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The map label for this gene is fadA [H]

Identifier: 225686561

GI number: 225686561

Start: 756169

End: 757377

Strand: Reverse

Name: fadA [H]

Synonym: BMEA_B0773

Alternate gene names: 225686561

Gene position: 757377-756169 (Counterclockwise)

Preceding gene: 225686562

Following gene: 225686560

Centisome position: 63.89

GC content: 60.46

Gene sequence:

>1209_bases
ATGGCTGAGGCTTATATTTACGATCACGTGCGCACGCCGCGCGGGCGCGGCAAGAAGGACGGCTCCCTGCACGAAGTGCC
TGCCGTTCGTCTGGGCGCGAAGGTTCTGGAATCCCTGCGCGACCGCAACGGCATCGACACCGCCAAGGTCGATGACATTA
TTTTCGGCTGCGTCGATCCGGTCGGCGAAGCAGGCGCGGTCATTCCGCGTTCGGCGGCTTTCGAGGCCGGTTATGATTTC
AAGGCGCCGGGCATCCAGATTTCGCGCTTCTGCGCTTCGGGCCTTGATGCCATCAATCTGGCCGCTGCCAAGGTGGCATT
CGGTTCGGATGATCTGGTGATTGCGGGCGGCGTGGAAAGCATGTCGCGCGTCGGCATGGGCATGTCGGGCGGCGCCTGGT
ACATGGACCCATCGGTTGGCTTCCCCGGCTATTTCATGCCGCAGGGCGTTTCCGCCGACCTGATTGCCACCAAATACGGT
TTCAGCCGCGATGATGTCGATGCCTATGCTGTCGAAAGCCAGAAGCGCGCTGCCAATTCGTGGGAAAAGGGCTATTTCAA
GAATTCGGTCATCACGATCAAGGACCAGAACGGCCTCACCATTCTCGACCGTGACGAGCATATGCGCCCCGGCACCGACA
TGCAGGCGCTGGGCCAGTTGAGCCCGTCCTTCGTGATGCCGGGCGAAATGGGTGGCTTCAATGCTGTCGGCATTCAGGCG
CACCCGGAAATCGAAACCGTCAACCATGTCCACCATGCCGGCAATTCGTCGGGCATCGTGGATGGCGCGGCGGGGGTTCT
CGTCGGCTCCAGGAAGGCTGGCAAGGCCTTCGATATCAAGCCGCGCGCGCGCATTCGTGCTTTTGCCAATATCGGTTCGG
AACCGGCGCTTATGCTGACCGGCCCGGTCGATGTGACGGAAAAGCTGCTGAAACAGGCCAAGATGAAGATTTCGGACATT
GATCTGTTCGAGTTGAACGAAGCCTTCGCCGCGGTGGTCCTGCGCTATATGCAGGCTTTCGATATTCCGCACGACAAGAT
CAACGTCAATGGCGGCGCCATTGCCATGGGCCATCCGCTCGGTGCCACCGGCGCGATGATCCTCGGCACGGTGCTGGATG
AACTGGAACGCCGCAATCTCAATACCGCTCTGGTGACGCTGTGCATCGGTTCCGGTATGGGCACGGCCACGATCATCGAG
CGCGTGTAA

Upstream 100 bases:

>100_bases
GATAGCATGATGGCGCTTAACGCGGGCACATTCTGAGGCTTTTTGATTTGAGCCGGTGCCGGGGGCACCGGCGGGCCAAA
TTTGGCTGGAAGGAGCAAAC

Downstream 100 bases:

>100_bases
GGGGAGGTTCAGACAATGGCTTATGTAAATTTCAAGGTTGAAACCGACGCCGACGGCATTGCTCTCGTTACATGGGACAT
GCCCGAAAAGTCGATGAATG

Product: acetyl-CoA acetyltransferase

Products: CoA; 3-oxoacyl-CoA

Alternate protein names: NA

Number of amino acids: Translated: 402; Mature: 401

Protein sequence:

>402_residues
MAEAYIYDHVRTPRGRGKKDGSLHEVPAVRLGAKVLESLRDRNGIDTAKVDDIIFGCVDPVGEAGAVIPRSAAFEAGYDF
KAPGIQISRFCASGLDAINLAAAKVAFGSDDLVIAGGVESMSRVGMGMSGGAWYMDPSVGFPGYFMPQGVSADLIATKYG
FSRDDVDAYAVESQKRAANSWEKGYFKNSVITIKDQNGLTILDRDEHMRPGTDMQALGQLSPSFVMPGEMGGFNAVGIQA
HPEIETVNHVHHAGNSSGIVDGAAGVLVGSRKAGKAFDIKPRARIRAFANIGSEPALMLTGPVDVTEKLLKQAKMKISDI
DLFELNEAFAAVVLRYMQAFDIPHDKINVNGGAIAMGHPLGATGAMILGTVLDELERRNLNTALVTLCIGSGMGTATIIE
RV

