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The map label for this gene is rhmD [H]

Identifier: 225851772

GI number: 225851772

Start: 255786

End: 257063

Strand: Direct

Name: rhmD [H]

Synonym: BMEA_A0253

Alternate gene names: 225851772

Gene position: 255786-257063 (Clockwise)

Preceding gene: 225851771

Following gene: 225851776

Centisome position: 12.03

GC content: 58.61

Gene sequence:

>1278_bases
ATGACGAAAATCACCGATCTGCGCGTTTTCGACCTGCGCTTTCCGACGTCGCAAAGTCTGGACGGCTCGGATGCGATGAA
TCCCGACCCGGACTATTCGGCGGCCTATGTCATCCTCGATACGGATGATGAGGCGCTGAAAGGGCACGGCCTTACCTTCA
CCATCGGCCGCGGTAACGATATTTGCTGCCATGCGATCCTGGCCATGCGCCATCTGGTCGTGGGGGCTTCGCTTGATGAA
ATCCGTGCCGCCCCCGGCAAGTTCTGGCATCACCTGACGGGTGACAGCCAGTTGCGCTGGATCGGCCCGGAGAAGGGCGC
CATGCACCTTGCCACCGGCGCTGTGGTCAACGCGATCTGGGATTTGCTTGCGAAACAAGCGGGAAAGCCGGTCTGGCGGC
TGGTCTCGGAGCTTTCGCCGGAAGAAATCGCCGATATCGTGGATTATCGTTATCTGACCGATGTGCTGACGCGCGATGAA
GCCATCGAAATTCTGCGGAAGGCTGAAAGCGGCAAGGCAGAGCGTATCGCCACGCTGGAGGCGGAGGGCTATGCCTGCTA
CACGACCTCTGCTGGCTGGCTTGGCTATGACGACGCGAAATTGCGCCGGCTTTGCCAGGAAGCGATCGATGAAGGCTTCA
ACCACGTCAAGATGAAGGTGGGCCACGATCTGGAAGACGATATCCGCCGCCTGACCATCGCGCGAGAGGTTATCGGGCCG
GACCGTTATCTCATGATCGACGCCAACCAGGTGTGGGAAGTCGATCAGGCCATTGAGTGGGTGAGGCGGCTTGCCTTTGC
CAATCCGTTCTTCATCGAGGAACCGACCAGCCCCGACGATGTGGCCGGGCATCGCAAGATTCGCGCCGCAATTGGTCCGG
TGAAGGTTGCCACCGGCGAAATGTGCCAGAACCGCATCATGTTCAAGCAGTTTATCGCGGAAGGTGCGATCGACGTCGTG
CAGATCGATAGCTGCCGCATGGGTGGCCTGAACGAGGTGCTGGCAGTGCTGCTGATGGCAGCAAAGTATGACCTTCCGGT
CTGGCCTCACGCGGGCGGTGTGGGCTTGTGCGAATATGTGCAGCACCTGTCTATGATCGATTATGTGGCTGTCTCCGGCA
CCAAGGAAGGCCGTGTGATCGAATATGTCGATCACCTGCACGAACATTTCCTCGATCCCTGCATTATCAGGAACGCGGCC
TATATGCCGCCTTCGCTGCCTGGCTTTTCCATCGAGATGAAGCCGCAATCCATCGCGCAATATGCATTCAAGGGCTGA

Upstream 100 bases:

>100_bases
CCGCGCTATCTCAAGGCTGGTGATGTCGTGGAACTCGGTATCGAGGGCCTCGGATCGCAGAAGCAGAACGTGCGCGCCGA
TAGCTGATAATGGACACACA

Downstream 100 bases:

>100_bases
CCAAACGCCGCGCGCAAAGCGCGGCGTTTTTTTAGCATTTCGAGCCAAAAATGCGAAGCTCCTAAGCGGGAAATCAGTCC
ACAGGACTGATTTCCGATCC

Product: mandelate racemase/muconate lactonizing enzyme domain-containing protein

Products: NA

Alternate protein names: RhamD [H]

Number of amino acids: Translated: 425; Mature: 424

Protein sequence:

>425_residues
MTKITDLRVFDLRFPTSQSLDGSDAMNPDPDYSAAYVILDTDDEALKGHGLTFTIGRGNDICCHAILAMRHLVVGASLDE
IRAAPGKFWHHLTGDSQLRWIGPEKGAMHLATGAVVNAIWDLLAKQAGKPVWRLVSELSPEEIADIVDYRYLTDVLTRDE
AIEILRKAESGKAERIATLEAEGYACYTTSAGWLGYDDAKLRRLCQEAIDEGFNHVKMKVGHDLEDDIRRLTIAREVIGP
DRYLMIDANQVWEVDQAIEWVRRLAFANPFFIEEPTSPDDVAGHRKIRAAIGPVKVATGEMCQNRIMFKQFIAEGAIDVV
QIDSCRMGGLNEVLAVLLMAAKYDLPVWPHAGGVGLCEYVQHLSMIDYVAVSGTKEGRVIEYVDHLHEHFLDPCIIRNAA
YMPPSLPGFSIEMKPQSIAQYAFKG

Sequences:

>Translated_425_residues
MTKITDLRVFDLRFPTSQSLDGSDAMNPDPDYSAAYVILDTDDEALKGHGLTFTIGRGNDICCHAILAMRHLVVGASLDE
IRAAPGKFWHHLTGDSQLRWIGPEKGAMHLATGAVVNAIWDLLAKQAGKPVWRLVSELSPEEIADIVDYRYLTDVLTRDE
AIEILRKAESGKAERIATLEAEGYACYTTSAGWLGYDDAKLRRLCQEAIDEGFNHVKMKVGHDLEDDIRRLTIAREVIGP
DRYLMIDANQVWEVDQAIEWVRRLAFANPFFIEEPTSPDDVAGHRKIRAAIGPVKVATGEMCQNRIMFKQFIAEGAIDVV
QIDSCRMGGLNEVLAVLLMAAKYDLPVWPHAGGVGLCEYVQHLSMIDYVAVSGTKEGRVIEYVDHLHEHFLDPCIIRNAA
YMPPSLPGFSIEMKPQSIAQYAFKG
>Mature_424_residues
TKITDLRVFDLRFPTSQSLDGSDAMNPDPDYSAAYVILDTDDEALKGHGLTFTIGRGNDICCHAILAMRHLVVGASLDEI
RAAPGKFWHHLTGDSQLRWIGPEKGAMHLATGAVVNAIWDLLAKQAGKPVWRLVSELSPEEIADIVDYRYLTDVLTRDEA
IEILRKAESGKAERIATLEAEGYACYTTSAGWLGYDDAKLRRLCQEAIDEGFNHVKMKVGHDLEDDIRRLTIAREVIGPD
RYLMIDANQVWEVDQAIEWVRRLAFANPFFIEEPTSPDDVAGHRKIRAAIGPVKVATGEMCQNRIMFKQFIAEGAIDVVQ
IDSCRMGGLNEVLAVLLMAAKYDLPVWPHAGGVGLCEYVQHLSMIDYVAVSGTKEGRVIEYVDHLHEHFLDPCIIRNAAY
MPPSLPGFSIEMKPQSIAQYAFKG

Specific function: Catalyzes the dehydration of L-rhamnonate to 2-keto-3- deoxy-L-rhamnonate (KDR) [H]

COG id: COG4948

COG function: function code MR; L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mandelate racemase/muconate lactonizing enzyme family. RhamD subfamily [H]

Homologues:

Organism=Homo sapiens, GI42544119, Length=424, Percent_Identity=53.0660377358491, Blast_Score=483, Evalue=1e-136,
Organism=Homo sapiens, GI42544117, Length=409, Percent_Identity=51.3447432762836, Blast_Score=454, Evalue=1e-128,
Organism=Homo sapiens, GI186972148, Length=331, Percent_Identity=54.0785498489426, Blast_Score=397, Evalue=1e-110,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018110
- InterPro:   IPR013342
- InterPro:   IPR013341
- InterPro:   IPR001354 [H]

Pfam domain/function: PF01188 MR_MLE; PF02746 MR_MLE_N [H]

EC number: =4.2.1.90 [H]

Molecular weight: Translated: 47312; Mature: 47180

Theoretical pI: Translated: 5.02; Mature: 5.02

Prosite motif: PS00909 MR_MLE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKITDLRVFDLRFPTSQSLDGSDAMNPDPDYSAAYVILDTDDEALKGHGLTFTIGRGND
CCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCEEEEEEECCCHHHCCCCEEEEECCCCH
ICCHAILAMRHLVVGASLDEIRAAPGKFWHHLTGDSQLRWIGPEKGAMHLATGAVVNAIW
HHHHHHHHHHHHHHCCCHHHHHCCCCHHHHHCCCCCEEEEECCCCCCEEHHHHHHHHHHH
DLLAKQAGKPVWRLVSELSPEEIADIVDYRYLTDVLTRDEAIEILRKAESGKAERIATLE
HHHHHHCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEE
AEGYACYTTSAGWLGYDDAKLRRLCQEAIDEGFNHVKMKVGHDLEDDIRRLTIAREVIGP
CCCEEEEECCCCCCCCCHHHHHHHHHHHHHCCHHEEEEECCCCHHHHHHHHHHHHHHHCC
DRYLMIDANQVWEVDQAIEWVRRLAFANPFFIEEPTSPDDVAGHRKIRAAIGPVKVATGE
CCEEEECCHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCHHCCHHHHHHHHCCEEECHHH
MCQNRIMFKQFIAEGAIDVVQIDSCRMGGLNEVLAVLLMAAKYDLPVWPHAGGVGLCEYV
HHHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHH
QHLSMIDYVAVSGTKEGRVIEYVDHLHEHFLDPCIIRNAAYMPPSLPGFSIEMKPQSIAQ
HHHHHHHHHEECCCCCCCHHHHHHHHHHHHCCHHHHCCCCCCCCCCCCCEEEECHHHHHH
YAFKG
HHCCC
>Mature Secondary Structure 
TKITDLRVFDLRFPTSQSLDGSDAMNPDPDYSAAYVILDTDDEALKGHGLTFTIGRGND
CCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCEEEEEEECCCHHHCCCCEEEEECCCCH
ICCHAILAMRHLVVGASLDEIRAAPGKFWHHLTGDSQLRWIGPEKGAMHLATGAVVNAIW
HHHHHHHHHHHHHHCCCHHHHHCCCCHHHHHCCCCCEEEEECCCCCCEEHHHHHHHHHHH
DLLAKQAGKPVWRLVSELSPEEIADIVDYRYLTDVLTRDEAIEILRKAESGKAERIATLE
HHHHHHCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEE
AEGYACYTTSAGWLGYDDAKLRRLCQEAIDEGFNHVKMKVGHDLEDDIRRLTIAREVIGP
CCCEEEEECCCCCCCCCHHHHHHHHHHHHHCCHHEEEEECCCCHHHHHHHHHHHHHHHCC
DRYLMIDANQVWEVDQAIEWVRRLAFANPFFIEEPTSPDDVAGHRKIRAAIGPVKVATGE
CCEEEECCHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCHHCCHHHHHHHHCCEEECHHH
MCQNRIMFKQFIAEGAIDVVQIDSCRMGGLNEVLAVLLMAAKYDLPVWPHAGGVGLCEYV
HHHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHH
QHLSMIDYVAVSGTKEGRVIEYVDHLHEHFLDPCIIRNAAYMPPSLPGFSIEMKPQSIAQ
HHHHHHHHHEECCCCCCCHHHHHHHHHHHHCCHHHHCCCCCCCCCCCCCEEEECHHHHHH
YAFKG
HHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA