Click here to switch to the map view.

The map label for this gene is thrS [H]

Identifier: 225852573

GI number: 225852573

Start: 1059753

End: 1061729

Strand: Reverse

Name: thrS [H]

Synonym: BMEA_A1112

Alternate gene names: 225852573

Gene position: 1061729-1059753 (Counterclockwise)

Preceding gene: 225852574

Following gene: 225852571

Centisome position: 49.95

GC content: 56.35

Gene sequence:

>1977_bases
ATGTCGAATACCGTTTCCCTGCAATTTCCCGATGGTTCCGTACGTGAATACGATGCATCGATGACAGGGGCCGCCCTTGC
GGAATCAATTTCCAAGTCGCTTGCCAAGAAGGCTGTCGCTTACGCTGTTGATGGCACGGTTCGTGATCTTTCCGATCCGC
TTGGCGCTTCCGGCAAGGTGGAAATCATCACCCGCGAAGACCCGCGCGCGCTGGAACTCATCCGCCACGACACTGCCCAT
GTGCTTGCAGAAGCCGTGCAGGAGCTTTTTCCCGGAACGCAGGTAACGATCGGCCCCGTGATCGAAAACGGCTTCTATTA
CGACTTTGCGCGCAACGAGCCGTTTACGCTCGATGACCTGCCGGTGATCGAAAAGAAGATGCGCGAGATCATTCAGCGCA
ACAAGCCGTTCACCAAGGAAGTCTGGTCACGCGAGAAGGCCAAACAGGTTTTTTCCGACAAGGGCGAAAGCTACAAGGTC
GAGCTGGTCGATGCCATTCCGGCCGGGCAGGACCTCAAGATCTATTATCAGGGTGACTGGTTCGACCTTTGCCGCGGGCC
GCATATGGCTTCCACGGGTCAGATCGGCAATTCATTCAAGTTGATGAAGGTGGCGGGCGCTTATTGGCGCGGCGATGCCA
ATAATCCGATGCTGACCCGCATCTACGGCACCGCCTTTGCAAACGATAATGACCTTCAAGCCTATCTCCATATGCTTGAG
GAAGCGGAGAAGCGCGACCACCGCCGCCTTGGCCGCGAAATGGACCTGTTCCATTTCCAGGAAGAGGGGCCGGGCGTCGT
GTTCTGGCACGCCAAAGGCTGGAAGATGTTCCAGAATCTGGTGAGCTATATGCGCCGCCGCCTCGACAGCCATGGCTATC
AGGAAGTGAATACGCCGCAGGTGCTGGACAAGTCGCTGTGGGAAACCTCCGGCCACTGGGGCTGGTATCGCGACAATATG
TTCAAGGTTACGGTTGCCGGTGACGATACCGACGATGACCGTGTCTTTGCGCTGAAGCCGATGAACTGCCCCGGCCATGT
GCAGATATTCAAGCATGGCCTTAAATCATACCGCGATCTTCCTATAAAGCTTGCGGAATTCGGCAATGTGCACCGCTATG
AGCCTTCCGGTGCGCTGCACGGGCTGATGCGTGTGCGCGGTTTCACGCAGGACGATGCGCATATTTTCTGCACTGAAGAG
CAGATGGCGGCGGAATGCCTGCAAATCAATGATCATATCTTGTCGGTCTATAAGGATTTCGGCTTCGAGGAAATCACCAT
CAAGCTCTCGACGCGCCCGGAAAAGCGCGTTGGCTCGGATGAGCTTTGGGATCGTGCCGAAAGCGTGATGATGACCGTTC
TGGAGCAGATCCGGCAGCAGTCGAACAATATCAAGACCGGCATTCTGCCGGGCGAGGGTGCGTTCTACGGGCCGAAGTTT
GAATATACGCTGAAGGACGCCATCGGCCGTGAATGGCAGTGCGGCACCACGCAGGTCGATTTCAACCTGCCGGAACGCTT
CGGCGCCTTCTATATCGGCGCGGATTCGGAAAAGAAGCAGCCGGTCATGATCCATCGCGCCATCTGCGGCTCGATGGAAC
GTTTCCTCGGCATTCTGATCGAGAATTTTGCCGGTCACATGCCGCTCTGGTTTGCGCCGGTACAGGTGGTTGTTGCAACC
ATCACGTCGGATGCCGATGAATATGCAAAGGAAGCGGCTGCGAAGCTCAAGGCTGCCGGTCTTCAGGTCGTGACCGATCT
GCGCAACGAGAAGATCAACTACAAGGTTCGCGAACATTCGCTCCAGAAAGTTCCGGTCATCCTCGTTTGCGGCAAGCGTG
AAGCAGAAGAAAAGACTGTCAACATGCGCCGTCTCGGCTCACGCGATCAGGAATCCATGACGCTGGATGAAGCGATTGCC
CGGCTTTGCGAAGAGGCGACCCCGCCCGATCTGCTTCGCCTGAAAAATGCAGGCTGA

Upstream 100 bases:

>100_bases
CTTTACTGCCTATGCAAAAGGGAATATGAGCCAAACTCATTTTCTATGCATGAGACGAACCACCCGCAATCGTTGGCGGG
ACTGGATAAGGATGATGACA

Downstream 100 bases:

>100_bases
TAAAAAGATACGTAAAAAGGCCGCGCGATGCGGCCTTTTTATTGCTCTATTGGATCAGTCGACAATGTCATCGGAGGCTT
CCGAATCGCTGTTGGCAAGA

Product: threonyl-tRNA synthetase

Products: NA

Alternate protein names: Threonine--tRNA ligase; ThrRS [H]

Number of amino acids: Translated: 658; Mature: 657

Protein sequence:

>658_residues
MSNTVSLQFPDGSVREYDASMTGAALAESISKSLAKKAVAYAVDGTVRDLSDPLGASGKVEIITREDPRALELIRHDTAH
VLAEAVQELFPGTQVTIGPVIENGFYYDFARNEPFTLDDLPVIEKKMREIIQRNKPFTKEVWSREKAKQVFSDKGESYKV
ELVDAIPAGQDLKIYYQGDWFDLCRGPHMASTGQIGNSFKLMKVAGAYWRGDANNPMLTRIYGTAFANDNDLQAYLHMLE
EAEKRDHRRLGREMDLFHFQEEGPGVVFWHAKGWKMFQNLVSYMRRRLDSHGYQEVNTPQVLDKSLWETSGHWGWYRDNM
FKVTVAGDDTDDDRVFALKPMNCPGHVQIFKHGLKSYRDLPIKLAEFGNVHRYEPSGALHGLMRVRGFTQDDAHIFCTEE
QMAAECLQINDHILSVYKDFGFEEITIKLSTRPEKRVGSDELWDRAESVMMTVLEQIRQQSNNIKTGILPGEGAFYGPKF
EYTLKDAIGREWQCGTTQVDFNLPERFGAFYIGADSEKKQPVMIHRAICGSMERFLGILIENFAGHMPLWFAPVQVVVAT
ITSDADEYAKEAAAKLKAAGLQVVTDLRNEKINYKVREHSLQKVPVILVCGKREAEEKTVNMRRLGSRDQESMTLDEAIA
RLCEEATPPDLLRLKNAG

Sequences:

>Translated_658_residues
MSNTVSLQFPDGSVREYDASMTGAALAESISKSLAKKAVAYAVDGTVRDLSDPLGASGKVEIITREDPRALELIRHDTAH
VLAEAVQELFPGTQVTIGPVIENGFYYDFARNEPFTLDDLPVIEKKMREIIQRNKPFTKEVWSREKAKQVFSDKGESYKV
ELVDAIPAGQDLKIYYQGDWFDLCRGPHMASTGQIGNSFKLMKVAGAYWRGDANNPMLTRIYGTAFANDNDLQAYLHMLE
EAEKRDHRRLGREMDLFHFQEEGPGVVFWHAKGWKMFQNLVSYMRRRLDSHGYQEVNTPQVLDKSLWETSGHWGWYRDNM
FKVTVAGDDTDDDRVFALKPMNCPGHVQIFKHGLKSYRDLPIKLAEFGNVHRYEPSGALHGLMRVRGFTQDDAHIFCTEE
QMAAECLQINDHILSVYKDFGFEEITIKLSTRPEKRVGSDELWDRAESVMMTVLEQIRQQSNNIKTGILPGEGAFYGPKF
EYTLKDAIGREWQCGTTQVDFNLPERFGAFYIGADSEKKQPVMIHRAICGSMERFLGILIENFAGHMPLWFAPVQVVVAT
ITSDADEYAKEAAAKLKAAGLQVVTDLRNEKINYKVREHSLQKVPVILVCGKREAEEKTVNMRRLGSRDQESMTLDEAIA
RLCEEATPPDLLRLKNAG
>Mature_657_residues
SNTVSLQFPDGSVREYDASMTGAALAESISKSLAKKAVAYAVDGTVRDLSDPLGASGKVEIITREDPRALELIRHDTAHV
LAEAVQELFPGTQVTIGPVIENGFYYDFARNEPFTLDDLPVIEKKMREIIQRNKPFTKEVWSREKAKQVFSDKGESYKVE
LVDAIPAGQDLKIYYQGDWFDLCRGPHMASTGQIGNSFKLMKVAGAYWRGDANNPMLTRIYGTAFANDNDLQAYLHMLEE
AEKRDHRRLGREMDLFHFQEEGPGVVFWHAKGWKMFQNLVSYMRRRLDSHGYQEVNTPQVLDKSLWETSGHWGWYRDNMF
KVTVAGDDTDDDRVFALKPMNCPGHVQIFKHGLKSYRDLPIKLAEFGNVHRYEPSGALHGLMRVRGFTQDDAHIFCTEEQ
MAAECLQINDHILSVYKDFGFEEITIKLSTRPEKRVGSDELWDRAESVMMTVLEQIRQQSNNIKTGILPGEGAFYGPKFE
YTLKDAIGREWQCGTTQVDFNLPERFGAFYIGADSEKKQPVMIHRAICGSMERFLGILIENFAGHMPLWFAPVQVVVATI
TSDADEYAKEAAAKLKAAGLQVVTDLRNEKINYKVREHSLQKVPVILVCGKREAEEKTVNMRRLGSRDQESMTLDEAIAR
LCEEATPPDLLRLKNAG

Specific function: Thrs Is Also A Translational Repressor Protein, It Controls The Translation Of Its Own Gene By Binding To Its mRNA. [C]

COG id: COG0441

COG function: function code J; Threonyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI38202255, Length=647, Percent_Identity=38.7944358578053, Blast_Score=446, Evalue=1e-125,
Organism=Homo sapiens, GI20070344, Length=661, Percent_Identity=38.8804841149773, Blast_Score=443, Evalue=1e-124,
Organism=Homo sapiens, GI38570111, Length=648, Percent_Identity=37.3456790123457, Blast_Score=439, Evalue=1e-123,
Organism=Escherichia coli, GI1788013, Length=653, Percent_Identity=50.5359877488515, Blast_Score=687, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71984192, Length=645, Percent_Identity=38.1395348837209, Blast_Score=459, Evalue=1e-129,
Organism=Caenorhabditis elegans, GI71984184, Length=645, Percent_Identity=38.1395348837209, Blast_Score=459, Evalue=1e-129,
Organism=Saccharomyces cerevisiae, GI6322112, Length=662, Percent_Identity=38.2175226586103, Blast_Score=443, Evalue=1e-125,
Organism=Saccharomyces cerevisiae, GI6322654, Length=423, Percent_Identity=34.2789598108747, Blast_Score=259, Evalue=8e-70,
Organism=Drosophila melanogaster, GI24583842, Length=643, Percent_Identity=37.4805598755832, Blast_Score=442, Evalue=1e-124,
Organism=Drosophila melanogaster, GI28574141, Length=643, Percent_Identity=37.4805598755832, Blast_Score=442, Evalue=1e-124,
Organism=Drosophila melanogaster, GI24583839, Length=643, Percent_Identity=37.4805598755832, Blast_Score=442, Evalue=1e-124,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR012675
- InterPro:   IPR012676
- InterPro:   IPR002320
- InterPro:   IPR018163
- InterPro:   IPR012947 [H]

Pfam domain/function: PF03129 HGTP_anticodon; PF00587 tRNA-synt_2b; PF07973 tRNA_SAD [H]

EC number: =6.1.1.3 [H]

Molecular weight: Translated: 74605; Mature: 74473

Theoretical pI: Translated: 6.06; Mature: 6.06

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNTVSLQFPDGSVREYDASMTGAALAESISKSLAKKAVAYAVDGTVRDLSDPLGASGKV
CCCEEEEECCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCEE
EIITREDPRALELIRHDTAHVLAEAVQELFPGTQVTIGPVIENGFYYDFARNEPFTLDDL
EEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCEEEEECCCCCCCCCCC
PVIEKKMREIIQRNKPFTKEVWSREKAKQVFSDKGESYKVELVDAIPAGQDLKIYYQGDW
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCEEEEECCCH
FDLCRGPHMASTGQIGNSFKLMKVAGAYWRGDANNPMLTRIYGTAFANDNDLQAYLHMLE
HHHHCCCCCCCCCCCCCCEEEEEECCHHCCCCCCCCEEEEEEEEECCCCCHHHHHHHHHH
EAEKRDHRRLGREMDLFHFQEEGPGVVFWHAKGWKMFQNLVSYMRRRLDSHGYQEVNTPQ
HHHHHHHHHHCCCCCCEEEECCCCEEEEEECCCHHHHHHHHHHHHHHHHCCCCCCCCCHH
VLDKSLWETSGHWGWYRDNMFKVTVAGDDTDDDRVFALKPMNCPGHVQIFKHGLKSYRDL
HHHHHHHHCCCCCCEEECCEEEEEECCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHCC
PIKLAEFGNVHRYEPSGALHGLMRVRGFTQDDAHIFCTEEQMAAECLQINDHILSVYKDF
CEEEHHCCCCEEECCCHHHHHHHHHCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHC
GFEEITIKLSTRPEKRVGSDELWDRAESVMMTVLEQIRQQSNNIKTGILPGEGAFYGPKF
CCEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCE
EYTLKDAIGREWQCGTTQVDFNLPERFGAFYIGADSEKKQPVMIHRAICGSMERFLGILI
EEEHHHHCCCCCCCCCEEEECCCHHHHCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHH
ENFAGHMPLWFAPVQVVVATITSDADEYAKEAAAKLKAAGLQVVTDLRNEKINYKVREHS
HHHCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHCC
LQKVPVILVCGKREAEEKTVNMRRLGSRDQESMTLDEAIARLCEEATPPDLLRLKNAG
CCCCCEEEEECCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCHHHHHCCCCC
>Mature Secondary Structure 
SNTVSLQFPDGSVREYDASMTGAALAESISKSLAKKAVAYAVDGTVRDLSDPLGASGKV
CCEEEEECCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCEE
EIITREDPRALELIRHDTAHVLAEAVQELFPGTQVTIGPVIENGFYYDFARNEPFTLDDL
EEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCEEEEECCCCCCCCCCC
PVIEKKMREIIQRNKPFTKEVWSREKAKQVFSDKGESYKVELVDAIPAGQDLKIYYQGDW
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCEEEEECCCH
FDLCRGPHMASTGQIGNSFKLMKVAGAYWRGDANNPMLTRIYGTAFANDNDLQAYLHMLE
HHHHCCCCCCCCCCCCCCEEEEEECCHHCCCCCCCCEEEEEEEEECCCCCHHHHHHHHHH
EAEKRDHRRLGREMDLFHFQEEGPGVVFWHAKGWKMFQNLVSYMRRRLDSHGYQEVNTPQ
HHHHHHHHHHCCCCCCEEEECCCCEEEEEECCCHHHHHHHHHHHHHHHHCCCCCCCCCHH
VLDKSLWETSGHWGWYRDNMFKVTVAGDDTDDDRVFALKPMNCPGHVQIFKHGLKSYRDL
HHHHHHHHCCCCCCEEECCEEEEEECCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHCC
PIKLAEFGNVHRYEPSGALHGLMRVRGFTQDDAHIFCTEEQMAAECLQINDHILSVYKDF
CEEEHHCCCCEEECCCHHHHHHHHHCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHC
GFEEITIKLSTRPEKRVGSDELWDRAESVMMTVLEQIRQQSNNIKTGILPGEGAFYGPKF
CCEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCE
EYTLKDAIGREWQCGTTQVDFNLPERFGAFYIGADSEKKQPVMIHRAICGSMERFLGILI
EEEHHHHCCCCCCCCCEEEECCCHHHHCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHH
ENFAGHMPLWFAPVQVVVATITSDADEYAKEAAAKLKAAGLQVVTDLRNEKINYKVREHS
HHHCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHCC
LQKVPVILVCGKREAEEKTVNMRRLGSRDQESMTLDEAIARLCEEATPPDLLRLKNAG
CCCCCEEEEECCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA