| Definition | Brucella melitensis ATCC 23457 chromosome chromosome I, complete sequence. |
|---|---|
| Accession | NC_012441 |
| Length | 2,125,701 |
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The map label for this gene is fixR [H]
Identifier: 225851656
GI number: 225851656
Start: 126989
End: 127795
Strand: Reverse
Name: fixR [H]
Synonym: BMEA_A0123
Alternate gene names: 225851656
Gene position: 127795-126989 (Counterclockwise)
Preceding gene: 225851657
Following gene: 225851655
Centisome position: 6.01
GC content: 59.6
Gene sequence:
>807_bases ATGTCCCCAGATTCCAACACCGATAATTCCAGGCCCGGCGTTTCCTCATCTGAAATCCCAAGGACGGATACGGAACGCAA AACACTGGTCCTGACCGGCGCAAGCCGCGGCATTGGCCATGCGACGGTGAAACGGTTTTCCCTTGCCGGATGGCGCGTCA TCACCTGCTCACGGCAGGATTTTTCCGAAAACTGCCCCTGGCCCGCAGGACCTGAAGACCATATCAAGGTCGATCTTTCC GACCCGGAAGATATCGGCAAGGCCATTGCCGAAATTCGCCGCAGGCTGGAAGCCAATGGCAGCAAGCTGCACGCCCTCGT CAATAATGCGGGCATTTCACCCAAGGCGGAAGGCGGCCGCCGCATGAACTCCATCGAAACGCCGATGGCCGTCTGGCGCG ATGTGTTTCAGGTGAATTTCATGGCCCCGATCATGCTGGCGCGCGGGCTGTTCAAGGAGCTTGAAGCAGCCCAGGGCTCG GTCGTCAACGTGACCTCCATCGCAGGCAGCCGCGTGCACCCCTTTGCCGGAACTGCCTATGCCACATCCAAGGCAGCCCT TGCCGCGCTGACCCGCGAAATGGCATCGGATTTCGGCCCCTATGGCATTCGCGTCAATGCGATTGCGCCGGGCGAGATCG ACACGGCTATCCTATCACCTGGCACCGACAAGCTGGTTGAACAACTGCCGATGCGCCGGCTCGGCAAGACCTCGGAAGTA GCCGAAACAATCTACTTCCTGTGCACCGAAGCCTCGTCCTATGTCACCGGCTCGGAAATCCACATCAATGGTGGCCAGCA CGTCTGA
Upstream 100 bases:
>100_bases CGGCCAGTCCCTTCATGGTGCTTTCATTCCCTTGCCATGCTGAATCCCCCTCGAAATCTTGAGCGGCATGGTCTATTCAA GATTTGAGAGCGAGGTTGTT
Downstream 100 bases:
>100_bases ACCGGAATCAAGAGCGCGGATTGAAAAGCTCCGCGCTCTAAGTATTTTCAATCGATTTAACAGCGCGGTTTAACAATATA AGTTGGAACAATGATCCTTT
Product: short-chain dehydrogenase/reductase SDR
Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]
Alternate protein names: NA
Number of amino acids: Translated: 268; Mature: 267
Protein sequence:
>268_residues MSPDSNTDNSRPGVSSSEIPRTDTERKTLVLTGASRGIGHATVKRFSLAGWRVITCSRQDFSENCPWPAGPEDHIKVDLS DPEDIGKAIAEIRRRLEANGSKLHALVNNAGISPKAEGGRRMNSIETPMAVWRDVFQVNFMAPIMLARGLFKELEAAQGS VVNVTSIAGSRVHPFAGTAYATSKAALAALTREMASDFGPYGIRVNAIAPGEIDTAILSPGTDKLVEQLPMRRLGKTSEV AETIYFLCTEASSYVTGSEIHINGGQHV
Sequences:
>Translated_268_residues MSPDSNTDNSRPGVSSSEIPRTDTERKTLVLTGASRGIGHATVKRFSLAGWRVITCSRQDFSENCPWPAGPEDHIKVDLS DPEDIGKAIAEIRRRLEANGSKLHALVNNAGISPKAEGGRRMNSIETPMAVWRDVFQVNFMAPIMLARGLFKELEAAQGS VVNVTSIAGSRVHPFAGTAYATSKAALAALTREMASDFGPYGIRVNAIAPGEIDTAILSPGTDKLVEQLPMRRLGKTSEV AETIYFLCTEASSYVTGSEIHINGGQHV >Mature_267_residues SPDSNTDNSRPGVSSSEIPRTDTERKTLVLTGASRGIGHATVKRFSLAGWRVITCSRQDFSENCPWPAGPEDHIKVDLSD PEDIGKAIAEIRRRLEANGSKLHALVNNAGISPKAEGGRRMNSIETPMAVWRDVFQVNFMAPIMLARGLFKELEAAQGSV VNVTSIAGSRVHPFAGTAYATSKAALAALTREMASDFGPYGIRVNAIAPGEIDTAILSPGTDKLVEQLPMRRLGKTSEVA ETIYFLCTEASSYVTGSEIHINGGQHV
Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]
COG id: NA
COG function: NA
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]
Homologues:
Organism=Homo sapiens, GI32483357, Length=264, Percent_Identity=33.3333333333333, Blast_Score=105, Evalue=4e-23, Organism=Homo sapiens, GI59889578, Length=241, Percent_Identity=27.3858921161826, Blast_Score=93, Evalue=2e-19, Organism=Homo sapiens, GI5031737, Length=264, Percent_Identity=28.7878787878788, Blast_Score=87, Evalue=1e-17, Organism=Homo sapiens, GI15277342, Length=255, Percent_Identity=29.0196078431373, Blast_Score=87, Evalue=2e-17, Organism=Homo sapiens, GI7705925, Length=255, Percent_Identity=30.1960784313725, Blast_Score=83, Evalue=2e-16, Organism=Homo sapiens, GI40254992, Length=245, Percent_Identity=27.7551020408163, Blast_Score=83, Evalue=2e-16, Organism=Homo sapiens, GI119392083, Length=201, Percent_Identity=29.3532338308458, Blast_Score=80, Evalue=3e-15, Organism=Homo sapiens, GI109715829, Length=240, Percent_Identity=29.1666666666667, Blast_Score=79, Evalue=6e-15, Organism=Homo sapiens, GI126723750, Length=264, Percent_Identity=27.6515151515151, Blast_Score=77, Evalue=1e-14, Organism=Homo sapiens, GI19923817, Length=265, Percent_Identity=24.9056603773585, Blast_Score=74, Evalue=1e-13, Organism=Homo sapiens, GI20149619, Length=199, Percent_Identity=31.6582914572864, Blast_Score=72, Evalue=5e-13, Organism=Homo sapiens, GI4503301, Length=206, Percent_Identity=27.6699029126214, Blast_Score=70, Evalue=2e-12, Organism=Homo sapiens, GI66933014, Length=132, Percent_Identity=30.3030303030303, Blast_Score=69, Evalue=3e-12, Organism=Homo sapiens, GI33667109, Length=209, Percent_Identity=29.1866028708134, Blast_Score=69, Evalue=4e-12, Organism=Homo sapiens, GI10190704, Length=294, Percent_Identity=26.1904761904762, Blast_Score=69, Evalue=5e-12, Organism=Homo sapiens, GI40548397, Length=201, Percent_Identity=24.8756218905473, Blast_Score=67, Evalue=2e-11, Organism=Homo sapiens, GI214010158, Length=201, Percent_Identity=24.8756218905473, Blast_Score=67, Evalue=2e-11, Organism=Homo sapiens, GI214010156, Length=201, Percent_Identity=24.8756218905473, Blast_Score=67, Evalue=2e-11, Organism=Homo sapiens, GI22758144, Length=201, Percent_Identity=24.8756218905473, Blast_Score=67, Evalue=2e-11, Organism=Escherichia coli, GI1787335, Length=252, Percent_Identity=28.968253968254, Blast_Score=103, Evalue=9e-24, Organism=Escherichia coli, GI87082100, Length=261, Percent_Identity=29.5019157088123, Blast_Score=93, Evalue=2e-20, Organism=Escherichia coli, GI2367175, Length=257, Percent_Identity=30.3501945525292, Blast_Score=92, Evalue=4e-20, Organism=Escherichia coli, GI2367365, Length=249, Percent_Identity=32.1285140562249, Blast_Score=88, Evalue=5e-19, Organism=Escherichia coli, GI1788459, Length=202, Percent_Identity=30.1980198019802, Blast_Score=88, Evalue=8e-19, Organism=Escherichia coli, GI1787905, Length=251, Percent_Identity=31.4741035856574, Blast_Score=86, Evalue=2e-18, Organism=Escherichia coli, GI1786812, Length=260, Percent_Identity=28.8461538461538, Blast_Score=84, Evalue=1e-17, Organism=Escherichia coli, GI1790717, Length=259, Percent_Identity=27.4131274131274, Blast_Score=80, Evalue=2e-16, Organism=Escherichia coli, GI1789208, Length=261, Percent_Identity=26.4367816091954, Blast_Score=74, Evalue=8e-15, Organism=Escherichia coli, GI87082160, Length=257, Percent_Identity=28.7937743190661, Blast_Score=74, Evalue=9e-15, Organism=Escherichia coli, GI1789378, Length=293, Percent_Identity=26.962457337884, Blast_Score=71, Evalue=6e-14, Organism=Caenorhabditis elegans, GI17555706, Length=248, Percent_Identity=31.8548387096774, Blast_Score=124, Evalue=7e-29, Organism=Caenorhabditis elegans, GI17560676, Length=258, Percent_Identity=31.7829457364341, Blast_Score=99, Evalue=2e-21, Organism=Caenorhabditis elegans, GI17562910, Length=258, Percent_Identity=30.2325581395349, Blast_Score=95, Evalue=4e-20, Organism=Caenorhabditis elegans, GI17562906, Length=261, Percent_Identity=31.0344827586207, Blast_Score=94, Evalue=6e-20, Organism=Caenorhabditis elegans, GI71994600, Length=259, Percent_Identity=31.6602316602317, Blast_Score=94, Evalue=1e-19, Organism=Caenorhabditis elegans, GI17560150, Length=262, Percent_Identity=32.0610687022901, Blast_Score=93, Evalue=1e-19, Organism=Caenorhabditis elegans, GI115534694, Length=255, Percent_Identity=29.8039215686275, Blast_Score=91, Evalue=4e-19, Organism=Caenorhabditis elegans, GI72000259, Length=263, Percent_Identity=30.0380228136882, Blast_Score=90, Evalue=9e-19, Organism=Caenorhabditis elegans, GI17562908, Length=261, Percent_Identity=29.5019157088123, Blast_Score=89, Evalue=2e-18, Organism=Caenorhabditis elegans, GI17560332, Length=263, Percent_Identity=31.1787072243346, Blast_Score=89, Evalue=2e-18, Organism=Caenorhabditis elegans, GI17562990, Length=259, Percent_Identity=32.046332046332, Blast_Score=89, Evalue=2e-18, Organism=Caenorhabditis elegans, GI17531453, Length=258, Percent_Identity=29.4573643410853, Blast_Score=86, Evalue=1e-17, Organism=Caenorhabditis elegans, GI17544670, Length=277, Percent_Identity=27.4368231046931, Blast_Score=86, Evalue=2e-17, Organism=Caenorhabditis elegans, GI17562904, Length=262, Percent_Identity=30.1526717557252, Blast_Score=82, Evalue=2e-16, Organism=Caenorhabditis elegans, GI71994604, Length=259, Percent_Identity=29.3436293436293, Blast_Score=82, Evalue=2e-16, Organism=Caenorhabditis elegans, GI17561402, Length=260, Percent_Identity=28.4615384615385, Blast_Score=82, Evalue=3e-16, Organism=Caenorhabditis elegans, GI25147288, Length=251, Percent_Identity=26.2948207171315, Blast_Score=81, Evalue=6e-16, Organism=Caenorhabditis elegans, GI17563726, Length=261, Percent_Identity=28.3524904214559, Blast_Score=80, Evalue=1e-15, Organism=Caenorhabditis elegans, GI17559104, Length=266, Percent_Identity=28.9473684210526, Blast_Score=79, Evalue=2e-15, Organism=Caenorhabditis elegans, GI17538480, Length=261, Percent_Identity=28.3524904214559, Blast_Score=77, Evalue=1e-14, Organism=Caenorhabditis elegans, GI193204405, Length=258, Percent_Identity=27.906976744186, Blast_Score=75, Evalue=3e-14, Organism=Caenorhabditis elegans, GI17565030, Length=263, Percent_Identity=28.1368821292776, Blast_Score=74, Evalue=9e-14, Organism=Caenorhabditis elegans, GI17560220, Length=262, Percent_Identity=27.4809160305344, Blast_Score=72, Evalue=3e-13, Organism=Caenorhabditis elegans, GI17551412, Length=261, Percent_Identity=27.5862068965517, Blast_Score=70, Evalue=2e-12, Organism=Caenorhabditis elegans, GI17538486, Length=265, Percent_Identity=28.3018867924528, Blast_Score=69, Evalue=4e-12, Organism=Caenorhabditis elegans, GI17561272, Length=211, Percent_Identity=26.5402843601896, Blast_Score=68, Evalue=5e-12, Organism=Caenorhabditis elegans, GI17536025, Length=265, Percent_Identity=24.9056603773585, Blast_Score=64, Evalue=9e-11, Organism=Saccharomyces cerevisiae, GI6324126, Length=143, Percent_Identity=32.1678321678322, Blast_Score=82, Evalue=1e-16, Organism=Saccharomyces cerevisiae, GI6322067, Length=196, Percent_Identity=31.6326530612245, Blast_Score=74, Evalue=3e-14, Organism=Saccharomyces cerevisiae, GI6323882, Length=201, Percent_Identity=30.3482587064677, Blast_Score=70, Evalue=4e-13, Organism=Drosophila melanogaster, GI24639444, Length=249, Percent_Identity=30.5220883534137, Blast_Score=110, Evalue=1e-24, Organism=Drosophila melanogaster, GI21355319, Length=251, Percent_Identity=33.0677290836653, Blast_Score=109, Evalue=2e-24, Organism=Drosophila melanogaster, GI23397609, Length=254, Percent_Identity=31.8897637795276, Blast_Score=105, Evalue=3e-23, Organism=Drosophila melanogaster, GI24643142, Length=265, Percent_Identity=32.4528301886792, Blast_Score=96, Evalue=2e-20, Organism=Drosophila melanogaster, GI24644337, Length=201, Percent_Identity=36.81592039801, Blast_Score=94, Evalue=1e-19, Organism=Drosophila melanogaster, GI21357041, Length=258, Percent_Identity=29.4573643410853, Blast_Score=87, Evalue=1e-17, Organism=Drosophila melanogaster, GI28571526, Length=258, Percent_Identity=28.2945736434109, Blast_Score=84, Evalue=1e-16, Organism=Drosophila melanogaster, GI24644339, Length=260, Percent_Identity=33.0769230769231, Blast_Score=80, Evalue=2e-15,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR002198 - InterPro: IPR002347 - InterPro: IPR016040 - InterPro: IPR020904 [H]
Pfam domain/function: PF00106 adh_short [H]
EC number: 1.1.1.100 [C]
Molecular weight: Translated: 28793; Mature: 28662
Theoretical pI: Translated: 7.13; Mature: 7.13
Prosite motif: PS00061 ADH_SHORT
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
1.1 %Cys (Translated Protein) 2.6 %Met (Translated Protein) 3.7 %Cys+Met (Translated Protein) 1.1 %Cys (Mature Protein) 2.2 %Met (Mature Protein) 3.4 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MSPDSNTDNSRPGVSSSEIPRTDTERKTLVLTGASRGIGHATVKRFSLAGWRVITCSRQD CCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHCCCEEEEEECCCC FSENCPWPAGPEDHIKVDLSDPEDIGKAIAEIRRRLEANGSKLHALVNNAGISPKAEGGR HHCCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHCCCHHEEEEHHCCCCCCCCCCCC RMNSIETPMAVWRDVFQVNFMAPIMLARGLFKELEAAQGSVVNVTSIAGSRVHPFAGTAY CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCHH ATSKAALAALTREMASDFGPYGIRVNAIAPGEIDTAILSPGTDKLVEQLPMRRLGKTSEV HHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCEEECCCHHHHHHHHHHHHCCCHHHH AETIYFLCTEASSYVTGSEIHINGGQHV HHHHHHHHHCCCCCCCCCEEEECCCCCC >Mature Secondary Structure SPDSNTDNSRPGVSSSEIPRTDTERKTLVLTGASRGIGHATVKRFSLAGWRVITCSRQD CCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHCCCEEEEEECCCC FSENCPWPAGPEDHIKVDLSDPEDIGKAIAEIRRRLEANGSKLHALVNNAGISPKAEGGR HHCCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHCCCHHEEEEHHCCCCCCCCCCCC RMNSIETPMAVWRDVFQVNFMAPIMLARGLFKELEAAQGSVVNVTSIAGSRVHPFAGTAY CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCHH ATSKAALAALTREMASDFGPYGIRVNAIAPGEIDTAILSPGTDKLVEQLPMRRLGKTSEV HHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCEEECCCHHHHHHHHHHHHCCCHHHH AETIYFLCTEASSYVTGSEIHINGGQHV HHHHHHHHHCCCCCCCCCEEEECCCCCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NADPH [C]
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]
Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]
General reaction: Redox reaction [C]
Inhibitor: NA
Structure determination priority: 10.0
TargetDB status: NA
Availability: NA
References: 3313281; 11157954; 12597275 [H]