| Definition | Brucella melitensis ATCC 23457 chromosome chromosome II, complete sequence. |
|---|---|
| Accession | NC_012442 |
| Length | 1,185,518 |
Click here to switch to the map view.
The map label for this gene is braF [H]
Identifier: 225686714
GI number: 225686714
Start: 922783
End: 923598
Strand: Direct
Name: braF [H]
Synonym: BMEA_B0940
Alternate gene names: 225686714
Gene position: 922783-923598 (Clockwise)
Preceding gene: 225686713
Following gene: 225686715
Centisome position: 77.84
GC content: 61.27
Gene sequence:
>816_bases ATGAACACGGCATCTGGCGCTATTCCGGTCCTGCATGAAGCAGGGCCGGGAACATCGCAAACCGCATCCGGCATTGTTTT GTCGGCGCGCGGACTGGGCAAGTCCTTTGGCGGCTTTCACGCGGTGAAGAATGTCGATCTTGATGTGGAACATGCCCGCG TTCACGCGCTGATCGGCCCGAACGGTGCCGGCAAGACGACGGTGTTCAACCTTCTGACCAAGTTTCTGCAACCGACCAGC GGCGAGATCACGCTTCTGGGCGAGACTATCACCAAAACCGATCCTGCCAGGGTGGCGCGCAAGGGTCTGGTGCGCTCATT CCAGATTTCGGCAACGTTTCCGCATCTGACGGTGCTGGAAAACGTCAAGGTCGCCCTACAGCGCCCCAACGGGCTTGCCA CGCAGTTCTGGCGTTCGCTGTCGGCGCTTGACCGGCTCGATGCACAGGCCGTTGAGCTTCTGGAGCGGGTCGGCCTGGCC GATGCCCGCCATGCGCTGGCCGCCGACCTGTCCTATGGCCGCAAGCGCGCGCTCGAAATAGCCACCACTCTGGCGCTTGA TCCGAAAGTACTGTTGCTCGACGAGCCCTTGGCCGGCATGGGCCATGAAGACGTTCACACCATTGCCGCCCTCATCACTG ACGTGGCGAAGGACCGCGCGGTCTTGATGGTGGAACACAATCTCAAGGTGGTGGCCGACATTGCCCACCATGTCACGGTG CTGCAACGCGGCGAGATTCTCGCCTCGGGCGATTACGCCACCGTCTCGAAGGACGAGCGTGTGCGCACCGCCTATATGGG AACCGAACATGAATAA
Upstream 100 bases:
>100_bases GGATTACTATAAGGTTCTTGCCACCATTCCGGGCGATCAGGCTTACATGAAGCCTGAAGAAAGCGGCTGCCCGCTGGTGA AGCAGTAAGAGGCTGGTTTG
Downstream 100 bases:
>100_bases ACGTCAACCGCTCTTGTCCGTGCGCGGGCTCTATGCCTGGTATGGGGAAAGCCATGCCTTGCAAGGTGTTGACCTCGATA TATGGCCGGGTGAGACGATC
Product: ABC transporter-like protein
Products: ADP; phosphate; L-valine [Cytoplasm]; ADP; L-iso-leucine [Cytoplasm]; L-leucine [Cytoplasm] [C]
Alternate protein names: NA
Number of amino acids: Translated: 271; Mature: 271
Protein sequence:
>271_residues MNTASGAIPVLHEAGPGTSQTASGIVLSARGLGKSFGGFHAVKNVDLDVEHARVHALIGPNGAGKTTVFNLLTKFLQPTS GEITLLGETITKTDPARVARKGLVRSFQISATFPHLTVLENVKVALQRPNGLATQFWRSLSALDRLDAQAVELLERVGLA DARHALAADLSYGRKRALEIATTLALDPKVLLLDEPLAGMGHEDVHTIAALITDVAKDRAVLMVEHNLKVVADIAHHVTV LQRGEILASGDYATVSKDERVRTAYMGTEHE
Sequences:
>Translated_271_residues MNTASGAIPVLHEAGPGTSQTASGIVLSARGLGKSFGGFHAVKNVDLDVEHARVHALIGPNGAGKTTVFNLLTKFLQPTS GEITLLGETITKTDPARVARKGLVRSFQISATFPHLTVLENVKVALQRPNGLATQFWRSLSALDRLDAQAVELLERVGLA DARHALAADLSYGRKRALEIATTLALDPKVLLLDEPLAGMGHEDVHTIAALITDVAKDRAVLMVEHNLKVVADIAHHVTV LQRGEILASGDYATVSKDERVRTAYMGTEHE >Mature_271_residues MNTASGAIPVLHEAGPGTSQTASGIVLSARGLGKSFGGFHAVKNVDLDVEHARVHALIGPNGAGKTTVFNLLTKFLQPTS GEITLLGETITKTDPARVARKGLVRSFQISATFPHLTVLENVKVALQRPNGLATQFWRSLSALDRLDAQAVELLERVGLA DARHALAADLSYGRKRALEIATTLALDPKVLLLDEPLAGMGHEDVHTIAALITDVAKDRAVLMVEHNLKVVADIAHHVTV LQRGEILASGDYATVSKDERVRTAYMGTEHE
Specific function: Component of the high affinity leucine, isoleucine, valine, transport system (LIV-I), which is operative without Na(+) and is specific for alanine and threonine, in addition to branched-chain amino acids [H]
COG id: COG0411
COG function: function code E; ABC-type branched-chain amino acid transport systems, ATPase component
Gene ontology:
Cell location: Cell inner membrane; Peripheral membrane protein (Potential) [H]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Contains 1 ABC transporter domain [H]
Homologues:
Organism=Homo sapiens, GI105990541, Length=215, Percent_Identity=29.7674418604651, Blast_Score=90, Evalue=3e-18, Organism=Homo sapiens, GI116734710, Length=210, Percent_Identity=29.5238095238095, Blast_Score=87, Evalue=2e-17, Organism=Homo sapiens, GI27881501, Length=237, Percent_Identity=28.2700421940928, Blast_Score=86, Evalue=4e-17, Organism=Homo sapiens, GI30795238, Length=237, Percent_Identity=28.2700421940928, Blast_Score=86, Evalue=4e-17, Organism=Homo sapiens, GI27477115, Length=225, Percent_Identity=26.6666666666667, Blast_Score=86, Evalue=5e-17, Organism=Homo sapiens, GI153792144, Length=222, Percent_Identity=27.027027027027, Blast_Score=82, Evalue=4e-16, Organism=Homo sapiens, GI45446740, Length=212, Percent_Identity=27.3584905660377, Blast_Score=80, Evalue=1e-15, Organism=Homo sapiens, GI47078218, Length=212, Percent_Identity=27.3584905660377, Blast_Score=80, Evalue=2e-15, Organism=Homo sapiens, GI27436953, Length=218, Percent_Identity=25.2293577981651, Blast_Score=80, Evalue=2e-15, Organism=Homo sapiens, GI27262624, Length=228, Percent_Identity=26.3157894736842, Blast_Score=79, Evalue=3e-15, Organism=Homo sapiens, GI27262626, Length=228, Percent_Identity=26.3157894736842, Blast_Score=79, Evalue=3e-15, Organism=Homo sapiens, GI31657092, Length=233, Percent_Identity=28.3261802575107, Blast_Score=79, Evalue=3e-15, Organism=Homo sapiens, GI171184400, Length=212, Percent_Identity=26.4150943396226, Blast_Score=76, Evalue=3e-14, Organism=Homo sapiens, GI150417984, Length=245, Percent_Identity=26.9387755102041, Blast_Score=74, Evalue=2e-13, Organism=Homo sapiens, GI21536376, Length=213, Percent_Identity=25.8215962441315, Blast_Score=70, Evalue=2e-12, Organism=Homo sapiens, GI9955968, Length=214, Percent_Identity=26.1682242990654, Blast_Score=68, Evalue=9e-12, Organism=Homo sapiens, GI9955966, Length=214, Percent_Identity=26.1682242990654, Blast_Score=68, Evalue=1e-11, Organism=Homo sapiens, GI45243524, Length=214, Percent_Identity=26.1682242990654, Blast_Score=68, Evalue=1e-11, Organism=Homo sapiens, GI6005701, Length=214, Percent_Identity=26.6355140186916, Blast_Score=66, Evalue=3e-11, Organism=Escherichia coli, GI1789864, Length=253, Percent_Identity=38.7351778656126, Blast_Score=159, Evalue=2e-40, Organism=Escherichia coli, GI1790525, Length=240, Percent_Identity=34.1666666666667, Blast_Score=129, Evalue=1e-31, Organism=Escherichia coli, GI1790190, Length=234, Percent_Identity=28.6324786324786, Blast_Score=111, Evalue=4e-26, Organism=Escherichia coli, GI1787029, Length=237, Percent_Identity=29.535864978903, Blast_Score=108, Evalue=4e-25, Organism=Escherichia coli, GI1789593, Length=244, Percent_Identity=31.1475409836066, Blast_Score=106, Evalue=2e-24, Organism=Escherichia coli, GI1790162, Length=231, Percent_Identity=30.3030303030303, Blast_Score=104, Evalue=5e-24, Organism=Escherichia coli, GI1789672, Length=245, Percent_Identity=28.9795918367347, Blast_Score=102, Evalue=2e-23, Organism=Escherichia coli, GI1788225, Length=251, Percent_Identity=31.0756972111554, Blast_Score=100, Evalue=1e-22, Organism=Escherichia coli, GI1788210, Length=220, Percent_Identity=29.0909090909091, Blast_Score=99, Evalue=4e-22, Organism=Escherichia coli, GI1787089, Length=235, Percent_Identity=29.7872340425532, Blast_Score=98, Evalue=6e-22, Organism=Escherichia coli, GI1788450, Length=230, Percent_Identity=28.695652173913, Blast_Score=96, Evalue=2e-21, Organism=Escherichia coli, GI87081791, Length=233, Percent_Identity=27.8969957081545, Blast_Score=96, Evalue=4e-21, Organism=Escherichia coli, GI1788761, Length=223, Percent_Identity=29.5964125560538, Blast_Score=94, Evalue=1e-20, Organism=Escherichia coli, GI1789032, Length=241, Percent_Identity=27.8008298755187, Blast_Score=94, Evalue=1e-20, Organism=Escherichia coli, GI1787792, Length=246, Percent_Identity=26.0162601626016, Blast_Score=93, Evalue=2e-20, Organism=Escherichia coli, GI87081782, Length=248, Percent_Identity=30.6451612903226, Blast_Score=91, Evalue=6e-20, Organism=Escherichia coli, GI87081709, Length=244, Percent_Identity=27.0491803278689, Blast_Score=91, Evalue=7e-20, Organism=Escherichia coli, GI1786319, Length=231, Percent_Identity=29.8701298701299, Blast_Score=91, Evalue=1e-19, Organism=Escherichia coli, GI1788897, Length=223, Percent_Identity=31.390134529148, Blast_Score=90, Evalue=1e-19, Organism=Escherichia coli, GI48995001, Length=240, Percent_Identity=27.9166666666667, Blast_Score=90, Evalue=2e-19, Organism=Escherichia coli, GI1789991, Length=248, Percent_Identity=28.2258064516129, Blast_Score=90, Evalue=2e-19, Organism=Escherichia coli, GI1786872, Length=230, Percent_Identity=28.2608695652174, Blast_Score=90, Evalue=2e-19, Organism=Escherichia coli, GI1786398, Length=213, Percent_Identity=29.1079812206573, Blast_Score=89, Evalue=3e-19, Organism=Escherichia coli, GI1786563, Length=211, Percent_Identity=29.3838862559242, Blast_Score=85, Evalue=6e-18, Organism=Escherichia coli, GI1790544, Length=237, Percent_Identity=27.8481012658228, Blast_Score=84, Evalue=8e-18, Organism=Escherichia coli, GI48994943, Length=227, Percent_Identity=26.431718061674, Blast_Score=84, Evalue=9e-18, Organism=Escherichia coli, GI1788472, Length=248, Percent_Identity=25.8064516129032, Blast_Score=84, Evalue=1e-17, Organism=Escherichia coli, GI1786253, Length=213, Percent_Identity=29.5774647887324, Blast_Score=82, Evalue=5e-17, Organism=Escherichia coli, GI1787712, Length=213, Percent_Identity=26.7605633802817, Blast_Score=82, Evalue=6e-17, Organism=Escherichia coli, GI1789586, Length=225, Percent_Identity=29.7777777777778, Blast_Score=81, Evalue=8e-17, Organism=Escherichia coli, GI87082268, Length=244, Percent_Identity=27.0491803278689, Blast_Score=80, Evalue=2e-16, Organism=Escherichia coli, GI1789962, Length=225, Percent_Identity=28, Blast_Score=75, Evalue=4e-15, Organism=Escherichia coli, GI145693107, Length=227, Percent_Identity=29.9559471365639, Blast_Score=75, Evalue=5e-15, Organism=Escherichia coli, GI1787370, Length=222, Percent_Identity=27.4774774774775, Blast_Score=75, Evalue=6e-15, Organism=Escherichia coli, GI1788644, Length=233, Percent_Identity=28.755364806867, Blast_Score=75, Evalue=7e-15, Organism=Escherichia coli, GI1787972, Length=239, Percent_Identity=25.9414225941423, Blast_Score=74, Evalue=7e-15, Organism=Escherichia coli, GI1786345, Length=223, Percent_Identity=27.8026905829596, Blast_Score=74, Evalue=1e-14, Organism=Escherichia coli, GI1789891, Length=244, Percent_Identity=30.327868852459, Blast_Score=74, Evalue=1e-14, Organism=Escherichia coli, GI1786803, Length=234, Percent_Identity=24.7863247863248, Blast_Score=73, Evalue=2e-14, Organism=Escherichia coli, GI87081834, Length=208, Percent_Identity=25.4807692307692, Blast_Score=73, Evalue=2e-14, Organism=Escherichia coli, GI1790467, Length=222, Percent_Identity=25.2252252252252, Blast_Score=72, Evalue=3e-14, Organism=Escherichia coli, GI1788506, Length=224, Percent_Identity=27.6785714285714, Blast_Score=72, Evalue=3e-14, Organism=Escherichia coli, GI1787105, Length=213, Percent_Identity=29.1079812206573, Blast_Score=71, Evalue=6e-14, Organism=Escherichia coli, GI1787759, Length=258, Percent_Identity=27.1317829457364, Blast_Score=71, Evalue=8e-14, Organism=Escherichia coli, GI87082267, Length=175, Percent_Identity=28, Blast_Score=70, Evalue=2e-13, Organism=Escherichia coli, GI1790739, Length=242, Percent_Identity=26.8595041322314, Blast_Score=68, Evalue=7e-13, Organism=Escherichia coli, GI1786703, Length=211, Percent_Identity=31.2796208530806, Blast_Score=68, Evalue=8e-13, Organism=Escherichia coli, GI1787758, Length=227, Percent_Identity=25.1101321585903, Blast_Score=65, Evalue=4e-12, Organism=Escherichia coli, GI1789873, Length=214, Percent_Identity=25.7009345794392, Blast_Score=62, Evalue=5e-11, Organism=Escherichia coli, GI1787112, Length=217, Percent_Identity=28.110599078341, Blast_Score=62, Evalue=6e-11, Organism=Caenorhabditis elegans, GI17510237, Length=242, Percent_Identity=31.404958677686, Blast_Score=87, Evalue=1e-17, Organism=Caenorhabditis elegans, GI71983516, Length=236, Percent_Identity=27.9661016949153, Blast_Score=80, Evalue=1e-15, Organism=Caenorhabditis elegans, GI71983510, Length=236, Percent_Identity=27.9661016949153, Blast_Score=80, Evalue=1e-15, Organism=Caenorhabditis elegans, GI71983523, Length=236, Percent_Identity=27.9661016949153, Blast_Score=80, Evalue=2e-15, Organism=Caenorhabditis elegans, GI212646699, Length=237, Percent_Identity=25.3164556962025, Blast_Score=78, Evalue=4e-15, Organism=Caenorhabditis elegans, GI71996809, Length=213, Percent_Identity=25.8215962441315, Blast_Score=77, Evalue=7e-15, Organism=Caenorhabditis elegans, GI193211015, Length=213, Percent_Identity=25.8215962441315, Blast_Score=77, Evalue=8e-15, Organism=Caenorhabditis elegans, GI17565586, Length=219, Percent_Identity=27.8538812785388, Blast_Score=77, Evalue=9e-15, Organism=Caenorhabditis elegans, GI193211017, Length=213, Percent_Identity=25.8215962441315, Blast_Score=77, Evalue=1e-14, Organism=Caenorhabditis elegans, GI17511077, Length=227, Percent_Identity=26.431718061674, Blast_Score=77, Evalue=1e-14, Organism=Caenorhabditis elegans, GI115533608, Length=228, Percent_Identity=28.0701754385965, Blast_Score=76, Evalue=1e-14, Organism=Caenorhabditis elegans, GI115533592, Length=217, Percent_Identity=26.2672811059908, Blast_Score=72, Evalue=4e-13, Organism=Caenorhabditis elegans, GI17558664, Length=214, Percent_Identity=26.1682242990654, Blast_Score=71, Evalue=7e-13, Organism=Caenorhabditis elegans, GI193202349, Length=218, Percent_Identity=27.5229357798165, Blast_Score=70, Evalue=8e-13, Organism=Caenorhabditis elegans, GI71984940, Length=237, Percent_Identity=27.0042194092827, Blast_Score=70, Evalue=2e-12, Organism=Caenorhabditis elegans, GI17565938, Length=224, Percent_Identity=25.8928571428571, Blast_Score=69, Evalue=2e-12, Organism=Caenorhabditis elegans, GI71992290, Length=218, Percent_Identity=25.2293577981651, Blast_Score=65, Evalue=4e-11, Organism=Caenorhabditis elegans, GI193208177, Length=218, Percent_Identity=24.7706422018349, Blast_Score=64, Evalue=6e-11, Organism=Saccharomyces cerevisiae, GI6321752, Length=235, Percent_Identity=26.8085106382979, Blast_Score=72, Evalue=8e-14, Organism=Drosophila melanogaster, GI28571209, Length=254, Percent_Identity=27.5590551181102, Blast_Score=94, Evalue=1e-19, Organism=Drosophila melanogaster, GI24666092, Length=228, Percent_Identity=27.6315789473684, Blast_Score=91, Evalue=1e-18, Organism=Drosophila melanogaster, GI24648314, Length=228, Percent_Identity=27.1929824561404, Blast_Score=88, Evalue=8e-18, Organism=Drosophila melanogaster, GI28573571, Length=244, Percent_Identity=27.0491803278689, Blast_Score=85, Evalue=4e-17, Organism=Drosophila melanogaster, GI221512771, Length=258, Percent_Identity=26.3565891472868, Blast_Score=83, Evalue=2e-16, Organism=Drosophila melanogaster, GI28573573, Length=235, Percent_Identity=27.2340425531915, Blast_Score=80, Evalue=2e-15, Organism=Drosophila melanogaster, GI24643674, Length=234, Percent_Identity=26.9230769230769, Blast_Score=78, Evalue=5e-15, Organism=Drosophila melanogaster, GI221500365, Length=213, Percent_Identity=27.6995305164319, Blast_Score=77, Evalue=1e-14, Organism=Drosophila melanogaster, GI116007184, Length=213, Percent_Identity=27.6995305164319, Blast_Score=77, Evalue=1e-14, Organism=Drosophila melanogaster, GI28574150, Length=210, Percent_Identity=25.7142857142857, Blast_Score=76, Evalue=2e-14, Organism=Drosophila melanogaster, GI116007328, Length=210, Percent_Identity=25.7142857142857, Blast_Score=76, Evalue=2e-14, Organism=Drosophila melanogaster, GI85724858, Length=199, Percent_Identity=31.1557788944724, Blast_Score=66, Evalue=3e-11, Organism=Drosophila melanogaster, GI85724856, Length=199, Percent_Identity=31.1557788944724, Blast_Score=66, Evalue=3e-11, Organism=Drosophila melanogaster, GI24580547, Length=199, Percent_Identity=31.1557788944724, Blast_Score=66, Evalue=3e-11, Organism=Drosophila melanogaster, GI24580551, Length=199, Percent_Identity=31.1557788944724, Blast_Score=66, Evalue=3e-11, Organism=Drosophila melanogaster, GI24580549, Length=199, Percent_Identity=31.1557788944724, Blast_Score=66, Evalue=3e-11, Organism=Drosophila melanogaster, GI24580545, Length=199, Percent_Identity=31.1557788944724, Blast_Score=66, Evalue=3e-11,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR003439 - InterPro: IPR017871 - InterPro: IPR003593 [H]
Pfam domain/function: PF00005 ABC_tran [H]
EC number: NA
Molecular weight: Translated: 28948; Mature: 28948
Theoretical pI: Translated: 7.19; Mature: 7.19
Prosite motif: PS50893 ABC_TRANSPORTER_2
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.0 %Cys (Translated Protein) 1.5 %Met (Translated Protein) 1.5 %Cys+Met (Translated Protein) 0.0 %Cys (Mature Protein) 1.5 %Met (Mature Protein) 1.5 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MNTASGAIPVLHEAGPGTSQTASGIVLSARGLGKSFGGFHAVKNVDLDVEHARVHALIGP CCCCCCCCEEEECCCCCCCCCCCCEEEEECCCCCCCCCHHHHCCCCCCEEEEEEEEEECC NGAGKTTVFNLLTKFLQPTSGEITLLGETITKTDPARVARKGLVRSFQISATFPHLTVLE CCCCHHHHHHHHHHHHCCCCCCEEEEECCCCCCCHHHHHHHHHHHEEEEEECCCCHHHHH NVKVALQRPNGLATQFWRSLSALDRLDAQAVELLERVGLADARHALAADLSYGRKRALEI HHHEEEECCCCHHHHHHHHHHHHHHCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH ATTLALDPKVLLLDEPLAGMGHEDVHTIAALITDVAKDRAVLMVEHNLKVVADIAHHVTV HHHHCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHH LQRGEILASGDYATVSKDERVRTAYMGTEHE HHCCCEEECCCEEECCCCCHHEEEECCCCCC >Mature Secondary Structure MNTASGAIPVLHEAGPGTSQTASGIVLSARGLGKSFGGFHAVKNVDLDVEHARVHALIGP CCCCCCCCEEEECCCCCCCCCCCCEEEEECCCCCCCCCHHHHCCCCCCEEEEEEEEEECC NGAGKTTVFNLLTKFLQPTSGEITLLGETITKTDPARVARKGLVRSFQISATFPHLTVLE CCCCHHHHHHHHHHHHCCCCCCEEEEECCCCCCCHHHHHHHHHHHEEEEEECCCCHHHHH NVKVALQRPNGLATQFWRSLSALDRLDAQAVELLERVGLADARHALAADLSYGRKRALEI HHHEEEECCCCHHHHHHHHHHHHHHCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH ATTLALDPKVLLLDEPLAGMGHEDVHTIAALITDVAKDRAVLMVEHNLKVVADIAHHVTV HHHHCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHH LQRGEILASGDYATVSKDERVRTAYMGTEHE HHCCCEEECCCEEECCCCCHHEEEECCCCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: ATP; L-valine [Periplasm]; H2O; ATP; L-iso-leucine [Periplasm]; L-leucine [Periplasm] [C]
Specific reaction: ATP + L-valine [Periplasm] + H2O = ADP + phosphate + L-valine [Cytoplasm] ATP + L-iso-leucine [Periplasm] + H2O = ADP + phosphate + L-iso-leucine [Cytoplasm] ATP + L-leucine [Periplasm] + H2O = ADP + phosphate + L-leucine [Cytoplasm] [C]
General reaction: NA
Inhibitor: NA
Structure determination priority: 7.0
TargetDB status: NA
Availability: NA
References: 2120183; 10984043 [H]