Click here to switch to the map view.

The map label for this gene is sir2 [H]

Identifier: 225851713

GI number: 225851713

Start: 191909

End: 193579

Strand: Direct

Name: sir2 [H]

Synonym: BMEA_A0188

Alternate gene names: 225851713

Gene position: 191909-193579 (Clockwise)

Preceding gene: 225851712

Following gene: 225851714

Centisome position: 9.03

GC content: 57.57

Gene sequence:

>1671_bases
ATGTATCGTTATGATGAATTCGACCGGGATTTTGTTGCAGCCCGCGTTGCCCAGTTCAAGGATCAGGTTGCGCGCCGCCT
TTCGGGCGAGCTGACGGAAGACCAGTTCAAGCCCTTGCGGCTGATGAACGGCCTTTACCTGCAATTGCATGCCTATATGC
TGCGCGTGGCAATCCCCTATGGAACGCTGTCCAGCCGCCAGTTGCGCAAGCTTGGGTCTATCGCGCGCACTTATGACCGT
GGCTTTGGCCATTTCACGACGCGCCAGAACATCCAGTATAACTGGCCTGCGCTGAAGGATGTTCCGCAGATTTTGGCAGA
GCTGGCAGAGGTGGAAATGCATTCCATCCAGACCTCCGGCAATTGCATTCGCAATGTGACTGCCGACCATTTTGCAGGTG
CTGCCGCCGACGAAGTGACGGACCCACGCCCGCTTGCCGAAATCCTGCGGCAATGGTCGTCGCTGCACCCGGAATTTTCC
TATCTGCCGCGCAAGTTCAAGATTGCGATTGTCGGGTCCGAGCATGACCGTGCGGCCATTCAGGTGCACGATATCGGCCT
GCAACTGAAGAAGAACGAGGCGGGCGAGCTTGGCCTTGCCGTTTATGTCGGCGGCGGGCAGGGCCGCACGCCGATGGTGG
CCAAGAAAATTCGTGACTTCCTGCCCATCGAGGACATGCTGACCTATGTGACGGCAATCGTCCGTGTCTATAATCTTCAT
GGTCGGCGTGACAACAAGTTCAAGGCGCGCATCAAGATCCTTGTGCATGAAACCGGCATCGAACAATTGACCCGCGAGAT
CGATGCGGAATGGGAAGAAATCCGCCATGGCGAATTGAAGCTGCCGCAGCGCGATATCGATGTCATTGAAAGCTATTTCC
GTATGCCCGACCTGCCGCAGCGCCCCGAAGGCTGGGAAATTCTCGCCGTGGCACAGAAGGCTGATGCGGAATTTGCAAGC
TGGGTCGCGCGCAATGTCACCGCGCACAAGCATCCCGATTATGCCGTCGTCACCATCTCGCTGAAGCCTGTCGGCGGCAT
TCCGGGCGATGCCAGTGCTGAACAGATGGAACTGGTGGCCGATGTGGCGCAAACCTGTTCCTTCGATGAAATCCGGGTGA
GCCACGAGCAGAACCTCGTGCTGCCACATGTGGCCAAGGCCGATCTGCCGGCAGTCTACGACCGCCTGCAATCGGGCGGA
CTGGTGACACCCCATGCCGGTCTCATCACCGATATCATTGCTTGCCCCGGTCTTGATTATTGCGCGCTGGCCAATGCACG
CTCCATTCCCGTTGCGCAGCGCATTTCCGAGCGCTTCGCCGATCTGGACCGTCAGCTTGAAATCGGCGATCTCAAGATCA
AGATTTCCGGCTGCATCAATGCCTGCGGCCATCATCATGTCGGCCATATCGGCATTCTGGGCGTGGAGAAGAAGGGTGAG
GAGCTTTACCAGATCACGCTTGGCGGCTCGGCGGACGAAAACTCGGCCATTGGTGAAATCACCGGGCGCGGTTTCTCGTC
GGAAGAGGTGGTCGATGCCATCGAAACCATTGTCGATACCTATCTGGGCCTGCGCGAAAGTGCGGAGGAAACTTTCCTTG
CCGCTTATCGCCGGGTGGGAATGGAGCCTTTCAAACGCGCTCTTTATGGGGAGATAAGAAGTGCTGCCTGA

Upstream 100 bases:

>100_bases
TCCGTCTGCGCGAACGCATCCGCCTGTCCGGCCCGACCATCGTGACCATGGGCCATGTATTCCCGGCGCCTGCCTCCTGA
TCTGTTGTTGGACATAGCCT

Downstream 100 bases:

>100_bases
CGCCGACATTGCCGATGCGGATGAGCGCGGTGCCGCGCAAGCCCGGCTTCTCGAAGCAAGCCACGGCGCATCCGCGCCGC
ACGAAATAATCGCGCTTGTC

Product: sulfite reductase ferredoxin

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 556; Mature: 556

Protein sequence:

>556_residues
MYRYDEFDRDFVAARVAQFKDQVARRLSGELTEDQFKPLRLMNGLYLQLHAYMLRVAIPYGTLSSRQLRKLGSIARTYDR
GFGHFTTRQNIQYNWPALKDVPQILAELAEVEMHSIQTSGNCIRNVTADHFAGAAADEVTDPRPLAEILRQWSSLHPEFS
YLPRKFKIAIVGSEHDRAAIQVHDIGLQLKKNEAGELGLAVYVGGGQGRTPMVAKKIRDFLPIEDMLTYVTAIVRVYNLH
GRRDNKFKARIKILVHETGIEQLTREIDAEWEEIRHGELKLPQRDIDVIESYFRMPDLPQRPEGWEILAVAQKADAEFAS
WVARNVTAHKHPDYAVVTISLKPVGGIPGDASAEQMELVADVAQTCSFDEIRVSHEQNLVLPHVAKADLPAVYDRLQSGG
LVTPHAGLITDIIACPGLDYCALANARSIPVAQRISERFADLDRQLEIGDLKIKISGCINACGHHHVGHIGILGVEKKGE
ELYQITLGGSADENSAIGEITGRGFSSEEVVDAIETIVDTYLGLRESAEETFLAAYRRVGMEPFKRALYGEIRSAA

Sequences:

>Translated_556_residues
MYRYDEFDRDFVAARVAQFKDQVARRLSGELTEDQFKPLRLMNGLYLQLHAYMLRVAIPYGTLSSRQLRKLGSIARTYDR
GFGHFTTRQNIQYNWPALKDVPQILAELAEVEMHSIQTSGNCIRNVTADHFAGAAADEVTDPRPLAEILRQWSSLHPEFS
YLPRKFKIAIVGSEHDRAAIQVHDIGLQLKKNEAGELGLAVYVGGGQGRTPMVAKKIRDFLPIEDMLTYVTAIVRVYNLH
GRRDNKFKARIKILVHETGIEQLTREIDAEWEEIRHGELKLPQRDIDVIESYFRMPDLPQRPEGWEILAVAQKADAEFAS
WVARNVTAHKHPDYAVVTISLKPVGGIPGDASAEQMELVADVAQTCSFDEIRVSHEQNLVLPHVAKADLPAVYDRLQSGG
LVTPHAGLITDIIACPGLDYCALANARSIPVAQRISERFADLDRQLEIGDLKIKISGCINACGHHHVGHIGILGVEKKGE
ELYQITLGGSADENSAIGEITGRGFSSEEVVDAIETIVDTYLGLRESAEETFLAAYRRVGMEPFKRALYGEIRSAA
>Mature_556_residues
MYRYDEFDRDFVAARVAQFKDQVARRLSGELTEDQFKPLRLMNGLYLQLHAYMLRVAIPYGTLSSRQLRKLGSIARTYDR
GFGHFTTRQNIQYNWPALKDVPQILAELAEVEMHSIQTSGNCIRNVTADHFAGAAADEVTDPRPLAEILRQWSSLHPEFS
YLPRKFKIAIVGSEHDRAAIQVHDIGLQLKKNEAGELGLAVYVGGGQGRTPMVAKKIRDFLPIEDMLTYVTAIVRVYNLH
GRRDNKFKARIKILVHETGIEQLTREIDAEWEEIRHGELKLPQRDIDVIESYFRMPDLPQRPEGWEILAVAQKADAEFAS
WVARNVTAHKHPDYAVVTISLKPVGGIPGDASAEQMELVADVAQTCSFDEIRVSHEQNLVLPHVAKADLPAVYDRLQSGG
LVTPHAGLITDIIACPGLDYCALANARSIPVAQRISERFADLDRQLEIGDLKIKISGCINACGHHHVGHIGILGVEKKGE
ELYQITLGGSADENSAIGEITGRGFSSEEVVDAIETIVDTYLGLRESAEETFLAAYRRVGMEPFKRALYGEIRSAA

Specific function: This Enzyme Catalyzes The 6-Electron Reduction Of Sulfite To Sulfide. This Is One Of Several Activities Required For The Biosynthesis Of L-Cysteine From Sulfate. [C]

COG id: COG0155

COG function: function code P; Sulfite reductase, beta subunit (hemoprotein)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nitrite and sulfite reductase 4Fe-4S domain family [H]

Homologues:

Organism=Saccharomyces cerevisiae, GI6322597, Length=548, Percent_Identity=21.8978102189781, Blast_Score=87, Evalue=1e-17,

Paralogues:

None

Copy number: 640 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005117
- InterPro:   IPR006067
- InterPro:   IPR006066 [H]

Pfam domain/function: PF01077 NIR_SIR; PF03460 NIR_SIR_ferr [H]

EC number: =1.8.7.1 [H]

Molecular weight: Translated: 62041; Mature: 62041

Theoretical pI: Translated: 6.21; Mature: 6.21

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYRYDEFDRDFVAARVAQFKDQVARRLSGELTEDQFKPLRLMNGLYLQLHAYMLRVAIPY
CCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCC
GTLSSRQLRKLGSIARTYDRGFGHFTTRQNIQYNWPALKDVPQILAELAEVEMHSIQTSG
CCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCEECCCCHHHHHHHHHHHHHHHHHHHHCCC
NCIRNVTADHFAGAAADEVTDPRPLAEILRQWSSLHPEFSYLPRKFKIAIVGSEHDRAAI
CHHHCCCHHHHCCCCHHCCCCCHHHHHHHHHHHHCCCCHHHCCCEEEEEEEECCCCCEEE
QVHDIGLQLKKNEAGELGLAVYVGGGQGRTPMVAKKIRDFLPIEDMLTYVTAIVRVYNLH
EEEECCEEEECCCCCCEEEEEEECCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHC
GRRDNKFKARIKILVHETGIEQLTREIDAEWEEIRHGELKLPQRDIDVIESYFRMPDLPQ
CCCCCCEEEEEEEEEECCCHHHHHHHHCCCHHHHCCCCCCCCHHHHHHHHHHHCCCCCCC
RPEGWEILAVAQKADAEFASWVARNVTAHKHPDYAVVTISLKPVGGIPGDASAEQMELVA
CCCCCEEEEEECHHHHHHHHHHHHCCCCCCCCCEEEEEEEEECCCCCCCCCCHHHHHHHH
DVAQTCSFDEIRVSHEQNLVLPHVAKADLPAVYDRLQSGGLVTPHAGLITDIIACPGLDY
HHHHHCCCHHEEECCCCCEECCCHHHCCHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCH
CALANARSIPVAQRISERFADLDRQLEIGDLKIKISGCINACGHHHVGHIGILGVEKKGE
HHHCCCCCCHHHHHHHHHHHHHCCCEEECEEEEEEHHHHHHCCCCCCCEEEEEEECCCCC
ELYQITLGGSADENSAIGEITGRGFSSEEVVDAIETIVDTYLGLRESAEETFLAAYRRVG
EEEEEEECCCCCCCCCCHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
MEPFKRALYGEIRSAA
HHHHHHHHHHHHHCCC
>Mature Secondary Structure
MYRYDEFDRDFVAARVAQFKDQVARRLSGELTEDQFKPLRLMNGLYLQLHAYMLRVAIPY
CCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCC
GTLSSRQLRKLGSIARTYDRGFGHFTTRQNIQYNWPALKDVPQILAELAEVEMHSIQTSG
CCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCEECCCCHHHHHHHHHHHHHHHHHHHHCCC
NCIRNVTADHFAGAAADEVTDPRPLAEILRQWSSLHPEFSYLPRKFKIAIVGSEHDRAAI
CHHHCCCHHHHCCCCHHCCCCCHHHHHHHHHHHHCCCCHHHCCCEEEEEEEECCCCCEEE
QVHDIGLQLKKNEAGELGLAVYVGGGQGRTPMVAKKIRDFLPIEDMLTYVTAIVRVYNLH
EEEECCEEEECCCCCCEEEEEEECCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHC
GRRDNKFKARIKILVHETGIEQLTREIDAEWEEIRHGELKLPQRDIDVIESYFRMPDLPQ
CCCCCCEEEEEEEEEECCCHHHHHHHHCCCHHHHCCCCCCCCHHHHHHHHHHHCCCCCCC
RPEGWEILAVAQKADAEFASWVARNVTAHKHPDYAVVTISLKPVGGIPGDASAEQMELVA
CCCCCEEEEEECHHHHHHHHHHHHCCCCCCCCCEEEEEEEEECCCCCCCCCCHHHHHHHH
DVAQTCSFDEIRVSHEQNLVLPHVAKADLPAVYDRLQSGGLVTPHAGLITDIIACPGLDY
HHHHHCCCHHEEECCCCCEECCCHHHCCHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCH
CALANARSIPVAQRISERFADLDRQLEIGDLKIKISGCINACGHHHVGHIGILGVEKKGE
HHHCCCCCCHHHHHHHHHHHHHCCCEEECEEEEEEHHHHHHCCCCCCCEEEEEEECCCCC
ELYQITLGGSADENSAIGEITGRGFSSEEVVDAIETIVDTYLGLRESAEETFLAAYRRVG
EEEEEEECCCCCCCCCCHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
MEPFKRALYGEIRSAA
HHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA