| Definition | Brucella melitensis ATCC 23457 chromosome chromosome II, complete sequence. |
|---|---|
| Accession | NC_012442 |
| Length | 1,185,518 |
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The map label for this gene is livF [H]
Identifier: 225686937
GI number: 225686937
Start: 1177829
End: 1178557
Strand: Direct
Name: livF [H]
Synonym: BMEA_B1192
Alternate gene names: 225686937
Gene position: 1177829-1178557 (Clockwise)
Preceding gene: 225686936
Following gene: 225686942
Centisome position: 99.35
GC content: 54.05
Gene sequence:
>729_bases ATGAGCCCCCACGGCAGCAACATCATTCTCGATGTACGCAACCTATCGGCTGGCTATGGTGAGCTGCCGGTCATTCGTGA TCTTAATCTTCATGTCAAGGAAGCGGAAATCGTAGCACTGGTTGGCAGCAACGGCGCTGGCAAGACAACGTTTCTGCGCG CGCTTTCTCATCTGATCCATTCCGAGGGCCAAATCGAGTTTTGTGGCGAAGACGTTTCCAGATCGACATCGGATTATGTA TTTCGACGCGGATTGGTACATATCCCCGAAGGGCGGCAACTCTTCGACCGTATGTCGGTGGAAGAAAACTTGTTGATGGG CGCTTATCGCAGCAAGGACAAGGCCCGGACCAAGGCTGATCTGGAAAAGGTCTATGTTCTATTTCCCCGCCTCGCCGAAA GGCGCAAGCAGTTGGCTGGCTCCATGTCAGGCGGAGAGCAGCAGATGTGCGCCATGGCTCGGGCGCTGATGGCCAATCCC GTTTTACTGCTGGTTGATGAAATGAGCCTCGGCCTTGCGCCCGTGGTTGTCGACCAGTTGATGACGATCCTGCATGACAT TCGCAAGTCAGAGCAGGTAACCGTGCTTCTGGTCGAGCAGGATATTCATCTTGCTCTGGACGGCGCAGACCGTGGATATG TGATGGAAACCGGCACCTTCACGCTGGAAGGCAAGGCGCAGGATCTTATTCACGATGAGAGGGTGCAAAAAGCATATTTG GGTTTGTAG
Upstream 100 bases:
>100_bases TAATGGTGCTGCACCACGGCGAAAAAATAGCGGAAGGCAGTACCGATGCGGTCCTGTCCAACCCGGTCGTGATCGAAGCC TATCTGGGAAAGAAGAGAGC
Downstream 100 bases:
>100_bases CGCCCCCATATGGTAACAATAATAGCCGCTATTTCTCCCTGTTCCCCCTGATCGGATCGGCAAGCAGACGCAGCCCGTTC AGGACGACAAGCACGGTGCC
Product: high-affinity branched-chain amino acid transporter ATP-binding protein
Products: ADP; phosphate; L-leucine [Cytoplasm]; ADP; L-valine [Cytoplasm]; L-iso-leucine [Cytoplasm] [C]
Alternate protein names: LIV-I protein F [H]
Number of amino acids: Translated: 242; Mature: 241
Protein sequence:
>242_residues MSPHGSNIILDVRNLSAGYGELPVIRDLNLHVKEAEIVALVGSNGAGKTTFLRALSHLIHSEGQIEFCGEDVSRSTSDYV FRRGLVHIPEGRQLFDRMSVEENLLMGAYRSKDKARTKADLEKVYVLFPRLAERRKQLAGSMSGGEQQMCAMARALMANP VLLLVDEMSLGLAPVVVDQLMTILHDIRKSEQVTVLLVEQDIHLALDGADRGYVMETGTFTLEGKAQDLIHDERVQKAYL GL
Sequences:
>Translated_242_residues MSPHGSNIILDVRNLSAGYGELPVIRDLNLHVKEAEIVALVGSNGAGKTTFLRALSHLIHSEGQIEFCGEDVSRSTSDYV FRRGLVHIPEGRQLFDRMSVEENLLMGAYRSKDKARTKADLEKVYVLFPRLAERRKQLAGSMSGGEQQMCAMARALMANP VLLLVDEMSLGLAPVVVDQLMTILHDIRKSEQVTVLLVEQDIHLALDGADRGYVMETGTFTLEGKAQDLIHDERVQKAYL GL >Mature_241_residues SPHGSNIILDVRNLSAGYGELPVIRDLNLHVKEAEIVALVGSNGAGKTTFLRALSHLIHSEGQIEFCGEDVSRSTSDYVF RRGLVHIPEGRQLFDRMSVEENLLMGAYRSKDKARTKADLEKVYVLFPRLAERRKQLAGSMSGGEQQMCAMARALMANPV LLLVDEMSLGLAPVVVDQLMTILHDIRKSEQVTVLLVEQDIHLALDGADRGYVMETGTFTLEGKAQDLIHDERVQKAYLG L
Specific function: Component of the leucine-specific transport system [H]
COG id: COG0410
COG function: function code E; ABC-type branched-chain amino acid transport systems, ATPase component
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Contains 1 ABC transporter domain [H]
Homologues:
Organism=Homo sapiens, GI148612844, Length=237, Percent_Identity=27.4261603375527, Blast_Score=72, Evalue=3e-13, Organism=Homo sapiens, GI255708477, Length=237, Percent_Identity=27.4261603375527, Blast_Score=72, Evalue=4e-13, Organism=Homo sapiens, GI27436953, Length=221, Percent_Identity=24.8868778280543, Blast_Score=72, Evalue=6e-13, Organism=Homo sapiens, GI9961252, Length=157, Percent_Identity=29.2993630573248, Blast_Score=70, Evalue=1e-12, Organism=Homo sapiens, GI9961250, Length=158, Percent_Identity=29.1139240506329, Blast_Score=70, Evalue=2e-12, Organism=Homo sapiens, GI4505771, Length=157, Percent_Identity=29.2993630573248, Blast_Score=70, Evalue=2e-12, Organism=Homo sapiens, GI153792144, Length=236, Percent_Identity=25.4237288135593, Blast_Score=69, Evalue=3e-12, Organism=Homo sapiens, GI42741659, Length=172, Percent_Identity=29.0697674418605, Blast_Score=69, Evalue=4e-12, Organism=Homo sapiens, GI27262624, Length=208, Percent_Identity=27.8846153846154, Blast_Score=68, Evalue=8e-12, Organism=Homo sapiens, GI27262626, Length=208, Percent_Identity=27.8846153846154, Blast_Score=68, Evalue=8e-12, Organism=Homo sapiens, GI9665248, Length=235, Percent_Identity=26.3829787234043, Blast_Score=67, Evalue=1e-11, Organism=Escherichia coli, GI87082268, Length=236, Percent_Identity=44.0677966101695, Blast_Score=198, Evalue=3e-52, Organism=Escherichia coli, GI1789593, Length=235, Percent_Identity=31.4893617021277, Blast_Score=103, Evalue=1e-23, Organism=Escherichia coli, GI1789864, Length=253, Percent_Identity=28.8537549407115, Blast_Score=101, Evalue=5e-23, Organism=Escherichia coli, GI87081709, Length=241, Percent_Identity=31.1203319502075, Blast_Score=96, Evalue=2e-21, Organism=Escherichia coli, GI1789672, Length=216, Percent_Identity=28.2407407407407, Blast_Score=93, Evalue=2e-20, Organism=Escherichia coli, GI1788225, Length=237, Percent_Identity=29.535864978903, Blast_Score=92, Evalue=2e-20, Organism=Escherichia coli, GI1788450, Length=219, Percent_Identity=29.6803652968037, Blast_Score=92, Evalue=3e-20, Organism=Escherichia coli, GI1787089, Length=229, Percent_Identity=28.82096069869, Blast_Score=92, Evalue=4e-20, Organism=Escherichia coli, GI1787029, Length=232, Percent_Identity=26.7241379310345, Blast_Score=91, Evalue=7e-20, Organism=Escherichia coli, GI1788761, Length=216, Percent_Identity=31.0185185185185, Blast_Score=91, Evalue=1e-19, Organism=Escherichia coli, GI87081791, Length=223, Percent_Identity=30.9417040358744, Blast_Score=90, Evalue=1e-19, Organism=Escherichia coli, GI1787792, Length=231, Percent_Identity=26.8398268398268, Blast_Score=89, Evalue=3e-19, Organism=Escherichia coli, GI1790544, Length=255, Percent_Identity=27.843137254902, Blast_Score=86, Evalue=3e-18, Organism=Escherichia coli, GI1786563, Length=211, Percent_Identity=28.436018957346, Blast_Score=82, Evalue=2e-17, Organism=Escherichia coli, GI48994943, Length=230, Percent_Identity=25.6521739130435, Blast_Score=82, Evalue=3e-17, Organism=Escherichia coli, GI1790162, Length=233, Percent_Identity=24.4635193133047, Blast_Score=82, Evalue=4e-17, Organism=Escherichia coli, GI1786872, Length=236, Percent_Identity=26.6949152542373, Blast_Score=79, Evalue=4e-16, Organism=Escherichia coli, GI1790467, Length=225, Percent_Identity=27.5555555555556, Blast_Score=78, Evalue=6e-16, Organism=Escherichia coli, GI1790190, Length=247, Percent_Identity=29.9595141700405, Blast_Score=77, Evalue=9e-16, Organism=Escherichia coli, GI1787712, Length=228, Percent_Identity=28.0701754385965, Blast_Score=74, Evalue=8e-15, Organism=Escherichia coli, GI1787370, Length=215, Percent_Identity=29.3023255813954, Blast_Score=74, Evalue=1e-14, Organism=Escherichia coli, GI1789032, Length=239, Percent_Identity=27.1966527196653, Blast_Score=73, Evalue=2e-14, Organism=Escherichia coli, GI1789586, Length=243, Percent_Identity=26.7489711934156, Blast_Score=72, Evalue=2e-14, Organism=Escherichia coli, GI1789873, Length=202, Percent_Identity=29.2079207920792, Blast_Score=72, Evalue=3e-14, Organism=Escherichia coli, GI87081834, Length=230, Percent_Identity=29.5652173913043, Blast_Score=71, Evalue=7e-14, Organism=Escherichia coli, GI48994883, Length=254, Percent_Identity=24.4094488188976, Blast_Score=70, Evalue=9e-14, Organism=Escherichia coli, GI1790739, Length=232, Percent_Identity=26.2931034482759, Blast_Score=70, Evalue=1e-13, Organism=Escherichia coli, GI1786703, Length=202, Percent_Identity=28.2178217821782, Blast_Score=70, Evalue=2e-13, Organism=Escherichia coli, GI1788506, Length=242, Percent_Identity=26.0330578512397, Blast_Score=69, Evalue=2e-13, Organism=Escherichia coli, GI1786253, Length=236, Percent_Identity=25.4237288135593, Blast_Score=69, Evalue=2e-13, Organism=Escherichia coli, GI87082267, Length=211, Percent_Identity=29.8578199052133, Blast_Score=69, Evalue=2e-13, Organism=Escherichia coli, GI87081782, Length=167, Percent_Identity=29.3413173652695, Blast_Score=69, Evalue=3e-13, Organism=Escherichia coli, GI1786345, Length=242, Percent_Identity=26.4462809917355, Blast_Score=69, Evalue=4e-13, Organism=Escherichia coli, GI48994997, Length=236, Percent_Identity=27.9661016949153, Blast_Score=68, Evalue=5e-13, Organism=Escherichia coli, GI1789963, Length=250, Percent_Identity=24.4, Blast_Score=68, Evalue=5e-13, Organism=Escherichia coli, GI1786398, Length=205, Percent_Identity=26.3414634146341, Blast_Score=68, Evalue=6e-13, Organism=Escherichia coli, GI1787164, Length=220, Percent_Identity=28.6363636363636, Blast_Score=67, Evalue=7e-13, Organism=Escherichia coli, GI1787105, Length=200, Percent_Identity=29, Blast_Score=67, Evalue=9e-13, Organism=Escherichia coli, GI1789991, Length=192, Percent_Identity=26.0416666666667, Blast_Score=67, Evalue=1e-12, Organism=Escherichia coli, GI48995001, Length=220, Percent_Identity=25, Blast_Score=67, Evalue=1e-12, Organism=Escherichia coli, GI1788472, Length=198, Percent_Identity=25.2525252525253, Blast_Score=67, Evalue=1e-12, Organism=Escherichia coli, GI1786803, Length=235, Percent_Identity=24.2553191489362, Blast_Score=66, Evalue=2e-12, Organism=Escherichia coli, GI1787759, Length=254, Percent_Identity=25.1968503937008, Blast_Score=66, Evalue=2e-12, Organism=Escherichia coli, GI1788897, Length=226, Percent_Identity=24.7787610619469, Blast_Score=66, Evalue=2e-12, Organism=Escherichia coli, GI1788165, Length=203, Percent_Identity=27.5862068965517, Blast_Score=64, Evalue=8e-12, Organism=Escherichia coli, GI1790525, Length=235, Percent_Identity=25.9574468085106, Blast_Score=64, Evalue=9e-12, Organism=Escherichia coli, GI145693107, Length=232, Percent_Identity=25.8620689655172, Blast_Score=62, Evalue=5e-11, Organism=Escherichia coli, GI1787500, Length=223, Percent_Identity=25.5605381165919, Blast_Score=60, Evalue=9e-11, Organism=Escherichia coli, GI1787758, Length=207, Percent_Identity=27.536231884058, Blast_Score=60, Evalue=1e-10, Organism=Caenorhabditis elegans, GI71992285, Length=259, Percent_Identity=28.957528957529, Blast_Score=85, Evalue=4e-17, Organism=Caenorhabditis elegans, GI17558664, Length=159, Percent_Identity=32.0754716981132, Blast_Score=72, Evalue=2e-13, Organism=Caenorhabditis elegans, GI71996809, Length=240, Percent_Identity=28.75, Blast_Score=72, Evalue=2e-13, Organism=Caenorhabditis elegans, GI193211017, Length=240, Percent_Identity=28.3333333333333, Blast_Score=72, Evalue=2e-13, Organism=Caenorhabditis elegans, GI193211015, Length=240, Percent_Identity=28.3333333333333, Blast_Score=72, Evalue=3e-13, Organism=Caenorhabditis elegans, GI17541710, Length=162, Percent_Identity=33.9506172839506, Blast_Score=69, Evalue=2e-12, Organism=Caenorhabditis elegans, GI71984940, Length=221, Percent_Identity=27.6018099547511, Blast_Score=68, Evalue=4e-12, Organism=Caenorhabditis elegans, GI17533971, Length=219, Percent_Identity=26.9406392694064, Blast_Score=68, Evalue=4e-12, Organism=Caenorhabditis elegans, GI71996550, Length=241, Percent_Identity=27.3858921161826, Blast_Score=67, Evalue=6e-12, Organism=Caenorhabditis elegans, GI212646699, Length=177, Percent_Identity=29.3785310734463, Blast_Score=65, Evalue=4e-11, Organism=Caenorhabditis elegans, GI17511077, Length=251, Percent_Identity=26.6932270916335, Blast_Score=64, Evalue=9e-11, Organism=Drosophila melanogaster, GI24648314, Length=217, Percent_Identity=30.8755760368664, Blast_Score=80, Evalue=1e-15, Organism=Drosophila melanogaster, GI24649703, Length=214, Percent_Identity=32.2429906542056, Blast_Score=77, Evalue=1e-14, Organism=Drosophila melanogaster, GI24650853, Length=210, Percent_Identity=28.5714285714286, Blast_Score=70, Evalue=2e-12, Organism=Drosophila melanogaster, GI28574744, Length=213, Percent_Identity=25.8215962441315, Blast_Score=69, Evalue=2e-12, Organism=Drosophila melanogaster, GI24650855, Length=210, Percent_Identity=28.5714285714286, Blast_Score=69, Evalue=2e-12, Organism=Drosophila melanogaster, GI281362751, Length=210, Percent_Identity=28.5714285714286, Blast_Score=69, Evalue=3e-12, Organism=Drosophila melanogaster, GI24643674, Length=230, Percent_Identity=29.1304347826087, Blast_Score=68, Evalue=6e-12, Organism=Drosophila melanogaster, GI19920532, Length=212, Percent_Identity=25.9433962264151, Blast_Score=66, Evalue=2e-11, Organism=Drosophila melanogaster, GI24580930, Length=212, Percent_Identity=25.9433962264151, Blast_Score=66, Evalue=2e-11, Organism=Drosophila melanogaster, GI24666092, Length=195, Percent_Identity=27.1794871794872, Blast_Score=66, Evalue=3e-11, Organism=Drosophila melanogaster, GI281363262, Length=221, Percent_Identity=28.0542986425339, Blast_Score=65, Evalue=3e-11, Organism=Drosophila melanogaster, GI24653245, Length=221, Percent_Identity=28.0542986425339, Blast_Score=65, Evalue=3e-11,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR003439 - InterPro: IPR017871 - InterPro: IPR003593 [H]
Pfam domain/function: PF00005 ABC_tran [H]
EC number: NA
Molecular weight: Translated: 26800; Mature: 26669
Theoretical pI: Translated: 6.10; Mature: 6.10
Prosite motif: PS50893 ABC_TRANSPORTER_2
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.8 %Cys (Translated Protein) 4.1 %Met (Translated Protein) 5.0 %Cys+Met (Translated Protein) 0.8 %Cys (Mature Protein) 3.7 %Met (Mature Protein) 4.6 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MSPHGSNIILDVRNLSAGYGELPVIRDLNLHVKEAEIVALVGSNGAGKTTFLRALSHLIH CCCCCCEEEEEEECCCCCCCCCCEEECCCCEEECEEEEEEECCCCCCHHHHHHHHHHHHH SEGQIEFCGEDVSRSTSDYVFRRGLVHIPEGRQLFDRMSVEENLLMGAYRSKDKARTKAD CCCCEEECCCHHCCCHHHHHHHCCCEECCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHH LEKVYVLFPRLAERRKQLAGSMSGGEQQMCAMARALMANPVLLLVDEMSLGLAPVVVDQL HHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCEEEEEECHHCCHHHHHHHHH MTILHDIRKSEQVTVLLVEQDIHLALDGADRGYVMETGTFTLEGKAQDLIHDERVQKAYL HHHHHHHCCCCCEEEEEEECCEEEEEECCCCCEEEECCEEEECCCHHHHHHHHHHHHHHC GL CC >Mature Secondary Structure SPHGSNIILDVRNLSAGYGELPVIRDLNLHVKEAEIVALVGSNGAGKTTFLRALSHLIH CCCCCEEEEEEECCCCCCCCCCEEECCCCEEECEEEEEEECCCCCCHHHHHHHHHHHHH SEGQIEFCGEDVSRSTSDYVFRRGLVHIPEGRQLFDRMSVEENLLMGAYRSKDKARTKAD CCCCEEECCCHHCCCHHHHHHHCCCEECCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHH LEKVYVLFPRLAERRKQLAGSMSGGEQQMCAMARALMANPVLLLVDEMSLGLAPVVVDQL HHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCEEEEEECHHCCHHHHHHHHH MTILHDIRKSEQVTVLLVEQDIHLALDGADRGYVMETGTFTLEGKAQDLIHDERVQKAYL HHHHHHHCCCCCEEEEEEECCEEEEEECCCCCEEEECCEEEECCCHHHHHHHHHHHHHHC GL CC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: ATP; L-leucine [Periplasm]; H2O; ATP; L-valine [Periplasm]; L-iso-leucine [Periplasm] [C]
Specific reaction: ATP + L-leucine [Periplasm] + H2O = ADP + phosphate + L-leucine [Cytoplasm] ATP + L-valine [Periplasm] + H2O = ADP + phosphate + L-valine [Cytoplasm] ATP + L-iso-leucine [Periplasm] + H2O = ADP + phosphate + L-iso-leucine [Cytoplasm] [C]
General reaction: NA
Inhibitor: NA
Structure determination priority: 10.0
TargetDB status: NA
Availability: NA
References: 2195019; 8041620; 9278503 [H]