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The map label for this gene is pepA [H]

Identifier: 225852209

GI number: 225852209

Start: 696678

End: 698171

Strand: Direct

Name: pepA [H]

Synonym: BMEA_A0725

Alternate gene names: 225852209

Gene position: 696678-698171 (Clockwise)

Preceding gene: 225852201

Following gene: 225852210

Centisome position: 32.77

GC content: 58.5

Gene sequence:

>1494_bases
ATGTCTAAACGTCCTTCGATCTCTTTCAGCGAATTTGAAGTACCGCAAAAGGGGGTGGCCGTCGTGCTGGTGGCCAAGGG
CGGCGGTTTTGCCGATGAGGCGGCCAAGGCCGTTGGCGGCGCTGAAAAGATTGCGCGTATTGCCGATATTTCCGGCTTCA
CCGGGGCTTTGGGCAAGACTGCCGAAGCAATCGAGACGACCCCGGCGGGTGTGGAAAAGATCGTCCTTGTCGGCGTCGGC
GAGCCGGGCAAACTTGGCAATGACGATTGGCTGAAGATTGGCGGCGCGGCATTTTCGCAAATCGGCAATGCCGAGCGTGT
TACGCTCACGCTGGCGCTGCCGGAAACGACGATTGCAGGCGATGAAGCCGCTGACGTAGCACTGGGCATGGTTCTGCGCT
CCTATAAGTTCGACCGCTACAAGACCCGCAAGAGCGAGGAAAACGGCGAGCCCAAACATGCAGCGAAGATCACCATTTGC
GTTGCCGACACCCATAGCGCCCGGAAGGCCTTTGAAGTGGCTGAAGCGGTGGCGGATGGCGTCATTCAGGCACGCAACCT
CGTCAACGAGCCGGCCAATATCCTTGGCCCCGTGGAGTTTGCGGAAGAAGCTGAAAAGCTGGAAAAACTCGGTGTGAAAG
TCGAGGTGCTTGGCGAAAAGGAATTGAAGAAGCTCGGCATGGGGGCGCTTCTTGGCGTTGCGCAAGGCTCCGTGCGCCCG
CCGCGTCTTGTCGTGATGGAATGGCATGGCGCCAAGGGCAAGGAAAAGCCGATTGCCTTCGTCGGCAAGGGCGTGGTGTT
TGATACGGGCGGTATTTCGATCAAGCCTGCCGCCAATATGGAAGATATGAAGGGCGATATGGGGGGCGCTGCCGCTGTCA
CCGGCCTGATGCGCGCGCTGGCGGGACGCAAGGCCAAGGTAAACGCCATCGGTGTCATTGGTCTGGTCGAGAATATGCCG
GACGGCAATGCCCAGCGTCCGGGAGATATCGTCACCTCCATGTCCGGTCAGACCATCGAAGTCATCAATACCGATGCTGA
AGGCCGTCTTGTTCTCGCCGATGCGCTCCACTACACGAACGACCGTTTCAAGCCGCGTTTCATCATCAATCTCGCCACGT
TGACAGGCGCGGTCATGGTCGCGCTCGGCCAATACCATGCGGGCCTTTTTTCCAATGACGATGAGCTTGCCGACCAGCTT
TATGATGCCGGCCAGTCAACGGGTGAAAAGCTGTGGCGTTTGCCACTCGGCACCGAATACGACAAGATGATCGATTCGAA
ATTTGCCGACATGAAGAACAGCGCCGGGCGATATGGCGGGTCCATCACGGCGGCGCAATTCCTCAAGCGTTTCGTGGGCG
AGACGCCATGGGCGCATCTCGATGTGGCAGGCACGGCAATGGGATCGCCCGCCAATGAATATAACCAGTCTTGGGCGTCG
GGTTTTGGCGTGCGCCTGCTCGATCGCCTTGTCCGCGATCAATTTGAAAGCTAA

Upstream 100 bases:

>100_bases
GACCTGGCAAGATTGCTGTTTTCGCCATATTCGTCTCACATGAGAGAGGAAAAAGTAGCGACACAATCGTGTCATTCTTC
AATCCAAGTCTGGAGTTATC

Downstream 100 bases:

>100_bases
AATCTTTATAAACAACGGGATGGATGGGGAAGCTGATTGCGTTTCCTCATCTTCCTTCAAGCAGGCAGGGCATGGCAGAA
ATACTTTTTTACCATCTGAC

Product: leucyl aminopeptidase

Products: NA

Alternate protein names: Leucine aminopeptidase; LAP; Leucyl aminopeptidase [H]

Number of amino acids: Translated: 497; Mature: 496

Protein sequence:

>497_residues
MSKRPSISFSEFEVPQKGVAVVLVAKGGGFADEAAKAVGGAEKIARIADISGFTGALGKTAEAIETTPAGVEKIVLVGVG
EPGKLGNDDWLKIGGAAFSQIGNAERVTLTLALPETTIAGDEAADVALGMVLRSYKFDRYKTRKSEENGEPKHAAKITIC
VADTHSARKAFEVAEAVADGVIQARNLVNEPANILGPVEFAEEAEKLEKLGVKVEVLGEKELKKLGMGALLGVAQGSVRP
PRLVVMEWHGAKGKEKPIAFVGKGVVFDTGGISIKPAANMEDMKGDMGGAAAVTGLMRALAGRKAKVNAIGVIGLVENMP
DGNAQRPGDIVTSMSGQTIEVINTDAEGRLVLADALHYTNDRFKPRFIINLATLTGAVMVALGQYHAGLFSNDDELADQL
YDAGQSTGEKLWRLPLGTEYDKMIDSKFADMKNSAGRYGGSITAAQFLKRFVGETPWAHLDVAGTAMGSPANEYNQSWAS
GFGVRLLDRLVRDQFES

Sequences:

>Translated_497_residues
MSKRPSISFSEFEVPQKGVAVVLVAKGGGFADEAAKAVGGAEKIARIADISGFTGALGKTAEAIETTPAGVEKIVLVGVG
EPGKLGNDDWLKIGGAAFSQIGNAERVTLTLALPETTIAGDEAADVALGMVLRSYKFDRYKTRKSEENGEPKHAAKITIC
VADTHSARKAFEVAEAVADGVIQARNLVNEPANILGPVEFAEEAEKLEKLGVKVEVLGEKELKKLGMGALLGVAQGSVRP
PRLVVMEWHGAKGKEKPIAFVGKGVVFDTGGISIKPAANMEDMKGDMGGAAAVTGLMRALAGRKAKVNAIGVIGLVENMP
DGNAQRPGDIVTSMSGQTIEVINTDAEGRLVLADALHYTNDRFKPRFIINLATLTGAVMVALGQYHAGLFSNDDELADQL
YDAGQSTGEKLWRLPLGTEYDKMIDSKFADMKNSAGRYGGSITAAQFLKRFVGETPWAHLDVAGTAMGSPANEYNQSWAS
GFGVRLLDRLVRDQFES
>Mature_496_residues
SKRPSISFSEFEVPQKGVAVVLVAKGGGFADEAAKAVGGAEKIARIADISGFTGALGKTAEAIETTPAGVEKIVLVGVGE
PGKLGNDDWLKIGGAAFSQIGNAERVTLTLALPETTIAGDEAADVALGMVLRSYKFDRYKTRKSEENGEPKHAAKITICV
ADTHSARKAFEVAEAVADGVIQARNLVNEPANILGPVEFAEEAEKLEKLGVKVEVLGEKELKKLGMGALLGVAQGSVRPP
RLVVMEWHGAKGKEKPIAFVGKGVVFDTGGISIKPAANMEDMKGDMGGAAAVTGLMRALAGRKAKVNAIGVIGLVENMPD
GNAQRPGDIVTSMSGQTIEVINTDAEGRLVLADALHYTNDRFKPRFIINLATLTGAVMVALGQYHAGLFSNDDELADQLY
DAGQSTGEKLWRLPLGTEYDKMIDSKFADMKNSAGRYGGSITAAQFLKRFVGETPWAHLDVAGTAMGSPANEYNQSWASG
FGVRLLDRLVRDQFES

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides [H]

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family [H]

Homologues:

Organism=Homo sapiens, GI41393561, Length=393, Percent_Identity=40.2035623409669, Blast_Score=249, Evalue=4e-66,
Organism=Homo sapiens, GI47155554, Length=316, Percent_Identity=39.873417721519, Blast_Score=187, Evalue=2e-47,
Organism=Escherichia coli, GI1790710, Length=455, Percent_Identity=39.7802197802198, Blast_Score=294, Evalue=7e-81,
Organism=Escherichia coli, GI87082123, Length=317, Percent_Identity=39.1167192429022, Blast_Score=194, Evalue=1e-50,
Organism=Caenorhabditis elegans, GI17556903, Length=298, Percent_Identity=36.241610738255, Blast_Score=164, Evalue=8e-41,
Organism=Caenorhabditis elegans, GI17565172, Length=189, Percent_Identity=32.8042328042328, Blast_Score=86, Evalue=5e-17,
Organism=Drosophila melanogaster, GI24661038, Length=293, Percent_Identity=40.2730375426621, Blast_Score=203, Evalue=3e-52,
Organism=Drosophila melanogaster, GI21355725, Length=280, Percent_Identity=40.3571428571429, Blast_Score=202, Evalue=4e-52,
Organism=Drosophila melanogaster, GI20129969, Length=288, Percent_Identity=35.0694444444444, Blast_Score=199, Evalue=3e-51,
Organism=Drosophila melanogaster, GI24662227, Length=351, Percent_Identity=32.4786324786325, Blast_Score=199, Evalue=3e-51,
Organism=Drosophila melanogaster, GI21355645, Length=439, Percent_Identity=29.8405466970387, Blast_Score=186, Evalue=5e-47,
Organism=Drosophila melanogaster, GI24662223, Length=439, Percent_Identity=29.8405466970387, Blast_Score=186, Evalue=5e-47,
Organism=Drosophila melanogaster, GI161077148, Length=291, Percent_Identity=32.9896907216495, Blast_Score=182, Evalue=5e-46,
Organism=Drosophila melanogaster, GI20130057, Length=291, Percent_Identity=32.9896907216495, Blast_Score=182, Evalue=5e-46,
Organism=Drosophila melanogaster, GI21357381, Length=308, Percent_Identity=38.6363636363636, Blast_Score=177, Evalue=1e-44,
Organism=Drosophila melanogaster, GI221379063, Length=308, Percent_Identity=38.6363636363636, Blast_Score=177, Evalue=1e-44,
Organism=Drosophila melanogaster, GI221379062, Length=308, Percent_Identity=38.6363636363636, Blast_Score=177, Evalue=1e-44,
Organism=Drosophila melanogaster, GI20129963, Length=291, Percent_Identity=34.7079037800687, Blast_Score=177, Evalue=2e-44,
Organism=Drosophila melanogaster, GI19922386, Length=286, Percent_Identity=33.2167832167832, Blast_Score=173, Evalue=3e-43,
Organism=Drosophila melanogaster, GI24646701, Length=258, Percent_Identity=27.5193798449612, Blast_Score=83, Evalue=5e-16,
Organism=Drosophila melanogaster, GI24646703, Length=258, Percent_Identity=27.5193798449612, Blast_Score=83, Evalue=5e-16,
Organism=Drosophila melanogaster, GI21358201, Length=258, Percent_Identity=27.5193798449612, Blast_Score=83, Evalue=5e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042
- InterPro:   IPR008283 [H]

Pfam domain/function: PF00883 Peptidase_M17; PF02789 Peptidase_M17_N [H]

EC number: =3.4.11.1; =3.4.11.10 [H]

Molecular weight: Translated: 52547; Mature: 52415

Theoretical pI: Translated: 5.60; Mature: 5.60

Prosite motif: PS00631 CYTOSOL_AP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKRPSISFSEFEVPQKGVAVVLVAKGGGFADEAAKAVGGAEKIARIADISGFTGALGKT
CCCCCCCCHHHCCCCCCCEEEEEEECCCCCHHHHHHHHCCHHHHHHHHHCCCCCCCCCCC
AEAIETTPAGVEKIVLVGVGEPGKLGNDDWLKIGGAAFSQIGNAERVTLTLALPETTIAG
HHHHHCCCCCCEEEEEEECCCCCCCCCCCCEEECCHHHHHCCCCCEEEEEEEECCCCCCC
DEAADVALGMVLRSYKFDRYKTRKSEENGEPKHAAKITICVADTHSARKAFEVAEAVADG
CHHHHHHHHHHHHHHCCHHHHHCCCCCCCCCCCEEEEEEEEECCCHHHHHHHHHHHHHHH
VIQARNLVNEPANILGPVEFAEEAEKLEKLGVKVEVLGEKELKKLGMGALLGVAQGSVRP
HHHHHHHHCCCHHHCCHHHHHHHHHHHHHCCCEEEEECHHHHHHHCCHHHHHHCCCCCCC
PRLVVMEWHGAKGKEKPIAFVGKGVVFDTGGISIKPAANMEDMKGDMGGAAAVTGLMRAL
CEEEEEEECCCCCCCCCEEEEECCEEEECCCEEECCCCCHHHHCCCCCHHHHHHHHHHHH
AGRKAKVNAIGVIGLVENMPDGNAQRPGDIVTSMSGQTIEVINTDAEGRLVLADALHYTN
CCCCCEEEEEEEEEEHHCCCCCCCCCCCHHHCCCCCCEEEEEECCCCCCEEEEEHHHHCC
DRFKPRFIINLATLTGAVMVALGQYHAGLFSNDDELADQLYDAGQSTGEKLWRLPLGTEY
CCCCCEEEEEHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCHHHHHEEECCCCCHH
DKMIDSKFADMKNSAGRYGGSITAAQFLKRFVGETPWAHLDVAGTAMGSPANEYNQSWAS
HHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHHHHH
GFGVRLLDRLVRDQFES
CCHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SKRPSISFSEFEVPQKGVAVVLVAKGGGFADEAAKAVGGAEKIARIADISGFTGALGKT
CCCCCCCHHHCCCCCCCEEEEEEECCCCCHHHHHHHHCCHHHHHHHHHCCCCCCCCCCC
AEAIETTPAGVEKIVLVGVGEPGKLGNDDWLKIGGAAFSQIGNAERVTLTLALPETTIAG
HHHHHCCCCCCEEEEEEECCCCCCCCCCCCEEECCHHHHHCCCCCEEEEEEEECCCCCCC
DEAADVALGMVLRSYKFDRYKTRKSEENGEPKHAAKITICVADTHSARKAFEVAEAVADG
CHHHHHHHHHHHHHHCCHHHHHCCCCCCCCCCCEEEEEEEEECCCHHHHHHHHHHHHHHH
VIQARNLVNEPANILGPVEFAEEAEKLEKLGVKVEVLGEKELKKLGMGALLGVAQGSVRP
HHHHHHHHCCCHHHCCHHHHHHHHHHHHHCCCEEEEECHHHHHHHCCHHHHHHCCCCCCC
PRLVVMEWHGAKGKEKPIAFVGKGVVFDTGGISIKPAANMEDMKGDMGGAAAVTGLMRAL
CEEEEEEECCCCCCCCCEEEEECCEEEECCCEEECCCCCHHHHCCCCCHHHHHHHHHHHH
AGRKAKVNAIGVIGLVENMPDGNAQRPGDIVTSMSGQTIEVINTDAEGRLVLADALHYTN
CCCCCEEEEEEEEEEHHCCCCCCCCCCCHHHCCCCCCEEEEEECCCCCCEEEEEHHHHCC
DRFKPRFIINLATLTGAVMVALGQYHAGLFSNDDELADQLYDAGQSTGEKLWRLPLGTEY
CCCCCEEEEEHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCHHHHHEEECCCCCHH
DKMIDSKFADMKNSAGRYGGSITAAQFLKRFVGETPWAHLDVAGTAMGSPANEYNQSWAS
HHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHHHHH
GFGVRLLDRLVRDQFES
CCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11756688 [H]