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The map label for this gene is glyA [H]

Identifier: 225852281

GI number: 225852281

Start: 771267

End: 772583

Strand: Direct

Name: glyA [H]

Synonym: BMEA_A0804

Alternate gene names: 225852281

Gene position: 771267-772583 (Clockwise)

Preceding gene: 225852280

Following gene: 225852282

Centisome position: 36.28

GC content: 58.39

Gene sequence:

>1317_bases
ATGTCTCAAGCCAACGCCGCCACGAAAGCGTCTTCGGACGTTTTCTTCAATGCAAGCCTCGAGGACATCGATCCCGAGAT
TTTCGGTGCAATCCGCAACGAACTTGGTCGCCAGCGCCATGAAATCGAGCTGATCGCTTCGGAAAACATCGTTTCGCGCG
CTGTTCTGGAAGCACAGGGTTCCATCCTCACCAACAAATATGCCGAAGGCTATCCGGGCAAGCGCTATTATGGCGGCTGC
CAGTATGTCGATGTCGTGGAAGAACTGGCGATCGAACGCGCCAAGAAGCTTTTCGGTGCCGAATTCGCCAATGTTCAGCC
GAATTCCGGCAGCCAGATGAATCAGGCGGTTTTCCTCGCGCTGCTTCAGCCAGGCGATACCTTCATGGGCCTCGACCTTA
ATTCAGGTGGCCACCTGACCCACGGTTCGCCGGTCAATATGTCCGGCAAGTGGTTCAATGTCGTGTCCTACGGCGTGCGC
AAGGACGATCATCTGCTCGACATGGACGAAGTCGCCCGCCTCGCACGCGAAAACAAGCCCAAGCTTATCCTTGCAGGCGG
CACGGCCTATTCGCGTATCTGGGACTGGAAGCGTTTCCGCGAGATCGCCGATGAAGTGGGCGCTTATCTCATGGTCGATA
TGGCGCATATTGCCGGTCTCGTGGCTGGCGGTCAGCATCCGTCGCCGGTTCCCCATGCCCATGTCTGCACCACGACAACG
CACAAATCGCTTCGCGGTCCGCGCGGCGGCATGATCCTCACCAATGATGCCGATATTGCCAAGAAGATCAATTCGGCTGT
CTTCCCCGGCCTTCAGGGCGGCCCGCTGATGCATGTCATCGCCGGTAAGGCTGTTGCCTTTGCCGAGGCGTTGAAGCCTG
AGTTCAAGCTCTATGCGAAGAATGTGGTGGATAACGCCCGTGCGCTTGCCGAGGAATTGAAGTCGCACGGCCTCGACATT
GTTTCGGGCGGCACCGACAACCATCTCATGCTGGTCGATCTGCGCCCGAAGAACGCAACCGGCAAGCGGGCGGAAGCCGC
TCTCGGACGCGCCAACATCACCTGCAACAAGAACGGCATTCCCTTCGACCCTGAAAAGCCGTTTGTGACCTCCGGCGTCC
GTCTTGGCACGCCTGCCGGCACCACGCGCGGCTTCGGCGTTGCGGAATTCAAGGAAATCGGTTCGCTGATCGCCGAGGTT
CTCGACGGTTTGAAGGTCGCCAATTCCGACGAAGGCAATGCGGCTGTCGAACAGGCCGTGAAGGAAAAGGTCATCGCCCT
GACCGGCCGTTTCCCGATGTACGGCTATCAGGGATAA

Upstream 100 bases:

>100_bases
CTACTCAAGTGTGATAATGCGCCTCATCCATGTCGCATTGTCCCACGCAAAACCGCTTCGCACTTTTGCTGGAAATGCCC
TAACCCGGAGGGTGTGAAAC

Downstream 100 bases:

>100_bases
GTCCGCTTTCGTAATACCGATGAAACCCCGTTCAACGCTGTTGGGCGGGGTTTTTTACACCGCTTTGTGATTGTCGCATC
CGGTAGGTGGAATGCCGCTT

Product: serine hydroxymethyltransferase

Products: NA

Alternate protein names: SHMT; Serine methylase [H]

Number of amino acids: Translated: 438; Mature: 437

Protein sequence:

>438_residues
MSQANAATKASSDVFFNASLEDIDPEIFGAIRNELGRQRHEIELIASENIVSRAVLEAQGSILTNKYAEGYPGKRYYGGC
QYVDVVEELAIERAKKLFGAEFANVQPNSGSQMNQAVFLALLQPGDTFMGLDLNSGGHLTHGSPVNMSGKWFNVVSYGVR
KDDHLLDMDEVARLARENKPKLILAGGTAYSRIWDWKRFREIADEVGAYLMVDMAHIAGLVAGGQHPSPVPHAHVCTTTT
HKSLRGPRGGMILTNDADIAKKINSAVFPGLQGGPLMHVIAGKAVAFAEALKPEFKLYAKNVVDNARALAEELKSHGLDI
VSGGTDNHLMLVDLRPKNATGKRAEAALGRANITCNKNGIPFDPEKPFVTSGVRLGTPAGTTRGFGVAEFKEIGSLIAEV
LDGLKVANSDEGNAAVEQAVKEKVIALTGRFPMYGYQG

Sequences:

>Translated_438_residues
MSQANAATKASSDVFFNASLEDIDPEIFGAIRNELGRQRHEIELIASENIVSRAVLEAQGSILTNKYAEGYPGKRYYGGC
QYVDVVEELAIERAKKLFGAEFANVQPNSGSQMNQAVFLALLQPGDTFMGLDLNSGGHLTHGSPVNMSGKWFNVVSYGVR
KDDHLLDMDEVARLARENKPKLILAGGTAYSRIWDWKRFREIADEVGAYLMVDMAHIAGLVAGGQHPSPVPHAHVCTTTT
HKSLRGPRGGMILTNDADIAKKINSAVFPGLQGGPLMHVIAGKAVAFAEALKPEFKLYAKNVVDNARALAEELKSHGLDI
VSGGTDNHLMLVDLRPKNATGKRAEAALGRANITCNKNGIPFDPEKPFVTSGVRLGTPAGTTRGFGVAEFKEIGSLIAEV
LDGLKVANSDEGNAAVEQAVKEKVIALTGRFPMYGYQG
>Mature_437_residues
SQANAATKASSDVFFNASLEDIDPEIFGAIRNELGRQRHEIELIASENIVSRAVLEAQGSILTNKYAEGYPGKRYYGGCQ
YVDVVEELAIERAKKLFGAEFANVQPNSGSQMNQAVFLALLQPGDTFMGLDLNSGGHLTHGSPVNMSGKWFNVVSYGVRK
DDHLLDMDEVARLARENKPKLILAGGTAYSRIWDWKRFREIADEVGAYLMVDMAHIAGLVAGGQHPSPVPHAHVCTTTTH
KSLRGPRGGMILTNDADIAKKINSAVFPGLQGGPLMHVIAGKAVAFAEALKPEFKLYAKNVVDNARALAEELKSHGLDIV
SGGTDNHLMLVDLRPKNATGKRAEAALGRANITCNKNGIPFDPEKPFVTSGVRLGTPAGTTRGFGVAEFKEIGSLIAEVL
DGLKVANSDEGNAAVEQAVKEKVIALTGRFPMYGYQG

Specific function: Interconversion of serine and glycine [H]

COG id: COG0112

COG function: function code E; Glycine/serine hydroxymethyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SHMT family [H]

Homologues:

Organism=Homo sapiens, GI19923315, Length=455, Percent_Identity=44.6153846153846, Blast_Score=352, Evalue=5e-97,
Organism=Homo sapiens, GI261862352, Length=455, Percent_Identity=44.6153846153846, Blast_Score=352, Evalue=5e-97,
Organism=Homo sapiens, GI261862350, Length=455, Percent_Identity=44.6153846153846, Blast_Score=352, Evalue=5e-97,
Organism=Homo sapiens, GI261862348, Length=455, Percent_Identity=44.6153846153846, Blast_Score=352, Evalue=5e-97,
Organism=Homo sapiens, GI22547186, Length=466, Percent_Identity=45.7081545064378, Blast_Score=347, Evalue=2e-95,
Organism=Homo sapiens, GI261862346, Length=450, Percent_Identity=45.1111111111111, Blast_Score=341, Evalue=7e-94,
Organism=Homo sapiens, GI22547189, Length=424, Percent_Identity=44.811320754717, Blast_Score=311, Evalue=7e-85,
Organism=Escherichia coli, GI1788902, Length=418, Percent_Identity=60.2870813397129, Blast_Score=490, Evalue=1e-140,
Organism=Caenorhabditis elegans, GI25144732, Length=415, Percent_Identity=48.1927710843374, Blast_Score=369, Evalue=1e-102,
Organism=Caenorhabditis elegans, GI25144729, Length=415, Percent_Identity=48.1927710843374, Blast_Score=368, Evalue=1e-102,
Organism=Saccharomyces cerevisiae, GI6319739, Length=397, Percent_Identity=47.6070528967254, Blast_Score=359, Evalue=1e-100,
Organism=Saccharomyces cerevisiae, GI6323087, Length=434, Percent_Identity=43.778801843318, Blast_Score=338, Evalue=1e-93,
Organism=Drosophila melanogaster, GI24640005, Length=400, Percent_Identity=46.75, Blast_Score=356, Evalue=2e-98,
Organism=Drosophila melanogaster, GI221329721, Length=400, Percent_Identity=46.75, Blast_Score=355, Evalue=2e-98,

Paralogues:

None

Copy number: 3180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 12,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR001085
- InterPro:   IPR019798 [H]

Pfam domain/function: PF00464 SHMT [H]

EC number: =2.1.2.1 [H]

Molecular weight: Translated: 47085; Mature: 46954

Theoretical pI: Translated: 6.97; Mature: 6.97

Prosite motif: PS00096 SHMT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQANAATKASSDVFFNASLEDIDPEIFGAIRNELGRQRHEIELIASENIVSRAVLEAQG
CCCCCCCCCCCCCEEEECCHHHCCHHHHHHHHHHHCCCHHEEEEEECCCHHHHHHHHHCC
SILTNKYAEGYPGKRYYGGCQYVDVVEELAIERAKKLFGAEFANVQPNSGSQMNQAVFLA
CHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHCCCCCCCCCHHHHEEEEE
LLQPGDTFMGLDLNSGGHLTHGSPVNMSGKWFNVVSYGVRKDDHLLDMDEVARLARENKP
EECCCCEEEEEEECCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHCCCC
KLILAGGTAYSRIWDWKRFREIADEVGAYLMVDMAHIAGLVAGGQHPSPVPHAHVCTTTT
CEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCC
HKSLRGPRGGMILTNDADIAKKINSAVFPGLQGGPLMHVIAGKAVAFAEALKPEFKLYAK
HHHHCCCCCCEEEECCHHHHHHHHHHHCCCCCCCCEEEEHHCHHHHHHHHHCHHHHHHHH
NVVDNARALAEELKSHGLDIVSGGTDNHLMLVDLRPKNATGKRAEAALGRANITCNKNGI
HHHHHHHHHHHHHHHCCCEEEECCCCCEEEEEEECCCCCCCCHHHHHHCCCEEEECCCCC
PFDPEKPFVTSGVRLGTPAGTTRGFGVAEFKEIGSLIAEVLDGLKVANSDEGNAAVEQAV
CCCCCCCCEECCEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCEECCCCCCHHHHHHHH
KEKVIALTGRFPMYGYQG
HHHHHHEECCCCCCCCCC
>Mature Secondary Structure 
SQANAATKASSDVFFNASLEDIDPEIFGAIRNELGRQRHEIELIASENIVSRAVLEAQG
CCCCCCCCCCCCEEEECCHHHCCHHHHHHHHHHHCCCHHEEEEEECCCHHHHHHHHHCC
SILTNKYAEGYPGKRYYGGCQYVDVVEELAIERAKKLFGAEFANVQPNSGSQMNQAVFLA
CHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHCCCCCCCCCHHHHEEEEE
LLQPGDTFMGLDLNSGGHLTHGSPVNMSGKWFNVVSYGVRKDDHLLDMDEVARLARENKP
EECCCCEEEEEEECCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHCCCC
KLILAGGTAYSRIWDWKRFREIADEVGAYLMVDMAHIAGLVAGGQHPSPVPHAHVCTTTT
CEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCC
HKSLRGPRGGMILTNDADIAKKINSAVFPGLQGGPLMHVIAGKAVAFAEALKPEFKLYAK
HHHHCCCCCCEEEECCHHHHHHHHHHHCCCCCCCCEEEEHHCHHHHHHHHHCHHHHHHHH
NVVDNARALAEELKSHGLDIVSGGTDNHLMLVDLRPKNATGKRAEAALGRANITCNKNGI
HHHHHHHHHHHHHHHCCCEEEECCCCCEEEEEEECCCCCCCCHHHHHHCCCEEEECCCCC
PFDPEKPFVTSGVRLGTPAGTTRGFGVAEFKEIGSLIAEVLDGLKVANSDEGNAAVEQAV
CCCCCCCCEECCEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCEECCCCCCHHHHHHHH
KEKVIALTGRFPMYGYQG
HHHHHHEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA