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The map label for this gene is pccB [H]

Identifier: 225852684

GI number: 225852684

Start: 1181773

End: 1182507

Strand: Direct

Name: pccB [H]

Synonym: BMEA_A1232

Alternate gene names: 225852684

Gene position: 1181773-1182507 (Clockwise)

Preceding gene: 225852682

Following gene: 225852685

Centisome position: 55.59

GC content: 59.05

Gene sequence:

>735_bases
ATGCGCCTCGACACGCTCGTACCGGACAGCGCCACCAAGCCCTACGACATGAAGGAGCTGATTCTCGCGCTTGCCGACGA
AGGCGATTTCTTCGAGATTCAGGAAGCCTTCGCGAAGAACATCATAACCGGCTTCATCCGCATGGATGGCCAGACGGTCG
GTGTGGTTGCCAATCAGCCGATGGTTCTGGCGGGCTGCCTCGATATCGACGCCTCGCGCAAGGCTGCACGTTTCGTGCGC
TTCTGCGATGCCTTCAACATTCCGATCCTGACGCTCGTGGACGTTCCGGGCTTCCTGCCCGGCACGGCACAGGAATATGG
CGGCGTCATCAAGCACGGCGCGAAGCTTCTTTTCGCCTATTCCCAGGCAACCGTGCCGATGGTCACGCTCATCACGCGCA
AGGCCTATGGCGGCGCCTATGACGTGATGGCTTCGAAACATATCGGTGCCGACATCAATTATGCATGGCCAACTGCGGAA
ATCGCGGTGATGGGCGCCAAGGGCGCAACGGAAATCCTCTATCGTTCGGAACTGGGCGACCCGGAAAAGATCGCCGCGCG
CACGAAGGAATATGAGGAGCGTTTTGCCAATCCATTCGTGGCTGCGGAGCGTGGCTTCATTGATGAGGTCATCATGCCGC
ATTCCTCACGCCGCCGCATTGCCCGCGCTTTTGCAAGCCTGCGCAACAAGCAGCAGAGCGCACCATGGAAAAAGCACGAC
ACCATCCCGCTCTAA

Upstream 100 bases:

>100_bases
GGCTCTGGAACAGGTACGCATCCTGTTCGACTTCCTGCCGCTCAACAATCGCGAGAAGCCACCTGTTCGCCCGATCTTCG
ATGATCCGGCGCGCCTTGAA

Downstream 100 bases:

>100_bases
TTTCGCATGATCTTATCCGCAAGCCGGTTCCCACTTTTTGGGGTCATGCCATGGCAATGATCCGGTTCATTTGAGTAAAC
GCACATGATCAAGAAAATCC

Product: propionyl-CoA carboxylase subunit beta

Products: NA

Alternate protein names: PCCase; Propanoyl-CoA:carbon dioxide ligase [H]

Number of amino acids: Translated: 244; Mature: 244

Protein sequence:

>244_residues
MRLDTLVPDSATKPYDMKELILALADEGDFFEIQEAFAKNIITGFIRMDGQTVGVVANQPMVLAGCLDIDASRKAARFVR
FCDAFNIPILTLVDVPGFLPGTAQEYGGVIKHGAKLLFAYSQATVPMVTLITRKAYGGAYDVMASKHIGADINYAWPTAE
IAVMGAKGATEILYRSELGDPEKIAARTKEYEERFANPFVAAERGFIDEVIMPHSSRRRIARAFASLRNKQQSAPWKKHD
TIPL

Sequences:

>Translated_244_residues
MRLDTLVPDSATKPYDMKELILALADEGDFFEIQEAFAKNIITGFIRMDGQTVGVVANQPMVLAGCLDIDASRKAARFVR
FCDAFNIPILTLVDVPGFLPGTAQEYGGVIKHGAKLLFAYSQATVPMVTLITRKAYGGAYDVMASKHIGADINYAWPTAE
IAVMGAKGATEILYRSELGDPEKIAARTKEYEERFANPFVAAERGFIDEVIMPHSSRRRIARAFASLRNKQQSAPWKKHD
TIPL
>Mature_244_residues
MRLDTLVPDSATKPYDMKELILALADEGDFFEIQEAFAKNIITGFIRMDGQTVGVVANQPMVLAGCLDIDASRKAARFVR
FCDAFNIPILTLVDVPGFLPGTAQEYGGVIKHGAKLLFAYSQATVPMVTLITRKAYGGAYDVMASKHIGADINYAWPTAE
IAVMGAKGATEILYRSELGDPEKIAARTKEYEERFANPFVAAERGFIDEVIMPHSSRRRIARAFASLRNKQQSAPWKKHD
TIPL

Specific function: This Protein Is A Component Of The Acetyl Coenzyme A Carboxylase Complex; First, Biotin Carboxylase Catalyzes The Carboxylation Of The Carrier Protein And Then The Transcarboxylase Transfers The Carboxyl Group To Form Malonyl-CoA. [C]

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI119943100, Length=242, Percent_Identity=62.8099173553719, Blast_Score=327, Evalue=8e-90,
Organism=Homo sapiens, GI295821216, Length=242, Percent_Identity=62.8099173553719, Blast_Score=326, Evalue=1e-89,
Organism=Homo sapiens, GI11545863, Length=251, Percent_Identity=29.4820717131474, Blast_Score=110, Evalue=9e-25,
Organism=Caenorhabditis elegans, GI25147362, Length=242, Percent_Identity=61.9834710743802, Blast_Score=331, Evalue=2e-91,
Organism=Caenorhabditis elegans, GI25147359, Length=242, Percent_Identity=61.9834710743802, Blast_Score=331, Evalue=2e-91,
Organism=Caenorhabditis elegans, GI17552936, Length=238, Percent_Identity=30.672268907563, Blast_Score=122, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24586065, Length=244, Percent_Identity=27.8688524590164, Blast_Score=108, Evalue=4e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000438
- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762 [H]

Pfam domain/function: PF01039 Carboxyl_trans [H]

EC number: =6.4.1.3 [H]

Molecular weight: Translated: 26903; Mature: 26903

Theoretical pI: Translated: 7.56; Mature: 7.56

Prosite motif: PS50989 COA_CT_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLDTLVPDSATKPYDMKELILALADEGDFFEIQEAFAKNIITGFIRMDGQTVGVVANQP
CCCCCCCCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHEECCEEEEEEECCC
MVLAGCLDIDASRKAARFVRFCDAFNIPILTLVDVPGFLPGTAQEYGGVIKHGAKLLFAY
EEEEEEECCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCHHHHCHHHHHCHHEEEEE
SQATVPMVTLITRKAYGGAYDVMASKHIGADINYAWPTAEIAVMGAKGATEILYRSELGD
CCCCCHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCCEEEEEECCCCHHHHHHHHCCCC
PEKIAARTKEYEERFANPFVAAERGFIDEVIMPHSSRRRIARAFASLRNKQQSAPWKKHD
HHHHHHHHHHHHHHHCCCCHHHHCCCHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCC
TIPL
CCCC
>Mature Secondary Structure
MRLDTLVPDSATKPYDMKELILALADEGDFFEIQEAFAKNIITGFIRMDGQTVGVVANQP
CCCCCCCCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHEECCEEEEEEECCC
MVLAGCLDIDASRKAARFVRFCDAFNIPILTLVDVPGFLPGTAQEYGGVIKHGAKLLFAY
EEEEEEECCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCHHHHCHHHHHCHHEEEEE
SQATVPMVTLITRKAYGGAYDVMASKHIGADINYAWPTAEIAVMGAKGATEILYRSELGD
CCCCCHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCCEEEEEECCCCHHHHHHHHCCCC
PEKIAARTKEYEERFANPFVAAERGFIDEVIMPHSSRRRIARAFASLRNKQQSAPWKKHD
HHHHHHHHHHHHHHHCCCCHHHHCCCHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCC
TIPL
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8830278 [H]