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The map label for this gene is trpC

Identifier: 225852640

GI number: 225852640

Start: 1138624

End: 1139430

Strand: Direct

Name: trpC

Synonym: BMEA_A1185

Alternate gene names: 225852640

Gene position: 1138624-1139430 (Clockwise)

Preceding gene: 225852639

Following gene: 225852641

Centisome position: 53.56

GC content: 58.36

Gene sequence:

>807_bases
ATGTCCACCGATATTCTTCGCAAGATCGAAGCCTATAAGCGGGAAGAAATAGCCGCCGCCAAGGCGCGTCTTGCCCTTGA
TGAACTGAAGGCCCGGACGAGGGATCAGTCAGCGCCGCGCGGTTTTCTGAAGGCACTTGAGGCCAAGCGCGCCGCCGGTC
AATTTGCACTGATCGCGGAGATAAAGAAAGCAAGCCCGTCCAAAGGCTTGATCCGCCCCGATTTCGACCCGCCAGCGCTT
GCAAAGGCTTATGAAGAAGGCGGTGCGGCCTGTCTTTCCGTGCTGACCGACACGCCTTCCTTTCAGGGCGCGCCGGAATT
CCTCACGGCCGCACGCCAGGCTTGCAGCCTGCCCGCATTGCGCAAGGATTTCCTGTTCGACCCCTATCAGGTCTATGAAG
CGCGTAGCTGGGGAGCGGATTGCATTCTCATCATCATGGCCAGCGTCGATGACGATCTTGCAAAAGAGCTGGAAGACACG
GCTTTCGCACTGGGCATGGATGCGCTGATCGAAGTGCATGACGAAGCTGAAATGGAACGCGCCCTGAAGCTTTCCTCGCG
CCTGCTCGGCGTCAACAATCGCAATCTGCGCAGCTTCGAGGTCAATCTCGCCGTTTCCGAGCGGCTTGCGAAAATGGCTC
CGTCCGACCGTCTGCTGGTTGGCGAAAGCGGCATCTTCACGCATGAGGACTGCCTGCGGCTTGAAAAGTCCGGCATCGGC
ACTTTTCTGATAGGCGAAAGCCTTATGCGACAACATGACGTTGCGGCAGCCACCCGCGCGCTTTTGACGGGTGCGGAAAA
GCTATGA

Upstream 100 bases:

>100_bases
CAAGCCGTACAGTCCATCGACAGCGGCGCAGCCCTTGCGGTTTTGCAAAAGGTCATTGCCGTTTCCAACGACAAGCCGGC
CTGACAGGAAGGATCGCGCC

Downstream 100 bases:

>100_bases
GCGGCAAACTCACCCATATCGACCAGACCGGCGCGGCAAACATGGTGGATGTCGGCAGCAAGGACGAAACCGAGCGGCAG
GCGGTCGCCGAAGGTGCGGT

Product: indole-3-glycerol-phosphate synthase

Products: NA

Alternate protein names: IGPS

Number of amino acids: Translated: 268; Mature: 267

Protein sequence:

>268_residues
MSTDILRKIEAYKREEIAAAKARLALDELKARTRDQSAPRGFLKALEAKRAAGQFALIAEIKKASPSKGLIRPDFDPPAL
AKAYEEGGAACLSVLTDTPSFQGAPEFLTAARQACSLPALRKDFLFDPYQVYEARSWGADCILIIMASVDDDLAKELEDT
AFALGMDALIEVHDEAEMERALKLSSRLLGVNNRNLRSFEVNLAVSERLAKMAPSDRLLVGESGIFTHEDCLRLEKSGIG
TFLIGESLMRQHDVAAATRALLTGAEKL

Sequences:

>Translated_268_residues
MSTDILRKIEAYKREEIAAAKARLALDELKARTRDQSAPRGFLKALEAKRAAGQFALIAEIKKASPSKGLIRPDFDPPAL
AKAYEEGGAACLSVLTDTPSFQGAPEFLTAARQACSLPALRKDFLFDPYQVYEARSWGADCILIIMASVDDDLAKELEDT
AFALGMDALIEVHDEAEMERALKLSSRLLGVNNRNLRSFEVNLAVSERLAKMAPSDRLLVGESGIFTHEDCLRLEKSGIG
TFLIGESLMRQHDVAAATRALLTGAEKL
>Mature_267_residues
STDILRKIEAYKREEIAAAKARLALDELKARTRDQSAPRGFLKALEAKRAAGQFALIAEIKKASPSKGLIRPDFDPPALA
KAYEEGGAACLSVLTDTPSFQGAPEFLTAARQACSLPALRKDFLFDPYQVYEARSWGADCILIIMASVDDDLAKELEDTA
FALGMDALIEVHDEAEMERALKLSSRLLGVNNRNLRSFEVNLAVSERLAKMAPSDRLLVGESGIFTHEDCLRLEKSGIGT
FLIGESLMRQHDVAAATRALLTGAEKL

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0134

COG function: function code E; Indole-3-glycerol phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpC family

Homologues:

Organism=Escherichia coli, GI87081863, Length=264, Percent_Identity=39.7727272727273, Blast_Score=170, Evalue=8e-44,
Organism=Saccharomyces cerevisiae, GI6322638, Length=207, Percent_Identity=39.6135265700483, Blast_Score=145, Evalue=6e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TRPC_BRUA1 (B2S5Z1)

Other databases:

- EMBL:   CP000887
- RefSeq:   YP_001935062.1
- ProteinModelPortal:   B2S5Z1
- SMR:   B2S5Z1
- GeneID:   6328630
- GenomeReviews:   CP000887_GR
- KEGG:   bmc:BAbS19_I10810
- HOGENOM:   HBG540956
- OMA:   LRKDFMF
- ProtClustDB:   PRK00278
- HAMAP:   MF_00134_B
- InterPro:   IPR013785
- InterPro:   IPR013798
- InterPro:   IPR001468
- InterPro:   IPR011060
- Gene3D:   G3DSA:3.20.20.70

Pfam domain/function: PF00218 IGPS; SSF51366 RibP_bind_barrel

EC number: =4.1.1.48

Molecular weight: Translated: 29269; Mature: 29138

Theoretical pI: Translated: 5.28; Mature: 5.28

Prosite motif: PS00614 IGPS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTDILRKIEAYKREEIAAAKARLALDELKARTRDQSAPRGFLKALEAKRAAGQFALIAE
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCHHHHHH
IKKASPSKGLIRPDFDPPALAKAYEEGGAACLSVLTDTPSFQGAPEFLTAARQACSLPAL
HHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCHHH
RKDFLFDPYQVYEARSWGADCILIIMASVDDDLAKELEDTAFALGMDALIEVHDEAEMER
HHHHCCCHHHHHHHHCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALKLSSRLLGVNNRNLRSFEVNLAVSERLAKMAPSDRLLVGESGIFTHEDCLRLEKSGIG
HHHHHHHHHCCCCCCCEEEEEHHHHHHHHHHHCCCCCEEECCCCCCCHHHHHHHHHCCCC
TFLIGESLMRQHDVAAATRALLTGAEKL
HHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
STDILRKIEAYKREEIAAAKARLALDELKARTRDQSAPRGFLKALEAKRAAGQFALIAE
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCHHHHHH
IKKASPSKGLIRPDFDPPALAKAYEEGGAACLSVLTDTPSFQGAPEFLTAARQACSLPAL
HHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCHHH
RKDFLFDPYQVYEARSWGADCILIIMASVDDDLAKELEDTAFALGMDALIEVHDEAEMER
HHHHCCCHHHHHHHHCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALKLSSRLLGVNNRNLRSFEVNLAVSERLAKMAPSDRLLVGESGIFTHEDCLRLEKSGIG
HHHHHHHHHCCCCCCCEEEEEHHHHHHHHHHHCCCCCEEECCCCCCCHHHHHHHHHCCCC
TFLIGESLMRQHDVAAATRALLTGAEKL
HHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA