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The map label for this gene is mmgC [H]

Identifier: 225852588

GI number: 225852588

Start: 1076605

End: 1077789

Strand: Reverse

Name: mmgC [H]

Synonym: BMEA_A1130

Alternate gene names: 225852588

Gene position: 1077789-1076605 (Counterclockwise)

Preceding gene: 225852589

Following gene: 225852587

Centisome position: 50.7

GC content: 56.71

Gene sequence:

>1185_bases
ATGTCACGTGCGGCTTTTGCCTGGGAAGATCCGTTTTTGCTGGAGGAGCAACTGACCGAAGACGAGCGCATGATCCGCGA
CTCGGCCAAGGCCTTTGCAAGCGACGTTCTTCTGCCTCGTGTCGAAAAAGCCTATCTGGAAGAAACCACCGACCCGGAAC
TGTTTCACCTCATGGGGCAGGCGGGGCTTCTGGGCGTAACGCTGCCGGAAGACTATGGCGCGGCCAATGCAAGCTATGTA
GCCTATGGGCTGGTGGCGCGCGAAGTGGAGCGCATTGATTCGGGATATCGTTCCATGATGAGCGTGCAATCGTCGCTCGT
CATGTATCCGATCTATGCCTATGGTTCGGATGAACAGCGCAAGAAATATCTTCCCGGCCTGGTTTCGGGTGAATTGATTG
GCTGTTTCGGCCTTACCGAACCCGATGCGGGTTCCGACCCGGCTGGCATGAAAACCCGCGCCGAAAAGATCGATGGCGGC
TATCGCCTCAGCGGCTCGAAGATGTGGATTTCCAATTCACCGATTGCCGATGTGTTCGTCGTCTGGGCAAAATCGGCTGC
GCATGACAACGCCATTCGCGGCTTCATTCTTGAAAAGGGCATGAAGGGACTTTCAGCACCGAAGATCGGGGGCAAGCTTT
CGCTGCGCGCTTCTATCACCGGCGAGATCGTGATGGATGGGGTTGAAGTTTCCGAAGACGCAATCCTGCCGAGTGTTTCC
GGTCTCAAGGGCCCGTTTGGCTGTCTCAACCGCGCGCGCTATGGCATTTCGTGGGGTGTGATCGGGGCTGCTGAAGATTG
CTGGTTCCGTGCGCGCCAATATGGTCTGGACCGCAAGCAATTCAACAAGCCGCTGGCTGGCACGCAGCTTTACCAGAAGA
AGCTTGCCGATATGCAGACGGAAATCGCGCTTGGGATTCAGGCATCGCTTCGCGTTGGCCGCCTGTTCGATGAAGGCAAG
ATGGCGCCCGAAATGATTTCTATCGTCAAGCGCAACAATTGCGACAAGGCTCTGGATATTGCCCGCCAGGCCCGTGATAT
GCATGGCGGCAACGGTATCCAGATTGAATATCACGTCATGCGCCACGCGCAGAATCTGGAAACCGTCAACACCTATGAGG
GCACGCACGACGTTCACGCGCTGATTCTCGGCCGTGCCCAGACCGGCATTCAGGCGTTCTTCTGA

Upstream 100 bases:

>100_bases
ATCTATTACTAAACGGAATAGATCGATGAGTAAACGTCGATTGCGTTCATCGTCGTGCCGCTCCATATTCCCTGCATATT
CAATCTGAGGAGAATACCTG

Downstream 100 bases:

>100_bases
TCGTCGGTTCCAAGCCTGCTTTTGGCCCGCTCGCAATTTGCGGGCGGGCTTTCTTATATTCATTTGGGATTGCTGAACAT
GCAGAACACACCGCTTGACG

Product: glutaryl-CoA dehydrogenase

Products: crotonoyl-CoA; CO2; reduced acceptor

Alternate protein names: NA

Number of amino acids: Translated: 394; Mature: 393

Protein sequence:

>394_residues
MSRAAFAWEDPFLLEEQLTEDERMIRDSAKAFASDVLLPRVEKAYLEETTDPELFHLMGQAGLLGVTLPEDYGAANASYV
AYGLVAREVERIDSGYRSMMSVQSSLVMYPIYAYGSDEQRKKYLPGLVSGELIGCFGLTEPDAGSDPAGMKTRAEKIDGG
YRLSGSKMWISNSPIADVFVVWAKSAAHDNAIRGFILEKGMKGLSAPKIGGKLSLRASITGEIVMDGVEVSEDAILPSVS
GLKGPFGCLNRARYGISWGVIGAAEDCWFRARQYGLDRKQFNKPLAGTQLYQKKLADMQTEIALGIQASLRVGRLFDEGK
MAPEMISIVKRNNCDKALDIARQARDMHGGNGIQIEYHVMRHAQNLETVNTYEGTHDVHALILGRAQTGIQAFF

Sequences:

>Translated_394_residues
MSRAAFAWEDPFLLEEQLTEDERMIRDSAKAFASDVLLPRVEKAYLEETTDPELFHLMGQAGLLGVTLPEDYGAANASYV
AYGLVAREVERIDSGYRSMMSVQSSLVMYPIYAYGSDEQRKKYLPGLVSGELIGCFGLTEPDAGSDPAGMKTRAEKIDGG
YRLSGSKMWISNSPIADVFVVWAKSAAHDNAIRGFILEKGMKGLSAPKIGGKLSLRASITGEIVMDGVEVSEDAILPSVS
GLKGPFGCLNRARYGISWGVIGAAEDCWFRARQYGLDRKQFNKPLAGTQLYQKKLADMQTEIALGIQASLRVGRLFDEGK
MAPEMISIVKRNNCDKALDIARQARDMHGGNGIQIEYHVMRHAQNLETVNTYEGTHDVHALILGRAQTGIQAFF
>Mature_393_residues
SRAAFAWEDPFLLEEQLTEDERMIRDSAKAFASDVLLPRVEKAYLEETTDPELFHLMGQAGLLGVTLPEDYGAANASYVA
YGLVAREVERIDSGYRSMMSVQSSLVMYPIYAYGSDEQRKKYLPGLVSGELIGCFGLTEPDAGSDPAGMKTRAEKIDGGY
RLSGSKMWISNSPIADVFVVWAKSAAHDNAIRGFILEKGMKGLSAPKIGGKLSLRASITGEIVMDGVEVSEDAILPSVSG
LKGPFGCLNRARYGISWGVIGAAEDCWFRARQYGLDRKQFNKPLAGTQLYQKKLADMQTEIALGIQASLRVGRLFDEGKM
APEMISIVKRNNCDKALDIARQARDMHGGNGIQIEYHVMRHAQNLETVNTYEGTHDVHALILGRAQTGIQAFF

Specific function: Catalyzes the reduction of crotonobetainyl-CoA to gamma-butyrobetainyl-CoA. [C]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4503943, Length=394, Percent_Identity=65.2284263959391, Blast_Score=528, Evalue=1e-150,
Organism=Homo sapiens, GI7669494, Length=374, Percent_Identity=63.903743315508, Blast_Score=490, Evalue=1e-139,
Organism=Homo sapiens, GI226958412, Length=376, Percent_Identity=30.5851063829787, Blast_Score=170, Evalue=3e-42,
Organism=Homo sapiens, GI4557233, Length=371, Percent_Identity=30.4582210242588, Blast_Score=167, Evalue=2e-41,
Organism=Homo sapiens, GI4501859, Length=371, Percent_Identity=31.266846361186, Blast_Score=166, Evalue=3e-41,
Organism=Homo sapiens, GI226958414, Length=346, Percent_Identity=31.5028901734104, Blast_Score=163, Evalue=2e-40,
Organism=Homo sapiens, GI4557231, Length=376, Percent_Identity=30.0531914893617, Blast_Score=153, Evalue=3e-37,
Organism=Homo sapiens, GI187960098, Length=376, Percent_Identity=30.0531914893617, Blast_Score=153, Evalue=3e-37,
Organism=Homo sapiens, GI76496475, Length=386, Percent_Identity=29.2746113989637, Blast_Score=150, Evalue=2e-36,
Organism=Homo sapiens, GI4557235, Length=386, Percent_Identity=29.2746113989637, Blast_Score=150, Evalue=2e-36,
Organism=Homo sapiens, GI21361497, Length=395, Percent_Identity=28.3544303797468, Blast_Score=140, Evalue=3e-33,
Organism=Homo sapiens, GI4501857, Length=375, Percent_Identity=27.4666666666667, Blast_Score=132, Evalue=7e-31,
Organism=Homo sapiens, GI7656849, Length=384, Percent_Identity=28.6458333333333, Blast_Score=128, Evalue=1e-29,
Organism=Escherichia coli, GI1786223, Length=339, Percent_Identity=24.188790560472, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI87081958, Length=382, Percent_Identity=24.3455497382199, Blast_Score=74, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17534353, Length=388, Percent_Identity=63.4020618556701, Blast_Score=509, Evalue=1e-145,
Organism=Caenorhabditis elegans, GI17538396, Length=375, Percent_Identity=33.6, Blast_Score=179, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI17506239, Length=365, Percent_Identity=31.2328767123288, Blast_Score=164, Evalue=5e-41,
Organism=Caenorhabditis elegans, GI17508101, Length=371, Percent_Identity=30.4582210242588, Blast_Score=160, Evalue=9e-40,
Organism=Caenorhabditis elegans, GI17569725, Length=375, Percent_Identity=29.3333333333333, Blast_Score=151, Evalue=7e-37,
Organism=Caenorhabditis elegans, GI71990804, Length=254, Percent_Identity=34.251968503937, Blast_Score=144, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI17534899, Length=377, Percent_Identity=28.6472148541114, Blast_Score=142, Evalue=3e-34,
Organism=Caenorhabditis elegans, GI17570075, Length=379, Percent_Identity=27.7044854881267, Blast_Score=138, Evalue=4e-33,
Organism=Caenorhabditis elegans, GI32563615, Length=230, Percent_Identity=36.0869565217391, Blast_Score=134, Evalue=9e-32,
Organism=Caenorhabditis elegans, GI71985184, Length=364, Percent_Identity=28.8461538461538, Blast_Score=130, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI71985192, Length=267, Percent_Identity=30.7116104868914, Blast_Score=117, Evalue=7e-27,
Organism=Caenorhabditis elegans, GI71982178, Length=270, Percent_Identity=29.6296296296296, Blast_Score=115, Evalue=4e-26,
Organism=Caenorhabditis elegans, GI17533517, Length=375, Percent_Identity=23.7333333333333, Blast_Score=97, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17551932, Length=293, Percent_Identity=25.938566552901, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17505929, Length=249, Percent_Identity=25.3012048192771, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI19920834, Length=392, Percent_Identity=59.4387755102041, Blast_Score=462, Evalue=1e-130,
Organism=Drosophila melanogaster, GI24666513, Length=365, Percent_Identity=31.2328767123288, Blast_Score=179, Evalue=3e-45,
Organism=Drosophila melanogaster, GI24660351, Length=379, Percent_Identity=31.6622691292876, Blast_Score=166, Evalue=3e-41,
Organism=Drosophila melanogaster, GI21356377, Length=370, Percent_Identity=28.9189189189189, Blast_Score=164, Evalue=1e-40,
Organism=Drosophila melanogaster, GI21355753, Length=375, Percent_Identity=31.4666666666667, Blast_Score=157, Evalue=9e-39,
Organism=Drosophila melanogaster, GI24646207, Length=373, Percent_Identity=29.7587131367292, Blast_Score=157, Evalue=1e-38,
Organism=Drosophila melanogaster, GI281363737, Length=408, Percent_Identity=26.9607843137255, Blast_Score=135, Evalue=5e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.7

Molecular weight: Translated: 43264; Mature: 43133

Theoretical pI: Translated: 5.96; Mature: 5.96

Prosite motif: PS00072 ACYL_COA_DH_1 ; PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRAAFAWEDPFLLEEQLTEDERMIRDSAKAFASDVLLPRVEKAYLEETTDPELFHLMGQ
CCCCCCCCCCCCHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCC
AGLLGVTLPEDYGAANASYVAYGLVAREVERIDSGYRSMMSVQSSLVMYPIYAYGSDEQR
CCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEECCCCHHH
KKYLPGLVSGELIGCFGLTEPDAGSDPAGMKTRAEKIDGGYRLSGSKMWISNSPIADVFV
HHHCCCCCCCCEEEEECCCCCCCCCCCCCCCHHHHHCCCCEEECCCEEEECCCCHHHHHH
VWAKSAAHDNAIRGFILEKGMKGLSAPKIGGKLSLRASITGEIVMDGVEVSEDAILPSVS
HHHHCCCCCHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCEEEECCCCCCCCCCCCCCC
GLKGPFGCLNRARYGISWGVIGAAEDCWFRARQYGLDRKQFNKPLAGTQLYQKKLADMQT
CCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCHHHHCCCCCHHHHHHHHHHHHHH
EIALGIQASLRVGRLFDEGKMAPEMISIVKRNNCDKALDIARQARDMHGGNGIQIEYHVM
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCEEEEEHHH
RHAQNLETVNTYEGTHDVHALILGRAQTGIQAFF
HHHHCCCCEECCCCCCCEEEEEEECHHCCHHHCC
>Mature Secondary Structure 
SRAAFAWEDPFLLEEQLTEDERMIRDSAKAFASDVLLPRVEKAYLEETTDPELFHLMGQ
CCCCCCCCCCCHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCC
AGLLGVTLPEDYGAANASYVAYGLVAREVERIDSGYRSMMSVQSSLVMYPIYAYGSDEQR
CCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEECCCCHHH
KKYLPGLVSGELIGCFGLTEPDAGSDPAGMKTRAEKIDGGYRLSGSKMWISNSPIADVFV
HHHCCCCCCCCEEEEECCCCCCCCCCCCCCCHHHHHCCCCEEECCCEEEECCCCHHHHHH
VWAKSAAHDNAIRGFILEKGMKGLSAPKIGGKLSLRASITGEIVMDGVEVSEDAILPSVS
HHHHCCCCCHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCEEEECCCCCCCCCCCCCCC
GLKGPFGCLNRARYGISWGVIGAAEDCWFRARQYGLDRKQFNKPLAGTQLYQKKLADMQT
CCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCHHHHCCCCCHHHHHHHHHHHHHH
EIALGIQASLRVGRLFDEGKMAPEMISIVKRNNCDKALDIARQARDMHGGNGIQIEYHVM
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCEEEEEHHH
RHAQNLETVNTYEGTHDVHALILGRAQTGIQAFF
HHHHCCCCEECCCCCCCEEEEEEECHHCCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: glutaryl-CoA; acceptor

Specific reaction: glutaryl-CoA + acceptor = crotonoyl-CoA + CO2 + reduced acceptor

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8759838; 8969508; 9384377 [H]