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The map label for this gene is gyrB [H]

Identifier: 225851665

GI number: 225851665

Start: 139976

End: 142417

Strand: Reverse

Name: gyrB [H]

Synonym: BMEA_A0132

Alternate gene names: 225851665

Gene position: 142417-139976 (Counterclockwise)

Preceding gene: 225851666

Following gene: 225851661

Centisome position: 6.7

GC content: 59.87

Gene sequence:

>2442_bases
ATGAGCGAGATGCCCGAGATGAATTCCGAAGCCCCCGCCGAATATGGCGCGGATTCCATTCGTGTTCTGAAAGGTCTGGA
TGCTGTTCGCAAGCGCCCCGGCATGTATATCGGCGACACGGACGACGGCTCCGGCCTGCATCACATGGTCTATGAAGTCG
TGGACAACGCCATCGACGAAGCACTGGCCGGACATGCCACGCTCGTCACCGTAACGCTCAATGCCGACGGCTCCTGCACC
GTGACCGACAACGGGCGCGGCATCCCGACCGACATCCACAAGGAAGAAGGCGTTTCAGCTGCCGAGGTCATCATGACCCA
GCTTCATGCGGGCGGCAAATTCGACCAGAATTCCTACAAGGTTTCCGGCGGCCTGCATGGCGTCGGCGTTTCAGTGGTGA
ATGCGCTGTCGATCTGGCTGAAGCTGAAAATCCGGCGCGCGGGCAAAATCCATGAAATGAGCTTCACACACGGCGTTGCC
GATGCGCCCTTGGTCGTAACCGGCGATGCAGGCAGTGAAACCGGCACGGAAGTGAGCTTCCTGCCCTCGCCTGACACCTT
CAGCATGGTCGAATTCGACTATGAAACGCTGGAACGCCGCCTGCGCGAACTTGCCTTCCTCAATTCGGGCGTGCGCATCA
AGCTCGCCGACCGCCGCCATGCGGATGTGAAGGAACAGGAACTGCATTATGACGGCGGCCTGGTCGAATTCGTCAAATAT
ACCGACCAGAGCAAGAAGTCGCTTCTGGAAGAGCCTATCTATATTCGCAGCGAAAAGGATGGCATGACGGTGGAAGTCGC
CATGTGGTGGAACGATTCCTACCACGAGAAGGTGCTGTGCTTCACCAACAACATCCCGCAGCGCGACGGCGGCACGCATC
TGGCCGGTTTCCGCGGCGCGCTGACCCGACAGATCACGGGCTATGCGGACTCTTCCGGCATGACGAAGAAGGAAAAGGTA
CAGCTTACCGGCGACGATTGCCGCGAGGGCCTGACCGCCGTTCTTTCCGTGAAGGTGCCGGATCCGAAATTCTCCTCGCA
GACCAAGGACAAGCTTGTTTCCTCCGAAGTGCGCCCGGTGGTGGAAGGCCTCGTCAATGAAGCGCTTTCCACATGGCTTG
AAGAACATCCGGCAGGCGGCAAGATCGTTGTCGAGAAGGTCATTCAGGCGGCGGCGGCCCGCGAAGCCGCCCGCAAGGCG
CGCGACATCACCCGCAAGAGCAATCTCAGCGTGACGTCCCTGCCCGGAAAGCTTGCCGATTGCCAGGAGCGCGATCCGGC
CAAGTCCGAAATCTTCATCGTCGAGGGCGATTCGGCAGGCGGTTCCGCCAAGAGCGGGCGCTCGCGCCAGAATCAGGCCA
TTCTGCCGCTGCGCGGCAAAATCCTGAACGTGGAACGCGTGCGTTTCGACCGGATGATTTCATCCGATCAGGTGGGCACC
CTCATCACGGCGCTTGGCACCTCCATCGGCAAGGATGAAACGCACGGCTTCAACGCCGACAAGCTGCGTTATCACAAGAT
CATCATCATGACCGACGCCGACGTCGATGGCGCCCATATTCGTACGCTTCTGCTCACCTTCTTCTTCCGGCAGATGCCGG
AACTGATCGAACGCGGGCATATCTATATCGCGCAGCCGCCGCTCTATAAGGTGACACGCGGCAAGTCTTCGCAATATATC
AAGAACGAAGCCGCCTTTGAGGATTTCCTCATCGAAACCGGCCTTGAAGAAACGACACTGGAACTGGTGACTGGCGAAAT
GCGCGCCGGGCCGGATTTGCGCTCGGTGGTGGAGGATGCGCGCACGCTGCGTCAGCTTCTGCACGGCCTGCACACCCGCT
ATGACCGCAGCGTGGTGGAACAGGCGGCAATTGCCGGCCTGCTCAACCCCGATGCCTCAAGGGACAATGCAACGGCACAG
CATTCCGCCGATACGGTTGCCAAGCGTCTCGACATGATTTCGGAAGAGACCGAGCGCGGCTGGAGCGGCCATGTGATGGA
AGACGGCGGCTATCGCTTCGAGCGTATGGTGCGCGGTGTAAAGGATATCGCCATTCTCGACATGGCCCTGCTCGGCTCGG
CCGATGCCCGCCAGGTCGACCGCGTTGCGGGCCGCATGGCTGAAATCTTCATGGAGCCGCCGGTGCTGCGCCGCAAGGAC
AAGGTGGAATCGCTTTCCGGCCCGGTGGCCCTGCTTGACGCCGTGTTTGCAACCGGCCGCAAGGGTCTGACCCTCCAGCG
TTACAAAGGCTTGGGCGAAATGAACGCCGAACAGCTTTGGGAAACGACACTTGATCCGAATGTGCGTTCGCTCCTGCAGG
TGAAGGTGAACGATGCAACCGATGCCGATTCCCTCTTCTCGCGCCTTATGGGCGACGAGGTGGAGCCGCGGCGTGAATTC
ATTCAGGATAATGCGCTAAACGTCGCCAATCTGGACGTTTGA

Upstream 100 bases:

>100_bases
TTGGAAAAATCGCTGTTAGCACCTATATTAAAGCCATGTTTGTCGCGTGATTCGACATATCTTTGGAGCTGCATTCGCAG
CAGTTTTTTGAAAGATTTTC

Downstream 100 bases:

>100_bases
TACAAAAAGCCCCGGAAATCCGGGGCTTTTTTGCACTTTTGACTTGAAATTGCTCCAGCCAAAACCCGGTGAGCGAAGCT
CATCGGGTTCTGCTATTATT

Product: DNA gyrase subunit B

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 813; Mature: 812

Protein sequence:

>813_residues
MSEMPEMNSEAPAEYGADSIRVLKGLDAVRKRPGMYIGDTDDGSGLHHMVYEVVDNAIDEALAGHATLVTVTLNADGSCT
VTDNGRGIPTDIHKEEGVSAAEVIMTQLHAGGKFDQNSYKVSGGLHGVGVSVVNALSIWLKLKIRRAGKIHEMSFTHGVA
DAPLVVTGDAGSETGTEVSFLPSPDTFSMVEFDYETLERRLRELAFLNSGVRIKLADRRHADVKEQELHYDGGLVEFVKY
TDQSKKSLLEEPIYIRSEKDGMTVEVAMWWNDSYHEKVLCFTNNIPQRDGGTHLAGFRGALTRQITGYADSSGMTKKEKV
QLTGDDCREGLTAVLSVKVPDPKFSSQTKDKLVSSEVRPVVEGLVNEALSTWLEEHPAGGKIVVEKVIQAAAAREAARKA
RDITRKSNLSVTSLPGKLADCQERDPAKSEIFIVEGDSAGGSAKSGRSRQNQAILPLRGKILNVERVRFDRMISSDQVGT
LITALGTSIGKDETHGFNADKLRYHKIIIMTDADVDGAHIRTLLLTFFFRQMPELIERGHIYIAQPPLYKVTRGKSSQYI
KNEAAFEDFLIETGLEETTLELVTGEMRAGPDLRSVVEDARTLRQLLHGLHTRYDRSVVEQAAIAGLLNPDASRDNATAQ
HSADTVAKRLDMISEETERGWSGHVMEDGGYRFERMVRGVKDIAILDMALLGSADARQVDRVAGRMAEIFMEPPVLRRKD
KVESLSGPVALLDAVFATGRKGLTLQRYKGLGEMNAEQLWETTLDPNVRSLLQVKVNDATDADSLFSRLMGDEVEPRREF
IQDNALNVANLDV

Sequences:

>Translated_813_residues
MSEMPEMNSEAPAEYGADSIRVLKGLDAVRKRPGMYIGDTDDGSGLHHMVYEVVDNAIDEALAGHATLVTVTLNADGSCT
VTDNGRGIPTDIHKEEGVSAAEVIMTQLHAGGKFDQNSYKVSGGLHGVGVSVVNALSIWLKLKIRRAGKIHEMSFTHGVA
DAPLVVTGDAGSETGTEVSFLPSPDTFSMVEFDYETLERRLRELAFLNSGVRIKLADRRHADVKEQELHYDGGLVEFVKY
TDQSKKSLLEEPIYIRSEKDGMTVEVAMWWNDSYHEKVLCFTNNIPQRDGGTHLAGFRGALTRQITGYADSSGMTKKEKV
QLTGDDCREGLTAVLSVKVPDPKFSSQTKDKLVSSEVRPVVEGLVNEALSTWLEEHPAGGKIVVEKVIQAAAAREAARKA
RDITRKSNLSVTSLPGKLADCQERDPAKSEIFIVEGDSAGGSAKSGRSRQNQAILPLRGKILNVERVRFDRMISSDQVGT
LITALGTSIGKDETHGFNADKLRYHKIIIMTDADVDGAHIRTLLLTFFFRQMPELIERGHIYIAQPPLYKVTRGKSSQYI
KNEAAFEDFLIETGLEETTLELVTGEMRAGPDLRSVVEDARTLRQLLHGLHTRYDRSVVEQAAIAGLLNPDASRDNATAQ
HSADTVAKRLDMISEETERGWSGHVMEDGGYRFERMVRGVKDIAILDMALLGSADARQVDRVAGRMAEIFMEPPVLRRKD
KVESLSGPVALLDAVFATGRKGLTLQRYKGLGEMNAEQLWETTLDPNVRSLLQVKVNDATDADSLFSRLMGDEVEPRREF
IQDNALNVANLDV
>Mature_812_residues
SEMPEMNSEAPAEYGADSIRVLKGLDAVRKRPGMYIGDTDDGSGLHHMVYEVVDNAIDEALAGHATLVTVTLNADGSCTV
TDNGRGIPTDIHKEEGVSAAEVIMTQLHAGGKFDQNSYKVSGGLHGVGVSVVNALSIWLKLKIRRAGKIHEMSFTHGVAD
APLVVTGDAGSETGTEVSFLPSPDTFSMVEFDYETLERRLRELAFLNSGVRIKLADRRHADVKEQELHYDGGLVEFVKYT
DQSKKSLLEEPIYIRSEKDGMTVEVAMWWNDSYHEKVLCFTNNIPQRDGGTHLAGFRGALTRQITGYADSSGMTKKEKVQ
LTGDDCREGLTAVLSVKVPDPKFSSQTKDKLVSSEVRPVVEGLVNEALSTWLEEHPAGGKIVVEKVIQAAAAREAARKAR
DITRKSNLSVTSLPGKLADCQERDPAKSEIFIVEGDSAGGSAKSGRSRQNQAILPLRGKILNVERVRFDRMISSDQVGTL
ITALGTSIGKDETHGFNADKLRYHKIIIMTDADVDGAHIRTLLLTFFFRQMPELIERGHIYIAQPPLYKVTRGKSSQYIK
NEAAFEDFLIETGLEETTLELVTGEMRAGPDLRSVVEDARTLRQLLHGLHTRYDRSVVEQAAIAGLLNPDASRDNATAQH
SADTVAKRLDMISEETERGWSGHVMEDGGYRFERMVRGVKDIAILDMALLGSADARQVDRVAGRMAEIFMEPPVLRRKDK
VESLSGPVALLDAVFATGRKGLTLQRYKGLGEMNAEQLWETTLDPNVRSLLQVKVNDATDADSLFSRLMGDEVEPRREFI
QDNALNVANLDV

Specific function: DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings [H]

COG id: COG0187

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the type II topoisomerase family [H]

Homologues:

Organism=Homo sapiens, GI19913406, Length=560, Percent_Identity=23.3928571428571, Blast_Score=131, Evalue=2e-30,
Organism=Homo sapiens, GI19913408, Length=550, Percent_Identity=24, Blast_Score=130, Evalue=3e-30,
Organism=Escherichia coli, GI48994957, Length=807, Percent_Identity=56.5055762081784, Blast_Score=865, Evalue=0.0,
Organism=Escherichia coli, GI1789408, Length=558, Percent_Identity=40.5017921146953, Blast_Score=395, Evalue=1e-111,
Organism=Caenorhabditis elegans, GI17535065, Length=537, Percent_Identity=24.5810055865922, Blast_Score=134, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI212645845, Length=509, Percent_Identity=24.3614931237721, Blast_Score=116, Evalue=5e-26,
Organism=Caenorhabditis elegans, GI212645657, Length=139, Percent_Identity=33.0935251798561, Blast_Score=76, Evalue=8e-14,
Organism=Saccharomyces cerevisiae, GI6324241, Length=606, Percent_Identity=24.4224422442244, Blast_Score=121, Evalue=5e-28,
Organism=Drosophila melanogaster, GI17136538, Length=553, Percent_Identity=25.3164556962025, Blast_Score=140, Evalue=3e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011557
- InterPro:   IPR020568
- InterPro:   IPR014721
- InterPro:   IPR001241
- InterPro:   IPR013759
- InterPro:   IPR002288
- InterPro:   IPR013506
- InterPro:   IPR013760
- InterPro:   IPR018522 [H]

Pfam domain/function: PF00204 DNA_gyraseB; PF00986 DNA_gyraseB_C; PF02518 HATPase_c [H]

EC number: =5.99.1.3 [H]

Molecular weight: Translated: 89477; Mature: 89346

Theoretical pI: Translated: 5.50; Mature: 5.50

Prosite motif: PS00177 TOPOISOMERASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEMPEMNSEAPAEYGADSIRVLKGLDAVRKRPGMYIGDTDDGSGLHHMVYEVVDNAIDE
CCCCCCCCCCCCHHHCCHHHHHHHHHHHHHHCCCCEECCCCCCCCHHHHHHHHHHHHHHH
ALAGHATLVTVTLNADGSCTVTDNGRGIPTDIHKEEGVSAAEVIMTQLHAGGKFDQNSYK
HHCCCEEEEEEEECCCCCEEECCCCCCCCCCCCHHCCCCHHHHHHHHHHCCCCCCCCCEE
VSGGLHGVGVSVVNALSIWLKLKIRRAGKIHEMSFTHGVADAPLVVTGDAGSETGTEVSF
ECCCCCHHHHHHHHHHHHHHHEEEHHCCCEEEEHHHCCCCCCCEEEECCCCCCCCCEEEE
LPSPDTFSMVEFDYETLERRLRELAFLNSGVRIKLADRRHADVKEQELHYDGGLVEFVKY
CCCCCCCEEEECCHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCHHHHCCCCCHHHHHHH
TDQSKKSLLEEPIYIRSEKDGMTVEVAMWWNDSYHEKVLCFTNNIPQRDGGTHLAGFRGA
CCHHHHHHHHCCCEEEECCCCCEEEEEEEECCCCCCEEEEEECCCCCCCCCCCCHHHHHH
LTRQITGYADSSGMTKKEKVQLTGDDCREGLTAVLSVKVPDPKFSSQTKDKLVSSEVRPV
HHHHHCCCCCCCCCCCHHEEEECCHHHHCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHH
VEGLVNEALSTWLEEHPAGGKIVVEKVIQAAAAREAARKARDITRKSNLSVTSLPGKLAD
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCHHC
CQERDPAKSEIFIVEGDSAGGSAKSGRSRQNQAILPLRGKILNVERVRFDRMISSDQVGT
CCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCEECCCCCCEECHHHHHHHHHHCCCHHHH
LITALGTSIGKDETHGFNADKLRYHKIIIMTDADVDGAHIRTLLLTFFFRQMPELIERGH
HHHHHHCCCCCCCCCCCCCCCEEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCC
IYIAQPPLYKVTRGKSSQYIKNEAAFEDFLIETGLEETTLELVTGEMRAGPDLRSVVEDA
EEEECCCCEEECCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHCHHCCCCHHHHHHHHH
RTLRQLLHGLHTRYDRSVVEQAAIAGLLNPDASRDNATAQHSADTVAKRLDMISEETERG
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCC
WSGHVMEDGGYRFERMVRGVKDIAILDMALLGSADARQVDRVAGRMAEIFMEPPVLRRKD
CCCCEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCHHHHH
KVESLSGPVALLDAVFATGRKGLTLQRYKGLGEMNAEQLWETTLDPNVRSLLQVKVNDAT
HHHHHCCHHHHHHHHHHCCCCCCCHHHHCCCCCCCHHHHHHHCCCCCHHHHEEEEECCCC
DADSLFSRLMGDEVEPRREFIQDNALNVANLDV
CHHHHHHHHHCCCCCHHHHHHHCCCCCEECCCC
>Mature Secondary Structure 
SEMPEMNSEAPAEYGADSIRVLKGLDAVRKRPGMYIGDTDDGSGLHHMVYEVVDNAIDE
CCCCCCCCCCCHHHCCHHHHHHHHHHHHHHCCCCEECCCCCCCCHHHHHHHHHHHHHHH
ALAGHATLVTVTLNADGSCTVTDNGRGIPTDIHKEEGVSAAEVIMTQLHAGGKFDQNSYK
HHCCCEEEEEEEECCCCCEEECCCCCCCCCCCCHHCCCCHHHHHHHHHHCCCCCCCCCEE
VSGGLHGVGVSVVNALSIWLKLKIRRAGKIHEMSFTHGVADAPLVVTGDAGSETGTEVSF
ECCCCCHHHHHHHHHHHHHHHEEEHHCCCEEEEHHHCCCCCCCEEEECCCCCCCCCEEEE
LPSPDTFSMVEFDYETLERRLRELAFLNSGVRIKLADRRHADVKEQELHYDGGLVEFVKY
CCCCCCCEEEECCHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCHHHHCCCCCHHHHHHH
TDQSKKSLLEEPIYIRSEKDGMTVEVAMWWNDSYHEKVLCFTNNIPQRDGGTHLAGFRGA
CCHHHHHHHHCCCEEEECCCCCEEEEEEEECCCCCCEEEEEECCCCCCCCCCCCHHHHHH
LTRQITGYADSSGMTKKEKVQLTGDDCREGLTAVLSVKVPDPKFSSQTKDKLVSSEVRPV
HHHHHCCCCCCCCCCCHHEEEECCHHHHCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHH
VEGLVNEALSTWLEEHPAGGKIVVEKVIQAAAAREAARKARDITRKSNLSVTSLPGKLAD
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCHHC
CQERDPAKSEIFIVEGDSAGGSAKSGRSRQNQAILPLRGKILNVERVRFDRMISSDQVGT
CCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCEECCCCCCEECHHHHHHHHHHCCCHHHH
LITALGTSIGKDETHGFNADKLRYHKIIIMTDADVDGAHIRTLLLTFFFRQMPELIERGH
HHHHHHCCCCCCCCCCCCCCCEEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCC
IYIAQPPLYKVTRGKSSQYIKNEAAFEDFLIETGLEETTLELVTGEMRAGPDLRSVVEDA
EEEECCCCEEECCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHCHHCCCCHHHHHHHHH
RTLRQLLHGLHTRYDRSVVEQAAIAGLLNPDASRDNATAQHSADTVAKRLDMISEETERG
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCC
WSGHVMEDGGYRFERMVRGVKDIAILDMALLGSADARQVDRVAGRMAEIFMEPPVLRRKD
CCCCEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCHHHHH
KVESLSGPVALLDAVFATGRKGLTLQRYKGLGEMNAEQLWETTLDPNVRSLLQVKVNDAT
HHHHHCCHHHHHHHHHHCCCCCCCHHHHCCCCCCCHHHHHHHCCCCCHHHHEEEEECCCC
DADSLFSRLMGDEVEPRREFIQDNALNVANLDV
CHHHHHHHHHCCCCCHHHHHHHCCCCCEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8226640 [H]