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The map label for this gene is hutC [H]

Identifier: 225686687

GI number: 225686687

Start: 891510

End: 892253

Strand: Reverse

Name: hutC [H]

Synonym: BMEA_B0910

Alternate gene names: 225686687

Gene position: 892253-891510 (Counterclockwise)

Preceding gene: 225686688

Following gene: 225686685

Centisome position: 75.26

GC content: 59.54

Gene sequence:

>744_bases
ATGGCTGGCGAAGATTCGATCGCAAAGGACGTACCGGCGCTTTCGCTGCATCAGCGTATTCTGGACGATATAGAATCGCG
CATCCTGTCGGGAGAGTGGCTGCCCGGCCACCGTATTCCGTTTGAACACGAGCTGACCGAGTATTACGGCTGTTCACGCA
TGACCGTGAACAAGGCTTTGACCCAGCTTGCCAAGGCCGGGCTGATTGAGCGCAAGCGCCGGTCTGGAAGCTTTGTGTCG
TTCCCGCAATCGCAGGCTGCCATTCTGGAAATCCACGATATACGCGAAGAGGTGGCAGCACTTGGCCTGCCTTATCGTTT
TGAACTGATGAACCGCTGGGAGCGGCTAAGCGGCCCTGCCGATGCCAGACGGCTCGACATTGCGCGCCATACGCCGCTTG
TTGAACTCCTCTGCCGTCATTACGCGGGCAAGCGCGTGTTTGCACTGGAAGAGCGCATCATCAATCTGGAGGCCGTTCCC
GCAGCCGCAGAGACGGATTTCGCGCAGAATTCACCGGGGCCATGGCTCGTTGCCTGTGTGCCGTGGAGCAGCGCCAAACA
TACCATCCGTGCCATTGCCGCGACGCAGGAAGCAGCGGCCAAACTTGATATCGCGCCCGGTTCGCCCTGCCTTGTGATCG
AGCGCCAGACATGGAACGCCGACCAGCCTGTGACCCATGTACGCTTTACCTATCCCGGTGACAGCCATGCACTGGTGGCG
CGGTTTACGCCATCTCACGGCTGA

Upstream 100 bases:

>100_bases
GTGTCAAACAGGTGGAAGGTGGACGTCACCGCTTGCGCGACGAAGCGGAGCGTGCTTTCCAGAAAGCCTTGGGCGAATTA
CTCGCCTGACAGGAGACGGC

Downstream 100 bases:

>100_bases
TAAAACCGAAAGAAAAAAGCCGCCGCAGGGGAACAGCGGCGGCCAGGTTGCGGCTTGATCCGGGTGATGATCAGGCCGCG
CGTTTGATGGCGTCACCGAG

Product: histidine utilization repressor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 247; Mature: 246

Protein sequence:

>247_residues
MAGEDSIAKDVPALSLHQRILDDIESRILSGEWLPGHRIPFEHELTEYYGCSRMTVNKALTQLAKAGLIERKRRSGSFVS
FPQSQAAILEIHDIREEVAALGLPYRFELMNRWERLSGPADARRLDIARHTPLVELLCRHYAGKRVFALEERIINLEAVP
AAAETDFAQNSPGPWLVACVPWSSAKHTIRAIAATQEAAAKLDIAPGSPCLVIERQTWNADQPVTHVRFTYPGDSHALVA
RFTPSHG

Sequences:

>Translated_247_residues
MAGEDSIAKDVPALSLHQRILDDIESRILSGEWLPGHRIPFEHELTEYYGCSRMTVNKALTQLAKAGLIERKRRSGSFVS
FPQSQAAILEIHDIREEVAALGLPYRFELMNRWERLSGPADARRLDIARHTPLVELLCRHYAGKRVFALEERIINLEAVP
AAAETDFAQNSPGPWLVACVPWSSAKHTIRAIAATQEAAAKLDIAPGSPCLVIERQTWNADQPVTHVRFTYPGDSHALVA
RFTPSHG
>Mature_246_residues
AGEDSIAKDVPALSLHQRILDDIESRILSGEWLPGHRIPFEHELTEYYGCSRMTVNKALTQLAKAGLIERKRRSGSFVSF
PQSQAAILEIHDIREEVAALGLPYRFELMNRWERLSGPADARRLDIARHTPLVELLCRHYAGKRVFALEERIINLEAVPA
AAETDFAQNSPGPWLVACVPWSSAKHTIRAIAATQEAAAKLDIAPGSPCLVIERQTWNADQPVTHVRFTYPGDSHALVAR
FTPSHG

Specific function: Repressor which binds to the hutP region in the histidine utilization (hut) operon. It blocks the expression of all the hut genes in the absence of inducer [H]

COG id: COG2188

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH gntR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082252, Length=230, Percent_Identity=25.2173913043478, Blast_Score=64, Evalue=7e-12,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010248
- InterPro:   IPR000524
- InterPro:   IPR011663
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00392 GntR; PF07702 UTRA [H]

EC number: NA

Molecular weight: Translated: 27503; Mature: 27371

Theoretical pI: Translated: 7.06; Mature: 7.06

Prosite motif: PS50949 HTH_GNTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAGEDSIAKDVPALSLHQRILDDIESRILSGEWLPGHRIPFEHELTEYYGCSRMTVNKAL
CCCCCCHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHH
TQLAKAGLIERKRRSGSFVSFPQSQAAILEIHDIREEVAALGLPYRFELMNRWERLSGPA
HHHHHHHHHHHHHHCCCEEECCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCC
DARRLDIARHTPLVELLCRHYAGKRVFALEERIINLEAVPAAAETDFAQNSPGPWLVACV
CHHHHHHHHCCHHHHHHHHHHCCCEEEEHHHHHHCCCCCCCCHHCCCCCCCCCCEEEEEE
PWSSAKHTIRAIAATQEAAAKLDIAPGSPCLVIERQTWNADQPVTHVRFTYPGDSHALVA
CCCCCHHHHHHHHHHHHHHHEEECCCCCCEEEEEECCCCCCCCCEEEEEECCCCCCEEEE
RFTPSHG
EECCCCC
>Mature Secondary Structure 
AGEDSIAKDVPALSLHQRILDDIESRILSGEWLPGHRIPFEHELTEYYGCSRMTVNKAL
CCCCCHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHH
TQLAKAGLIERKRRSGSFVSFPQSQAAILEIHDIREEVAALGLPYRFELMNRWERLSGPA
HHHHHHHHHHHHHHCCCEEECCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCC
DARRLDIARHTPLVELLCRHYAGKRVFALEERIINLEAVPAAAETDFAQNSPGPWLVACV
CHHHHHHHHCCHHHHHHHHHHCCCEEEEHHHHHHCCCCCCCCHHCCCCCCCCCCEEEEEE
PWSSAKHTIRAIAATQEAAAKLDIAPGSPCLVIERQTWNADQPVTHVRFTYPGDSHALVA
CCCCCHHHHHHHHHHHHHHHEEECCCCCCEEEEEECCCCCCCCCEEEEEECCCCCCEEEE
RFTPSHG
EECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]