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The map label for this gene is icd [H]

Identifier: 225852695

GI number: 225852695

Start: 1193921

End: 1195135

Strand: Direct

Name: icd [H]

Synonym: BMEA_A1243

Alternate gene names: 225852695

Gene position: 1193921-1195135 (Clockwise)

Preceding gene: 225852694

Following gene: 225852696

Centisome position: 56.17

GC content: 57.37

Gene sequence:

>1215_bases
ATGGCAAAAATCAAGGTTGCAAACCCGGTCGTCGAGCTCGACGGCGACGAGATGACCCGCATTATCTGGCAGTTCATCAA
GGACAAGCTTATCCATCCCTATCTCGACATCGACCTGAAATACTACGATCTTTCGGTCGAGAACCGCGATGCGACCAATG
ATCAGGTCACGATCGATGCAGCCAATGCCATCAAGGAATATGGCGTGGGCGTAAAATGCGCGACCATCACGCCCGACGAA
GCGCGCGTGGAAGAATTCAAGCTGAAGAAAATGTGGAAGTCGCCCAACGGCACCATCCGCAATATCCTCGGCGGCGTGAT
CTTCCGCGAGCCGATCATCTGCAAGAACGTGCCGCGCCTCGTGCCGGGCTGGACCCAGCCGATCATCGTCGGCCGCCATG
CTTTCGGCGACCAGTACCGCGCGACTGACTTCAAGTTCCCCGGCAAGGGCACACTGACGATCAAGTTCGTCGGTGAAGAT
GGCCAGACCATCGAACATGAAGTCTATCAGGCCCCTTCGGCTGGCGTGGCCATGGCCATGTATAATCTGGACGAATCGAT
CCGCGAATTCGCACGCGCTTCCTTCAATTACGGCTTGCAGCGCGGCTATCCGGTCTATCTCTCCACGAAGAACACCATCC
TCAAGGCCTATGATGGCCGCTTCAAGGACATCTTCCAGGAAGTCTTCGACGCCGAATTCAAGTCGAAGTTTGAAGAAAAG
AAGATCTGGTACGAACACCGCCTCATCGACGACATGGTCGCCTCGGCGCTCAAGTGGTCGGGCGGCTATGTCTGGGCCTG
TAAGAACTATGATGGCGACGTGCAGTCGGATATCGTCGCGCAGGGCTTCGGCTCGCTCGGCCTGATGACCTCGGTTCTGA
TGACGCCGGATGGCAAGACGGTGGAAGCGGAAGCCGCCCACGGCACCGTAACCCGCCACTATCGCCAGCATCAGAAGGGC
GAGGAAACCTCGACCAACTCCATCGCTTCGATCTTCGCATGGACCCGCGGTCTGGCGCATCGCGCCAAGCTCGACAACAA
TGCCGATCTGAAGAAGTTCGCCGAAACGCTGGAAAAGGTCTGCGTGGACACCGTTGAAAGCGGCTTCATGACCAAGGATC
TGGCGCTCCTCATCGGCCCGGATCAGCCTTGGCTCTCGACCACCGGCTTCCTCGACAAGATCGACGAAAATCTTCAGAAA
GCCATGGCTGCCTGA

Upstream 100 bases:

>100_bases
GTCAAACAGGCCTATAGGCCAAAGAATAAGCCTCTTACGCTTTGCCTTATCCTTTACGGGTGCTATACGGGCGCGACGCA
TTCAGAAAGAGGCTTCATCC

Downstream 100 bases:

>100_bases
TTATAGTTCTGGCATTTAGCCAGTGTGGAACCCGGCCTTTCGAGGCCGGGTTTTTCATTTTCCGACCAAAAAGCATCCTG
TTGTCGAAGGCGGCACACTC

Product: isocitrate dehydrogenase

Products: NA

Alternate protein names: IDH; IDP; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase [H]

Number of amino acids: Translated: 404; Mature: 403

Protein sequence:

>404_residues
MAKIKVANPVVELDGDEMTRIIWQFIKDKLIHPYLDIDLKYYDLSVENRDATNDQVTIDAANAIKEYGVGVKCATITPDE
ARVEEFKLKKMWKSPNGTIRNILGGVIFREPIICKNVPRLVPGWTQPIIVGRHAFGDQYRATDFKFPGKGTLTIKFVGED
GQTIEHEVYQAPSAGVAMAMYNLDESIREFARASFNYGLQRGYPVYLSTKNTILKAYDGRFKDIFQEVFDAEFKSKFEEK
KIWYEHRLIDDMVASALKWSGGYVWACKNYDGDVQSDIVAQGFGSLGLMTSVLMTPDGKTVEAEAAHGTVTRHYRQHQKG
EETSTNSIASIFAWTRGLAHRAKLDNNADLKKFAETLEKVCVDTVESGFMTKDLALLIGPDQPWLSTTGFLDKIDENLQK
AMAA

Sequences:

>Translated_404_residues
MAKIKVANPVVELDGDEMTRIIWQFIKDKLIHPYLDIDLKYYDLSVENRDATNDQVTIDAANAIKEYGVGVKCATITPDE
ARVEEFKLKKMWKSPNGTIRNILGGVIFREPIICKNVPRLVPGWTQPIIVGRHAFGDQYRATDFKFPGKGTLTIKFVGED
GQTIEHEVYQAPSAGVAMAMYNLDESIREFARASFNYGLQRGYPVYLSTKNTILKAYDGRFKDIFQEVFDAEFKSKFEEK
KIWYEHRLIDDMVASALKWSGGYVWACKNYDGDVQSDIVAQGFGSLGLMTSVLMTPDGKTVEAEAAHGTVTRHYRQHQKG
EETSTNSIASIFAWTRGLAHRAKLDNNADLKKFAETLEKVCVDTVESGFMTKDLALLIGPDQPWLSTTGFLDKIDENLQK
AMAA
>Mature_403_residues
AKIKVANPVVELDGDEMTRIIWQFIKDKLIHPYLDIDLKYYDLSVENRDATNDQVTIDAANAIKEYGVGVKCATITPDEA
RVEEFKLKKMWKSPNGTIRNILGGVIFREPIICKNVPRLVPGWTQPIIVGRHAFGDQYRATDFKFPGKGTLTIKFVGEDG
QTIEHEVYQAPSAGVAMAMYNLDESIREFARASFNYGLQRGYPVYLSTKNTILKAYDGRFKDIFQEVFDAEFKSKFEEKK
IWYEHRLIDDMVASALKWSGGYVWACKNYDGDVQSDIVAQGFGSLGLMTSVLMTPDGKTVEAEAAHGTVTRHYRQHQKGE
ETSTNSIASIFAWTRGLAHRAKLDNNADLKKFAETLEKVCVDTVESGFMTKDLALLIGPDQPWLSTTGFLDKIDENLQKA
MAA

Specific function: Unknown

COG id: COG0538

COG function: function code C; Isocitrate dehydrogenases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate and isopropylmalate dehydrogenases family [H]

Homologues:

Organism=Homo sapiens, GI28178832, Length=408, Percent_Identity=70.5882352941177, Blast_Score=602, Evalue=1e-172,
Organism=Homo sapiens, GI28178825, Length=410, Percent_Identity=67.8048780487805, Blast_Score=581, Evalue=1e-166,
Organism=Caenorhabditis elegans, GI17550822, Length=407, Percent_Identity=68.0589680589681, Blast_Score=580, Evalue=1e-166,
Organism=Caenorhabditis elegans, GI17540874, Length=402, Percent_Identity=68.1592039800995, Blast_Score=575, Evalue=1e-164,
Organism=Saccharomyces cerevisiae, GI6320137, Length=409, Percent_Identity=65.7701711491442, Blast_Score=552, Evalue=1e-158,
Organism=Saccharomyces cerevisiae, GI6323203, Length=409, Percent_Identity=64.5476772616137, Blast_Score=551, Evalue=1e-158,
Organism=Saccharomyces cerevisiae, GI6324319, Length=409, Percent_Identity=63.5696821515892, Blast_Score=547, Evalue=1e-157,
Organism=Drosophila melanogaster, GI21356561, Length=409, Percent_Identity=65.0366748166259, Blast_Score=562, Evalue=1e-160,
Organism=Drosophila melanogaster, GI221330987, Length=409, Percent_Identity=65.0366748166259, Blast_Score=561, Evalue=1e-160,
Organism=Drosophila melanogaster, GI221330985, Length=409, Percent_Identity=65.0366748166259, Blast_Score=561, Evalue=1e-160,
Organism=Drosophila melanogaster, GI28574947, Length=409, Percent_Identity=65.0366748166259, Blast_Score=561, Evalue=1e-160,
Organism=Drosophila melanogaster, GI24660849, Length=409, Percent_Identity=65.0366748166259, Blast_Score=561, Evalue=1e-160,
Organism=Drosophila melanogaster, GI24660856, Length=409, Percent_Identity=65.0366748166259, Blast_Score=561, Evalue=1e-160,
Organism=Drosophila melanogaster, GI221330983, Length=409, Percent_Identity=65.0366748166259, Blast_Score=561, Evalue=1e-160,
Organism=Drosophila melanogaster, GI24660868, Length=409, Percent_Identity=65.0366748166259, Blast_Score=560, Evalue=1e-160,
Organism=Drosophila melanogaster, GI24660860, Length=409, Percent_Identity=65.0366748166259, Blast_Score=560, Evalue=1e-160,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019818
- InterPro:   IPR001804
- InterPro:   IPR004790 [H]

Pfam domain/function: PF00180 Iso_dh [H]

EC number: =1.1.1.42 [H]

Molecular weight: Translated: 45455; Mature: 45324

Theoretical pI: Translated: 6.13; Mature: 6.13

Prosite motif: PS00470 IDH_IMDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKIKVANPVVELDGDEMTRIIWQFIKDKLIHPYLDIDLKYYDLSVENRDATNDQVTIDA
CCEEEECCCEEEECCHHHHHHHHHHHHHHHCCCEEEEEEEEEEEEECCCCCCCCEEEEEH
ANAIKEYGVGVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGVIFREPIICKNVPRL
HHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHCCCCCC
VPGWTQPIIVGRHAFGDQYRATDFKFPGKGTLTIKFVGEDGQTIEHEVYQAPSAGVAMAM
CCCCCCCEEEEECCCCCCCCCCCCCCCCCCEEEEEEECCCCCCHHHHHHCCCCCCHHHHH
YNLDESIREFARASFNYGLQRGYPVYLSTKNTILKAYDGRFKDIFQEVFDAEFKSKFEEK
HHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCEEEHHCCHHHHHHHHHHHHHHHHHHHHH
KIWYEHRLIDDMVASALKWSGGYVWACKNYDGDVQSDIVAQGFGSLGLMTSVLMTPDGKT
HHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHCCCHHHHHHHHHCCCCCCE
VEAEAAHGTVTRHYRQHQKGEETSTNSIASIFAWTRGLAHRAKLDNNADLKKFAETLEKV
EECCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
CVDTVESGFMTKDLALLIGPDQPWLSTTGFLDKIDENLQKAMAA
HHHHHHCCCCEECEEEEECCCCCCCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
AKIKVANPVVELDGDEMTRIIWQFIKDKLIHPYLDIDLKYYDLSVENRDATNDQVTIDA
CEEEECCCEEEECCHHHHHHHHHHHHHHHCCCEEEEEEEEEEEEECCCCCCCCEEEEEH
ANAIKEYGVGVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGVIFREPIICKNVPRL
HHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHCCCCCC
VPGWTQPIIVGRHAFGDQYRATDFKFPGKGTLTIKFVGEDGQTIEHEVYQAPSAGVAMAM
CCCCCCCEEEEECCCCCCCCCCCCCCCCCCEEEEEEECCCCCCHHHHHHCCCCCCHHHHH
YNLDESIREFARASFNYGLQRGYPVYLSTKNTILKAYDGRFKDIFQEVFDAEFKSKFEEK
HHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCEEEHHCCHHHHHHHHHHHHHHHHHHHHH
KIWYEHRLIDDMVASALKWSGGYVWACKNYDGDVQSDIVAQGFGSLGLMTSVLMTPDGKT
HHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHCCCHHHHHHHHHCCCCCCE
VEAEAAHGTVTRHYRQHQKGEETSTNSIASIFAWTRGLAHRAKLDNNADLKKFAETLEKV
EECCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
CVDTVESGFMTKDLALLIGPDQPWLSTTGFLDKIDENLQKAMAA
HHHHHHCCCCEECEEEEECCCCCCCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8626059 [H]