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The map label for this gene is cyoB [H]

Identifier: 225851586

GI number: 225851586

Start: 47536

End: 49515

Strand: Direct

Name: cyoB [H]

Synonym: BMEA_A0045

Alternate gene names: 225851586

Gene position: 47536-49515 (Clockwise)

Preceding gene: 225851585

Following gene: 225851587

Centisome position: 2.24

GC content: 58.03

Gene sequence:

>1980_bases
ATGTTCGGAAAACTTACGCTCGAAGCGATACCCTATCACGAGCCAATCATCATGGTCACTTTGGCCGCGGTGGCTGGCGG
GGCGCTCGCTATTCTCGCCGCCATAACCTACTATCGCAAGTGGGTTCCGCTCTGGAACGACTGGCTTACCTCCGTCGATC
ACAAGCGTATTGGCGTCATGTATATCGTCCTGGCGCTGGTGATGCTGTTCCGCGGCTTCTCCGATGCCGTGATGATGCGC
GCGCAGCAGGCTTTGGCCTCCGGCGCCAATGAAGGCTTTCTGCCGCCACATCACTATGACCAGATTTTCACGGCCCATGG
CGTGATCATGATCTTCTTCGTGGCGATGCCTTTCATTGTCGGCCTGATGAATTTCGTGGTGCCTTTGCAGATCGGCGCGC
GCGACGTGGCCTTCCCCTACCTCAACTCGCTGAGCTTCTGGCTCACGGTTGCAGGCGCGATCCTCGTCAATATCTCGCTC
GGCGTCGGCGAATTCGCCAAGACCGGCTGGCTCGCCTATCCGCCGCTGTCCGGCAAGGCCTTCAGCCCCGATGTCGGCAT
GGATTACTATCTGTGGGCGCTTAATATTTCGGGTATGGGCACGCTGCTTTCCGCAGTCAACCTCATCACCACCATCATCA
AGATGCGTGCGCCCGGCATGGGCATGATGCAGCTTCCGGTCTTTACCTGGACTGCGCTCTGCTCGAACGTTCTGATCGTT
GCCGCCTTCCCGATCCTCACCGTCACCCTGTCGCTGCTGACACTCGACCGTTATCTGGATTTCCACTTCTTCACCAATGA
TGCCGGTGGCAATCCGATGATGTATGTGAACCTGATCTGGATCTGGGGCCACCCGGAAGTCTATATTCTGGTTCTGCCCT
GCTTCGGCATCTATTCGGAAATCATCGCCACGTTCTCCGGCAAGCGTCTCTTCGGCTACACGTCGATGGTCTATGCCACG
GTCGCGATCACCGTCCTGTCGTTCCTTGTCTGGGTGCACCACTTCTTCACCATGGGTGGTGGGGCCAGCGTGAACTCCTT
CTTCGGTGTCGCGACGATGATTATCTCGATCCCGACCGGCGCCAAGGTGTTCAACTGGCTTTTCACCATGTACAAGGGCC
GCGTCCGCATGGAGACGCCGGTTATGTGGACCATCGGTTTCATGTGCACCTTCGTCATCGGCGGTATGACGGGCGTTCTG
CTCGCCGTTCCCCCGGCAGACTTCGTGCTGCACAATTCGGTGTTCCTCATCGCCCACTTCCACAACGTCATCATTTCGGG
CGTTCTGTTCGGCTGCTTCGCTGGCGTGGTTTACTGGTGGCCGAAGGCTTTTGGCTTCAAGCTCAATGAACGCCTGGGCA
AGAACGCCTTCTGGTGCTGGCTGGTCGGCTTCATGCTCGCCTTCATGCCGCTTTATGTGCTCGGCCTGATGGGTATGACC
CGCCGTCTCAACCATACCGAAAATCCGGCATGGCATATCTACCTCATCATTGCCGCCATCGGCGTGGCCGTCATCCTCTG
CGGCATCGTCTGCCAGATTCTCCAGATCATGGTTTCCATCCGTGACCGCGATAAACTGCGCGACACCAATGGCGATACCT
GGGGTTCGGGCCGTACGCTGGAATGGTCGATCTCGTCGCCGCCTCCGTTCTACAACTTCGCCGAAACCCCGACCGTGCGT
GATCACGACGCCTGGTGGGATATGAAGCAGAACGGTTATGTGCGCCGCACCGAGAAGTTTGCCCGCATCCATATGCCCAA
GAACACGGCGACGGGCTTCCTTGTCGGCATCCTGTCGATCCCGTTCGGCTTTGCCATGATCTGGCATATCTGGTGGCTGG
CCATAGCCTCGGCTCTGGCAATGTTCGTCGTCGCCATCGCCCATTCCTTCAACAATGACAGAGACTATTACGTCTCGGCC
GATGAGGTGCAGCGTGTCGAAGATGCGCGCACGCGGCAACTGACTGCTCAGGAGGCTTGA

Upstream 100 bases:

>100_bases
CTTTCGCAGCTTGAAAACTGATTTGCCGATGCTGTAGCGCCCGCCGGCTTTTCTGCCGGGCACTGCGGTCGTTCGCACTC
CAATCAAAGCAAGAATAGAA

Downstream 100 bases:

>100_bases
TCCATGAGCGCCATTCAACACACCGCCGCTCCCTATCTGGGCGGAAACGATCATCCCGCCCATGAGGACCATCATGATGC
AGGGTCGACCACGCTGGTCG

Product: cytochrome o ubiquinol oxidase subunit I

Products: NA

Alternate protein names: Cytochrome o subunit 1; Cytochrome o ubiquinol oxidase subunit 1; Oxidase BO(3) subunit 1; Ubiquinol oxidase polypeptide I [H]

Number of amino acids: Translated: 659; Mature: 659

Protein sequence:

>659_residues
MFGKLTLEAIPYHEPIIMVTLAAVAGGALAILAAITYYRKWVPLWNDWLTSVDHKRIGVMYIVLALVMLFRGFSDAVMMR
AQQALASGANEGFLPPHHYDQIFTAHGVIMIFFVAMPFIVGLMNFVVPLQIGARDVAFPYLNSLSFWLTVAGAILVNISL
GVGEFAKTGWLAYPPLSGKAFSPDVGMDYYLWALNISGMGTLLSAVNLITTIIKMRAPGMGMMQLPVFTWTALCSNVLIV
AAFPILTVTLSLLTLDRYLDFHFFTNDAGGNPMMYVNLIWIWGHPEVYILVLPCFGIYSEIIATFSGKRLFGYTSMVYAT
VAITVLSFLVWVHHFFTMGGGASVNSFFGVATMIISIPTGAKVFNWLFTMYKGRVRMETPVMWTIGFMCTFVIGGMTGVL
LAVPPADFVLHNSVFLIAHFHNVIISGVLFGCFAGVVYWWPKAFGFKLNERLGKNAFWCWLVGFMLAFMPLYVLGLMGMT
RRLNHTENPAWHIYLIIAAIGVAVILCGIVCQILQIMVSIRDRDKLRDTNGDTWGSGRTLEWSISSPPPFYNFAETPTVR
DHDAWWDMKQNGYVRRTEKFARIHMPKNTATGFLVGILSIPFGFAMIWHIWWLAIASALAMFVVAIAHSFNNDRDYYVSA
DEVQRVEDARTRQLTAQEA

Sequences:

>Translated_659_residues
MFGKLTLEAIPYHEPIIMVTLAAVAGGALAILAAITYYRKWVPLWNDWLTSVDHKRIGVMYIVLALVMLFRGFSDAVMMR
AQQALASGANEGFLPPHHYDQIFTAHGVIMIFFVAMPFIVGLMNFVVPLQIGARDVAFPYLNSLSFWLTVAGAILVNISL
GVGEFAKTGWLAYPPLSGKAFSPDVGMDYYLWALNISGMGTLLSAVNLITTIIKMRAPGMGMMQLPVFTWTALCSNVLIV
AAFPILTVTLSLLTLDRYLDFHFFTNDAGGNPMMYVNLIWIWGHPEVYILVLPCFGIYSEIIATFSGKRLFGYTSMVYAT
VAITVLSFLVWVHHFFTMGGGASVNSFFGVATMIISIPTGAKVFNWLFTMYKGRVRMETPVMWTIGFMCTFVIGGMTGVL
LAVPPADFVLHNSVFLIAHFHNVIISGVLFGCFAGVVYWWPKAFGFKLNERLGKNAFWCWLVGFMLAFMPLYVLGLMGMT
RRLNHTENPAWHIYLIIAAIGVAVILCGIVCQILQIMVSIRDRDKLRDTNGDTWGSGRTLEWSISSPPPFYNFAETPTVR
DHDAWWDMKQNGYVRRTEKFARIHMPKNTATGFLVGILSIPFGFAMIWHIWWLAIASALAMFVVAIAHSFNNDRDYYVSA
DEVQRVEDARTRQLTAQEA
>Mature_659_residues
MFGKLTLEAIPYHEPIIMVTLAAVAGGALAILAAITYYRKWVPLWNDWLTSVDHKRIGVMYIVLALVMLFRGFSDAVMMR
AQQALASGANEGFLPPHHYDQIFTAHGVIMIFFVAMPFIVGLMNFVVPLQIGARDVAFPYLNSLSFWLTVAGAILVNISL
GVGEFAKTGWLAYPPLSGKAFSPDVGMDYYLWALNISGMGTLLSAVNLITTIIKMRAPGMGMMQLPVFTWTALCSNVLIV
AAFPILTVTLSLLTLDRYLDFHFFTNDAGGNPMMYVNLIWIWGHPEVYILVLPCFGIYSEIIATFSGKRLFGYTSMVYAT
VAITVLSFLVWVHHFFTMGGGASVNSFFGVATMIISIPTGAKVFNWLFTMYKGRVRMETPVMWTIGFMCTFVIGGMTGVL
LAVPPADFVLHNSVFLIAHFHNVIISGVLFGCFAGVVYWWPKAFGFKLNERLGKNAFWCWLVGFMLAFMPLYVLGLMGMT
RRLNHTENPAWHIYLIIAAIGVAVILCGIVCQILQIMVSIRDRDKLRDTNGDTWGSGRTLEWSISSPPPFYNFAETPTVR
DHDAWWDMKQNGYVRRTEKFARIHMPKNTATGFLVGILSIPFGFAMIWHIWWLAIASALAMFVVAIAHSFNNDRDYYVSA
DEVQRVEDARTRQLTAQEA

Specific function: Cytochrome o terminal oxidase complex is the component of the aerobic respiratory chain that predominates when cells are grown at high aeration. This ubiquinol oxidase shows proton pump activity across the membrane in addition to the electron transfer [H]

COG id: COG0843

COG function: function code C; Heme/copper-type cytochrome/quinol oxidases, subunit 1

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the heme-copper respiratory oxidase family [H]

Homologues:

Organism=Homo sapiens, GI251831109, Length=514, Percent_Identity=37.5486381322957, Blast_Score=340, Evalue=2e-93,
Organism=Escherichia coli, GI1786634, Length=656, Percent_Identity=66.7682926829268, Blast_Score=941, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6226519, Length=534, Percent_Identity=36.1423220973783, Blast_Score=329, Evalue=9e-91,
Organism=Saccharomyces cerevisiae, GI6226524, Length=321, Percent_Identity=39.8753894080997, Blast_Score=234, Evalue=3e-62,
Organism=Saccharomyces cerevisiae, GI6226523, Length=247, Percent_Identity=33.1983805668016, Blast_Score=125, Evalue=2e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000883
- InterPro:   IPR014207 [H]

Pfam domain/function: PF00115 COX1 [H]

EC number: 1.10.3.-

Molecular weight: Translated: 73732; Mature: 73732

Theoretical pI: Translated: 8.44; Mature: 8.44

Prosite motif: PS50855 COX1 ; PS00077 COX1_CUB

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
5.2 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
5.2 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFGKLTLEAIPYHEPIIMVTLAAVAGGALAILAAITYYRKWVPLWNDWLTSVDHKRIGVM
CCCCEEEEECCCCCCHHHHHHHHHHCHHHHHHHHHHHHHHHCCHHHHHHHHCCCHHHHHH
YIVLALVMLFRGFSDAVMMRAQQALASGANEGFLPPHHYDQIFTAHGVIMIFFVAMPFIV
HHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
GLMNFVVPLQIGARDVAFPYLNSLSFWLTVAGAILVNISLGVGEFAKTGWLAYPPLSGKA
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHEEEECCCCHHHHCCCEECCCCCCCC
FSPDVGMDYYLWALNISGMGTLLSAVNLITTIIKMRAPGMGMMQLPVFTWTALCSNVLIV
CCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHH
AAFPILTVTLSLLTLDRYLDFHFFTNDAGGNPMMYVNLIWIWGHPEVYILVLPCFGIYSE
HHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCEEEEEEEEEECCCCEEEEEEEHHHHHHH
IIATFSGKRLFGYTSMVYATVAITVLSFLVWVHHFFTMGGGASVNSFFGVATMIISIPTG
HHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCC
AKVFNWLFTMYKGRVRMETPVMWTIGFMCTFVIGGMTGVLLAVPPADFVLHNSVFLIAHF
HHHHHHHHHHHCCCEEECCCHHHHHHHHHHHHHHCHHCEEEECCCHHHHHCCCEEEEHHH
HNVIISGVLFGCFAGVVYWWPKAFGFKLNERLGKNAFWCWLVGFMLAFMPLYVLGLMGMT
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
RRLNHTENPAWHIYLIIAAIGVAVILCGIVCQILQIMVSIRDRDKLRDTNGDTWGSGRTL
HHCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEE
EWSISSPPPFYNFAETPTVRDHDAWWDMKQNGYVRRTEKFARIHMPKNTATGFLVGILSI
EEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEHHHHHHHEECCCCCCHHHHHHHHHH
PFGFAMIWHIWWLAIASALAMFVVAIAHSFNNDRDYYVSADEVQRVEDARTRQLTAQEA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MFGKLTLEAIPYHEPIIMVTLAAVAGGALAILAAITYYRKWVPLWNDWLTSVDHKRIGVM
CCCCEEEEECCCCCCHHHHHHHHHHCHHHHHHHHHHHHHHHCCHHHHHHHHCCCHHHHHH
YIVLALVMLFRGFSDAVMMRAQQALASGANEGFLPPHHYDQIFTAHGVIMIFFVAMPFIV
HHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
GLMNFVVPLQIGARDVAFPYLNSLSFWLTVAGAILVNISLGVGEFAKTGWLAYPPLSGKA
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHEEEECCCCHHHHCCCEECCCCCCCC
FSPDVGMDYYLWALNISGMGTLLSAVNLITTIIKMRAPGMGMMQLPVFTWTALCSNVLIV
CCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHH
AAFPILTVTLSLLTLDRYLDFHFFTNDAGGNPMMYVNLIWIWGHPEVYILVLPCFGIYSE
HHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCEEEEEEEEEECCCCEEEEEEEHHHHHHH
IIATFSGKRLFGYTSMVYATVAITVLSFLVWVHHFFTMGGGASVNSFFGVATMIISIPTG
HHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCC
AKVFNWLFTMYKGRVRMETPVMWTIGFMCTFVIGGMTGVLLAVPPADFVLHNSVFLIAHF
HHHHHHHHHHHCCCEEECCCHHHHHHHHHHHHHHCHHCEEEECCCHHHHHCCCEEEEHHH
HNVIISGVLFGCFAGVVYWWPKAFGFKLNERLGKNAFWCWLVGFMLAFMPLYVLGLMGMT
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
RRLNHTENPAWHIYLIIAAIGVAVILCGIVCQILQIMVSIRDRDKLRDTNGDTWGSGRTL
HHCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEE
EWSISSPPPFYNFAETPTVRDHDAWWDMKQNGYVRRTEKFARIHMPKNTATGFLVGILSI
EEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEHHHHHHHEECCCCCCHHHHHHHHHH
PFGFAMIWHIWWLAIASALAMFVVAIAHSFNNDRDYYVSADEVQRVEDARTRQLTAQEA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: Protoheme IX (Heme B55 and B562); Copper B. [C]

Metal ions: Fe; Cu [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Oxidoreductases [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]