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The map label for this gene is ppx [H]

Identifier: 225852266

GI number: 225852266

Start: 755419

End: 756957

Strand: Direct

Name: ppx [H]

Synonym: BMEA_A0789

Alternate gene names: 225852266

Gene position: 755419-756957 (Clockwise)

Preceding gene: 225852265

Following gene: 225852268

Centisome position: 35.54

GC content: 59.13

Gene sequence:

>1539_bases
ATGAGCCCCGCATTCGCACAAGGTCGCCTGAAGGGGCTGAAACCCGTTGCGGTGATCGATATAGGATCGAACTCGATCCG
CGTCGTCATATATGAAGGCATCGTCCGTTCGCCGACGGTGCTTTTCAATGAAAAGATTCTCTGCGGCCTCGGAAAAGGCC
TCGCGAAAACCGGCAAGCTCAACGAGAAATCCGTTGAGGCGGCGTTGCGCGCGCTGAAACGTTTTCGCGCTCTGGCGGAA
CAGGCGGGTGCGGTTTCCATCCACGCACTGGCTACGGCTGCGGCGCGGGAGGCCAAGAACGGCCCCGATTTCATCGCTCA
GGCAGAAGCCATCCTTGGACGCCATATTGAAGTCCTGTCCGGCAAGGAAGAAGCCTATTATTCTGCGCTTGGCATTATTT
CCGGCTTCTACAAGCCGAAGGGTGTGACGGGCGATCTTGGCGGCGGCAGTCTGGAACTGGTAGCCGTGGACGATCATGAA
GTGGGCGAGGGGATCACCCTGCCGCTGGGTGGCCTGCGCTTGCAGGATATGTCCGATGGGCGCTTGCCCGAAGCGGTAAA
AATTGCGCGCACGCAACTTGCAAAGGCGGTCATGCTGCAAGCGCATGAAGGGCAGGCCTTTTATGCTGTCGGCGGCACAT
GGCGAAACCTCGCCAAGCTGCACATGACTGCCAGGAACTATCCGCTGCATGTCATGCATGGCTATGAGATGGACGCCGCA
GAGGCACAGAGTTTCCTGAAACGCGTGGCCAAGGGCAATCTTGATACGATGCGCGGCATCGAGGCGGTTTCCAAAAATCG
CCGTCAGCTTCTGTCCTATGGGGCGACGGTCCTTCTGGAAACGCTGCGCTGCATGAAGCCGTCGAAGATTATTTTCTCGG
CGCTTGGTGTACGTGAAGGCTATCTCTATTCGCTCCTGCCCAAGAACGAACAGCGGCTTGATCCGCTGCTGGCTTCGGCG
GAGGAACTGTCCATTCTTCGCTCGCGCTCGCCGCGCCATGCGCGTGAACTGACGATCTGGACCGGGCTAAGCCTGTCTGT
TCTGGGTTATGACGAGACGCCGGATGAGGCGCGTTATCGCGAGGCTGCTTGTCTCGTGGCGGATATAAGCTGGCGTGCAC
ACCCCGATTATCGTGGCTCGCAGGCGCTGAATATCATTGCCCATGGCTCTTTCGGCGGCATCGACCATGCGGGCCGTTCT
TTCATGGCGCTTGCCAATTATTATCGCCATGAGGGTTTGATCGAGGACGAGATCGCGCCCGAAATGGTCCAGCTTTCCAC
GCCGCGCCTACGTGAACGCGCTAAACTGCTTGGGGCTTTGCTGCGCGTTGTCTATCTTCTGTCGGCTTCCATGCCCGGCG
TCATCCCGCGCCTTGTCTGGCGCGAGGACGAAGAGGGCATTGCGCTGGTCGTGCCGGGAGACCTCGCCGATCTGATTTCA
GACCGCCCCGAGGGACGGCTGCAACAGCTTTCCAAGCTGACGGGGAAGAACATCTATTTCGCGGTCGGCGACGGCGCGAT
TGAGGAGATGCGGGAGTGA

Upstream 100 bases:

>100_bases
CCAATCCCAGCCTGTCGGGTCGCGGAAAGTCGCTGAAGTCTTCGGCCCCCCGCCTTATCGCGCATCGCAAGCGCGCGCAG
GCGGAGAGAAAAACGACTGC

Downstream 100 bases:

>100_bases
TTTAGGGGAATAGGGGAATAGGGGAACAGGGTGCGGGCAGGTGGTGGACAAGGCAAGTAAAATATTTGCCTTGACTGAAA
AAGGGTGATTTTTTCCCTTA

Product: Ppx/GppA phosphatase

Products: NA

Alternate protein names: ExopolyPase; Metaphosphatase [H]

Number of amino acids: Translated: 512; Mature: 511

Protein sequence:

>512_residues
MSPAFAQGRLKGLKPVAVIDIGSNSIRVVIYEGIVRSPTVLFNEKILCGLGKGLAKTGKLNEKSVEAALRALKRFRALAE
QAGAVSIHALATAAAREAKNGPDFIAQAEAILGRHIEVLSGKEEAYYSALGIISGFYKPKGVTGDLGGGSLELVAVDDHE
VGEGITLPLGGLRLQDMSDGRLPEAVKIARTQLAKAVMLQAHEGQAFYAVGGTWRNLAKLHMTARNYPLHVMHGYEMDAA
EAQSFLKRVAKGNLDTMRGIEAVSKNRRQLLSYGATVLLETLRCMKPSKIIFSALGVREGYLYSLLPKNEQRLDPLLASA
EELSILRSRSPRHARELTIWTGLSLSVLGYDETPDEARYREAACLVADISWRAHPDYRGSQALNIIAHGSFGGIDHAGRS
FMALANYYRHEGLIEDEIAPEMVQLSTPRLRERAKLLGALLRVVYLLSASMPGVIPRLVWREDEEGIALVVPGDLADLIS
DRPEGRLQQLSKLTGKNIYFAVGDGAIEEMRE

Sequences:

>Translated_512_residues
MSPAFAQGRLKGLKPVAVIDIGSNSIRVVIYEGIVRSPTVLFNEKILCGLGKGLAKTGKLNEKSVEAALRALKRFRALAE
QAGAVSIHALATAAAREAKNGPDFIAQAEAILGRHIEVLSGKEEAYYSALGIISGFYKPKGVTGDLGGGSLELVAVDDHE
VGEGITLPLGGLRLQDMSDGRLPEAVKIARTQLAKAVMLQAHEGQAFYAVGGTWRNLAKLHMTARNYPLHVMHGYEMDAA
EAQSFLKRVAKGNLDTMRGIEAVSKNRRQLLSYGATVLLETLRCMKPSKIIFSALGVREGYLYSLLPKNEQRLDPLLASA
EELSILRSRSPRHARELTIWTGLSLSVLGYDETPDEARYREAACLVADISWRAHPDYRGSQALNIIAHGSFGGIDHAGRS
FMALANYYRHEGLIEDEIAPEMVQLSTPRLRERAKLLGALLRVVYLLSASMPGVIPRLVWREDEEGIALVVPGDLADLIS
DRPEGRLQQLSKLTGKNIYFAVGDGAIEEMRE
>Mature_511_residues
SPAFAQGRLKGLKPVAVIDIGSNSIRVVIYEGIVRSPTVLFNEKILCGLGKGLAKTGKLNEKSVEAALRALKRFRALAEQ
AGAVSIHALATAAAREAKNGPDFIAQAEAILGRHIEVLSGKEEAYYSALGIISGFYKPKGVTGDLGGGSLELVAVDDHEV
GEGITLPLGGLRLQDMSDGRLPEAVKIARTQLAKAVMLQAHEGQAFYAVGGTWRNLAKLHMTARNYPLHVMHGYEMDAAE
AQSFLKRVAKGNLDTMRGIEAVSKNRRQLLSYGATVLLETLRCMKPSKIIFSALGVREGYLYSLLPKNEQRLDPLLASAE
ELSILRSRSPRHARELTIWTGLSLSVLGYDETPDEARYREAACLVADISWRAHPDYRGSQALNIIAHGSFGGIDHAGRSF
MALANYYRHEGLIEDEIAPEMVQLSTPRLRERAKLLGALLRVVYLLSASMPGVIPRLVWREDEEGIALVVPGDLADLISD
RPEGRLQQLSKLTGKNIYFAVGDGAIEEMRE

Specific function: Degradation of inorganic polyphosphates. Orthophosphate is released progressively from the ends of polyphosphate [H]

COG id: COG0248

COG function: function code FP; Exopolyphosphatase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gppA/ppx family [H]

Homologues:

Organism=Escherichia coli, GI48994966, Length=156, Percent_Identity=32.0512820512821, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1788848, Length=148, Percent_Identity=29.7297297297297, Blast_Score=64, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6321185, Length=470, Percent_Identity=24.8936170212766, Blast_Score=88, Evalue=3e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022371
- InterPro:   IPR003695 [H]

Pfam domain/function: PF02541 Ppx-GppA [H]

EC number: =3.6.1.11 [H]

Molecular weight: Translated: 55812; Mature: 55681

Theoretical pI: Translated: 8.66; Mature: 8.66

Prosite motif: PS00213 LIPOCALIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSPAFAQGRLKGLKPVAVIDIGSNSIRVVIYEGIVRSPTVLFNEKILCGLGKGLAKTGKL
CCCCCCCCHHCCCCCEEEEEECCCCEEEEEEECCCCCCEEEECCCHHHHCCCCHHHCCCC
NEKSVEAALRALKRFRALAEQAGAVSIHALATAAAREAKNGPDFIAQAEAILGRHIEVLS
CHHHHHHHHHHHHHHHHHHHHCCCEEHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHC
GKEEAYYSALGIISGFYKPKGVTGDLGGGSLELVAVDDHEVGEGITLPLGGLRLQDMSDG
CCHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEECCCCCCCCEEECCCCEEECCCCCC
RLPEAVKIARTQLAKAVMLQAHEGQAFYAVGGTWRNLAKLHMTARNYPLHVMHGYEMDAA
CCCHHHHHHHHHHHHHHHHEECCCCEEEEECCCHHHHHHHHHHHCCCCEEEEECCCCCHH
EAQSFLKRVAKGNLDTMRGIEAVSKNRRQLLSYGATVLLETLRCMKPSKIIFSALGVREG
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCC
YLYSLLPKNEQRLDPLLASAEELSILRSRSPRHARELTIWTGLSLSVLGYDETPDEARYR
CEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCHHEEEEEECCEEEEEECCCCCCHHHHH
EAACLVADISWRAHPDYRGSQALNIIAHGSFGGIDHAGRSFMALANYYRHEGLIEDEIAP
HHHEEEEECCCCCCCCCCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCHHCCH
EMVQLSTPRLRERAKLLGALLRVVYLLSASMPGVIPRLVWREDEEGIALVVPGDLADLIS
HHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCCEEEEECCCHHHHHC
DRPEGRLQQLSKLTGKNIYFAVGDGAIEEMRE
CCCCHHHHHHHHHCCCEEEEEECCCHHHHHCC
>Mature Secondary Structure 
SPAFAQGRLKGLKPVAVIDIGSNSIRVVIYEGIVRSPTVLFNEKILCGLGKGLAKTGKL
CCCCCCCHHCCCCCEEEEEECCCCEEEEEEECCCCCCEEEECCCHHHHCCCCHHHCCCC
NEKSVEAALRALKRFRALAEQAGAVSIHALATAAAREAKNGPDFIAQAEAILGRHIEVLS
CHHHHHHHHHHHHHHHHHHHHCCCEEHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHC
GKEEAYYSALGIISGFYKPKGVTGDLGGGSLELVAVDDHEVGEGITLPLGGLRLQDMSDG
CCHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEECCCCCCCCEEECCCCEEECCCCCC
RLPEAVKIARTQLAKAVMLQAHEGQAFYAVGGTWRNLAKLHMTARNYPLHVMHGYEMDAA
CCCHHHHHHHHHHHHHHHHEECCCCEEEEECCCHHHHHHHHHHHCCCCEEEEECCCCCHH
EAQSFLKRVAKGNLDTMRGIEAVSKNRRQLLSYGATVLLETLRCMKPSKIIFSALGVREG
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCC
YLYSLLPKNEQRLDPLLASAEELSILRSRSPRHARELTIWTGLSLSVLGYDETPDEARYR
CEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCHHEEEEEECCEEEEEECCCCCCHHHHH
EAACLVADISWRAHPDYRGSQALNIIAHGSFGGIDHAGRSFMALANYYRHEGLIEDEIAP
HHHEEEEECCCCCCCCCCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCHHCCH
EMVQLSTPRLRERAKLLGALLRVVYLLSASMPGVIPRLVWREDEEGIALVVPGDLADLIS
HHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCCEEEEECCCHHHHHC
DRPEGRLQQLSKLTGKNIYFAVGDGAIEEMRE
CCCCHHHHHHHHHCCCEEEEEECCCHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10382967; 10984043 [H]