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The map label for this gene is gor [H]

Identifier: 225852517

GI number: 225852517

Start: 992385

End: 993779

Strand: Direct

Name: gor [H]

Synonym: BMEA_A1053

Alternate gene names: 225852517

Gene position: 992385-993779 (Clockwise)

Preceding gene: 225852516

Following gene: 225852518

Centisome position: 46.69

GC content: 55.77

Gene sequence:

>1395_bases
ATGACCGGTTTTGACTACGACCTTTTTGTTATTGGCGGCGGCTCCGGCGGCGTTCGTGCGGGGCGTCTGGCAGGGGCCAT
AGGTAAGAAGGTGGGGCTGGCCGAGGAATACCGCATGGGGGGCACATGCGTTATCCGTGGTTGCGTTCCCAAAAAACTGT
TTGTCTACGCATCGCAATTTCCCGAACATTTCGAGGATTCCGCCGGTTATGGCTGGAGCATGGGCGAGGCGGCTTTCGAC
TGGAAAAAGCTGATCGCGGCAAAAGACAAGGAAATCAGCCGTCTTGAGGGCCTTTATCGTAAAGGGCTTGAGAATTCTCA
CGTTGATATCTTCGCCAGCCGCGCGGAACTGATCGACGAGCACACAATCGAATTGAAGGCTGATGGGCGCCGCGTGACGG
CGGATAAAATCCTGATCGCCACCGGCGGCCGGCCGAACACGCACGAATCCTTGCCGGGCCACGAATATTGCATCAGCTCC
AACGAGGCTTTTCATCTGGAAGAATTGCCGAAATCCATCGTGATTGCGGGCGGCGGTTATATCGCCGTTGAATTTGCCAA
TATTTTCCATGGGCTTGGCGTTGAAACCACGCTGGTCTATCGAGGCAAGGAAATCCTTTCCCGCTTTGATCACGATATTC
GCAGCCTGCTGCACGAAACGATGGAGGCGAAAGGTATCCGCATTCTTTGCGGCGCTATTTTCGAGAAGGTTGAAAAGAAG
GCGGACGGAAAGCTTTCGGTCGAACTGTCCAATGGCGAGACGCTGGAGACGGACCAGGCCATGCTGGCCCTTGGCCGCAT
CCCGAACACGGATGGCCTGGGCCTTGAAAAGGCCGGTGTAAAGATAGACAAGTCCGGCGCCATCGAGGTTGACGATTATT
CGCGCACCAATGTCGAAAATATCTGGGCGGTCGGCGATGTGACCAATCGCGTGCAACTCACCCCGGTTGCGATCCATGAA
GCCATGTGTTTCCTTGAAACCGCCTTCAAGGACAATCCGACCAAGCCCGACCATGAGCTGATTGCAACGGCAGTCTTTTC
GCAGCCCGAAATCGGCACTGTGGGGCTTTCAGAAGATGAAGCCGCGAAGAAGTACCCGGAGCTTGAAATCTACCGCGCCC
TGTTCCGTCCCATGAAGAACACGCTCTCCGGCCGCAGCGAAAAAACGCTGATGAAGCTCGTCGTGGAAAGTAAAAGCCGC
AAGGTTCTGGGCGCACACATCATGGGGCCGGATGCTGGCGAGATGGCGCAGCTTCTGGGCATTTCCCTCAAGGCCGGAGC
CACCAAGGACGACTTCGACCGCACCATGGCGGTGCATCCGACTGCGACGGAAGAACTCGTCACCATGTATAAGCCAACCT
ATCGCGTAGTGAATGGCAAAAAGATAGAAGGCTGA

Upstream 100 bases:

>100_bases
CTTTTGCTACATATAGGCAAACATATCGAAATGAATGGAGAGGGTGGCTCCCCCTCTTCAAAACAGAAACCTCTCGATAA
CGCTTGAAGCGGGGATTTCC

Downstream 100 bases:

>100_bases
ATATTTCTCTGATCGAGCGTATTCTTAACAATTCTTGCTGGCATAAAATCTCTGTGTGCATTATATCAGCGCGACCACGC
ATGCCGGGTTTGCGAGCGCG

Product: glutathione reductase

Products: NA

Alternate protein names: GR; GRase [H]

Number of amino acids: Translated: 464; Mature: 463

Protein sequence:

>464_residues
MTGFDYDLFVIGGGSGGVRAGRLAGAIGKKVGLAEEYRMGGTCVIRGCVPKKLFVYASQFPEHFEDSAGYGWSMGEAAFD
WKKLIAAKDKEISRLEGLYRKGLENSHVDIFASRAELIDEHTIELKADGRRVTADKILIATGGRPNTHESLPGHEYCISS
NEAFHLEELPKSIVIAGGGYIAVEFANIFHGLGVETTLVYRGKEILSRFDHDIRSLLHETMEAKGIRILCGAIFEKVEKK
ADGKLSVELSNGETLETDQAMLALGRIPNTDGLGLEKAGVKIDKSGAIEVDDYSRTNVENIWAVGDVTNRVQLTPVAIHE
AMCFLETAFKDNPTKPDHELIATAVFSQPEIGTVGLSEDEAAKKYPELEIYRALFRPMKNTLSGRSEKTLMKLVVESKSR
KVLGAHIMGPDAGEMAQLLGISLKAGATKDDFDRTMAVHPTATEELVTMYKPTYRVVNGKKIEG

Sequences:

>Translated_464_residues
MTGFDYDLFVIGGGSGGVRAGRLAGAIGKKVGLAEEYRMGGTCVIRGCVPKKLFVYASQFPEHFEDSAGYGWSMGEAAFD
WKKLIAAKDKEISRLEGLYRKGLENSHVDIFASRAELIDEHTIELKADGRRVTADKILIATGGRPNTHESLPGHEYCISS
NEAFHLEELPKSIVIAGGGYIAVEFANIFHGLGVETTLVYRGKEILSRFDHDIRSLLHETMEAKGIRILCGAIFEKVEKK
ADGKLSVELSNGETLETDQAMLALGRIPNTDGLGLEKAGVKIDKSGAIEVDDYSRTNVENIWAVGDVTNRVQLTPVAIHE
AMCFLETAFKDNPTKPDHELIATAVFSQPEIGTVGLSEDEAAKKYPELEIYRALFRPMKNTLSGRSEKTLMKLVVESKSR
KVLGAHIMGPDAGEMAQLLGISLKAGATKDDFDRTMAVHPTATEELVTMYKPTYRVVNGKKIEG
>Mature_463_residues
TGFDYDLFVIGGGSGGVRAGRLAGAIGKKVGLAEEYRMGGTCVIRGCVPKKLFVYASQFPEHFEDSAGYGWSMGEAAFDW
KKLIAAKDKEISRLEGLYRKGLENSHVDIFASRAELIDEHTIELKADGRRVTADKILIATGGRPNTHESLPGHEYCISSN
EAFHLEELPKSIVIAGGGYIAVEFANIFHGLGVETTLVYRGKEILSRFDHDIRSLLHETMEAKGIRILCGAIFEKVEKKA
DGKLSVELSNGETLETDQAMLALGRIPNTDGLGLEKAGVKIDKSGAIEVDDYSRTNVENIWAVGDVTNRVQLTPVAIHEA
MCFLETAFKDNPTKPDHELIATAVFSQPEIGTVGLSEDEAAKKYPELEIYRALFRPMKNTLSGRSEKTLMKLVVESKSRK
VLGAHIMGPDAGEMAQLLGISLKAGATKDDFDRTMAVHPTATEELVTMYKPTYRVVNGKKIEG

Specific function: Maintains High Levels Of Reduced Glutathione In The Cytosol. [C]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI50301238, Length=459, Percent_Identity=40.3050108932462, Blast_Score=312, Evalue=4e-85,
Organism=Homo sapiens, GI22035672, Length=470, Percent_Identity=35.1063829787234, Blast_Score=253, Evalue=2e-67,
Organism=Homo sapiens, GI33519430, Length=474, Percent_Identity=36.0759493670886, Blast_Score=250, Evalue=3e-66,
Organism=Homo sapiens, GI33519428, Length=474, Percent_Identity=36.0759493670886, Blast_Score=250, Evalue=3e-66,
Organism=Homo sapiens, GI33519426, Length=474, Percent_Identity=36.0759493670886, Blast_Score=250, Evalue=3e-66,
Organism=Homo sapiens, GI148277065, Length=474, Percent_Identity=36.0759493670886, Blast_Score=249, Evalue=3e-66,
Organism=Homo sapiens, GI148277071, Length=474, Percent_Identity=36.0759493670886, Blast_Score=249, Evalue=4e-66,
Organism=Homo sapiens, GI291045266, Length=473, Percent_Identity=35.0951374207188, Blast_Score=239, Evalue=3e-63,
Organism=Homo sapiens, GI291045268, Length=471, Percent_Identity=32.9087048832272, Blast_Score=204, Evalue=1e-52,
Organism=Homo sapiens, GI91199540, Length=457, Percent_Identity=28.2275711159737, Blast_Score=176, Evalue=6e-44,
Organism=Escherichia coli, GI1789915, Length=430, Percent_Identity=41.3953488372093, Blast_Score=311, Evalue=5e-86,
Organism=Escherichia coli, GI1786307, Length=453, Percent_Identity=26.9315673289183, Blast_Score=175, Evalue=7e-45,
Organism=Escherichia coli, GI87082354, Length=450, Percent_Identity=27.7777777777778, Blast_Score=160, Evalue=2e-40,
Organism=Escherichia coli, GI87081717, Length=454, Percent_Identity=25.5506607929515, Blast_Score=142, Evalue=5e-35,
Organism=Caenorhabditis elegans, GI71983419, Length=450, Percent_Identity=41.1111111111111, Blast_Score=276, Evalue=2e-74,
Organism=Caenorhabditis elegans, GI71983429, Length=450, Percent_Identity=41.1111111111111, Blast_Score=276, Evalue=2e-74,
Organism=Caenorhabditis elegans, GI17557007, Length=469, Percent_Identity=29.8507462686567, Blast_Score=229, Evalue=2e-60,
Organism=Caenorhabditis elegans, GI71982272, Length=479, Percent_Identity=34.0292275574113, Blast_Score=213, Evalue=1e-55,
Organism=Caenorhabditis elegans, GI32565766, Length=461, Percent_Identity=27.765726681128, Blast_Score=171, Evalue=6e-43,
Organism=Caenorhabditis elegans, GI17559934, Length=190, Percent_Identity=31.0526315789474, Blast_Score=72, Evalue=8e-13,
Organism=Saccharomyces cerevisiae, GI6325166, Length=460, Percent_Identity=37.1739130434783, Blast_Score=285, Evalue=2e-77,
Organism=Saccharomyces cerevisiae, GI6321091, Length=463, Percent_Identity=27.8617710583153, Blast_Score=154, Evalue=3e-38,
Organism=Saccharomyces cerevisiae, GI6325240, Length=465, Percent_Identity=27.5268817204301, Blast_Score=153, Evalue=5e-38,
Organism=Drosophila melanogaster, GI24640553, Length=470, Percent_Identity=35.1063829787234, Blast_Score=253, Evalue=2e-67,
Organism=Drosophila melanogaster, GI24640549, Length=470, Percent_Identity=35.1063829787234, Blast_Score=252, Evalue=3e-67,
Organism=Drosophila melanogaster, GI24640551, Length=470, Percent_Identity=35.1063829787234, Blast_Score=252, Evalue=4e-67,
Organism=Drosophila melanogaster, GI17737741, Length=472, Percent_Identity=33.4745762711864, Blast_Score=230, Evalue=1e-60,
Organism=Drosophila melanogaster, GI21358499, Length=458, Percent_Identity=27.5109170305677, Blast_Score=172, Evalue=3e-43,

Paralogues:

None

Copy number: 650 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR006324
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.7 [H]

Molecular weight: Translated: 50713; Mature: 50581

Theoretical pI: Translated: 6.08; Mature: 6.08

Prosite motif: PS00076 PYRIDINE_REDOX_1 ; PS00697 DNA_LIGASE_A1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGFDYDLFVIGGGSGGVRAGRLAGAIGKKVGLAEEYRMGGTCVIRGCVPKKLFVYASQF
CCCCCEEEEEEECCCCCCCHHHHHHHHHHHCCCHHHHCCCCEEEEECCCCCHHHHHHHHC
PEHFEDSAGYGWSMGEAAFDWKKLIAAKDKEISRLEGLYRKGLENSHVDIFASRAELIDE
CHHHHHCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCEEEEEHHHHHHCC
HTIELKADGRRVTADKILIATGGRPNTHESLPGHEYCISSNEAFHLEELPKSIVIAGGGY
CEEEEECCCCEEEECEEEEEECCCCCCCCCCCCCCEEECCCCEEEHHHCCCEEEEECCCE
IAVEFANIFHGLGVETTLVYRGKEILSRFDHDIRSLLHETMEAKGIRILCGAIFEKVEKK
EEEEHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHCCCEEHHHHHHHHHHHC
ADGKLSVELSNGETLETDQAMLALGRIPNTDGLGLEKAGVKIDKSGAIEVDDYSRTNVEN
CCCEEEEEECCCCEECHHHHHHHHCCCCCCCCCCCCCCCEEECCCCCEEECCCCCCCCCC
IWAVGDVTNRVQLTPVAIHEAMCFLETAFKDNPTKPDHELIATAVFSQPEIGTVGLSEDE
EEEECCCCCEEEEEHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCEECCCCCH
AAKKYPELEIYRALFRPMKNTLSGRSEKTLMKLVVESKSRKVLGAHIMGPDAGEMAQLLG
HHHHCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCEEEEEEEECCCHHHHHHHHC
ISLKAGATKDDFDRTMAVHPTATEELVTMYKPTYRVVNGKKIEG
CEEECCCCCCCCCCEEEECCCCHHHHHHHHCCCEEEECCEECCC
>Mature Secondary Structure 
TGFDYDLFVIGGGSGGVRAGRLAGAIGKKVGLAEEYRMGGTCVIRGCVPKKLFVYASQF
CCCCEEEEEEECCCCCCCHHHHHHHHHHHCCCHHHHCCCCEEEEECCCCCHHHHHHHHC
PEHFEDSAGYGWSMGEAAFDWKKLIAAKDKEISRLEGLYRKGLENSHVDIFASRAELIDE
CHHHHHCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCEEEEEHHHHHHCC
HTIELKADGRRVTADKILIATGGRPNTHESLPGHEYCISSNEAFHLEELPKSIVIAGGGY
CEEEEECCCCEEEECEEEEEECCCCCCCCCCCCCCEEECCCCEEEHHHCCCEEEEECCCE
IAVEFANIFHGLGVETTLVYRGKEILSRFDHDIRSLLHETMEAKGIRILCGAIFEKVEKK
EEEEHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHCCCEEHHHHHHHHHHHC
ADGKLSVELSNGETLETDQAMLALGRIPNTDGLGLEKAGVKIDKSGAIEVDDYSRTNVEN
CCCEEEEEECCCCEECHHHHHHHHCCCCCCCCCCCCCCCEEECCCCCEEECCCCCCCCCC
IWAVGDVTNRVQLTPVAIHEAMCFLETAFKDNPTKPDHELIATAVFSQPEIGTVGLSEDE
EEEECCCCCEEEEEHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCEECCCCCH
AAKKYPELEIYRALFRPMKNTLSGRSEKTLMKLVVESKSRKVLGAHIMGPDAGEMAQLLG
HHHHCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCEEEEEEEECCCHHHHHHHHC
ISLKAGATKDDFDRTMAVHPTATEELVTMYKPTYRVVNGKKIEG
CEEECCCCCCCCCCEEEECCCCHHHHHHHHCCCEEEECCEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7538273 [H]