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The map label for this gene is nth [H]

Identifier: 225851699

GI number: 225851699

Start: 179817

End: 180563

Strand: Direct

Name: nth [H]

Synonym: BMEA_A0172

Alternate gene names: 225851699

Gene position: 179817-180563 (Clockwise)

Preceding gene: 225851694

Following gene: 225851702

Centisome position: 8.46

GC content: 60.64

Gene sequence:

>747_bases
ATGCAAGAGACAAAAATCAAATCCGCTGTGAATGGCTCCACTTCACCCGTGCGCCGCCCGCGCCGCGTGGCGGGTACGCT
TTACACGGCCGACGAGATCCATGAAATTTTCCGCCGTTTCTCCATCCAGCGCCCCGAGCCGAAGGGCGAGCTTGAACATG
TGAACGCCTTTACCCTGCTCGTGGCCGTGGTTCTGTCGGCGCAGGCGACGGATGCCGGCGTCAACAAGGCGACACGCGCC
CTTTTCGCTGTCGCCGATACGCCGCAAAAGATGCTGGCGCTGGGTGAGGAAAAGGTCGGTGAATATATCCGTACCATCGG
GCTTTGGCGCAACAAGGCGAAGAATGTCATCCTGCTTTCCGAAGCGCTGATCCGCGATTATGGCGGTGAGGTGCCGGGCG
ATCGCGACGAGCTGGTGAAACTGCCGGGCGTGGGGCGCAAGACGGCCAATGTCGTGCTCAACATGGCTTTCGGCCAGCCG
ACCATGGCGGTGGACACGCATATATTGCGCATTGGCAACCGCATCGGGCTTGCACCGGGCAAGACGCCGGAAGCGGTGGA
GGCCATTCTGGTTCGGGTCATCCCGCGTGAATATATGCTTCACGCCCATCATTGGCTGATCCTGCACGGACGCTATGTGT
GCAAGGCACGCAAGCCCGAATGCGAGAAATGCGTGATTGCCGATCTCTGCAAATATCCCGCCAAGACCTGCGATATCCCC
GCCGCGCTCGTGCCGCTGGCGCCTTAG

Upstream 100 bases:

>100_bases
TTCTGGCCTTGAAGTTCCGGCCTTGAGGGCCGCCTCAATATGGGGGACTGCGTCAAGCTGCTGATTGTCTTCCGAAGATG
GAACCGAGTATAGACAAGGA

Downstream 100 bases:

>100_bases
AGAATTTCCAGCAAAGCGATTTCACACTTTTGCTGGATCTCTAACTATAGGTTTTTATCGCTCGTTTCGAGATGGCCTTG
TGCAGATGCACCATCATCGT

Product: endonuclease III

Products: NA

Alternate protein names: DNA-(apurinic or apyrimidinic site) lyase [H]

Number of amino acids: Translated: 248; Mature: 248

Protein sequence:

>248_residues
MQETKIKSAVNGSTSPVRRPRRVAGTLYTADEIHEIFRRFSIQRPEPKGELEHVNAFTLLVAVVLSAQATDAGVNKATRA
LFAVADTPQKMLALGEEKVGEYIRTIGLWRNKAKNVILLSEALIRDYGGEVPGDRDELVKLPGVGRKTANVVLNMAFGQP
TMAVDTHILRIGNRIGLAPGKTPEAVEAILVRVIPREYMLHAHHWLILHGRYVCKARKPECEKCVIADLCKYPAKTCDIP
AALVPLAP

Sequences:

>Translated_248_residues
MQETKIKSAVNGSTSPVRRPRRVAGTLYTADEIHEIFRRFSIQRPEPKGELEHVNAFTLLVAVVLSAQATDAGVNKATRA
LFAVADTPQKMLALGEEKVGEYIRTIGLWRNKAKNVILLSEALIRDYGGEVPGDRDELVKLPGVGRKTANVVLNMAFGQP
TMAVDTHILRIGNRIGLAPGKTPEAVEAILVRVIPREYMLHAHHWLILHGRYVCKARKPECEKCVIADLCKYPAKTCDIP
AALVPLAP
>Mature_248_residues
MQETKIKSAVNGSTSPVRRPRRVAGTLYTADEIHEIFRRFSIQRPEPKGELEHVNAFTLLVAVVLSAQATDAGVNKATRA
LFAVADTPQKMLALGEEKVGEYIRTIGLWRNKAKNVILLSEALIRDYGGEVPGDRDELVKLPGVGRKTANVVLNMAFGQP
TMAVDTHILRIGNRIGLAPGKTPEAVEAILVRVIPREYMLHAHHWLILHGRYVCKARKPECEKCVIADLCKYPAKTCDIP
AALVPLAP

Specific function: Has both an apurinic and/or apyrimidinic endonuclease activity and a DNA N-glycosylase activity. Incises damaged DNA at cytosines, thymines and guanines. Acts on a damaged strand, 5' from the damaged site [H]

COG id: COG0177

COG function: function code L; Predicted EndoIII-related endonuclease

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Nth/MutY family [H]

Homologues:

Organism=Homo sapiens, GI4505471, Length=180, Percent_Identity=33.8888888888889, Blast_Score=101, Evalue=7e-22,
Organism=Escherichia coli, GI1787920, Length=201, Percent_Identity=57.2139303482587, Blast_Score=234, Evalue=5e-63,
Organism=Caenorhabditis elegans, GI17554540, Length=180, Percent_Identity=31.6666666666667, Blast_Score=95, Evalue=3e-20,
Organism=Drosophila melanogaster, GI45550361, Length=177, Percent_Identity=31.0734463276836, Blast_Score=98, Evalue=5e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011257
- InterPro:   IPR004036
- InterPro:   IPR005759
- InterPro:   IPR003651
- InterPro:   IPR003265
- InterPro:   IPR000445
- InterPro:   IPR003583
- InterPro:   IPR023170 [H]

Pfam domain/function: PF10576 EndIII_4Fe-2S; PF00633 HHH; PF00730 HhH-GPD [H]

EC number: =4.2.99.18 [H]

Molecular weight: Translated: 27298; Mature: 27298

Theoretical pI: Translated: 9.77; Mature: 9.77

Prosite motif: PS01155 ENDONUCLEASE_III_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQETKIKSAVNGSTSPVRRPRRVAGTLYTADEIHEIFRRFSIQRPEPKGELEHVNAFTLL
CCCHHHHHHHCCCCCCCCCCHHHHHHCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHH
VAVVLSAQATDAGVNKATRALFAVADTPQKMLALGEEKVGEYIRTIGLWRNKAKNVILLS
HHHHHHHCCCCCCHHHHHHHHHHHCCCHHHHHHHCHHHHHHHHHHHHHHHHCCCCEEEHH
EALIRDYGGEVPGDRDELVKLPGVGRKTANVVLNMAFGQPTMAVDTHILRIGNRIGLAPG
HHHHHHHCCCCCCCHHHEEECCCCCCHHHHEEEEECCCCCCHHHHHHHHHHCCEECCCCC
KTPEAVEAILVRVIPREYMLHAHHWLILHGRYVCKARKPECEKCVIADLCKYPAKTCDIP
CCHHHHHHHHHHHHHHHHHHHHHHEEEEECEEEECCCCCCHHHHHHHHHHHCCCCCCCCC
AALVPLAP
HHHCCCCC
>Mature Secondary Structure
MQETKIKSAVNGSTSPVRRPRRVAGTLYTADEIHEIFRRFSIQRPEPKGELEHVNAFTLL
CCCHHHHHHHCCCCCCCCCCHHHHHHCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHH
VAVVLSAQATDAGVNKATRALFAVADTPQKMLALGEEKVGEYIRTIGLWRNKAKNVILLS
HHHHHHHCCCCCCHHHHHHHHHHHCCCHHHHHHHCHHHHHHHHHHHHHHHHCCCCEEEHH
EALIRDYGGEVPGDRDELVKLPGVGRKTANVVLNMAFGQPTMAVDTHILRIGNRIGLAPG
HHHHHHHCCCCCCCHHHEEECCCCCCHHHHEEEEECCCCCCHHHHHHHHHHCCEECCCCC
KTPEAVEAILVRVIPREYMLHAHHWLILHGRYVCKARKPECEKCVIADLCKYPAKTCDIP
CCHHHHHHHHHHHHHHHHHHHHHHEEEEECEEEECCCCCCHHHHHHHHHHHCCCCCCCCC
AALVPLAP
HHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA