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The map label for this gene is mscM [H]

Identifier: 225852545

GI number: 225852545

Start: 1028143

End: 1029369

Strand: Reverse

Name: mscM [H]

Synonym: BMEA_A1082

Alternate gene names: 225852545

Gene position: 1029369-1028143 (Counterclockwise)

Preceding gene: 225852546

Following gene: 225852541

Centisome position: 48.42

GC content: 51.18

Gene sequence:

>1227_bases
TTGACGGAATTCATTCTTGAGCATCCCTGGGCTGAGACGCTTATAGCTCTTGGCGGTTTGTTTTTTTCAGCTTTCATTGC
CAATTTTTTGATTAAGGCAATTCTGCTGAAGATGCTCAAGCACATCATTCAGAAAACCTCGTTCGGTCAGGATGAGGAGC
TGAAAAACCTTGGTGTTATCAGCCGTCTGGCGAATATCGTTCCGGCGCTGATTATCGCATCCGGCATTCTTGCCGTTCCG
GGGCTGCCCGACGGCGCATTGACGATCATTCGGAATGTGTCGATTTCCTTCATCATTCTGACACTGGCGCTGGCGGTAAA
TTCTGCGCTGAGCGTAGTCGACACGCTTTACCATCGCCGCACCGAGGCGCGAAGCCGGCCGATAAAGGGTTATATTCAGG
TCACGAAACTGGCCATATATCTTATTGCAACGGTTCTTATCATCGCGACATTGCTGGACCGTTCGCCTGTTATTCTGCTT
TCAGGCGTCGGCGCCATGGCTGCGGTTCTCATTCTGGTTTTTCAGGATACCCTGCTGTCGCTTGTCGCCAGTATGCAGAT
CGCCTCGTCAAATATGGTGCGGGTGGGCGACTGGATCGAAATGAAGAACCTGGACGCGAATGGCGATGTCACCGAAATCG
CGCTTTATACGGTCAAGGTGCAGAATTTCGATAAAACCATTACCACCATCCCCATCCGCAAGCTCATTACCGAACCGATG
AAGAATTATCGGGGAATGCAGGAATCAGGCGGGCGGCGTATCAAGCGCGCTCTTTACATCGATCAGAACACGATTGGCTT
TCTGGATGAGGCTGAACGCAAGCGCCTCGCTTCCATCGGTCTGCTGGAAGATTATCTGCCCCGCAAGGAAAAGGAAATTG
CCGAGTGGAATGCGAAGCTTGGAGAACGCGCTAAAAACCCAGTCAACACGCGCCGTGTGACCAATATCGGCACATTCCGC
GCCTATGTTGAAACCTATCTGCGCAATCATCCGGGGATTCACAAAAGCATGACGCTGCTTGTGCGCCAGATGGATCCGAC
GCCGGAAGGCCTGCCGCTTGAAATATATTGTTTTACGAATACGACCAATTGGGCCGCATTCGAGCAAATTCAGTCAGATA
TTTTCGATCATCTCTATGCCATATTGCCGGAATTCGGGCTGAATGCTTTCCAGAACCCCAGCGGCAAGGATTTCCGAAGC
CTTCTGGTCAAGGATAAAGCGCCTTGA

Upstream 100 bases:

>100_bases
GTTGCAGTTGATCCCGCGACAGAAACAACGATATAAAAGGCTCGCCTTGTGCGGGCCTTTTACATGCAGAGCGCACCTCT
ATTGATATTGGGAAATTCTA

Downstream 100 bases:

>100_bases
TAATGGCGGCGTTGAGGTTCTGAACGTTATAGCCCGTGCGGGAAGGTGTCAGCCCCAGCCGCGCCACGGCAAGCTTCCGG
GAAGGTACGATCATCACGCT

Product: mechanosensitive ion channel protein MscS

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 408; Mature: 407

Protein sequence:

>408_residues
MTEFILEHPWAETLIALGGLFFSAFIANFLIKAILLKMLKHIIQKTSFGQDEELKNLGVISRLANIVPALIIASGILAVP
GLPDGALTIIRNVSISFIILTLALAVNSALSVVDTLYHRRTEARSRPIKGYIQVTKLAIYLIATVLIIATLLDRSPVILL
SGVGAMAAVLILVFQDTLLSLVASMQIASSNMVRVGDWIEMKNLDANGDVTEIALYTVKVQNFDKTITTIPIRKLITEPM
KNYRGMQESGGRRIKRALYIDQNTIGFLDEAERKRLASIGLLEDYLPRKEKEIAEWNAKLGERAKNPVNTRRVTNIGTFR
AYVETYLRNHPGIHKSMTLLVRQMDPTPEGLPLEIYCFTNTTNWAAFEQIQSDIFDHLYAILPEFGLNAFQNPSGKDFRS
LLVKDKAP

Sequences:

>Translated_408_residues
MTEFILEHPWAETLIALGGLFFSAFIANFLIKAILLKMLKHIIQKTSFGQDEELKNLGVISRLANIVPALIIASGILAVP
GLPDGALTIIRNVSISFIILTLALAVNSALSVVDTLYHRRTEARSRPIKGYIQVTKLAIYLIATVLIIATLLDRSPVILL
SGVGAMAAVLILVFQDTLLSLVASMQIASSNMVRVGDWIEMKNLDANGDVTEIALYTVKVQNFDKTITTIPIRKLITEPM
KNYRGMQESGGRRIKRALYIDQNTIGFLDEAERKRLASIGLLEDYLPRKEKEIAEWNAKLGERAKNPVNTRRVTNIGTFR
AYVETYLRNHPGIHKSMTLLVRQMDPTPEGLPLEIYCFTNTTNWAAFEQIQSDIFDHLYAILPEFGLNAFQNPSGKDFRS
LLVKDKAP
>Mature_407_residues
TEFILEHPWAETLIALGGLFFSAFIANFLIKAILLKMLKHIIQKTSFGQDEELKNLGVISRLANIVPALIIASGILAVPG
LPDGALTIIRNVSISFIILTLALAVNSALSVVDTLYHRRTEARSRPIKGYIQVTKLAIYLIATVLIIATLLDRSPVILLS
GVGAMAAVLILVFQDTLLSLVASMQIASSNMVRVGDWIEMKNLDANGDVTEIALYTVKVQNFDKTITTIPIRKLITEPMK
NYRGMQESGGRRIKRALYIDQNTIGFLDEAERKRLASIGLLEDYLPRKEKEIAEWNAKLGERAKNPVNTRRVTNIGTFRA
YVETYLRNHPGIHKSMTLLVRQMDPTPEGLPLEIYCFTNTTNWAAFEQIQSDIFDHLYAILPEFGLNAFQNPSGKDFRSL
LVKDKAP

Specific function: Mechanosensitive channel of miniconductance that confers protection against mild hypoosmotic shock. Overexpression confers protection against severe shocks [H]

COG id: COG0668

COG function: function code M; Small-conductance mechanosensitive channel

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mscS (TC 1.A.23) family [H]

Homologues:

Organism=Escherichia coli, GI1786791, Length=387, Percent_Identity=44.1860465116279, Blast_Score=317, Evalue=1e-87,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010920
- InterPro:   IPR011066
- InterPro:   IPR006685 [H]

Pfam domain/function: PF00924 MS_channel [H]

EC number: NA

Molecular weight: Translated: 45537; Mature: 45406

Theoretical pI: Translated: 9.62; Mature: 9.62

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEFILEHPWAETLIALGGLFFSAFIANFLIKAILLKMLKHIIQKTSFGQDEELKNLGVI
CCCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
SRLANIVPALIIASGILAVPGLPDGALTIIRNVSISFIILTLALAVNSALSVVDTLYHRR
HHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TEARSRPIKGYIQVTKLAIYLIATVLIIATLLDRSPVILLSGVGAMAAVLILVFQDTLLS
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECHHHHHHHHHHHHHHHHHH
LVASMQIASSNMVRVGDWIEMKNLDANGDVTEIALYTVKVQNFDKTITTIPIRKLITEPM
HHHHHHHHCCCCEEECCHHEECCCCCCCCEEEEEEEEEEECCCCCHHHHHHHHHHHHHHH
KNYRGMQESGGRRIKRALYIDQNTIGFLDEAERKRLASIGLLEDYLPRKEKEIAEWNAKL
HHHCCCHHCCHHHHHHHHEECCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
GERAKNPVNTRRVTNIGTFRAYVETYLRNHPGIHKSMTLLVRQMDPTPEGLPLEIYCFTN
HHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCEEEEEEEC
TTNWAAFEQIQSDIFDHLYAILPEFGLNAFQNPSGKDFRSLLVKDKAP
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCC
>Mature Secondary Structure 
TEFILEHPWAETLIALGGLFFSAFIANFLIKAILLKMLKHIIQKTSFGQDEELKNLGVI
CCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
SRLANIVPALIIASGILAVPGLPDGALTIIRNVSISFIILTLALAVNSALSVVDTLYHRR
HHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TEARSRPIKGYIQVTKLAIYLIATVLIIATLLDRSPVILLSGVGAMAAVLILVFQDTLLS
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECHHHHHHHHHHHHHHHHHH
LVASMQIASSNMVRVGDWIEMKNLDANGDVTEIALYTVKVQNFDKTITTIPIRKLITEPM
HHHHHHHHCCCCEEECCHHEECCCCCCCCEEEEEEEEEEECCCCCHHHHHHHHHHHHHHH
KNYRGMQESGGRRIKRALYIDQNTIGFLDEAERKRLASIGLLEDYLPRKEKEIAEWNAKL
HHHCCCHHCCHHHHHHHHEECCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
GERAKNPVNTRRVTNIGTFRAYVETYLRNHPGIHKSMTLLVRQMDPTPEGLPLEIYCFTN
HHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCEEEEEEEC
TTNWAAFEQIQSDIFDHLYAILPEFGLNAFQNPSGKDFRSLLVKDKAP
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8905232; 9278503; 7813889 [H]