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The map label for this gene is ilvD [H]

Identifier: 225686700

GI number: 225686700

Start: 906479

End: 908284

Strand: Reverse

Name: ilvD [H]

Synonym: BMEA_B0925

Alternate gene names: 225686700

Gene position: 908284-906479 (Counterclockwise)

Preceding gene: 225686701

Following gene: 225686699

Centisome position: 76.61

GC content: 58.47

Gene sequence:

>1806_bases
ATGAACAAGCCGGTTACGCCAAAAACACCCAAATTGCGGTCACGCGCATGGTTCGACAATCCCGACAATGTCGATATGAC
GGCGCTCTATCTTGAGCGTTACATGAATTACGGGCTGAGCCAGGAAGAGCTGCAATCCGGCCGTCCCATCATCGGTATTG
CGCAAACCGGTTCTGATCTTTCGCCCTGCAACCGGCATCATCTGGAACTGGCCAAGCGTGTGAGGGATGGAGTTCGCGAG
GCGGGTGGCATCGTCATCGAATTTCCGGTTCATCCCATTCAGGAAACCGGCAAGCGCCCCACTGCGGGTCTCGACCGCAA
TCTGGCCTATCTTGGTCTGGTCGAAGTGCTTTACGGCTATCCGCTCGATGGTGTGGTGCTGACCATCGGCTGCGACAAGA
CCACGCCCGCCTGCCTGATGGCAGCGGCGACCGTCAATATTCCGGCCATCGCGCTGTCGGTCGGGCCGATGCTGAACGGC
TGGTTCCGGGGTGAGCGCACGGGTTCGGGCACCATCGTCTGGAAGGCGCGCGAACTGCTTGCCAAGGGCGAAATCGACTA
TCAGGGCTTTGTGAAACTGGTGGCTTCTTCGGCTCCATCGACCGGCTATTGCAACACGATGGGCACGGCCACGACCATGA
ATTCTCTGGCCGAAGCGCTGGGTATGCAGCTTCCGGGCTCGGCGGCTATCCCCGCACCTTATCGTGACCGTCAGGAAGTC
GCCTATCTGACGGGGCGGCGTATTGTCGAGATGGTTCATGAAGACCTGAAACCATCGGATATCCTGACGAAGGAAGCCTT
TATCAATGCGATCCGCGTCAATTCCGCCATTGGCGGCTCCACCAATGCGCCGATCCATCTCAATGCGCTCGCGCGCCATA
TCGGTGTGGAACTGACGGTGGATGACTGGCAGAAATATGGCGAGGAAATTCCGCTTCTGGTCAATCTCCAGCCTGCGGGC
GAATATCTGGGCGAAGACTATTATCACGCAGGCGGTGTGCCAGCGGTGGTCAACCAGTTGATGGGGCAGGGCCTCATCCA
TGAGGACGCAATCACGGTCAATGGCAAGACCATCGGCGAAAATTGCAAGAATGCGACCATCGAAGACGGCAATGTCATCA
AGACCTACGATCAGCCGCTCAAGAAACATGCCGGTTTCCGCGTGCTGCGCGGCAATCTGTTCTCGTCGGCCATCATGAAG
CTCAGCGTGATTTCGGACGAATTCCGCAATCGCTACCTGTCCGATGCCAAGGATCCCAATGCCTTTGAAGGCAAGGCGGT
CGTGTTCGATGGGCCGGAGGATTATCATCACCGTATTGATGATCCGGCGCTGGAAATAGATGAACATACGGTGCTTTTCA
TGCGCGGTGCGGGACCGATCGGCTATCCGGGTGCGGCGGAAGTCGTCAACATGCGCGCGCCGGATTACCTTTTGAAGAAG
GGCATCACGTCGCTGCCCTGTATCGGCGACGGCCGCCAGTCGGGTACGTCGGGTTCGCCGTCGATCCTCAATGCCTCGCC
GGAAGCGGCGGCAGGCGGGGGGCTTGCCATTCTCAAGACCGGCGACCGCGTGCGCATCGATCTTGGCCGCGGGACGGCGG
ATATCCTGATTTCCGATGAGGAATTGGCCGAACGCCGCAAGGCGCTGGAAGCGGTTGGCGGTTATAAATATCCTGAAAGC
CAGACGCCATGGCAGGAAATCCAGCGTGCTGTCATCGGCCAGATGGAAACCGGGGCCGTGCTGGAAAACGCGGTCAAATA
TCAGGATATCGCGCATACGCGCGGGCTTCCGCGAGATAACCATTGA

Upstream 100 bases:

>100_bases
TTGACCTTTCGTTAGAGCGGTTCCGGCAATTCTGCTGAAACCGGAACCGCTTTCGGAATTGAGATTGTTTTCCAATCTCT
TACCCACGCAGGACAGTGAA

Downstream 100 bases:

>100_bases
AGCCGGAGATGCCGATGGGTGCTGGAAAAAAGCCATTTGCCGCCGTGGCCGATTGGGGAACGACCCGGTTCCGGCTCTGG
ACGCTTGATGCGGATGGAGC

Product: dihydroxy-acid dehydratase

Products: NA

Alternate protein names: DAD [H]

Number of amino acids: Translated: 601; Mature: 601

Protein sequence:

>601_residues
MNKPVTPKTPKLRSRAWFDNPDNVDMTALYLERYMNYGLSQEELQSGRPIIGIAQTGSDLSPCNRHHLELAKRVRDGVRE
AGGIVIEFPVHPIQETGKRPTAGLDRNLAYLGLVEVLYGYPLDGVVLTIGCDKTTPACLMAAATVNIPAIALSVGPMLNG
WFRGERTGSGTIVWKARELLAKGEIDYQGFVKLVASSAPSTGYCNTMGTATTMNSLAEALGMQLPGSAAIPAPYRDRQEV
AYLTGRRIVEMVHEDLKPSDILTKEAFINAIRVNSAIGGSTNAPIHLNALARHIGVELTVDDWQKYGEEIPLLVNLQPAG
EYLGEDYYHAGGVPAVVNQLMGQGLIHEDAITVNGKTIGENCKNATIEDGNVIKTYDQPLKKHAGFRVLRGNLFSSAIMK
LSVISDEFRNRYLSDAKDPNAFEGKAVVFDGPEDYHHRIDDPALEIDEHTVLFMRGAGPIGYPGAAEVVNMRAPDYLLKK
GITSLPCIGDGRQSGTSGSPSILNASPEAAAGGGLAILKTGDRVRIDLGRGTADILISDEELAERRKALEAVGGYKYPES
QTPWQEIQRAVIGQMETGAVLENAVKYQDIAHTRGLPRDNH

Sequences:

>Translated_601_residues
MNKPVTPKTPKLRSRAWFDNPDNVDMTALYLERYMNYGLSQEELQSGRPIIGIAQTGSDLSPCNRHHLELAKRVRDGVRE
AGGIVIEFPVHPIQETGKRPTAGLDRNLAYLGLVEVLYGYPLDGVVLTIGCDKTTPACLMAAATVNIPAIALSVGPMLNG
WFRGERTGSGTIVWKARELLAKGEIDYQGFVKLVASSAPSTGYCNTMGTATTMNSLAEALGMQLPGSAAIPAPYRDRQEV
AYLTGRRIVEMVHEDLKPSDILTKEAFINAIRVNSAIGGSTNAPIHLNALARHIGVELTVDDWQKYGEEIPLLVNLQPAG
EYLGEDYYHAGGVPAVVNQLMGQGLIHEDAITVNGKTIGENCKNATIEDGNVIKTYDQPLKKHAGFRVLRGNLFSSAIMK
LSVISDEFRNRYLSDAKDPNAFEGKAVVFDGPEDYHHRIDDPALEIDEHTVLFMRGAGPIGYPGAAEVVNMRAPDYLLKK
GITSLPCIGDGRQSGTSGSPSILNASPEAAAGGGLAILKTGDRVRIDLGRGTADILISDEELAERRKALEAVGGYKYPES
QTPWQEIQRAVIGQMETGAVLENAVKYQDIAHTRGLPRDNH
>Mature_601_residues
MNKPVTPKTPKLRSRAWFDNPDNVDMTALYLERYMNYGLSQEELQSGRPIIGIAQTGSDLSPCNRHHLELAKRVRDGVRE
AGGIVIEFPVHPIQETGKRPTAGLDRNLAYLGLVEVLYGYPLDGVVLTIGCDKTTPACLMAAATVNIPAIALSVGPMLNG
WFRGERTGSGTIVWKARELLAKGEIDYQGFVKLVASSAPSTGYCNTMGTATTMNSLAEALGMQLPGSAAIPAPYRDRQEV
AYLTGRRIVEMVHEDLKPSDILTKEAFINAIRVNSAIGGSTNAPIHLNALARHIGVELTVDDWQKYGEEIPLLVNLQPAG
EYLGEDYYHAGGVPAVVNQLMGQGLIHEDAITVNGKTIGENCKNATIEDGNVIKTYDQPLKKHAGFRVLRGNLFSSAIMK
LSVISDEFRNRYLSDAKDPNAFEGKAVVFDGPEDYHHRIDDPALEIDEHTVLFMRGAGPIGYPGAAEVVNMRAPDYLLKK
GITSLPCIGDGRQSGTSGSPSILNASPEAAAGGGLAILKTGDRVRIDLGRGTADILISDEELAERRKALEAVGGYKYPES
QTPWQEIQRAVIGQMETGAVLENAVKYQDIAHTRGLPRDNH

Specific function: Valine and isoleucine biosynthesis; fourth step. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family [H]

Homologues:

Organism=Escherichia coli, GI48994964, Length=563, Percent_Identity=28.5968028419183, Blast_Score=196, Evalue=4e-51,
Organism=Escherichia coli, GI1788157, Length=448, Percent_Identity=31.9196428571429, Blast_Score=189, Evalue=4e-49,
Organism=Escherichia coli, GI2367371, Length=524, Percent_Identity=28.4351145038168, Blast_Score=133, Evalue=3e-32,
Organism=Escherichia coli, GI1786464, Length=505, Percent_Identity=28.5148514851485, Blast_Score=124, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6322476, Length=528, Percent_Identity=28.9772727272727, Blast_Score=214, Evalue=3e-56,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015928
- InterPro:   IPR004404
- InterPro:   IPR000581
- InterPro:   IPR020558 [H]

Pfam domain/function: PF00920 ILVD_EDD [H]

EC number: =4.2.1.9 [H]

Molecular weight: Translated: 65119; Mature: 65119

Theoretical pI: Translated: 5.92; Mature: 5.92

Prosite motif: PS00886 ILVD_EDD_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKPVTPKTPKLRSRAWFDNPDNVDMTALYLERYMNYGLSQEELQSGRPIIGIAQTGSDL
CCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHCCCCEEEEECCCCCC
SPCNRHHLELAKRVRDGVREAGGIVIEFPVHPIQETGKRPTAGLDRNLAYLGLVEVLYGY
CCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCHHHCCCCCCCCCCCCHHHHHHHHHHHCC
PLDGVVLTIGCDKTTPACLMAAATVNIPAIALSVGPMLNGWFRGERTGSGTIVWKARELL
CCCCEEEEEECCCCCHHHHHHHHHCCCCEEEEECCHHHHCCCCCCCCCCCEEEEEHHHHH
AKGEIDYQGFVKLVASSAPSTGYCNTMGTATTMNSLAEALGMQLPGSAAIPAPYRDRQEV
HCCCCCHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHH
AYLTGRRIVEMVHEDLKPSDILTKEAFINAIRVNSAIGGSTNAPIHLNALARHIGVELTV
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCEEHHHHHHHHCCEEEH
DDWQKYGEEIPLLVNLQPAGEYLGEDYYHAGGVPAVVNQLMGQGLIHEDAITVNGKTIGE
HHHHHCCCCCCEEEEECCHHHHHCCCHHCCCCHHHHHHHHHCCCCEECCEEEECCCCCCC
NCKNATIEDGNVIKTYDQPLKKHAGFRVLRGNLFSSAIMKLSVISDEFRNRYLSDAKDPN
CCCCCCCCCCCEEEHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
AFEGKAVVFDGPEDYHHRIDDPALEIDEHTVLFMRGAGPIGYPGAAEVVNMRAPDYLLKK
CCCCCEEEECCCHHHHHCCCCCCEEECCCEEEEEECCCCCCCCCHHHEEECCCCHHHHHC
GITSLPCIGDGRQSGTSGSPSILNASPEAAAGGGLAILKTGDRVRIDLGRGTADILISDE
CCCCCCCCCCCCCCCCCCCCCEECCCCCCCCCCCEEEEECCCEEEEEECCCCEEEEECCH
ELAERRKALEAVGGYKYPESQTPWQEIQRAVIGQMETGAVLENAVKYQDIAHTRGLPRDN
HHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCC
H
C
>Mature Secondary Structure
MNKPVTPKTPKLRSRAWFDNPDNVDMTALYLERYMNYGLSQEELQSGRPIIGIAQTGSDL
CCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHCCCCEEEEECCCCCC
SPCNRHHLELAKRVRDGVREAGGIVIEFPVHPIQETGKRPTAGLDRNLAYLGLVEVLYGY
CCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCHHHCCCCCCCCCCCCHHHHHHHHHHHCC
PLDGVVLTIGCDKTTPACLMAAATVNIPAIALSVGPMLNGWFRGERTGSGTIVWKARELL
CCCCEEEEEECCCCCHHHHHHHHHCCCCEEEEECCHHHHCCCCCCCCCCCEEEEEHHHHH
AKGEIDYQGFVKLVASSAPSTGYCNTMGTATTMNSLAEALGMQLPGSAAIPAPYRDRQEV
HCCCCCHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHH
AYLTGRRIVEMVHEDLKPSDILTKEAFINAIRVNSAIGGSTNAPIHLNALARHIGVELTV
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCEEHHHHHHHHCCEEEH
DDWQKYGEEIPLLVNLQPAGEYLGEDYYHAGGVPAVVNQLMGQGLIHEDAITVNGKTIGE
HHHHHCCCCCCEEEEECCHHHHHCCCHHCCCCHHHHHHHHHCCCCEECCEEEECCCCCCC
NCKNATIEDGNVIKTYDQPLKKHAGFRVLRGNLFSSAIMKLSVISDEFRNRYLSDAKDPN
CCCCCCCCCCCEEEHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
AFEGKAVVFDGPEDYHHRIDDPALEIDEHTVLFMRGAGPIGYPGAAEVVNMRAPDYLLKK
CCCCCEEEECCCHHHHHCCCCCCEEECCCEEEEEECCCCCCCCCHHHEEECCCCHHHHHC
GITSLPCIGDGRQSGTSGSPSILNASPEAAAGGGLAILKTGDRVRIDLGRGTADILISDE
CCCCCCCCCCCCCCCCCCCCCEECCCCCCCCCCCEEEEECCCEEEEEECCCCEEEEECCH
ELAERRKALEAVGGYKYPESQTPWQEIQRAVIGQMETGAVLENAVKYQDIAHTRGLPRDN
HHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCC
H
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12622808 [H]