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The map label for this gene is ilvD

Identifier: 225851638

GI number: 225851638

Start: 103278

End: 105113

Strand: Reverse

Name: ilvD

Synonym: BMEA_A0105

Alternate gene names: 225851638

Gene position: 105113-103278 (Counterclockwise)

Preceding gene: 225851640

Following gene: 225851632

Centisome position: 4.94

GC content: 61.0

Gene sequence:

>1836_bases
ATGCCTCCTTATCGTTCGCGTACAACCACCCATGGCCGCAATATGGCCGGCGCGCGCGGCCTATGGCGCGCCACCGGCAT
GAAGGATGAGGATTTCGGCAAGCCGATTATCGCCGTGGTGAACTCGTTCACCCAGTTCGTGCCCGGCCATGTGCATCTGA
AGGATCTCGGCCAGCTCGTCGCGCGCGAAATCGAAAGTGCGGGCGGCGTCGCCAAGGAATTCAATACCATTGCGGTCGAT
GACGGCATCGCCATGGGCCATGACGGCATGCTCTATTCGCTCCCCTCCCGTGAGCTCATCGCCGACTCGGTCGAATATAT
GGTCAATGCGCATTGCGCCGATGCGATGGTCTGCATCTCCAATTGCGACAAGATCACGCCCGGCATGCTGATGGCGGCGC
TGCGTCTCAATATTCCGGTCGTGTTCGTCTCCGGTGGGCCGATGGAAGCAGGCAAGGTCGTGTGGGAGGATTCTGTCAAG
AAGCTCGACCTCGTGGACGCCATGGTGGCGGCGGCCGACGACCATTATACCGACGAGCAGGTGAAGGCGATTGAGCGTTC
CGCCTGCCCGACCTGTGGGTCGTGTTCGGGCATGTTCACGGCCAATTCGATGAATTGCCTTACCGAAGCGCTCGGCCTGT
CGCTGCCCGGCAATGGTTCGACGCTCGCCACCCATGCAGACCGCAAGCGCCTCTTCGTCGAAGCTGGCCACCTGATCGTC
GATCTCGCCCGCCGCTATTACGAGCAGGATGACGAAAGTGTGCTGCCGCGCTCCATCGCCACTTTCTCGGCTTTCGAGAA
CGCGATGACGCTCGATATCGCCATGGGCGGTTCGACCAATACGGTTCTGCATCTGCTCGCGGCTGCGCAGGAAGCGGAAA
TCGATTTCACCATGGCGGATATAGACCGTCTGTCGCGCCGCGTGCCGGTGCTGTGCAAGGTGGCGCCCGCCGTGTCGTCG
GTTCACATGGAAGACGTGCATCATGCCGGCGGCATCATGGGCATTCTCGGACAGCTCGACAATGCGGGCCTGCTGACCAC
CAGCATCCCGACCGTGCACAGCGAAACGCTCGCTAAGGCGCTTGATCATTGGGATGTAACGCGCACAAACAGCGAAATGG
TGCACAAATTCTATTCCGCCGCTCCCGGCGGCGTGCCGACGCAGGTGGCTTTCAGCCAGGAGCGGCGCTTCGACAAGGTG
GACACCGACCGCGAAAAAGGCGTCATCCGCTCAAAGGAACACGCTTTCAGCCAGGATGGCGGCTTGGCCGTGCTTTACGG
CAATCTGGCGGAAGACGGCTGCATCGTGAAGACGGCAGGCGTGGACGATTCCATCCTGAAATTCTCCGGCCCGGCCCGCA
TTTTTGAAAGCCAGGATTCGGCTGTGCTTGGCATTTTGAACGGCAAGATCAAGCCGGGCGACATCGTGCTGATCCGCTAT
GAAGGCCCGCGCGGCGGCCCCGGAATGCAGGAAATGCTCTACCCGACCAGCTATCTGAAGTCGAAGGGCCTCGGCAAAGC
CTGCGCACTTATCACCGACGGACGTTTCTCGGGCGGTTCATCGGGCCTTTCCATCGGCCATGTTTCGCCGGAAGCAGCCG
AAGGCGGCACGATCGGTCTGGTGCGCGAAGGCGATATCATCGATATCGACATTCCGAACCGCAAGATCCACCTTGCCGTT
GACGACGCCACACTTGCCGAACGCCGCGCCGAGCAGGATGCAGCAGGCTGGAAACCGGCAGAGGAACGCAAGCGTAAAAT
CTCCACTGCGCTGAAAGCCTATGCGGCAATGGCGACAAGTGCCGCCAGGGGCGCGGTGCGAAAGCTGCCGGATTGA

Upstream 100 bases:

>100_bases
ATGGCCCATTTTTTAGCAATATGGGGCAATTTGCGCTTTGCTCGGCGAGAGCGGTTCTGTCATATCGGTGAAGTTAGAAT
AGTTCCTAAAAGGTTTGAAA

Downstream 100 bases:

>100_bases
TCGATAATTAAGAAAAGCAAAAGCCCCGCCCATTGAACTGCCCCCGAAAGTTGGACGACCAACTTCGGGGGAATGCGGGG
CTCTTCATTTTAGAAATTCC

Product: dihydroxy-acid dehydratase

Products: NA

Alternate protein names: DAD

Number of amino acids: Translated: 611; Mature: 610

Protein sequence:

>611_residues
MPPYRSRTTTHGRNMAGARGLWRATGMKDEDFGKPIIAVVNSFTQFVPGHVHLKDLGQLVAREIESAGGVAKEFNTIAVD
DGIAMGHDGMLYSLPSRELIADSVEYMVNAHCADAMVCISNCDKITPGMLMAALRLNIPVVFVSGGPMEAGKVVWEDSVK
KLDLVDAMVAAADDHYTDEQVKAIERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGSTLATHADRKRLFVEAGHLIV
DLARRYYEQDDESVLPRSIATFSAFENAMTLDIAMGGSTNTVLHLLAAAQEAEIDFTMADIDRLSRRVPVLCKVAPAVSS
VHMEDVHHAGGIMGILGQLDNAGLLTTSIPTVHSETLAKALDHWDVTRTNSEMVHKFYSAAPGGVPTQVAFSQERRFDKV
DTDREKGVIRSKEHAFSQDGGLAVLYGNLAEDGCIVKTAGVDDSILKFSGPARIFESQDSAVLGILNGKIKPGDIVLIRY
EGPRGGPGMQEMLYPTSYLKSKGLGKACALITDGRFSGGSSGLSIGHVSPEAAEGGTIGLVREGDIIDIDIPNRKIHLAV
DDATLAERRAEQDAAGWKPAEERKRKISTALKAYAAMATSAARGAVRKLPD

Sequences:

>Translated_611_residues
MPPYRSRTTTHGRNMAGARGLWRATGMKDEDFGKPIIAVVNSFTQFVPGHVHLKDLGQLVAREIESAGGVAKEFNTIAVD
DGIAMGHDGMLYSLPSRELIADSVEYMVNAHCADAMVCISNCDKITPGMLMAALRLNIPVVFVSGGPMEAGKVVWEDSVK
KLDLVDAMVAAADDHYTDEQVKAIERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGSTLATHADRKRLFVEAGHLIV
DLARRYYEQDDESVLPRSIATFSAFENAMTLDIAMGGSTNTVLHLLAAAQEAEIDFTMADIDRLSRRVPVLCKVAPAVSS
VHMEDVHHAGGIMGILGQLDNAGLLTTSIPTVHSETLAKALDHWDVTRTNSEMVHKFYSAAPGGVPTQVAFSQERRFDKV
DTDREKGVIRSKEHAFSQDGGLAVLYGNLAEDGCIVKTAGVDDSILKFSGPARIFESQDSAVLGILNGKIKPGDIVLIRY
EGPRGGPGMQEMLYPTSYLKSKGLGKACALITDGRFSGGSSGLSIGHVSPEAAEGGTIGLVREGDIIDIDIPNRKIHLAV
DDATLAERRAEQDAAGWKPAEERKRKISTALKAYAAMATSAARGAVRKLPD
>Mature_610_residues
PPYRSRTTTHGRNMAGARGLWRATGMKDEDFGKPIIAVVNSFTQFVPGHVHLKDLGQLVAREIESAGGVAKEFNTIAVDD
GIAMGHDGMLYSLPSRELIADSVEYMVNAHCADAMVCISNCDKITPGMLMAALRLNIPVVFVSGGPMEAGKVVWEDSVKK
LDLVDAMVAAADDHYTDEQVKAIERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGSTLATHADRKRLFVEAGHLIVD
LARRYYEQDDESVLPRSIATFSAFENAMTLDIAMGGSTNTVLHLLAAAQEAEIDFTMADIDRLSRRVPVLCKVAPAVSSV
HMEDVHHAGGIMGILGQLDNAGLLTTSIPTVHSETLAKALDHWDVTRTNSEMVHKFYSAAPGGVPTQVAFSQERRFDKVD
TDREKGVIRSKEHAFSQDGGLAVLYGNLAEDGCIVKTAGVDDSILKFSGPARIFESQDSAVLGILNGKIKPGDIVLIRYE
GPRGGPGMQEMLYPTSYLKSKGLGKACALITDGRFSGGSSGLSIGHVSPEAAEGGTIGLVREGDIIDIDIPNRKIHLAVD
DATLAERRAEQDAAGWKPAEERKRKISTALKAYAAMATSAARGAVRKLPD

Specific function: Valine and isoleucine biosynthesis; fourth step. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family

Homologues:

Organism=Escherichia coli, GI48994964, Length=610, Percent_Identity=74.2622950819672, Blast_Score=941, Evalue=0.0,
Organism=Escherichia coli, GI2367371, Length=533, Percent_Identity=32.0825515947467, Blast_Score=194, Evalue=1e-50,
Organism=Escherichia coli, GI1788157, Length=551, Percent_Identity=28.3121597096189, Blast_Score=180, Evalue=2e-46,
Organism=Escherichia coli, GI1786464, Length=523, Percent_Identity=32.1223709369025, Blast_Score=175, Evalue=9e-45,
Organism=Saccharomyces cerevisiae, GI6322476, Length=609, Percent_Identity=37.4384236453202, Blast_Score=350, Evalue=5e-97,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ILVD_BRUA1 (B2S7Z5)

Other databases:

- EMBL:   CP000887
- RefSeq:   YP_001934123.1
- GeneID:   6328038
- GenomeReviews:   CP000887_GR
- KEGG:   bmc:BAbS19_I00910
- HOGENOM:   HBG671001
- OMA:   KVPCLSK
- ProtClustDB:   PRK12448
- HAMAP:   MF_00012
- InterPro:   IPR015928
- InterPro:   IPR004404
- InterPro:   IPR000581
- InterPro:   IPR020558
- PANTHER:   PTHR21000
- TIGRFAMs:   TIGR00110

Pfam domain/function: PF00920 ILVD_EDD; SSF52016 Aconitase/3IPM_dehydase_swvl

EC number: =4.2.1.9

Molecular weight: Translated: 65311; Mature: 65180

Theoretical pI: Translated: 5.94; Mature: 5.94

Prosite motif: PS00886 ILVD_EDD_1; PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPPYRSRTTTHGRNMAGARGLWRATGMKDEDFGKPIIAVVNSFTQFVPGHVHLKDLGQLV
CCCCCCCCCCCCCCCCCCCCHHHHCCCCCHHHCCHHHHHHHHHHHHCCCCEEHHHHHHHH
AREIESAGGVAKEFNTIAVDDGIAMGHDGMLYSLPSRELIADSVEYMVNAHCADAMVCIS
HHHHHHHCCHHHHCCEEEECCCEEECCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHH
NCDKITPGMLMAALRLNIPVVFVSGGPMEAGKVVWEDSVKKLDLVDAMVAAADDHYTDEQ
CCCCCCHHHHHHHHHHCCCEEEEECCCCCCCCEEEHHHHHHHHHHHHHHHHCCCCCCHHH
VKAIERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGSTLATHADRKRLFVEAGHLIV
HHHHHHHCCCCCCCCCCCEECCHHHHHHHHHCCCCCCCCCEEEECCCHHHHHHHHHHHHH
DLARRYYEQDDESVLPRSIATFSAFENAMTLDIAMGGSTNTVLHLLAAAQEAEIDFTMAD
HHHHHHHCCCCCHHCHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHHHHHCCCEEEHHH
IDRLSRRVPVLCKVAPAVSSVHMEDVHHAGGIMGILGQLDNAGLLTTSIPTVHSETLAKA
HHHHHCCCCEEEEECHHHHHHHHHHHHHHCCHHHHHHCCCCCCEEEECCCCHHHHHHHHH
LDHWDVTRTNSEMVHKFYSAAPGGVPTQVAFSQERRFDKVDTDREKGVIRSKEHAFSQDG
HHHCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCCHHCCCHHCHHHCCCCCC
GLAVLYGNLAEDGCIVKTAGVDDSILKFSGPARIFESQDSAVLGILNGKIKPGDIVLIRY
CEEEEECCCCCCCEEEEECCCCCHHHCCCCCHHHCCCCCCEEEEEECCCCCCCCEEEEEE
EGPRGGPGMQEMLYPTSYLKSKGLGKACALITDGRFSGGSSGLSIGHVSPEAAEGGTIGL
CCCCCCCCHHHHHCCHHHHHHCCCCCEEEEEECCCCCCCCCCCEEECCCCCCCCCCEEEE
VREGDIIDIDIPNRKIHLAVDDATLAERRAEQDAAGWKPAEERKRKISTALKAYAAMATS
EECCCEEEEECCCCEEEEEECCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHH
AARGAVRKLPD
HHHHHHHCCCC
>Mature Secondary Structure 
PPYRSRTTTHGRNMAGARGLWRATGMKDEDFGKPIIAVVNSFTQFVPGHVHLKDLGQLV
CCCCCCCCCCCCCCCCCCCHHHHCCCCCHHHCCHHHHHHHHHHHHCCCCEEHHHHHHHH
AREIESAGGVAKEFNTIAVDDGIAMGHDGMLYSLPSRELIADSVEYMVNAHCADAMVCIS
HHHHHHHCCHHHHCCEEEECCCEEECCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHH
NCDKITPGMLMAALRLNIPVVFVSGGPMEAGKVVWEDSVKKLDLVDAMVAAADDHYTDEQ
CCCCCCHHHHHHHHHHCCCEEEEECCCCCCCCEEEHHHHHHHHHHHHHHHHCCCCCCHHH
VKAIERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGSTLATHADRKRLFVEAGHLIV
HHHHHHHCCCCCCCCCCCEECCHHHHHHHHHCCCCCCCCCEEEECCCHHHHHHHHHHHHH
DLARRYYEQDDESVLPRSIATFSAFENAMTLDIAMGGSTNTVLHLLAAAQEAEIDFTMAD
HHHHHHHCCCCCHHCHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHHHHHCCCEEEHHH
IDRLSRRVPVLCKVAPAVSSVHMEDVHHAGGIMGILGQLDNAGLLTTSIPTVHSETLAKA
HHHHHCCCCEEEEECHHHHHHHHHHHHHHCCHHHHHHCCCCCCEEEECCCCHHHHHHHHH
LDHWDVTRTNSEMVHKFYSAAPGGVPTQVAFSQERRFDKVDTDREKGVIRSKEHAFSQDG
HHHCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCCHHCCCHHCHHHCCCCCC
GLAVLYGNLAEDGCIVKTAGVDDSILKFSGPARIFESQDSAVLGILNGKIKPGDIVLIRY
CEEEEECCCCCCCEEEEECCCCCHHHCCCCCHHHCCCCCCEEEEEECCCCCCCCEEEEEE
EGPRGGPGMQEMLYPTSYLKSKGLGKACALITDGRFSGGSSGLSIGHVSPEAAEGGTIGL
CCCCCCCCHHHHHCCHHHHHHCCCCCEEEEEECCCCCCCCCCCEEECCCCCCCCCCEEEE
VREGDIIDIDIPNRKIHLAVDDATLAERRAEQDAAGWKPAEERKRKISTALKAYAAMATS
EECCCEEEEECCCCEEEEEECCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHH
AARGAVRKLPD
HHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA