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The map label for this gene is dprE1 [H]

Identifier: 225686616

GI number: 225686616

Start: 818325

End: 819659

Strand: Reverse

Name: dprE1 [H]

Synonym: BMEA_B0833

Alternate gene names: 225686616

Gene position: 819659-818325 (Counterclockwise)

Preceding gene: 225686617

Following gene: 225686615

Centisome position: 69.14

GC content: 58.58

Gene sequence:

>1335_bases
ATGACACGCAACTTCGATAGTTTCGGACGCATCGAACGGCATGAAAGGGCAAGCCGCTCCTTTGAAAAAGTAAGGGCCGG
TTTCGCCGCTTCCGCGGCAGAAGAAACCAGCCTGCTTGCCTTCGGCAATGGCTGCTCCTATGGCGATAGCTGCCATAACG
ATGCCGGTCTTCTGGTGCCAATGCGCAGCGTTGCGGCAATTGAAAGTTTTGACCCCGCAACCGGGATTCTGCAAGCGCAA
GCGGGGGTGCTGCTAAGCGAGATCATCGGTTTTGTTGCACCCCACGGTTATTTTCTGCCGGTCACGCCGGGCACCCGTTT
TGTGACGCTTGGCGGCGCCATTGCCAATGATGTGCATGGCAAGAACCACCATCTGCGCGGTACCTTTGGTTGTCACGTGG
AAAGTCTGGAGCTTCTGCGCTCGGACGGCGTGCAATATCATTGCTCTCTGCATGAAAATGAAGGGCTTTTTGCGGCCACC
ATCGGTGGAATGGGCCTGACGGGCGTGATCGTCAGCGCGCGGCTTCGCCTTATGCCGGTCGGCTCGCTGGATGTGGAGGA
GCGGATCGTTCCCTTCGACAATCTCGATGCCTATTTCGATATGGCTGAAGCGGCAGACCGGCAGAACGAATATGCCGTAG
CGTGGGTTGACCAGCTTTCGAGGGGAAAAACCGCCGGGCGTGGCGTTCTCATCACCGGCAATCATGCCGGGAATGGAAAC
CGAAGCGTTGAAGACGAGCGCGTACGGCTCGGCGTGCCGTTCGACCTTCCTTTTTCCGTGCTGAACCGGGTGAGCCTGAG
GCTGTTCAATATGGCCTATTTCAATGCCAAACGCCGCAAGCAGAAGCCGCATCTGGCAAGCTTTGGAAGCTTCTTCTATC
CGCTCGATGGTGTCGGGCAGTGGAACCGGCTTTACGGTCCGGCGGGCCTCTACCAGCACCAGAGCGTCATTCCCTTCGAT
GCGGCGCGGCACATTATTCCCGCCATGCTGGCGGCAAGCCGCGAGGCTGGACAGGCTTCGTTTCTCACCGTCCTGAAGCG
GTTTGGAGACACGGCTTCGCCCGGCCTGCTGTCGTTTCCCAAGCCCGGCTATACCTTGACAATGGATTTTCCCAATCGTG
GCGGGAAAACGCGCGCCCTCCTGCAAACCCTCGATAATATGACAATCGGCGCGGGCGGGCGGGTCAATCCATACAAGGAC
CAGCGCATGGGTGCTGCAACTTTCAAGGCCGGTTTTCCGCAATGGCCCGAACTTGAGCAATGGCGGGACAAGCGTTTCTG
TTCCGATTTCTGGCGGCGCACCGCGCTTGCGCCCGAGCTTCAGCAGGGAAGATGA

Upstream 100 bases:

>100_bases
AAATGGACGACGATCCCGTAATGTTCATCGCGTTTGACTGGCGCAGTCAGGTTATGATCGCACTTGGTGCGGTGCTGTTA
TTCGTGGCCGGTATGCGCTG

Downstream 100 bases:

>100_bases
GCGGCAGGCGCAATCCGATCAAGGAAAAACGATGAAATATATTCCTTTTATCCTCTTCACAGTGATGACCAATGCGGCGG
CGCAGCTCATGCTGAAATAT

Product: FAD linked oxidase domain-containing protein

Products: L-xylo-hexulonolactone; H2O2

Alternate protein names: NA

Number of amino acids: Translated: 444; Mature: 443

Protein sequence:

>444_residues
MTRNFDSFGRIERHERASRSFEKVRAGFAASAAEETSLLAFGNGCSYGDSCHNDAGLLVPMRSVAAIESFDPATGILQAQ
AGVLLSEIIGFVAPHGYFLPVTPGTRFVTLGGAIANDVHGKNHHLRGTFGCHVESLELLRSDGVQYHCSLHENEGLFAAT
IGGMGLTGVIVSARLRLMPVGSLDVEERIVPFDNLDAYFDMAEAADRQNEYAVAWVDQLSRGKTAGRGVLITGNHAGNGN
RSVEDERVRLGVPFDLPFSVLNRVSLRLFNMAYFNAKRRKQKPHLASFGSFFYPLDGVGQWNRLYGPAGLYQHQSVIPFD
AARHIIPAMLAASREAGQASFLTVLKRFGDTASPGLLSFPKPGYTLTMDFPNRGGKTRALLQTLDNMTIGAGGRVNPYKD
QRMGAATFKAGFPQWPELEQWRDKRFCSDFWRRTALAPELQQGR

Sequences:

>Translated_444_residues
MTRNFDSFGRIERHERASRSFEKVRAGFAASAAEETSLLAFGNGCSYGDSCHNDAGLLVPMRSVAAIESFDPATGILQAQ
AGVLLSEIIGFVAPHGYFLPVTPGTRFVTLGGAIANDVHGKNHHLRGTFGCHVESLELLRSDGVQYHCSLHENEGLFAAT
IGGMGLTGVIVSARLRLMPVGSLDVEERIVPFDNLDAYFDMAEAADRQNEYAVAWVDQLSRGKTAGRGVLITGNHAGNGN
RSVEDERVRLGVPFDLPFSVLNRVSLRLFNMAYFNAKRRKQKPHLASFGSFFYPLDGVGQWNRLYGPAGLYQHQSVIPFD
AARHIIPAMLAASREAGQASFLTVLKRFGDTASPGLLSFPKPGYTLTMDFPNRGGKTRALLQTLDNMTIGAGGRVNPYKD
QRMGAATFKAGFPQWPELEQWRDKRFCSDFWRRTALAPELQQGR
>Mature_443_residues
TRNFDSFGRIERHERASRSFEKVRAGFAASAAEETSLLAFGNGCSYGDSCHNDAGLLVPMRSVAAIESFDPATGILQAQA
GVLLSEIIGFVAPHGYFLPVTPGTRFVTLGGAIANDVHGKNHHLRGTFGCHVESLELLRSDGVQYHCSLHENEGLFAATI
GGMGLTGVIVSARLRLMPVGSLDVEERIVPFDNLDAYFDMAEAADRQNEYAVAWVDQLSRGKTAGRGVLITGNHAGNGNR
SVEDERVRLGVPFDLPFSVLNRVSLRLFNMAYFNAKRRKQKPHLASFGSFFYPLDGVGQWNRLYGPAGLYQHQSVIPFDA
ARHIIPAMLAASREAGQASFLTVLKRFGDTASPGLLSFPKPGYTLTMDFPNRGGKTRALLQTLDNMTIGAGGRVNPYKDQ
RMGAATFKAGFPQWPELEQWRDKRFCSDFWRRTALAPELQQGR

Specific function: Involved in the epimerization of decaprenylphosphoryl ribose (DPR) to decaprenylphosphoryl arabinose (DPA) a precursor for arabinan synthesis in mycobacterial cell wall biosynthesis. Probably catalyzes the oxidation at C-2 of decaprenylphosphoryl ribose (

COG id: COG0277

COG function: function code C; FAD/FMN-containing dehydrogenases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding PCMH-type domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007173
- InterPro:   IPR016166
- InterPro:   IPR016168
- InterPro:   IPR006094 [H]

Pfam domain/function: PF04030 ALO; PF01565 FAD_binding_4 [H]

EC number: 1.1.3.8

Molecular weight: Translated: 48719; Mature: 48588

Theoretical pI: Translated: 8.90; Mature: 8.90

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRNFDSFGRIERHERASRSFEKVRAGFAASAAEETSLLAFGNGCSYGDSCHNDAGLLVP
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCCEEEE
MRSVAAIESFDPATGILQAQAGVLLSEIIGFVAPHGYFLPVTPGTRFVTLGGAIANDVHG
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCEEEEECCHHHHCCCC
KNHHLRGTFGCHVESLELLRSDGVQYHCSLHENEGLFAATIGGMGLTGVIVSARLRLMPV
CCCCCCEEECCCHHHHHHHHHCCCEEEEEEECCCCEEEEEECCCCHHHHHHHHHEEEEEC
GSLDVEERIVPFDNLDAYFDMAEAADRQNEYAVAWVDQLSRGKTAGRGVLITGNHAGNGN
CCCCHHHCCCCCCCCHHHHHHHHHHCCCCCEEEEEHHHHHCCCCCCCEEEEECCCCCCCC
RSVEDERVRLGVPFDLPFSVLNRVSLRLFNMAYFNAKRRKQKPHLASFGSFFYPLDGVGQ
CCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCCCCCCC
WNRLYGPAGLYQHQSVIPFDAARHIIPAMLAASREAGQASFLTVLKRFGDTASPGLLSFP
CHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCCC
KPGYTLTMDFPNRGGKTRALLQTLDNMTIGAGGRVNPYKDQRMGAATFKAGFPQWPELEQ
CCCEEEEECCCCCCCHHHHHHHHHHCCEECCCCCCCCCHHHHCCCHHHCCCCCCCCCHHH
WRDKRFCSDFWRRTALAPELQQGR
HHHHHHHHHHHHHHCCCCCHHCCC
>Mature Secondary Structure 
TRNFDSFGRIERHERASRSFEKVRAGFAASAAEETSLLAFGNGCSYGDSCHNDAGLLVP
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCCEEEE
MRSVAAIESFDPATGILQAQAGVLLSEIIGFVAPHGYFLPVTPGTRFVTLGGAIANDVHG
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCEEEEECCHHHHCCCC
KNHHLRGTFGCHVESLELLRSDGVQYHCSLHENEGLFAATIGGMGLTGVIVSARLRLMPV
CCCCCCEEECCCHHHHHHHHHCCCEEEEEEECCCCEEEEEECCCCHHHHHHHHHEEEEEC
GSLDVEERIVPFDNLDAYFDMAEAADRQNEYAVAWVDQLSRGKTAGRGVLITGNHAGNGN
CCCCHHHCCCCCCCCHHHHHHHHHHCCCCCEEEEEHHHHHCCCCCCCEEEEECCCCCCCC
RSVEDERVRLGVPFDLPFSVLNRVSLRLFNMAYFNAKRRKQKPHLASFGSFFYPLDGVGQ
CCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCCCCCCC
WNRLYGPAGLYQHQSVIPFDAARHIIPAMLAASREAGQASFLTVLKRFGDTASPGLLSFP
CHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCCC
KPGYTLTMDFPNRGGKTRALLQTLDNMTIGAGGRVNPYKDQRMGAATFKAGFPQWPELEQ
CCCEEEEECCCCCCCHHHHHHHHHHCCEECCCCCCCCCHHHHCCCHHHCCCCCCCCCHHH
WRDKRFCSDFWRRTALAPELQQGR
HHHHHHHHHHHHHHCCCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-gulono-1,4-lactone; O2

Specific reaction: L-gulono-1,4-lactone + O2 = L-xylo-hexulonolactone + H2O2

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]