Sequences:

>Translated_402_residues
MAEAYIYDHVRTPRGRGKKDGSLHEVPAVRLGAKVLESLRDRNGIDTAKVDDIIFGCVDPVGEAGAVIPRSAAFEAGYDF
KAPGIQISRFCASGLDAINLAAAKVAFGSDDLVIAGGVESMSRVGMGMSGGAWYMDPSVGFPGYFMPQGVSADLIATKYG
FSRDDVDAYAVESQKRAANSWEKGYFKNSVITIKDQNGLTILDRDEHMRPGTDMQALGQLSPSFVMPGEMGGFNAVGIQA
HPEIETVNHVHHAGNSSGIVDGAAGVLVGSRKAGKAFDIKPRARIRAFANIGSEPALMLTGPVDVTEKLLKQAKMKISDI
DLFELNEAFAAVVLRYMQAFDIPHDKINVNGGAIAMGHPLGATGAMILGTVLDELERRNLNTALVTLCIGSGMGTATIIE
RV
>Mature_401_residues
AEAYIYDHVRTPRGRGKKDGSLHEVPAVRLGAKVLESLRDRNGIDTAKVDDIIFGCVDPVGEAGAVIPRSAAFEAGYDFK
APGIQISRFCASGLDAINLAAAKVAFGSDDLVIAGGVESMSRVGMGMSGGAWYMDPSVGFPGYFMPQGVSADLIATKYGF
SRDDVDAYAVESQKRAANSWEKGYFKNSVITIKDQNGLTILDRDEHMRPGTDMQALGQLSPSFVMPGEMGGFNAVGIQAH
PEIETVNHVHHAGNSSGIVDGAAGVLVGSRKAGKAFDIKPRARIRAFANIGSEPALMLTGPVDVTEKLLKQAKMKISDID
LFELNEAFAAVVLRYMQAFDIPHDKINVNGGAIAMGHPLGATGAMILGTVLDELERRNLNTALVTLCIGSGMGTATIIER
V

Specific function: Thiolytic Cleavage Of Beta-Ketoadipyl-CoA To Succinate And Acetyl-CoA (By Similarity). [C]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI148539872, Length=398, Percent_Identity=32.6633165829146, Blast_Score=206, Evalue=2e-53,
Organism=Homo sapiens, GI4501853, Length=409, Percent_Identity=32.2738386308068, Blast_Score=193, Evalue=2e-49,
Organism=Homo sapiens, GI167614485, Length=404, Percent_Identity=31.4356435643564, Blast_Score=190, Evalue=2e-48,
Organism=Homo sapiens, GI4557237, Length=416, Percent_Identity=31.7307692307692, Blast_Score=183, Evalue=3e-46,
Organism=Homo sapiens, GI4504327, Length=445, Percent_Identity=28.314606741573, Blast_Score=139, Evalue=5e-33,
Organism=Homo sapiens, GI194353979, Length=89, Percent_Identity=46.0674157303371, Blast_Score=89, Evalue=7e-18,
Organism=Escherichia coli, GI1787663, Length=424, Percent_Identity=38.9150943396226, Blast_Score=248, Evalue=5e-67,
Organism=Escherichia coli, GI48994986, Length=409, Percent_Identity=37.1638141809291, Blast_Score=238, Evalue=4e-64,
Organism=Escherichia coli, GI87082165, Length=417, Percent_Identity=36.6906474820144, Blast_Score=230, Evalue=1e-61,
Organism=Escherichia coli, GI1788554, Length=419, Percent_Identity=35.0835322195704, Blast_Score=209, Evalue=2e-55,
Organism=Escherichia coli, GI1788683, Length=427, Percent_Identity=27.6346604215457, Blast_Score=126, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI133906874, Length=396, Percent_Identity=32.8282828282828, Blast_Score=207, Evalue=8e-54,
Organism=Caenorhabditis elegans, GI17535921, Length=419, Percent_Identity=30.3102625298329, Blast_Score=174, Evalue=7e-44,
Organism=Caenorhabditis elegans, GI25147385, Length=423, Percent_Identity=28.1323877068558, Blast_Score=165, Evalue=4e-41,
Organism=Caenorhabditis elegans, GI17551802, Length=450, Percent_Identity=27.1111111111111, Blast_Score=130, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI17535917, Length=411, Percent_Identity=25.0608272506083, Blast_Score=108, Evalue=4e-24,
Organism=Saccharomyces cerevisiae, GI6322031, Length=360, Percent_Identity=32.2222222222222, Blast_Score=181, Evalue=2e-46,
Organism=Saccharomyces cerevisiae, GI6325229, Length=417, Percent_Identity=30.6954436450839, Blast_Score=151, Evalue=2e-37,
Organism=Drosophila melanogaster, GI24655093, Length=415, Percent_Identity=34.9397590361446, Blast_Score=226, Evalue=2e-59,
Organism=Drosophila melanogaster, GI17648125, Length=413, Percent_Identity=33.6561743341404, Blast_Score=204, Evalue=9e-53,
Organism=Drosophila melanogaster, GI24640423, Length=416, Percent_Identity=30.2884615384615, Blast_Score=173, Evalue=2e-43,
Organism=Drosophila melanogaster, GI17137578, Length=446, Percent_Identity=28.6995515695067, Blast_Score=144, Evalue=2e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: 2.3.1.16

Molecular weight: Translated: 42658; Mature: 42527

Theoretical pI: Translated: 6.06; Mature: 6.06

Prosite motif: PS00098 THIOLASE_1 ; PS00737 THIOLASE_2 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEAYIYDHVRTPRGRGKKDGSLHEVPAVRLGAKVLESLRDRNGIDTAKVDDIIFGCVDP
CCCEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCC
VGEAGAVIPRSAAFEAGYDFKAPGIQISRFCASGLDAINLAAAKVAFGSDDLVIAGGVES
CCCCCCCCCCCCHHCCCCCCCCCCCHHHHHHHCCCCHHHHHHHEEEECCCCEEEECCHHH
MSRVGMGMSGGAWYMDPSVGFPGYFMPQGVSADLIATKYGFSRDDVDAYAVESQKRAANS
HHHHCCCCCCCEEEECCCCCCCCCCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHH
WEKGYFKNSVITIKDQNGLTILDRDEHMRPGTDMQALGQLSPSFVMPGEMGGFNAVGIQA
HHHCCCCCCEEEEECCCCCEEEECCCCCCCCCCHHHHHCCCCCEECCCCCCCCEEEEEEC
HPEIETVNHVHHAGNSSGIVDGAAGVLVGSRKAGKAFDIKPRARIRAFANIGSEPALMLT
CCCHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCCEECCCCHHHHHHHHHCCCCCEEEEE
GPVDVTEKLLKQAKMKISDIDLFELNEAFAAVVLRYMQAFDIPHDKINVNGGAIAMGHPL
CCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCEEEECCCC
GATGAMILGTVLDELERRNLNTALVTLCIGSGMGTATIIERV
CCHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHCC
>Mature Secondary Structure 
AEAYIYDHVRTPRGRGKKDGSLHEVPAVRLGAKVLESLRDRNGIDTAKVDDIIFGCVDP
CCEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCC
VGEAGAVIPRSAAFEAGYDFKAPGIQISRFCASGLDAINLAAAKVAFGSDDLVIAGGVES
CCCCCCCCCCCCHHCCCCCCCCCCCHHHHHHHCCCCHHHHHHHEEEECCCCEEEECCHHH
MSRVGMGMSGGAWYMDPSVGFPGYFMPQGVSADLIATKYGFSRDDVDAYAVESQKRAANS
HHHHCCCCCCCEEEECCCCCCCCCCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHH
WEKGYFKNSVITIKDQNGLTILDRDEHMRPGTDMQALGQLSPSFVMPGEMGGFNAVGIQA
HHHCCCCCCEEEEECCCCCEEEECCCCCCCCCCHHHHHCCCCCEECCCCCCCCEEEEEEC
HPEIETVNHVHHAGNSSGIVDGAAGVLVGSRKAGKAFDIKPRARIRAFANIGSEPALMLT
CCCHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCCEECCCCHHHHHHHHHCCCCCEEEEE
GPVDVTEKLLKQAKMKISDIDLFELNEAFAAVVLRYMQAFDIPHDKINVNGGAIAMGHPL
CCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCEEEECCCC
GATGAMILGTVLDELERRNLNTALVTLCIGSGMGTATIIERV
CCHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA; acetyl-CoA

Specific reaction: acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230 [H]