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The map label for this gene is ndk

Identifier: 225852214

GI number: 225852214

Start: 702000

End: 702422

Strand: Direct

Name: ndk

Synonym: BMEA_A0730

Alternate gene names: 225852214

Gene position: 702000-702422 (Clockwise)

Preceding gene: 225852211

Following gene: 225852221

Centisome position: 33.02

GC content: 57.92

Gene sequence:

>423_bases
ATGGCAATTGAACGTACTTTCTCCATGATCAAGCCCGATGCGACCCGCCGCAACCTGACTGGCGCGATCATCGCCAAGCT
TGAAGAAGCGGGCCTGCGCGTTGTCGCATCGAAGCGCGTCTGGATGAGCCGCCGTGAAGCTGAAGGCTTCTACGCCGTTC
ACAAGGACCGTCCGTTCTTTGGCGAACTGGTTGAATTCATGTCCTCCGGCCCGACGGTCGTTCAGGTTCTCGAAGGCGAA
AACGCAATTGCCAAGAACCGTGAAGTCATGGGCGCCACCAACCCGGCCAATGCCGACGAAGGCACCATCCGCAAGACCTT
CGCCCTGTCCATCGGTGAAAATTCGGTTCACGGTTCGGATGCTCCCGAAACCGCTGCCGAAGAAATCGCCTACTGGTTTT
CGGGCACCGAAATCGTTGGCTGA

Upstream 100 bases:

>100_bases
CCAAAAACCGTTCCCGCTTGCGGGCTTGCGCCTCTTGGCATTTTAACGCATCGACGTTATAGAGCCTCACTTTTCTCCAT
TCATCAAACAAGGTGTCATA

Downstream 100 bases:

>100_bases
TAGTCACAATGTGAATGAAAAAACCGGGCAATCGCCCGGTTTTTTTTTAACTGTTCTTCCGAGAACCGATTAAAAAAGGA
TGATGACCTGACTTGAAGTC

Product: nucleoside diphosphate kinase

Products: NA

Alternate protein names: NDK; NDP kinase; Nucleoside-2-P kinase

Number of amino acids: Translated: 140; Mature: 139

Protein sequence:

>140_residues
MAIERTFSMIKPDATRRNLTGAIIAKLEEAGLRVVASKRVWMSRREAEGFYAVHKDRPFFGELVEFMSSGPTVVQVLEGE
NAIAKNREVMGATNPANADEGTIRKTFALSIGENSVHGSDAPETAAEEIAYWFSGTEIVG

Sequences:

>Translated_140_residues
MAIERTFSMIKPDATRRNLTGAIIAKLEEAGLRVVASKRVWMSRREAEGFYAVHKDRPFFGELVEFMSSGPTVVQVLEGE
NAIAKNREVMGATNPANADEGTIRKTFALSIGENSVHGSDAPETAAEEIAYWFSGTEIVG
>Mature_139_residues
AIERTFSMIKPDATRRNLTGAIIAKLEEAGLRVVASKRVWMSRREAEGFYAVHKDRPFFGELVEFMSSGPTVVQVLEGEN
AIAKNREVMGATNPANADEGTIRKTFALSIGENSVHGSDAPETAAEEIAYWFSGTEIVG

Specific function: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate

COG id: COG0105

COG function: function code F; Nucleoside diphosphate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NDK family

Homologues:

Organism=Homo sapiens, GI66392203, Length=137, Percent_Identity=45.2554744525547, Blast_Score=130, Evalue=5e-31,
Organism=Homo sapiens, GI66392227, Length=137, Percent_Identity=45.2554744525547, Blast_Score=130, Evalue=5e-31,
Organism=Homo sapiens, GI66392205, Length=137, Percent_Identity=45.2554744525547, Blast_Score=130, Evalue=5e-31,
Organism=Homo sapiens, GI4505409, Length=137, Percent_Identity=45.2554744525547, Blast_Score=130, Evalue=5e-31,
Organism=Homo sapiens, GI66392192, Length=137, Percent_Identity=45.2554744525547, Blast_Score=130, Evalue=5e-31,
Organism=Homo sapiens, GI37693993, Length=138, Percent_Identity=44.2028985507246, Blast_Score=129, Evalue=1e-30,
Organism=Homo sapiens, GI38045913, Length=137, Percent_Identity=45.2554744525547, Blast_Score=127, Evalue=2e-30,
Organism=Homo sapiens, GI4557797, Length=137, Percent_Identity=45.2554744525547, Blast_Score=127, Evalue=3e-30,
Organism=Homo sapiens, GI4826862, Length=136, Percent_Identity=37.5, Blast_Score=102, Evalue=1e-22,
Organism=Homo sapiens, GI37574614, Length=136, Percent_Identity=33.0882352941176, Blast_Score=84, Evalue=5e-17,
Organism=Homo sapiens, GI7019465, Length=136, Percent_Identity=33.0882352941176, Blast_Score=84, Evalue=6e-17,
Organism=Homo sapiens, GI5031951, Length=136, Percent_Identity=33.0882352941176, Blast_Score=74, Evalue=3e-14,
Organism=Homo sapiens, GI148839372, Length=138, Percent_Identity=30.4347826086957, Blast_Score=69, Evalue=1e-12,
Organism=Homo sapiens, GI30023828, Length=135, Percent_Identity=33.3333333333333, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1788866, Length=139, Percent_Identity=54.6762589928058, Blast_Score=162, Evalue=6e-42,
Organism=Caenorhabditis elegans, GI17506807, Length=135, Percent_Identity=47.4074074074074, Blast_Score=132, Evalue=8e-32,
Organism=Saccharomyces cerevisiae, GI6322783, Length=136, Percent_Identity=41.1764705882353, Blast_Score=120, Evalue=7e-29,
Organism=Drosophila melanogaster, GI45549037, Length=136, Percent_Identity=48.5294117647059, Blast_Score=138, Evalue=9e-34,
Organism=Drosophila melanogaster, GI18860097, Length=134, Percent_Identity=32.8358208955224, Blast_Score=81, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NDK_BRUA1 (B2S4V2)

Other databases:

- EMBL:   CP000887
- RefSeq:   YP_001934673.1
- ProteinModelPortal:   B2S4V2
- SMR:   B2S4V2
- GeneID:   6327829
- GenomeReviews:   CP000887_GR
- KEGG:   bmc:BAbS19_I06680
- HOGENOM:   HBG445152
- OMA:   ERPFFGA
- ProtClustDB:   PRK00668
- GO:   GO:0005737
- HAMAP:   MF_00451
- InterPro:   IPR001564
- InterPro:   IPR023005
- Gene3D:   G3DSA:3.30.70.141
- PANTHER:   PTHR11349
- PRINTS:   PR01243
- SMART:   SM00562

Pfam domain/function: PF00334 NDK; SSF54919 NDK

EC number: =2.7.4.6

Molecular weight: Translated: 15278; Mature: 15147

Theoretical pI: Translated: 5.01; Mature: 5.01

Prosite motif: PS00469 NDP_KINASES

Important sites: ACT_SITE 117-117 BINDING 11-11 BINDING 59-59 BINDING 87-87 BINDING 93-93 BINDING 104-104 BINDING 114-114

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIERTFSMIKPDATRRNLTGAIIAKLEEAGLRVVASKRVWMSRREAEGFYAVHKDRPFF
CCCCHHHHHHCCCCCHHCCHHHHHHHHHHCCEEEEEHHHHHHHHHCCCCEEEEECCCCCH
GELVEFMSSGPTVVQVLEGENAIAKNREVMGATNPANADEGTIRKTFALSIGENSVHGSD
HHHHHHHCCCCEEEEEECCCCCCCCCCEEECCCCCCCCCCCCEEEEEEEEECCCCCCCCC
APETAAEEIAYWFSGTEIVG
CCHHHHHHHHHHHCCEEECC
>Mature Secondary Structure 
AIERTFSMIKPDATRRNLTGAIIAKLEEAGLRVVASKRVWMSRREAEGFYAVHKDRPFF
CCCHHHHHHCCCCCHHCCHHHHHHHHHHCCEEEEEHHHHHHHHHCCCCEEEEECCCCCH
GELVEFMSSGPTVVQVLEGENAIAKNREVMGATNPANADEGTIRKTFALSIGENSVHGSD
HHHHHHHCCCCEEEEEECCCCCCCCCCEEECCCCCCCCCCCCEEEEEEEEECCCCCCCCC
APETAAEEIAYWFSGTEIVG
CCHHHHHHHHHHHCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA