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The map label for this gene is fabF [H]

Identifier: 225851998

GI number: 225851998

Start: 479228

End: 480490

Strand: Direct

Name: fabF [H]

Synonym: BMEA_A0497

Alternate gene names: 225851998

Gene position: 479228-480490 (Clockwise)

Preceding gene: 225851997

Following gene: 225851999

Centisome position: 22.54

GC content: 62.0

Gene sequence:

>1263_bases
ATGAGGCGTGTCGTCATCACCGGTCTCGGTCTGGTGTCACCGCTCGCAAGCGGTGTGGAAGAGACTTGGAAGCGGCTTCT
TGCCGGTGAAAGCGGGGCTCGCCGCGTTACGGAATTCGAGGTGGACGATCTGGCCTGCCAGATTGCCTGCCGCATTCCCG
TTGGCGATGGCACGAACGGTACGTTCAATCCCGACCTGCATATGGACCCGAAGGAACAGCGCAAGGTCGATCCTTTCATC
GTTTATGCCGTCGGTGCAGCCGATCAGGCTCTGGATGATGCCGGCTGGCACCCGGAAAATGATGAGGATCAGGTCCGCAC
CGGCGTTCTTATCGGTTCGGGCATCGGCGGCATCGAAGGCATTGTCGAGGCGGGCTACACGCTGCGCGACAAGGGCCCGC
GCCGTATTTCGCCCTTCTTCATTCCGGGCCGTCTCATCAATCTGGCCTCCGGCCATGTGTCGATCAAGCACAAGCTGCGC
GGGCCGAACCACTCGGTCGTCACGGCCTGTGCAACCGGCACGCACGCTATTGGCGATGCCGCCCGCCTCATTGCTTTCGG
CGATGCGGATGTGATGGTTGCCGGTGGCACGGAATCGCCGGTGAGCCGCATTTCGCTTGCTGGCTTTGCCGCCTGCAAGG
CGCTTTCCACCGAGCGCAATGACGATCCGACCGCCGCTTCACGTCCTTATGACGAGGATCGTGACGGCTTCGTCATGGGC
GAAGGCGCTGGCATTGTGGTGCTTGAAGAGCTGGAACACGCTTTGGCGCGCGGTGCGAAGATTTATGCCGAAGTCATCGG
CTATGGCATGTCGGGCGATGCCTTCCATATCACGGCCCCGACCGAGAGCGGTGAGGGCGCACAGCGCTGCATGGTGGCGG
CTCTCAAGCGTGCCGGGATCGTGCCGGACGAGATCGACTATATCAATGCGCATGGCACGTCCACCATGGCCGATACGATC
GAGCTTGGCGCGGTGGAGCGCGTGGTGGGTGAGGCGGCTGCGAAGATTTCGATGTCTTCCACCAAATCATCCATCGGCCA
CCTGTTGGGTGCGGCAGGGGCTGCCGAAGCGGTCTTCTCCACGCTGGCCATTCGCGACAATATCGCGCCTGCCACACTCA
ATCTGGACAATCCGGCGGCGCAGACCAGGATCGATCTCGTGCCGCACAAGCCGCGCGAACGCAAGATCGATGTGGCGCTG
TCGAATTCGTTCGGTTTCGGTGGCACCAATGCATCGCTGGTGTTGCGCCGCTACACGGCCTGA

Upstream 100 bases:

>100_bases
GCATCGTTCCCGAAAGTCGGGCTGGCACATTGGACGGCCAATGAAGCGGTCTGCGGTTCGATGCTGGAAACATGTATTTA
ACGGATCTTAAGGGGTTAAC

Downstream 100 bases:

>100_bases
CAGGTTCGCAAAACCGGGTAATGATAAAAACGCGGGGATTTCTCCGCGTTTTTGCCAAAATAAAACCGGATGCGATGTTT
AAAATTGATGGCACAGTTTA

Product: 3-oxoacyl-(acyl carrier protein) synthase II

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase II; Beta-ketoacyl-ACP synthase II; KAS II [H]

Number of amino acids: Translated: 420; Mature: 420

Protein sequence:

>420_residues
MRRVVITGLGLVSPLASGVEETWKRLLAGESGARRVTEFEVDDLACQIACRIPVGDGTNGTFNPDLHMDPKEQRKVDPFI
VYAVGAADQALDDAGWHPENDEDQVRTGVLIGSGIGGIEGIVEAGYTLRDKGPRRISPFFIPGRLINLASGHVSIKHKLR
GPNHSVVTACATGTHAIGDAARLIAFGDADVMVAGGTESPVSRISLAGFAACKALSTERNDDPTAASRPYDEDRDGFVMG
EGAGIVVLEELEHALARGAKIYAEVIGYGMSGDAFHITAPTESGEGAQRCMVAALKRAGIVPDEIDYINAHGTSTMADTI
ELGAVERVVGEAAAKISMSSTKSSIGHLLGAAGAAEAVFSTLAIRDNIAPATLNLDNPAAQTRIDLVPHKPRERKIDVAL
SNSFGFGGTNASLVLRRYTA

Sequences:

>Translated_420_residues
MRRVVITGLGLVSPLASGVEETWKRLLAGESGARRVTEFEVDDLACQIACRIPVGDGTNGTFNPDLHMDPKEQRKVDPFI
VYAVGAADQALDDAGWHPENDEDQVRTGVLIGSGIGGIEGIVEAGYTLRDKGPRRISPFFIPGRLINLASGHVSIKHKLR
GPNHSVVTACATGTHAIGDAARLIAFGDADVMVAGGTESPVSRISLAGFAACKALSTERNDDPTAASRPYDEDRDGFVMG
EGAGIVVLEELEHALARGAKIYAEVIGYGMSGDAFHITAPTESGEGAQRCMVAALKRAGIVPDEIDYINAHGTSTMADTI
ELGAVERVVGEAAAKISMSSTKSSIGHLLGAAGAAEAVFSTLAIRDNIAPATLNLDNPAAQTRIDLVPHKPRERKIDVAL
SNSFGFGGTNASLVLRRYTA
>Mature_420_residues
MRRVVITGLGLVSPLASGVEETWKRLLAGESGARRVTEFEVDDLACQIACRIPVGDGTNGTFNPDLHMDPKEQRKVDPFI
VYAVGAADQALDDAGWHPENDEDQVRTGVLIGSGIGGIEGIVEAGYTLRDKGPRRISPFFIPGRLINLASGHVSIKHKLR
GPNHSVVTACATGTHAIGDAARLIAFGDADVMVAGGTESPVSRISLAGFAACKALSTERNDDPTAASRPYDEDRDGFVMG
EGAGIVVLEELEHALARGAKIYAEVIGYGMSGDAFHITAPTESGEGAQRCMVAALKRAGIVPDEIDYINAHGTSTMADTI
ELGAVERVVGEAAAKISMSSTKSSIGHLLGAAGAAEAVFSTLAIRDNIAPATLNLDNPAAQTRIDLVPHKPRERKIDVAL
SNSFGFGGTNASLVLRRYTA

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Has a preference for short chain acid substrates and may function to supply the octanoic substrates for lipoic acid biosynthes

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=418, Percent_Identity=51.6746411483254, Blast_Score=421, Evalue=1e-118,
Organism=Homo sapiens, GI223972627, Length=193, Percent_Identity=44.559585492228, Blast_Score=179, Evalue=5e-45,
Organism=Homo sapiens, GI41872631, Length=436, Percent_Identity=25.2293577981651, Blast_Score=99, Evalue=1e-20,
Organism=Escherichia coli, GI1787337, Length=418, Percent_Identity=51.9138755980861, Blast_Score=388, Evalue=1e-109,
Organism=Escherichia coli, GI1788663, Length=419, Percent_Identity=38.4248210023866, Blast_Score=254, Evalue=6e-69,
Organism=Caenorhabditis elegans, GI71983541, Length=424, Percent_Identity=38.6792452830189, Blast_Score=264, Evalue=6e-71,
Organism=Caenorhabditis elegans, GI71983535, Length=266, Percent_Identity=44.3609022556391, Blast_Score=205, Evalue=3e-53,
Organism=Caenorhabditis elegans, GI212642053, Length=429, Percent_Identity=26.5734265734266, Blast_Score=105, Evalue=5e-23,
Organism=Caenorhabditis elegans, GI17550940, Length=420, Percent_Identity=24.047619047619, Blast_Score=95, Evalue=9e-20,
Organism=Saccharomyces cerevisiae, GI6320904, Length=446, Percent_Identity=40.8071748878924, Blast_Score=300, Evalue=2e-82,
Organism=Drosophila melanogaster, GI24644341, Length=423, Percent_Identity=46.0992907801418, Blast_Score=357, Evalue=7e-99,
Organism=Drosophila melanogaster, GI221330659, Length=362, Percent_Identity=25.414364640884, Blast_Score=89, Evalue=5e-18,
Organism=Drosophila melanogaster, GI19920632, Length=362, Percent_Identity=25.414364640884, Blast_Score=89, Evalue=6e-18,
Organism=Drosophila melanogaster, GI24581345, Length=432, Percent_Identity=23.6111111111111, Blast_Score=84, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017568
- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.179 [H]

Molecular weight: Translated: 44089; Mature: 44089

Theoretical pI: Translated: 5.30; Mature: 5.30

Prosite motif: PS00606 B_KETOACYL_SYNTHASE ; PS00107 PROTEIN_KINASE_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRVVITGLGLVSPLASGVEETWKRLLAGESGARRVTEFEVDDLACQIACRIPVGDGTNG
CCEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCEEEEEEEEEECCCCCCC
TFNPDLHMDPKEQRKVDPFIVYAVGAADQALDDAGWHPENDEDQVRTGVLIGSGIGGIEG
CCCCCCCCCCHHHHCCCCEEEEEECCCHHHHHCCCCCCCCCCCHHEEEEEEECCCCHHHH
IVEAGYTLRDKGPRRISPFFIPGRLINLASGHVSIKHKLRGPNHSVVTACATGTHAIGDA
HHHCCCEEECCCCCCCCCEECCCEEEEECCCCEEEEEECCCCCCCEEEEECCCCCHHCCC
ARLIAFGDADVMVAGGTESPVSRISLAGFAACKALSTERNDDPTAASRPYDEDRDGFVMG
EEEEEECCCCEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEE
EGAGIVVLEELEHALARGAKIYAEVIGYGMSGDAFHITAPTESGEGAQRCMVAALKRAGI
CCCCEEEHHHHHHHHHCCHHHHHHHHCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHCCC
VPDEIDYINAHGTSTMADTIELGAVERVVGEAAAKISMSSTKSSIGHLLGAAGAAEAVFS
CCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHEEHHHHHHHHHHHHHCCHHHHHHHH
TLAIRDNIAPATLNLDNPAAQTRIDLVPHKPRERKIDVALSNSFGFGGTNASLVLRRYTA
HHHHHCCCCCEEEECCCCCHHCEEECCCCCCCCCEEEEEEECCCCCCCCCCEEEEEEECC
>Mature Secondary Structure
MRRVVITGLGLVSPLASGVEETWKRLLAGESGARRVTEFEVDDLACQIACRIPVGDGTNG
CCEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCEEEEEEEEEECCCCCCC
TFNPDLHMDPKEQRKVDPFIVYAVGAADQALDDAGWHPENDEDQVRTGVLIGSGIGGIEG
CCCCCCCCCCHHHHCCCCEEEEEECCCHHHHHCCCCCCCCCCCHHEEEEEEECCCCHHHH
IVEAGYTLRDKGPRRISPFFIPGRLINLASGHVSIKHKLRGPNHSVVTACATGTHAIGDA
HHHCCCEEECCCCCCCCCEECCCEEEEECCCCEEEEEECCCCCCCEEEEECCCCCHHCCC
ARLIAFGDADVMVAGGTESPVSRISLAGFAACKALSTERNDDPTAASRPYDEDRDGFVMG
EEEEEECCCCEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEE
EGAGIVVLEELEHALARGAKIYAEVIGYGMSGDAFHITAPTESGEGAQRCMVAALKRAGI
CCCCEEEHHHHHHHHHCCHHHHHHHHCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHCCC
VPDEIDYINAHGTSTMADTIELGAVERVVGEAAAKISMSSTKSSIGHLLGAAGAAEAVFS
CCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHEEHHHHHHHHHHHHHCCHHHHHHHH
TLAIRDNIAPATLNLDNPAAQTRIDLVPHKPRERKIDVALSNSFGFGGTNASLVLRRYTA
HHHHHCCCCCEEEECCCCCHHCEEECCCCCCCCCEEEEEEECCCCCCCCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10784042; 11481430 [H]