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The map label for this gene is galE [H]

Identifier: 225852568

GI number: 225852568

Start: 1055245

End: 1056252

Strand: Reverse

Name: galE [H]

Synonym: BMEA_A1107

Alternate gene names: 225852568

Gene position: 1056252-1055245 (Counterclockwise)

Preceding gene: 225852570

Following gene: 225852567

Centisome position: 49.69

GC content: 53.87

Gene sequence:

>1008_bases
ATGACAATTCTTGTAACAGGTGGTGCTGGCTATATCGGCTCCCACACGTGTGTGCAGTTGATCGAGGCAGGCCATGAAGT
GGTTGTGGTCGATAATTTCGACAACAGCCATCCTGAGGCACTGCATCGGATTGAAAAGATCACGGGCCGCGCGCCGCGCC
GCGAACCGGGCGATATTCGCGATCGCGCCCTTATGGAACAGATGATCAAACGCCATAAATGCACTGCGGTTATCCATTTT
GCCGGGCTGAAGGCCGTGGGTGAATCGAGCGAAAAGCCGCTGCTCTATTATGATTGCAATGTGCTGGGCACACTTCGGCT
TCTGCAGGCCATGGAAGCGACAGGCGTGAAGAAGCTCGTTTTCAGCTCTTCGGCCACCGTCTATGGCGACCCGGATAAAC
TGCCGATCACCGAAGATCAGCCCCTTTCGGCCACCAATCCCTATGGCCGGACCAAGCTTGTCATCGAAGACATGCTGCGC
GACCTTTATAACAGTGACAATAGCTGGGCGATTGCGATTCTGCGCTATTTCAATCCTGTCGGCGCTCATGAAAGCGGGCT
TATCGGTGAAGACCCGAAGGGTATTCCCAACAATCTGATGCCCATTATTGCTCAGGTCGCAACTGGACGACGCGAAAAGC
TGAACATCTGGGGCAACGACTATCCGACACCGGATGGCACCGGCGTACGCGACTATATCCATGTCAACGATCTGGCTGCC
GGGCACCTCAAGGCCCTGAAAAAGCTGGATAAGCCCAAGTGCTTCGCCGTCAATCTTGGAACGGGGCAGGGCTATAGTGT
TCTTGATGTGATCAAGGCGTTTGAACATGTCTCCAATCGCGAGATCAAATATGAGATTGCGCCGCGCCGTCCCGGCGATG
TTGCCGAATGCTATGCCGATCCCGGCTTTGCAAAGAAATTTCTGGGCTGGTCGGCTGAGAAAAACCTGCGTGAAATGTGT
CAGGACATGTGGAACTGGCAATCGAAAAATCCGAACGGCTACGAATAA

Upstream 100 bases:

>100_bases
GAGAATCGATCCATGCAGCTTGAAGTCTGTTGCCGATTTTGCATAGTCAGCCGGGGATCGCATATCGGAGCGGTATGTTC
AACAAGCGGATACGTGAACG

Downstream 100 bases:

>100_bases
ACATCGTTGCCGAAACGGCTTGTCGTTTCAGCCATTCATGGCTCGGCGTGAATTTCCCGGCATATCGGATTTGCCAGAAA
ATGCCGGAACCGGCGCAATG

Product: UDP-glucose 4-epimerase

Products: NA

Alternate protein names: Galactowaldenase; UDP-galactose 4-epimerase [H]

Number of amino acids: Translated: 335; Mature: 334

Protein sequence:

>335_residues
MTILVTGGAGYIGSHTCVQLIEAGHEVVVVDNFDNSHPEALHRIEKITGRAPRREPGDIRDRALMEQMIKRHKCTAVIHF
AGLKAVGESSEKPLLYYDCNVLGTLRLLQAMEATGVKKLVFSSSATVYGDPDKLPITEDQPLSATNPYGRTKLVIEDMLR
DLYNSDNSWAIAILRYFNPVGAHESGLIGEDPKGIPNNLMPIIAQVATGRREKLNIWGNDYPTPDGTGVRDYIHVNDLAA
GHLKALKKLDKPKCFAVNLGTGQGYSVLDVIKAFEHVSNREIKYEIAPRRPGDVAECYADPGFAKKFLGWSAEKNLREMC
QDMWNWQSKNPNGYE

Sequences:

>Translated_335_residues
MTILVTGGAGYIGSHTCVQLIEAGHEVVVVDNFDNSHPEALHRIEKITGRAPRREPGDIRDRALMEQMIKRHKCTAVIHF
AGLKAVGESSEKPLLYYDCNVLGTLRLLQAMEATGVKKLVFSSSATVYGDPDKLPITEDQPLSATNPYGRTKLVIEDMLR
DLYNSDNSWAIAILRYFNPVGAHESGLIGEDPKGIPNNLMPIIAQVATGRREKLNIWGNDYPTPDGTGVRDYIHVNDLAA
GHLKALKKLDKPKCFAVNLGTGQGYSVLDVIKAFEHVSNREIKYEIAPRRPGDVAECYADPGFAKKFLGWSAEKNLREMC
QDMWNWQSKNPNGYE
>Mature_334_residues
TILVTGGAGYIGSHTCVQLIEAGHEVVVVDNFDNSHPEALHRIEKITGRAPRREPGDIRDRALMEQMIKRHKCTAVIHFA
GLKAVGESSEKPLLYYDCNVLGTLRLLQAMEATGVKKLVFSSSATVYGDPDKLPITEDQPLSATNPYGRTKLVIEDMLRD
LYNSDNSWAIAILRYFNPVGAHESGLIGEDPKGIPNNLMPIIAQVATGRREKLNIWGNDYPTPDGTGVRDYIHVNDLAAG
HLKALKKLDKPKCFAVNLGTGQGYSVLDVIKAFEHVSNREIKYEIAPRRPGDVAECYADPGFAKKFLGWSAEKNLREMCQ
DMWNWQSKNPNGYE

Specific function: Galactose metabolism; third step. [C]

COG id: COG1087

COG function: function code M; UDP-glucose 4-epimerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sugar epimerase family [H]

Homologues:

Organism=Homo sapiens, GI56237023, Length=340, Percent_Identity=57.0588235294118, Blast_Score=408, Evalue=1e-114,
Organism=Homo sapiens, GI56118217, Length=340, Percent_Identity=57.0588235294118, Blast_Score=408, Evalue=1e-114,
Organism=Homo sapiens, GI189083684, Length=340, Percent_Identity=57.0588235294118, Blast_Score=408, Evalue=1e-114,
Organism=Homo sapiens, GI7657641, Length=273, Percent_Identity=27.1062271062271, Blast_Score=89, Evalue=7e-18,
Organism=Homo sapiens, GI42516563, Length=313, Percent_Identity=26.517571884984, Blast_Score=80, Evalue=3e-15,
Organism=Escherichia coli, GI1786974, Length=336, Percent_Identity=56.8452380952381, Blast_Score=389, Evalue=1e-109,
Organism=Escherichia coli, GI1788366, Length=359, Percent_Identity=24.2339832869081, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI48994969, Length=315, Percent_Identity=27.9365079365079, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1788353, Length=359, Percent_Identity=23.6768802228412, Blast_Score=63, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71982035, Length=346, Percent_Identity=49.7109826589595, Blast_Score=346, Evalue=9e-96,
Organism=Caenorhabditis elegans, GI71982038, Length=348, Percent_Identity=50, Blast_Score=345, Evalue=1e-95,
Organism=Caenorhabditis elegans, GI133901786, Length=350, Percent_Identity=24.8571428571429, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17539422, Length=350, Percent_Identity=24.8571428571429, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI133901790, Length=350, Percent_Identity=24.8571428571429, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17539424, Length=350, Percent_Identity=24.8571428571429, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI133901788, Length=350, Percent_Identity=24.8571428571429, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17568069, Length=334, Percent_Identity=25.1497005988024, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17507723, Length=352, Percent_Identity=23.5795454545455, Blast_Score=68, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI115532424, Length=330, Percent_Identity=25.4545454545455, Blast_Score=64, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6319493, Length=343, Percent_Identity=53.3527696793003, Blast_Score=358, Evalue=1e-100,
Organism=Drosophila melanogaster, GI19923002, Length=343, Percent_Identity=56.268221574344, Blast_Score=389, Evalue=1e-108,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001509
- InterPro:   IPR005886
- InterPro:   IPR016040
- InterPro:   IPR008089 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: =5.1.3.2 [H]

Molecular weight: Translated: 37207; Mature: 37076

Theoretical pI: Translated: 7.05; Mature: 7.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTILVTGGAGYIGSHTCVQLIEAGHEVVVVDNFDNSHPEALHRIEKITGRAPRREPGDIR
CEEEEECCCCCCCHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHCCCCCCCCCCHH
DRALMEQMIKRHKCTAVIHFAGLKAVGESSEKPLLYYDCNVLGTLRLLQAMEATGVKKLV
HHHHHHHHHHHHHHHEEEEEHHHHHHCCCCCCCEEEECCCHHHHHHHHHHHHHCCHHHHH
FSSSATVYGDPDKLPITEDQPLSATNPYGRTKLVIEDMLRDLYNSDNSWAIAILRYFNPV
HCCCCEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEHEEHHCCC
GAHESGLIGEDPKGIPNNLMPIIAQVATGRREKLNIWGNDYPTPDGTGVRDYIHVNDLAA
CCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCEEEEEECCCCH
GHLKALKKLDKPKCFAVNLGTGQGYSVLDVIKAFEHVSNREIKYEIAPRRPGDVAECYAD
HHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHCC
PGFAKKFLGWSAEKNLREMCQDMWNWQSKNPNGYE
CCHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
TILVTGGAGYIGSHTCVQLIEAGHEVVVVDNFDNSHPEALHRIEKITGRAPRREPGDIR
EEEEECCCCCCCHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHCCCCCCCCCCHH
DRALMEQMIKRHKCTAVIHFAGLKAVGESSEKPLLYYDCNVLGTLRLLQAMEATGVKKLV
HHHHHHHHHHHHHHHEEEEEHHHHHHCCCCCCCEEEECCCHHHHHHHHHHHHHCCHHHHH
FSSSATVYGDPDKLPITEDQPLSATNPYGRTKLVIEDMLRDLYNSDNSWAIAILRYFNPV
HCCCCEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEHEEHHCCC
GAHESGLIGEDPKGIPNNLMPIIAQVATGRREKLNIWGNDYPTPDGTGVRDYIHVNDLAA
CCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCEEEEEECCCCH
GHLKALKKLDKPKCFAVNLGTGQGYSVLDVIKAFEHVSNREIKYEIAPRRPGDVAECYAD
HHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHCC
PGFAKKFLGWSAEKNLREMCQDMWNWQSKNPNGYE
CCHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8978088; 8969509; 9384377 [H]