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The map label for this gene is hemN [H]

Identifier: 225686939

GI number: 225686939

Start: 1180806

End: 1182158

Strand: Reverse

Name: hemN [H]

Synonym: BMEA_B1194

Alternate gene names: 225686939

Gene position: 1182158-1180806 (Counterclockwise)

Preceding gene: 225686940

Following gene: 225686938

Centisome position: 99.72

GC content: 56.25

Gene sequence:

>1353_bases
ATGTCGCAGACAATCGTGGAAAAATATGGCGAGGCGCGGCTACCCCGGTATACGAGCTACCCGACGGCTCCCAATTTCAA
GGCCGAGATTGTGCCCGGTGCCTATGGGCGCTGGCTGAATTCGATCCCGGACGATCAGGACACCTCGCTTTATCTTCATA
TTCCGTTTTGCCGGTCTATGTGCTGGTATTGCGGGTGCCACACCACGATTACGGAGAAAGACCAGCCGATCCTCGATTAT
CTCGATGTTCTGCACAAGGAAATCGAGATGATAGCCAGGCAACGCGGCCGCAGTTTCAATCTCGGTGAAATTCATTTTGG
CGGCGGAACGCCGACCATCATTCAGCCCGATGAATTAGTCGCACTCATGGCGGCCCTTCGAGACCGGCTCGGCTTTGCCG
GGGAATTGAATGCAGCGGTGGAGATCGATCCGCGCCGGATGACGCCTGAAATGGCCGCAGCCCTGGCATATTCCGGCATA
ACGCGGGCAAGTCTTGGTGTGCAGAGCTTCGACCCCAAGGTGCAAAAGGCAATCAACCGCATTCAAACGGCCAAGACCAC
GCTTGAAACCGTCTCAAGCCTGCGGAAGAACAATATTCAGGCGATAAACTTCGACCTTATCTATGGGTTGCCACATCAGA
CGGTGGCATCCTGCATCGAGACAGTCGATATAGCGGTTGAGATGCGGCCAAACCGGTTTGCGGTATTTGGCTATGCGCAT
GTGCCGGGTTTCAAAAAGCACCAGAGACTGATCGATGAGAAGGCGCTTCCCGATGTGCAGGCGCGGCACGCCCAGGCAGC
GGCAATTGCCGAGCGTCTGGTTGAGGCCGGTTACGAACAGATCGGTCTGGATCATTTCGCGCTGCCGGATGATGATCTCT
CTATCGCCCAGCGCGAGGGGCGGCTGCATCGCAATTTCCAGGGCTATACCACCGATGCCTGCAAGACGCTGATCGGGATC
GGCGCTTCTGCAATTGGCAGGTTCGGCAATGGCTATCATCAGAATATCGTTCCTCCGGGGCTTTATGCGAGCTGTGTTGC
ATCGGGTGAACTGCCCACCGCCAAGATTTATGAACTGACGGCGGAGGACCGGGTGAGGGCCGATGTGATTGAACAGCTCA
TGTGCAATTTCTCGGTCAATGTAGCCGCAGTCTGCGCTGCACACGGCTTCGACCCGGAAGTGCTGATGAAGCAAAACGAC
ACGCTGGATGAACTGGAGAAAGACGGCCTCGTGCAGCGGGAAGGGTTTATGGTTCGCGTGGATGGCAGGCATCGCTTCAT
CGTGCGCGCCGTTGCATCGGCTTTCGATGCCTATCTGGCCAGCTCGAAAACAAACTTCAGCAAGACTGCCTGA

Upstream 100 bases:

>100_bases
GCAGATAGTTGATCTTTCGCCCAGATAATTGATTTCTCGCAAAGAGTTATCTTCCACACCCGCTACCTCCTTTCCTATGA
CGGATGAAAGGAACGAGGCA

Downstream 100 bases:

>100_bases
CGCCCGCATGTTTTTGGATGCCAAGGGCAGAAACCGGCTGAGAGCCTGATCCAGTCTCAATGGATCGCGCATATTCTTGT
TGCGCTGGAGCGTGGGCTTT

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 450; Mature: 449

Protein sequence:

>450_residues
MSQTIVEKYGEARLPRYTSYPTAPNFKAEIVPGAYGRWLNSIPDDQDTSLYLHIPFCRSMCWYCGCHTTITEKDQPILDY
LDVLHKEIEMIARQRGRSFNLGEIHFGGGTPTIIQPDELVALMAALRDRLGFAGELNAAVEIDPRRMTPEMAAALAYSGI
TRASLGVQSFDPKVQKAINRIQTAKTTLETVSSLRKNNIQAINFDLIYGLPHQTVASCIETVDIAVEMRPNRFAVFGYAH
VPGFKKHQRLIDEKALPDVQARHAQAAAIAERLVEAGYEQIGLDHFALPDDDLSIAQREGRLHRNFQGYTTDACKTLIGI
GASAIGRFGNGYHQNIVPPGLYASCVASGELPTAKIYELTAEDRVRADVIEQLMCNFSVNVAAVCAAHGFDPEVLMKQND
TLDELEKDGLVQREGFMVRVDGRHRFIVRAVASAFDAYLASSKTNFSKTA

Sequences:

>Translated_450_residues
MSQTIVEKYGEARLPRYTSYPTAPNFKAEIVPGAYGRWLNSIPDDQDTSLYLHIPFCRSMCWYCGCHTTITEKDQPILDY
LDVLHKEIEMIARQRGRSFNLGEIHFGGGTPTIIQPDELVALMAALRDRLGFAGELNAAVEIDPRRMTPEMAAALAYSGI
TRASLGVQSFDPKVQKAINRIQTAKTTLETVSSLRKNNIQAINFDLIYGLPHQTVASCIETVDIAVEMRPNRFAVFGYAH
VPGFKKHQRLIDEKALPDVQARHAQAAAIAERLVEAGYEQIGLDHFALPDDDLSIAQREGRLHRNFQGYTTDACKTLIGI
GASAIGRFGNGYHQNIVPPGLYASCVASGELPTAKIYELTAEDRVRADVIEQLMCNFSVNVAAVCAAHGFDPEVLMKQND
TLDELEKDGLVQREGFMVRVDGRHRFIVRAVASAFDAYLASSKTNFSKTA
>Mature_449_residues
SQTIVEKYGEARLPRYTSYPTAPNFKAEIVPGAYGRWLNSIPDDQDTSLYLHIPFCRSMCWYCGCHTTITEKDQPILDYL
DVLHKEIEMIARQRGRSFNLGEIHFGGGTPTIIQPDELVALMAALRDRLGFAGELNAAVEIDPRRMTPEMAAALAYSGIT
RASLGVQSFDPKVQKAINRIQTAKTTLETVSSLRKNNIQAINFDLIYGLPHQTVASCIETVDIAVEMRPNRFAVFGYAHV
PGFKKHQRLIDEKALPDVQARHAQAAAIAERLVEAGYEQIGLDHFALPDDDLSIAQREGRLHRNFQGYTTDACKTLIGIG
ASAIGRFGNGYHQNIVPPGLYASCVASGELPTAKIYELTAEDRVRADVIEQLMCNFSVNVAAVCAAHGFDPEVLMKQNDT
LDELEKDGLVQREGFMVRVDGRHRFIVRAVASAFDAYLASSKTNFSKTA

Specific function: Anaerobic transformation of coproporphyrinogen-III into protoporphyrinogen-IX [H]

COG id: COG0635

COG function: function code H; Coproporphyrinogen III oxidase and related Fe-S oxidoreductases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anaerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI8922911, Length=297, Percent_Identity=24.9158249158249, Blast_Score=87, Evalue=3e-17,
Organism=Escherichia coli, GI87082341, Length=437, Percent_Identity=36.3844393592677, Blast_Score=281, Evalue=7e-77,
Organism=Escherichia coli, GI1789325, Length=248, Percent_Identity=28.6290322580645, Blast_Score=97, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006638
- InterPro:   IPR004558
- InterPro:   IPR010723
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06969 HemN_C; PF04055 Radical_SAM [H]

EC number: =1.3.99.22 [H]

Molecular weight: Translated: 49814; Mature: 49683

Theoretical pI: Translated: 6.45; Mature: 6.45

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQTIVEKYGEARLPRYTSYPTAPNFKAEIVPGAYGRWLNSIPDDQDTSLYLHIPFCRSM
CCCHHHHHHCCCCCCCCCCCCCCCCCCEEECCCHHHHHHHCCCCCCCCEEEEECHHHHHH
CWYCGCHTTITEKDQPILDYLDVLHKEIEMIARQRGRSFNLGEIHFGGGTPTIIQPDELV
HHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCEECHHHHH
ALMAALRDRLGFAGELNAAVEIDPRRMTPEMAAALAYSGITRASLGVQSFDPKVQKAINR
HHHHHHHHHCCCCCCCCCEEEECCHHCCHHHHHHHHHHCCHHHHCCCCCCCHHHHHHHHH
IQTAKTTLETVSSLRKNNIQAINFDLIYGLPHQTVASCIETVDIAVEMRPNRFAVFGYAH
HHHHHHHHHHHHHHHHCCCEEEEEEEEECCCHHHHHHHHHHHHEEEEECCCEEEEEEECC
VPGFKKHQRLIDEKALPDVQARHAQAAAIAERLVEAGYEQIGLDHFALPDDDLSIAQREG
CCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCHHHHCCCCCCCCCCCHHHHHHCC
RLHRNFQGYTTDACKTLIGIGASAIGRFGNGYHQNIVPPGLYASCVASGELPTAKIYELT
HHHCCCCCCCHHHHHHHHHCCHHHHHHCCCCCCCCCCCCCHHHHHHCCCCCCCCCEEEEC
AEDRVRADVIEQLMCNFSVNVAAVCAAHGFDPEVLMKQNDTLDELEKDGLVQREGFMVRV
HHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCHHHHCCCCCCHHHHHHCCCEECCCEEEEE
DGRHRFIVRAVASAFDAYLASSKTNFSKTA
CCCHHHHHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
SQTIVEKYGEARLPRYTSYPTAPNFKAEIVPGAYGRWLNSIPDDQDTSLYLHIPFCRSM
CCHHHHHHCCCCCCCCCCCCCCCCCCEEECCCHHHHHHHCCCCCCCCEEEEECHHHHHH
CWYCGCHTTITEKDQPILDYLDVLHKEIEMIARQRGRSFNLGEIHFGGGTPTIIQPDELV
HHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCEECHHHHH
ALMAALRDRLGFAGELNAAVEIDPRRMTPEMAAALAYSGITRASLGVQSFDPKVQKAINR
HHHHHHHHHCCCCCCCCCEEEECCHHCCHHHHHHHHHHCCHHHHCCCCCCCHHHHHHHHH
IQTAKTTLETVSSLRKNNIQAINFDLIYGLPHQTVASCIETVDIAVEMRPNRFAVFGYAH
HHHHHHHHHHHHHHHHCCCEEEEEEEEECCCHHHHHHHHHHHHEEEEECCCEEEEEEECC
VPGFKKHQRLIDEKALPDVQARHAQAAAIAERLVEAGYEQIGLDHFALPDDDLSIAQREG
CCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCHHHHCCCCCCCCCCCHHHHHHCC
RLHRNFQGYTTDACKTLIGIGASAIGRFGNGYHQNIVPPGLYASCVASGELPTAKIYELT
HHHCCCCCCCHHHHHHHHHCCHHHHHHCCCCCCCCCCCCCHHHHHHCCCCCCCCCEEEEC
AEDRVRADVIEQLMCNFSVNVAAVCAAHGFDPEVLMKQNDTLDELEKDGLVQREGFMVRV
HHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCHHHHCCCCCCHHHHHHCCCEECCCEEEEE
DGRHRFIVRAVASAFDAYLASSKTNFSKTA
CCCHHHHHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11157943; 12597275 [H]