Click here to switch to the map view.

The map label for this gene is adk

Identifier: 225852709

GI number: 225852709

Start: 1208955

End: 1209539

Strand: Reverse

Name: adk

Synonym: BMEA_A1257

Alternate gene names: 225852709

Gene position: 1209539-1208955 (Counterclockwise)

Preceding gene: 225852710

Following gene: 225852707

Centisome position: 56.9

GC content: 58.8

Gene sequence:

>585_bases
ATGAGACTGATACTTCTTGGGCCGCCCGGAGCAGGTAAGGGGACGCAGGCTGGACTTCTTACCAAGAAGCATGGAATACC
TCAGCTCTCGACCGGCGATATGCTGCGCGCGGCAGTCGCTCAGCAGAGCGAGATCGGGAAGCGCGCCAAGGCCGTGATGG
ATGCCGGGCAACTGGTTTCCGACGAGATCGTGAACCAGATCGTTTCGGAACGGATCGATGCGCCGGACTGTGCGAATGGT
TTCATTCTCGACGGCTATCCGCGCACTGTGCCGCAGGCTCAGGCCTTGAGCCAGATGCTGTCGGGCAAGGGGCTTAAGCT
GGATGCCGTCATCGAGCTGAAGGTCGATGAGAATGCTCTGGTCAAGCGGATGGAAAGCCGTGTGGCCGAAACGATTGCCA
AGGGCGGTCAGGTCCGTTCGGACGACAACCCGGAAGCCTTCCGCAAGCGTCTTGTGGAATACCGCGAAAAGACTGCGCCG
CTTTCAAGCTATTATGCCGGAACCGGCGAACTGCGCATCATCAATGGCATGGCGCCGGTTGAAGAAGTCACCGCCGAAAT
CGAGAGAATTCTTGTTCCGGCCTGA

Upstream 100 bases:

>100_bases
TGACGCTCGATACGGTTGCGCAAATTCAGGGGCATCTGATCGCCCATCAGTATGAAGGGCTGATCAAGAAGTCCAAACTC
AGAGGTGGGAAACGTAATAG

Downstream 100 bases:

>100_bases
TTGGTCGGCATGAAAATTGAGGGGACTTGAAAAAGTCTCGTCTTAGGCGGGCAGGGAAAGCGTGAAGCGTTTTCTGCCCG
TTTGTTGCTTCCAAAAGTTG

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase

Number of amino acids: Translated: 194; Mature: 194

Protein sequence:

>194_residues
MRLILLGPPGAGKGTQAGLLTKKHGIPQLSTGDMLRAAVAQQSEIGKRAKAVMDAGQLVSDEIVNQIVSERIDAPDCANG
FILDGYPRTVPQAQALSQMLSGKGLKLDAVIELKVDENALVKRMESRVAETIAKGGQVRSDDNPEAFRKRLVEYREKTAP
LSSYYAGTGELRIINGMAPVEEVTAEIERILVPA

Sequences:

>Translated_194_residues
MRLILLGPPGAGKGTQAGLLTKKHGIPQLSTGDMLRAAVAQQSEIGKRAKAVMDAGQLVSDEIVNQIVSERIDAPDCANG
FILDGYPRTVPQAQALSQMLSGKGLKLDAVIELKVDENALVKRMESRVAETIAKGGQVRSDDNPEAFRKRLVEYREKTAP
LSSYYAGTGELRIINGMAPVEEVTAEIERILVPA
>Mature_194_residues
MRLILLGPPGAGKGTQAGLLTKKHGIPQLSTGDMLRAAVAQQSEIGKRAKAVMDAGQLVSDEIVNQIVSERIDAPDCANG
FILDGYPRTVPQAQALSQMLSGKGLKLDAVIELKVDENALVKRMESRVAETIAKGGQVRSDDNPEAFRKRLVEYREKTAP
LSSYYAGTGELRIINGMAPVEEVTAEIERILVPA

Specific function: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in the energy metabolism and nucleotide synthesis, is essential for maintenance and cell growth

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family

Homologues:

Organism=Homo sapiens, GI4502013, Length=192, Percent_Identity=42.7083333333333, Blast_Score=154, Evalue=5e-38,
Organism=Homo sapiens, GI7524346, Length=192, Percent_Identity=42.7083333333333, Blast_Score=154, Evalue=6e-38,
Organism=Homo sapiens, GI19923437, Length=199, Percent_Identity=30.6532663316583, Blast_Score=100, Evalue=9e-22,
Organism=Homo sapiens, GI4502011, Length=186, Percent_Identity=32.7956989247312, Blast_Score=100, Evalue=1e-21,
Organism=Homo sapiens, GI28144897, Length=186, Percent_Identity=30.6451612903226, Blast_Score=89, Evalue=3e-18,
Organism=Homo sapiens, GI28144899, Length=186, Percent_Identity=30.6451612903226, Blast_Score=89, Evalue=3e-18,
Organism=Homo sapiens, GI7706497, Length=195, Percent_Identity=30.2564102564103, Blast_Score=88, Evalue=5e-18,
Organism=Homo sapiens, GI310110345, Length=199, Percent_Identity=27.6381909547739, Blast_Score=86, Evalue=3e-17,
Organism=Homo sapiens, GI53832003, Length=199, Percent_Identity=27.6381909547739, Blast_Score=86, Evalue=3e-17,
Organism=Homo sapiens, GI8051579, Length=199, Percent_Identity=27.6381909547739, Blast_Score=86, Evalue=3e-17,
Organism=Homo sapiens, GI53832001, Length=199, Percent_Identity=27.6381909547739, Blast_Score=86, Evalue=3e-17,
Organism=Homo sapiens, GI22749187, Length=127, Percent_Identity=31.496062992126, Blast_Score=75, Evalue=3e-14,
Organism=Escherichia coli, GI1786680, Length=219, Percent_Identity=47.0319634703196, Blast_Score=182, Evalue=9e-48,
Organism=Caenorhabditis elegans, GI17552384, Length=213, Percent_Identity=40.3755868544601, Blast_Score=166, Evalue=6e-42,
Organism=Caenorhabditis elegans, GI17567503, Length=187, Percent_Identity=35.8288770053476, Blast_Score=105, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17533833, Length=190, Percent_Identity=30.5263157894737, Blast_Score=100, Evalue=8e-22,
Organism=Caenorhabditis elegans, GI17550688, Length=193, Percent_Identity=30.5699481865285, Blast_Score=96, Evalue=9e-21,
Organism=Caenorhabditis elegans, GI17537943, Length=215, Percent_Identity=27.906976744186, Blast_Score=67, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI25147457, Length=193, Percent_Identity=23.8341968911917, Blast_Score=65, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6320432, Length=210, Percent_Identity=42.3809523809524, Blast_Score=159, Evalue=4e-40,
Organism=Saccharomyces cerevisiae, GI6321018, Length=199, Percent_Identity=32.6633165829146, Blast_Score=107, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6322828, Length=191, Percent_Identity=28.7958115183246, Blast_Score=80, Evalue=2e-16,
Organism=Drosophila melanogaster, GI22026816, Length=210, Percent_Identity=41.9047619047619, Blast_Score=162, Evalue=1e-40,
Organism=Drosophila melanogaster, GI17737899, Length=200, Percent_Identity=33, Blast_Score=104, Evalue=4e-23,
Organism=Drosophila melanogaster, GI24645822, Length=200, Percent_Identity=33, Blast_Score=104, Evalue=4e-23,
Organism=Drosophila melanogaster, GI17647141, Length=164, Percent_Identity=34.1463414634146, Blast_Score=97, Evalue=7e-21,
Organism=Drosophila melanogaster, GI24663208, Length=164, Percent_Identity=34.1463414634146, Blast_Score=97, Evalue=8e-21,
Organism=Drosophila melanogaster, GI221459597, Length=193, Percent_Identity=28.4974093264249, Blast_Score=94, Evalue=4e-20,
Organism=Drosophila melanogaster, GI21356893, Length=193, Percent_Identity=28.4974093264249, Blast_Score=94, Evalue=4e-20,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): KAD_BRUA1 (B2S658)

Other databases:

- EMBL:   CP000887
- RefSeq:   YP_001935129.1
- ProteinModelPortal:   B2S658
- SMR:   B2S658
- GeneID:   6328698
- GenomeReviews:   CP000887_GR
- KEGG:   bmc:BAbS19_I11500
- HOGENOM:   HBG630208
- OMA:   CGEGYHD
- ProtClustDB:   PRK00279
- GO:   GO:0005737
- HAMAP:   MF_00235
- InterPro:   IPR006259
- InterPro:   IPR000850
- PANTHER:   PTHR23359
- PRINTS:   PR00094
- TIGRFAMs:   TIGR01351

Pfam domain/function: PF00406 ADK

EC number: =2.7.4.3

Molecular weight: Translated: 20850; Mature: 20850

Theoretical pI: Translated: 7.36; Mature: 7.36

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLILLGPPGAGKGTQAGLLTKKHGIPQLSTGDMLRAAVAQQSEIGKRAKAVMDAGQLVS
CEEEEECCCCCCCCCCCCCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DEIVNQIVSERIDAPDCANGFILDGYPRTVPQAQALSQMLSGKGLKLDAVIELKVDENAL
HHHHHHHHHHHCCCCCCCCCCEECCCCCCCCHHHHHHHHHCCCCCEEEEEEEEEECHHHH
VKRMESRVAETIAKGGQVRSDDNPEAFRKRLVEYREKTAPLSSYYAGTGELRIINGMAPV
HHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHCCCCCEEEECCCCCH
EEVTAEIERILVPA
HHHHHHHHHHHCCC
>Mature Secondary Structure
MRLILLGPPGAGKGTQAGLLTKKHGIPQLSTGDMLRAAVAQQSEIGKRAKAVMDAGQLVS
CEEEEECCCCCCCCCCCCCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DEIVNQIVSERIDAPDCANGFILDGYPRTVPQAQALSQMLSGKGLKLDAVIELKVDENAL
HHHHHHHHHHHCCCCCCCCCCEECCCCCCCCHHHHHHHHHCCCCCEEEEEEEEEECHHHH
VKRMESRVAETIAKGGQVRSDDNPEAFRKRLVEYREKTAPLSSYYAGTGELRIINGMAPV
HHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHCCCCCEEEECCCCCH
EEVTAEIERILVPA
HHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA