEEEEEEHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCHHHHHHHHHHCCC
STDAISGEHLILTAGGMDTHVHYIAPQQVEAALSNGITTLWGGGIGPVDGTNGVTTTNGP
CCCCCCCCEEEEEECCCCCEEEEECHHHHHHHHHCCCEEECCCCCCCCCCCCCEECCCCC
WNLEMMLRSIEGLPINFGIQGKGNSTGIAPLIEQLEAGAAGFKVHEDYGATPATIRACLS
CHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHH
VADEYDVSVAVHTDTLNESGYVEDTIAAFDGRSVHTYHSEGAGGGHAPDLLKMVGQNNIL
HHCCCCEEEEEEECCCCCCCCCHHHHHHCCCCEEEEECCCCCCCCCCHHHHHHHCCCCCC
PSSTNPTLPCGKNSVAELFDMIMVCHNLNPRIPSDVAFAESRVRAETIVAESVLHDMGAI
CCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCE
SMIGSDSQAMGRIGETYLRAIQTADAMKKARGPLPEDAPGNDNFRVLRYIAKVTINPALT
EEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCHHH
AGVGDVIGSIESGKFADLVLWEPAFFGVKPKLVLKGGLVAWANMGDPNASLPTPQPMYYR
HCHHHHHHCCCCCCEEEEEEECCHHHCCCCEEEEECCEEEEECCCCCCCCCCCCCCCEEC
PMFAAYGSALQKTSITFVSRAAYDKGVADRFGLQRLVMPVSGTRVIGKAHMVRNSYLPNI
HHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCHHHEEECCCCCEEEHHHHHHHHCCCCCC
EVDPQTFAVKVDGVHATVKPPQSISLNQLYFFS
EECCCEEEEEECCEEEECCCCCCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA