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The map label for this gene is iclR [H]

Identifier: 225686753

GI number: 225686753

Start: 963245

End: 964039

Strand: Direct

Name: iclR [H]

Synonym: BMEA_B0982

Alternate gene names: 225686753

Gene position: 963245-964039 (Clockwise)

Preceding gene: 225686748

Following gene: 225686761

Centisome position: 81.25

GC content: 55.35

Gene sequence:

>795_bases
ATGGATAAACTTCATATCGAACCCACGGCAAAGCGTTCACGCGGACTGGAACGCGCCTTCGAGATTCTCGATTATCTGCG
CGTCAGCCGTGCGCCAGCCAACCCCAACGAGATCGCCGCGCGCATCAAGGCTCCGCGTTCGACAGTCTATGAGCTGGTCA
ATCTGCTGCTTAGTAATGGCGTTCTTGAATATTGCGACGATGAAGGCCGTGTTTATCTGGGGCGCAAGCTTTATTTTCTG
GGTGCGGCCTACGAAGACCACTTCAATTTCATACGCGAGTGTGACCGCGCCCTTTCAAAGGTGGCGGAACAAACGCGGGA
AACAGCCCAGTTCTGCATGCTCGATGAGAATAAATACACCGTCGTGCGTATGCACGAGGGAGCCCGGCCATTCCGCATTT
CATCAGATGTAGGGCAGCGCGTTCCCATTCCATGGACCGCTTCGGGACGGCTTTTATTGTCACATCTCAATGATGCGGAG
ATTCTGGCCTTCATTCCGCCGGAGGATTTTCAGCTCCCCAATGGCCAATGGCTCGCGCCGGAGGTTTTCCTCCGCGAGGT
TCATGCCGCACGCGAGGCCAGAGCCTTCACCTTCGACAGCATTGTCGATAGTTTCACCCATTGCTTCGCGGTTCCCGTTG
AAAACGACCACGGAAAGTTCTGCGCGACAGTCTGTCTTGTCGCCCCGCGCGATGACGGCATTCGCAACCACGACATGTAT
TTACAGTCGCTGCGGGAAGCAGCTCTCAGCCTGAAGGGAAAAGTTTCAGCCTTTCAACGCGACCAGAGCGTTTGA

Upstream 100 bases:

>100_bases
CTTATCGATCCTCGTTTCACTCCGGTCGGATTATGCTTTAATTGACAGCCGGGCCTGTGCCGCCCACAAAGAACCAAAGC
CGGAGACCATCGTAGAAACT

Downstream 100 bases:

>100_bases
ATGACTGGACATGCTGCCCATCTGCCGTTACGCATATCCCCCGACCGGCTCCCCCTTGGGGAGATATGCGCCAGGCTACC
AGCAAGATATGATTCAACGC

Product: Pectin degradation repressor protein kdgR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 264; Mature: 264

Protein sequence:

>264_residues
MDKLHIEPTAKRSRGLERAFEILDYLRVSRAPANPNEIAARIKAPRSTVYELVNLLLSNGVLEYCDDEGRVYLGRKLYFL
GAAYEDHFNFIRECDRALSKVAEQTRETAQFCMLDENKYTVVRMHEGARPFRISSDVGQRVPIPWTASGRLLLSHLNDAE
ILAFIPPEDFQLPNGQWLAPEVFLREVHAAREARAFTFDSIVDSFTHCFAVPVENDHGKFCATVCLVAPRDDGIRNHDMY
LQSLREAALSLKGKVSAFQRDQSV

Sequences:

>Translated_264_residues
MDKLHIEPTAKRSRGLERAFEILDYLRVSRAPANPNEIAARIKAPRSTVYELVNLLLSNGVLEYCDDEGRVYLGRKLYFL
GAAYEDHFNFIRECDRALSKVAEQTRETAQFCMLDENKYTVVRMHEGARPFRISSDVGQRVPIPWTASGRLLLSHLNDAE
ILAFIPPEDFQLPNGQWLAPEVFLREVHAAREARAFTFDSIVDSFTHCFAVPVENDHGKFCATVCLVAPRDDGIRNHDMY
LQSLREAALSLKGKVSAFQRDQSV
>Mature_264_residues
MDKLHIEPTAKRSRGLERAFEILDYLRVSRAPANPNEIAARIKAPRSTVYELVNLLLSNGVLEYCDDEGRVYLGRKLYFL
GAAYEDHFNFIRECDRALSKVAEQTRETAQFCMLDENKYTVVRMHEGARPFRISSDVGQRVPIPWTASGRLLLSHLNDAE
ILAFIPPEDFQLPNGQWLAPEVFLREVHAAREARAFTFDSIVDSFTHCFAVPVENDHGKFCATVCLVAPRDDGIRNHDMY
LQSLREAALSLKGKVSAFQRDQSV

Specific function: Regulation of the glyoxylate bypass operon (aceBAK), which encodes isocitrate lyase, malate synthase as well as isocitrate dehydrogenase kinase/phosphorylase. Glyoxylate disrupts the interaction with the promoter by favoring the inactive dimeric form. Pyr

COG id: COG1414

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 iclR-ED (iclR effector binding) domain [H]

Homologues:

Organism=Escherichia coli, GI87082359, Length=254, Percent_Identity=18.8976377952756, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1786468, Length=214, Percent_Identity=23.8317757009346, Blast_Score=68, Evalue=6e-13,
Organism=Escherichia coli, GI1786715, Length=229, Percent_Identity=23.1441048034935, Blast_Score=66, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014757
- InterPro:   IPR005471
- InterPro:   IPR011991 [H]

Pfam domain/function: PF09339 HTH_IclR; PF01614 IclR [H]

EC number: NA

Molecular weight: Translated: 30017; Mature: 30017

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS51077 HTH_ICLR ; PS51078 ICLR_ED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDKLHIEPTAKRSRGLERAFEILDYLRVSRAPANPNEIAARIKAPRSTVYELVNLLLSNG
CCCEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCHHHHHHHHHHHHHCC
VLEYCDDEGRVYLGRKLYFLGAAYEDHFNFIRECDRALSKVAEQTRETAQFCMLDENKYT
HHEEECCCCCEEECEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCEE
VVRMHEGARPFRISSDVGQRVPIPWTASGRLLLSHLNDAEILAFIPPEDFQLPNGQWLAP
EEEEECCCCCEEECCCCCCCCCCCCCCCCCEEEECCCCCEEEEEECCCCCCCCCCCEECH
EVFLREVHAAREARAFTFDSIVDSFTHCFAVPVENDHGKFCATVCLVAPRDDGIRNHDMY
HHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCEEEEEEEEECCCCCCCHHHHH
LQSLREAALSLKGKVSAFQRDQSV
HHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MDKLHIEPTAKRSRGLERAFEILDYLRVSRAPANPNEIAARIKAPRSTVYELVNLLLSNG
CCCEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCHHHHHHHHHHHHHCC
VLEYCDDEGRVYLGRKLYFLGAAYEDHFNFIRECDRALSKVAEQTRETAQFCMLDENKYT
HHEEECCCCCEEECEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCEE
VVRMHEGARPFRISSDVGQRVPIPWTASGRLLLSHLNDAEILAFIPPEDFQLPNGQWLAP
EEEEECCCCCEEECCCCCCCCCCCCCCCCCEEEECCCCCEEEEEECCCCCCCCCCCEECH
EVFLREVHAAREARAFTFDSIVDSFTHCFAVPVENDHGKFCATVCLVAPRDDGIRNHDMY
HHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCEEEEEEEEECCCCCCCHHHHH
LQSLREAALSLKGKVSAFQRDQSV
HHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2185227; 1995431; 8265357; 9278503; 1995429 [H]