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The map label for this gene is uxuB [H]

Identifier: 225686575

GI number: 225686575

Start: 773967

End: 775469

Strand: Reverse

Name: uxuB [H]

Synonym: BMEA_B0790

Alternate gene names: 225686575

Gene position: 775469-773967 (Counterclockwise)

Preceding gene: 225686578

Following gene: 225686574

Centisome position: 65.41

GC content: 55.16

Gene sequence:

>1503_bases
ATGATGCCCGTGCGTACTTCGGAACCGCGCCTTTCCAACCGAACCATGTCGGGCTTGCCTTCCAGCGTGAAAGTACCGGC
CTATGATCGCTCTCGAATAACGACAGGCATTGCCCATCTTGGCATCGGCGCCTTCCATCGTGCCCATCAGGCCGCGTATA
CGGATGCGGTTTTGACGAGCGGGTCAAATGAATGGGGAATTGTTGGTGTCTCACTACGCCGCCCCGATACCCGTGATGCG
CTCCAGATACAGGATGAGCTCTACACTTTGGCAATCCGCGACGGTGATAGTGAAAAGCTTCAGGTCATTGGCAGTATCCA
GAATATCCTGGTCGCGCCGGAGGACCCGCAAGCCGTTCTGGATATCATGAGCCACCCGGACACCCGCATTGTTTCATTGA
CAATCACCGAAAAGGGTTATTGCCGCGATGCGGCGGTGAGCGGGCTGGACCGGTCTCATCCCGATATTATTTATGATTTG
GCTCATCCCGCGACACCACGCTCGGCCCTCGGCTTCATCACAGAAGCACTCAGGCGGCGGCGCGCCCAGGGAACGGCGCC
GTTTACCGTTCTTTCCTGTGATAATCTGCCTGCCAATGGCGAAACCTGCAAAAACGTGATCGTGCAGTTTGCGGGATGCA
CGGACACAGATCTGGCGCATTACATTGAAGAAACGGTTGCCTTTCCGTCAACAATGGTCGATCGCATTGTACCGGCAACG
ACAGATGAAGACCGCATATCCATCAGCAGGACGCTGAAAGTTCTGGATCAATGGCCAATCACCACCGAGCCTTTCTCGCA
ATGGGTCATTGAAGACCGTTTCCCGACCGGGCGGCCTGCCTGGGAAATTGCTGGCGCAACCTTCGTGCAGGATGTAGCAG
CTTTTGAATTGATGAAACTGCGCCTGCTCAATGGCAGCCATTCGACGCTTGCCTATCTGGGTTTTCTGGCAGGCCACCGG
ACCGTTTCCCAAACGATGGCGGCTCCCGGTTTCAAGCAACTCATTAAAGCTTTGATGGAGATCGAGATCGCTCCAACCTT
GCCTAAGCTGGAGGGGTTCGATCTTTCGTCGTATCAAGCTGCACTGATCCATCGGTTTGAGAACCATGCCTTGCATCACC
TCACCTCGCAGATAGCGATGGACGGCTCACAAAAGCTTCCGCAACGCCTGCTGAACACGATACAGGAACGATTGGATGGT
GGAGGATCGATCGATCTGTTGGCGCTCGGTGTAGCGGCATGGATGCGTTATGTAACTGGCAAGGACGAAGCCGGAACTCC
CATAGATGTGCGGGATCCCTTGTCCGGCCAACTGCTTGACCAGACGCAAGGCAAATTTGCACCTGACGAGATTATGGATG
CGCTTTTGTCATTCCGGCAGATATTTACCGCTCGGCTTGCGGCAAATGAGCTGTTTCGGGAGAAGCTTCGGCTGGCTCTT
GGCAGCCTTTACGCGGTCGGCTCTGCCGAAACCGTCCGCCGATACGCAGAAATTGCTATGTGA

Upstream 100 bases:

>100_bases
CAGGCCTCGTGGCAGATCACCGGCTAGAGGAAGATGAGGCATATGAAGTTGCCCATGATCTCGCCTACCGTTTGGCCAAA
CAGACCTACAAGCTTTGAGG

Downstream 100 bases:

>100_bases
ACATCAGGCACCTTGGCCAGGCGGCGGGTGCAAGAAGCGAAATAGACACAGTGATGAATTTGCTTGCATCGCCAACTAAT
AGACTAATATATTAGATTTT

Product: mannitol dehydrogenase domain -containing protein

Products: NA

Alternate protein names: Fructuronate reductase [H]

Number of amino acids: Translated: 500; Mature: 500

Protein sequence:

>500_residues
MMPVRTSEPRLSNRTMSGLPSSVKVPAYDRSRITTGIAHLGIGAFHRAHQAAYTDAVLTSGSNEWGIVGVSLRRPDTRDA
LQIQDELYTLAIRDGDSEKLQVIGSIQNILVAPEDPQAVLDIMSHPDTRIVSLTITEKGYCRDAAVSGLDRSHPDIIYDL
AHPATPRSALGFITEALRRRRAQGTAPFTVLSCDNLPANGETCKNVIVQFAGCTDTDLAHYIEETVAFPSTMVDRIVPAT
TDEDRISISRTLKVLDQWPITTEPFSQWVIEDRFPTGRPAWEIAGATFVQDVAAFELMKLRLLNGSHSTLAYLGFLAGHR
TVSQTMAAPGFKQLIKALMEIEIAPTLPKLEGFDLSSYQAALIHRFENHALHHLTSQIAMDGSQKLPQRLLNTIQERLDG
GGSIDLLALGVAAWMRYVTGKDEAGTPIDVRDPLSGQLLDQTQGKFAPDEIMDALLSFRQIFTARLAANELFREKLRLAL
GSLYAVGSAETVRRYAEIAM

Sequences:

>Translated_500_residues
MMPVRTSEPRLSNRTMSGLPSSVKVPAYDRSRITTGIAHLGIGAFHRAHQAAYTDAVLTSGSNEWGIVGVSLRRPDTRDA
LQIQDELYTLAIRDGDSEKLQVIGSIQNILVAPEDPQAVLDIMSHPDTRIVSLTITEKGYCRDAAVSGLDRSHPDIIYDL
AHPATPRSALGFITEALRRRRAQGTAPFTVLSCDNLPANGETCKNVIVQFAGCTDTDLAHYIEETVAFPSTMVDRIVPAT
TDEDRISISRTLKVLDQWPITTEPFSQWVIEDRFPTGRPAWEIAGATFVQDVAAFELMKLRLLNGSHSTLAYLGFLAGHR
TVSQTMAAPGFKQLIKALMEIEIAPTLPKLEGFDLSSYQAALIHRFENHALHHLTSQIAMDGSQKLPQRLLNTIQERLDG
GGSIDLLALGVAAWMRYVTGKDEAGTPIDVRDPLSGQLLDQTQGKFAPDEIMDALLSFRQIFTARLAANELFREKLRLAL
GSLYAVGSAETVRRYAEIAM
>Mature_500_residues
MMPVRTSEPRLSNRTMSGLPSSVKVPAYDRSRITTGIAHLGIGAFHRAHQAAYTDAVLTSGSNEWGIVGVSLRRPDTRDA
LQIQDELYTLAIRDGDSEKLQVIGSIQNILVAPEDPQAVLDIMSHPDTRIVSLTITEKGYCRDAAVSGLDRSHPDIIYDL
AHPATPRSALGFITEALRRRRAQGTAPFTVLSCDNLPANGETCKNVIVQFAGCTDTDLAHYIEETVAFPSTMVDRIVPAT
TDEDRISISRTLKVLDQWPITTEPFSQWVIEDRFPTGRPAWEIAGATFVQDVAAFELMKLRLLNGSHSTLAYLGFLAGHR
TVSQTMAAPGFKQLIKALMEIEIAPTLPKLEGFDLSSYQAALIHRFENHALHHLTSQIAMDGSQKLPQRLLNTIQERLDG
GGSIDLLALGVAAWMRYVTGKDEAGTPIDVRDPLSGQLLDQTQGKFAPDEIMDALLSFRQIFTARLAANELFREKLRLAL
GSLYAVGSAETVRRYAEIAM

Specific function: Hexuronate conversion to KDG. [C]

COG id: COG0246

COG function: function code G; Mannitol-1-phosphate/altronate dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mannitol dehydrogenase family. UxuB subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790779, Length=480, Percent_Identity=48.125, Blast_Score=421, Evalue=1e-119,
Organism=Escherichia coli, GI1788497, Length=478, Percent_Identity=47.907949790795, Blast_Score=420, Evalue=1e-118,
Organism=Escherichia coli, GI1787823, Length=480, Percent_Identity=45.2083333333333, Blast_Score=395, Evalue=1e-111,
Organism=Escherichia coli, GI1790028, Length=257, Percent_Identity=28.0155642023346, Blast_Score=89, Evalue=9e-19,
Organism=Escherichia coli, GI48994885, Length=410, Percent_Identity=22.9268292682927, Blast_Score=83, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6324401, Length=496, Percent_Identity=39.7177419354839, Blast_Score=388, Evalue=1e-108,
Organism=Saccharomyces cerevisiae, GI6320765, Length=496, Percent_Identity=39.7177419354839, Blast_Score=388, Evalue=1e-108,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR000669
- InterPro:   IPR013118
- InterPro:   IPR023027
- InterPro:   IPR013131
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01232 Mannitol_dh; PF08125 Mannitol_dh_C [H]

EC number: =1.1.1.57 [H]

Molecular weight: Translated: 54945; Mature: 54945

Theoretical pI: Translated: 6.06; Mature: 6.06

Prosite motif: PS00974 MANNITOL_DHGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMPVRTSEPRLSNRTMSGLPSSVKVPAYDRSRITTGIAHLGIGAFHRAHQAAYTDAVLTS
CCCCCCCCCCCCCCHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
GSNEWGIVGVSLRRPDTRDALQIQDELYTLAIRDGDSEKLQVIGSIQNILVAPEDPQAVL
CCCCCEEEEEEECCCCCHHHHHHHCCEEEEEEECCCCHHHHHHHHHHHHEECCCCHHHHH
DIMSHPDTRIVSLTITEKGYCRDAAVSGLDRSHPDIIYDLAHPATPRSALGFITEALRRR
HHHCCCCCEEEEEEECCCCCCHHHHHCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHH
RAQGTAPFTVLSCDNLPANGETCKNVIVQFAGCTDTDLAHYIEETVAFPSTMVDRIVPAT
HHCCCCCEEEEECCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHCCHHHHHHHHCCCC
TDEDRISISRTLKVLDQWPITTEPFSQWVIEDRFPTGRPAWEIAGATFVQDVAAFELMKL
CCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
RLLNGSHSTLAYLGFLAGHRTVSQTMAAPGFKQLIKALMEIEIAPTLPKLEGFDLSSYQA
HHCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHEECCCCCCCCCCCCCHHHHH
ALIHRFENHALHHLTSQIAMDGSQKLPQRLLNTIQERLDGGGSIDLLALGVAAWMRYVTG
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCC
KDEAGTPIDVRDPLSGQLLDQTQGKFAPDEIMDALLSFRQIFTARLAANELFREKLRLAL
CCCCCCCCCCCCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GSLYAVGSAETVRRYAEIAM
HHHHHCCCHHHHHHHHHHCC
>Mature Secondary Structure
MMPVRTSEPRLSNRTMSGLPSSVKVPAYDRSRITTGIAHLGIGAFHRAHQAAYTDAVLTS
CCCCCCCCCCCCCCHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
GSNEWGIVGVSLRRPDTRDALQIQDELYTLAIRDGDSEKLQVIGSIQNILVAPEDPQAVL
CCCCCEEEEEEECCCCCHHHHHHHCCEEEEEEECCCCHHHHHHHHHHHHEECCCCHHHHH
DIMSHPDTRIVSLTITEKGYCRDAAVSGLDRSHPDIIYDLAHPATPRSALGFITEALRRR
HHHCCCCCEEEEEEECCCCCCHHHHHCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHH
RAQGTAPFTVLSCDNLPANGETCKNVIVQFAGCTDTDLAHYIEETVAFPSTMVDRIVPAT
HHCCCCCEEEEECCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHCCHHHHHHHHCCCC
TDEDRISISRTLKVLDQWPITTEPFSQWVIEDRFPTGRPAWEIAGATFVQDVAAFELMKL
CCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
RLLNGSHSTLAYLGFLAGHRTVSQTMAAPGFKQLIKALMEIEIAPTLPKLEGFDLSSYQA
HHCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHEECCCCCCCCCCCCCHHHHH
ALIHRFENHALHHLTSQIAMDGSQKLPQRLLNTIQERLDGGGSIDLLALGVAAWMRYVTG
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCC
KDEAGTPIDVRDPLSGQLLDQTQGKFAPDEIMDALLSFRQIFTARLAANELFREKLRLAL
CCCCCCCCCCCCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GSLYAVGSAETVRRYAEIAM
HHHHHCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7610040; 9278503 [H]