| Definition | Brucella melitensis ATCC 23457 chromosome chromosome II, complete sequence. |
|---|---|
| Accession | NC_012442 |
| Length | 1,185,518 |
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The map label for this gene is fabG [H]
Identifier: 225686544
GI number: 225686544
Start: 735815
End: 736564
Strand: Reverse
Name: fabG [H]
Synonym: BMEA_B0755
Alternate gene names: 225686544
Gene position: 736564-735815 (Counterclockwise)
Preceding gene: 225686548
Following gene: 225686540
Centisome position: 62.13
GC content: 59.33
Gene sequence:
>750_bases ATGAATAGGCTGCAAGATAAGGTCGCGATTATCACCGGCGCCGGTTCCGGCTTCGGTCTGGGCATGGCGCGCCGGTTTGC AGCCGAGGGTGCCAGGGTGGTTCTGGCCGATGTGAATGTGAAGCGCGTCGAGGACGGGCTTGCCGATATCAGCAGTAACG GCATTTCCATCCAGGCGGATGTTTCGCGCAAGGATGACATGGAGCGTGTGGCGCGCACTGCTTTTGAAGAATTCGGCCGT ATCGACATTATGGTCAACAATGCTGGTTTCACGCACCGCAACATGCCGCTGACCGATGTGGACGAGCATAATTTCGATCT CATCGTCGCGGTGAACATGAAGGCGCTTTACTATTCGACGCAGCTCGTCGTGCCGATCATGGAGCATCAGGGCGGCGGTG TTATCATCAATACGGCGTCTGCCACGGGGCTGCATCCGCGCAAGGGTCTCACCTGGTATTGCGCGTCCAAGAGCTGGGTG GTGAGCGCCACGAAAGCCATGGCGCTGGAGCTTGCGGAGCGGAACATTCGTGTGAATTGCCTGTGCCCGGCGGAAAGCGA CGGTGAGGGATTGAAGATGTTTCTGGCGGAAGACACGCCGGAAGCGCGCGCAGCACTGAAAAGCACCATTCCGCTTGGCC GGTTTTCCACGCCGAAGGATGTTGCGGAAGCCGCGCTCTGGCTGGCCTCCGACGATGCTTCCATGGTGACGGGCGTGGCG CTCGGTATCGATGGCGGCTATTCGATCTGA
Upstream 100 bases:
>100_bases CAAATGCACACATGATATGTTCATCATAAGTCCATATTGGGACACTCAATCGCGTTTCAAGTGATTTCGGATTAGCGCAA GATTACCAAAGGAGAATGAC
Downstream 100 bases:
>100_bases TCGAAAAGCATTCAAGATTCCGACGCGATCCACGCCCTGAAAAGGCTCAATCGCGGCACGGACTTAACCAAAACCCGATG AGGCAAGCTCATCGGGTTTT
Product: 3-ketoacyl-(acyl-carrier-protein) reductase
Products: NA
Alternate protein names: 3-ketoacyl-acyl carrier protein reductase [H]
Number of amino acids: Translated: 249; Mature: 249
Protein sequence:
>249_residues MNRLQDKVAIITGAGSGFGLGMARRFAAEGARVVLADVNVKRVEDGLADISSNGISIQADVSRKDDMERVARTAFEEFGR IDIMVNNAGFTHRNMPLTDVDEHNFDLIVAVNMKALYYSTQLVVPIMEHQGGGVIINTASATGLHPRKGLTWYCASKSWV VSATKAMALELAERNIRVNCLCPAESDGEGLKMFLAEDTPEARAALKSTIPLGRFSTPKDVAEAALWLASDDASMVTGVA LGIDGGYSI
Sequences:
>Translated_249_residues MNRLQDKVAIITGAGSGFGLGMARRFAAEGARVVLADVNVKRVEDGLADISSNGISIQADVSRKDDMERVARTAFEEFGR IDIMVNNAGFTHRNMPLTDVDEHNFDLIVAVNMKALYYSTQLVVPIMEHQGGGVIINTASATGLHPRKGLTWYCASKSWV VSATKAMALELAERNIRVNCLCPAESDGEGLKMFLAEDTPEARAALKSTIPLGRFSTPKDVAEAALWLASDDASMVTGVA LGIDGGYSI >Mature_249_residues MNRLQDKVAIITGAGSGFGLGMARRFAAEGARVVLADVNVKRVEDGLADISSNGISIQADVSRKDDMERVARTAFEEFGR IDIMVNNAGFTHRNMPLTDVDEHNFDLIVAVNMKALYYSTQLVVPIMEHQGGGVIINTASATGLHPRKGLTWYCASKSWV VSATKAMALELAERNIRVNCLCPAESDGEGLKMFLAEDTPEARAALKSTIPLGRFSTPKDVAEAALWLASDDASMVTGVA LGIDGGYSI
Specific function: 7-Alpha-Dehydroxylation Of Cholic Acid, Yielding Deoxycholic Acid And Lithocholic Acid, Respectively. Highest Affinity With Taurochenodeoxycholic Acid. [C]
COG id: NA
COG function: NA
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]
Homologues:
Organism=Homo sapiens, GI32483357, Length=246, Percent_Identity=34.9593495934959, Blast_Score=145, Evalue=3e-35, Organism=Homo sapiens, GI126723750, Length=249, Percent_Identity=32.1285140562249, Blast_Score=119, Evalue=2e-27, Organism=Homo sapiens, GI66933014, Length=254, Percent_Identity=33.8582677165354, Blast_Score=118, Evalue=6e-27, Organism=Homo sapiens, GI126723191, Length=181, Percent_Identity=35.9116022099448, Blast_Score=113, Evalue=2e-25, Organism=Homo sapiens, GI5031737, Length=248, Percent_Identity=31.4516129032258, Blast_Score=112, Evalue=4e-25, Organism=Homo sapiens, GI15277342, Length=262, Percent_Identity=30.9160305343511, Blast_Score=104, Evalue=6e-23, Organism=Homo sapiens, GI33667109, Length=183, Percent_Identity=33.3333333333333, Blast_Score=102, Evalue=2e-22, Organism=Homo sapiens, GI59889578, Length=229, Percent_Identity=32.3144104803493, Blast_Score=101, Evalue=7e-22, Organism=Homo sapiens, GI40254992, Length=244, Percent_Identity=27.8688524590164, Blast_Score=99, Evalue=2e-21, Organism=Homo sapiens, GI10190704, Length=249, Percent_Identity=30.5220883534137, Blast_Score=97, Evalue=1e-20, Organism=Homo sapiens, GI7705925, Length=248, Percent_Identity=31.0483870967742, Blast_Score=97, Evalue=2e-20, Organism=Homo sapiens, GI31542939, Length=241, Percent_Identity=29.8755186721992, Blast_Score=96, Evalue=4e-20, Organism=Homo sapiens, GI19923817, Length=266, Percent_Identity=25.187969924812, Blast_Score=95, Evalue=6e-20, Organism=Homo sapiens, GI4504505, Length=238, Percent_Identity=30.2521008403361, Blast_Score=93, Evalue=3e-19, Organism=Homo sapiens, GI4758504, Length=211, Percent_Identity=33.175355450237, Blast_Score=86, Evalue=3e-17, Organism=Homo sapiens, GI142976729, Length=183, Percent_Identity=31.1475409836066, Blast_Score=83, Evalue=3e-16, Organism=Homo sapiens, GI224922801, Length=170, Percent_Identity=32.3529411764706, Blast_Score=82, Evalue=6e-16, Organism=Homo sapiens, GI83715985, Length=176, Percent_Identity=34.0909090909091, Blast_Score=79, Evalue=4e-15, Organism=Homo sapiens, GI210032110, Length=184, Percent_Identity=29.8913043478261, Blast_Score=79, Evalue=5e-15, Organism=Homo sapiens, GI109715829, Length=249, Percent_Identity=28.5140562248996, Blast_Score=78, Evalue=9e-15, Organism=Homo sapiens, GI302344755, Length=108, Percent_Identity=39.8148148148148, Blast_Score=77, Evalue=1e-14, Organism=Homo sapiens, GI40807363, Length=187, Percent_Identity=30.4812834224599, Blast_Score=74, Evalue=8e-14, Organism=Homo sapiens, GI25282469, Length=212, Percent_Identity=28.3018867924528, Blast_Score=74, Evalue=1e-13, Organism=Homo sapiens, GI4557649, Length=183, Percent_Identity=31.1475409836066, Blast_Score=72, Evalue=5e-13, Organism=Homo sapiens, GI7706318, Length=188, Percent_Identity=28.1914893617021, Blast_Score=66, Evalue=3e-11, Organism=Homo sapiens, GI4503817, Length=190, Percent_Identity=25.2631578947368, Blast_Score=65, Evalue=4e-11, Organism=Escherichia coli, GI1787905, Length=250, Percent_Identity=34.8, Blast_Score=132, Evalue=2e-32, Organism=Escherichia coli, GI87082100, Length=256, Percent_Identity=33.59375, Blast_Score=129, Evalue=2e-31, Organism=Escherichia coli, GI1789208, Length=248, Percent_Identity=32.258064516129, Blast_Score=118, Evalue=3e-28, Organism=Escherichia coli, GI1787335, Length=249, Percent_Identity=32.1285140562249, Blast_Score=116, Evalue=1e-27, Organism=Escherichia coli, GI1790717, Length=246, Percent_Identity=31.7073170731707, Blast_Score=114, Evalue=4e-27, Organism=Escherichia coli, GI87082160, Length=252, Percent_Identity=30.5555555555556, Blast_Score=97, Evalue=1e-21, Organism=Escherichia coli, GI1789378, Length=256, Percent_Identity=26.953125, Blast_Score=94, Evalue=6e-21, Organism=Escherichia coli, GI1788459, Length=248, Percent_Identity=29.8387096774194, Blast_Score=94, Evalue=1e-20, Organism=Escherichia coli, GI1786812, Length=246, Percent_Identity=29.6747967479675, Blast_Score=93, Evalue=2e-20, Organism=Escherichia coli, GI1787820, Length=224, Percent_Identity=28.5714285714286, Blast_Score=92, Evalue=4e-20, Organism=Escherichia coli, GI2367175, Length=249, Percent_Identity=29.718875502008, Blast_Score=80, Evalue=2e-16, Organism=Escherichia coli, GI2367365, Length=247, Percent_Identity=27.1255060728745, Blast_Score=76, Evalue=2e-15, Organism=Escherichia coli, GI1789057, Length=261, Percent_Identity=27.2030651340996, Blast_Score=74, Evalue=1e-14, Organism=Escherichia coli, GI1787526, Length=256, Percent_Identity=25, Blast_Score=73, Evalue=2e-14, Organism=Escherichia coli, GI1788891, Length=263, Percent_Identity=25.8555133079848, Blast_Score=63, Evalue=2e-11, Organism=Caenorhabditis elegans, GI17561402, Length=250, Percent_Identity=34, Blast_Score=136, Evalue=9e-33, Organism=Caenorhabditis elegans, GI17560676, Length=250, Percent_Identity=31.2, Blast_Score=120, Evalue=7e-28, Organism=Caenorhabditis elegans, GI17559104, Length=264, Percent_Identity=30.3030303030303, Blast_Score=119, Evalue=2e-27, Organism=Caenorhabditis elegans, GI71994600, Length=260, Percent_Identity=34.2307692307692, Blast_Score=119, Evalue=2e-27, Organism=Caenorhabditis elegans, GI17555706, Length=251, Percent_Identity=33.8645418326693, Blast_Score=115, Evalue=2e-26, Organism=Caenorhabditis elegans, GI25147288, Length=251, Percent_Identity=31.0756972111554, Blast_Score=110, Evalue=7e-25, Organism=Caenorhabditis elegans, GI71994604, Length=252, Percent_Identity=32.5396825396825, Blast_Score=109, Evalue=1e-24, Organism=Caenorhabditis elegans, GI17531453, Length=272, Percent_Identity=29.4117647058824, Blast_Score=103, Evalue=7e-23, Organism=Caenorhabditis elegans, GI17562908, Length=267, Percent_Identity=28.8389513108614, Blast_Score=103, Evalue=8e-23, Organism=Caenorhabditis elegans, GI17562906, Length=267, Percent_Identity=29.2134831460674, Blast_Score=102, Evalue=2e-22, Organism=Caenorhabditis elegans, GI17568967, Length=190, Percent_Identity=34.2105263157895, Blast_Score=101, Evalue=4e-22, Organism=Caenorhabditis elegans, GI17562910, Length=268, Percent_Identity=28.3582089552239, Blast_Score=100, Evalue=1e-21, Organism=Caenorhabditis elegans, GI17560332, Length=270, Percent_Identity=28.8888888888889, Blast_Score=98, Evalue=4e-21, Organism=Caenorhabditis elegans, GI17562904, Length=264, Percent_Identity=26.8939393939394, Blast_Score=98, Evalue=5e-21, Organism=Caenorhabditis elegans, GI115534694, Length=250, Percent_Identity=30.4, Blast_Score=97, Evalue=8e-21, Organism=Caenorhabditis elegans, GI193203117, Length=186, Percent_Identity=33.3333333333333, Blast_Score=96, Evalue=2e-20, Organism=Caenorhabditis elegans, GI17560220, Length=267, Percent_Identity=30.7116104868914, Blast_Score=96, Evalue=2e-20, Organism=Caenorhabditis elegans, GI193203115, Length=185, Percent_Identity=33.5135135135135, Blast_Score=95, Evalue=4e-20, Organism=Caenorhabditis elegans, GI193204405, Length=268, Percent_Identity=28.3582089552239, Blast_Score=94, Evalue=5e-20, Organism=Caenorhabditis elegans, GI17564282, Length=186, Percent_Identity=34.4086021505376, Blast_Score=92, Evalue=2e-19, Organism=Caenorhabditis elegans, GI17508895, Length=186, Percent_Identity=31.7204301075269, Blast_Score=91, Evalue=4e-19, Organism=Caenorhabditis elegans, GI17538480, Length=268, Percent_Identity=28.7313432835821, Blast_Score=91, Evalue=5e-19, Organism=Caenorhabditis elegans, GI17560150, Length=265, Percent_Identity=28.6792452830189, Blast_Score=91, Evalue=6e-19, Organism=Caenorhabditis elegans, GI17562990, Length=268, Percent_Identity=29.1044776119403, Blast_Score=89, Evalue=3e-18, Organism=Caenorhabditis elegans, GI72000259, Length=265, Percent_Identity=27.1698113207547, Blast_Score=87, Evalue=1e-17, Organism=Caenorhabditis elegans, GI17551412, Length=266, Percent_Identity=28.1954887218045, Blast_Score=85, Evalue=4e-17, Organism=Caenorhabditis elegans, GI17544670, Length=267, Percent_Identity=26.9662921348315, Blast_Score=82, Evalue=3e-16, Organism=Caenorhabditis elegans, GI17538486, Length=268, Percent_Identity=25, Blast_Score=81, Evalue=5e-16, Organism=Caenorhabditis elegans, GI17563726, Length=272, Percent_Identity=26.8382352941176, Blast_Score=77, Evalue=6e-15, Organism=Caenorhabditis elegans, GI17565030, Length=269, Percent_Identity=25.6505576208178, Blast_Score=77, Evalue=1e-14, Organism=Caenorhabditis elegans, GI17538182, Length=211, Percent_Identity=29.8578199052133, Blast_Score=73, Evalue=2e-13, Organism=Caenorhabditis elegans, GI17508651, Length=254, Percent_Identity=27.5590551181102, Blast_Score=72, Evalue=2e-13, Organism=Caenorhabditis elegans, GI17536025, Length=254, Percent_Identity=26.7716535433071, Blast_Score=69, Evalue=3e-12, Organism=Caenorhabditis elegans, GI17567345, Length=177, Percent_Identity=28.2485875706215, Blast_Score=64, Evalue=5e-11, Organism=Saccharomyces cerevisiae, GI6322861, Length=190, Percent_Identity=34.2105263157895, Blast_Score=98, Evalue=1e-21, Organism=Saccharomyces cerevisiae, GI6323882, Length=242, Percent_Identity=26.8595041322314, Blast_Score=72, Evalue=1e-13, Organism=Saccharomyces cerevisiae, GI6324126, Length=260, Percent_Identity=25, Blast_Score=71, Evalue=2e-13, Organism=Drosophila melanogaster, GI24644339, Length=254, Percent_Identity=34.251968503937, Blast_Score=128, Evalue=3e-30, Organism=Drosophila melanogaster, GI21355319, Length=251, Percent_Identity=31.8725099601594, Blast_Score=122, Evalue=2e-28, Organism=Drosophila melanogaster, GI28571526, Length=261, Percent_Identity=32.5670498084291, Blast_Score=119, Evalue=2e-27, Organism=Drosophila melanogaster, GI21357041, Length=260, Percent_Identity=31.9230769230769, Blast_Score=119, Evalue=2e-27, Organism=Drosophila melanogaster, GI23397609, Length=247, Percent_Identity=34.0080971659919, Blast_Score=117, Evalue=5e-27, Organism=Drosophila melanogaster, GI24639444, Length=247, Percent_Identity=31.5789473684211, Blast_Score=114, Evalue=8e-26, Organism=Drosophila melanogaster, GI24643142, Length=248, Percent_Identity=31.0483870967742, Blast_Score=101, Evalue=5e-22, Organism=Drosophila melanogaster, GI18859837, Length=190, Percent_Identity=33.6842105263158, Blast_Score=100, Evalue=1e-21, Organism=Drosophila melanogaster, GI24644337, Length=256, Percent_Identity=32.421875, Blast_Score=87, Evalue=1e-17, Organism=Drosophila melanogaster, GI24649181, Length=186, Percent_Identity=27.4193548387097, Blast_Score=86, Evalue=2e-17, Organism=Drosophila melanogaster, GI17737361, Length=255, Percent_Identity=27.4509803921569, Blast_Score=85, Evalue=5e-17, Organism=Drosophila melanogaster, GI24640492, Length=176, Percent_Identity=29.5454545454545, Blast_Score=80, Evalue=1e-15, Organism=Drosophila melanogaster, GI161076933, Length=185, Percent_Identity=32.4324324324324, Blast_Score=78, Evalue=6e-15, Organism=Drosophila melanogaster, GI24584748, Length=185, Percent_Identity=32.4324324324324, Blast_Score=78, Evalue=7e-15, Organism=Drosophila melanogaster, GI221510726, Length=187, Percent_Identity=31.5508021390374, Blast_Score=77, Evalue=8e-15, Organism=Drosophila melanogaster, GI28574402, Length=185, Percent_Identity=30.8108108108108, Blast_Score=74, Evalue=7e-14, Organism=Drosophila melanogaster, GI24584744, Length=185, Percent_Identity=30.8108108108108, Blast_Score=74, Evalue=7e-14, Organism=Drosophila melanogaster, GI281364892, Length=177, Percent_Identity=28.8135593220339, Blast_Score=69, Evalue=2e-12, Organism=Drosophila melanogaster, GI21358495, Length=191, Percent_Identity=29.3193717277487, Blast_Score=67, Evalue=1e-11, Organism=Drosophila melanogaster, GI21355631, Length=172, Percent_Identity=27.3255813953488, Blast_Score=66, Evalue=2e-11, Organism=Drosophila melanogaster, GI24665243, Length=191, Percent_Identity=26.7015706806283, Blast_Score=65, Evalue=5e-11, Organism=Drosophila melanogaster, GI221331218, Length=192, Percent_Identity=27.6041666666667, Blast_Score=64, Evalue=7e-11,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR011284 - InterPro: IPR002198 - InterPro: IPR002347 - InterPro: IPR016040 - InterPro: IPR020904 [H]
Pfam domain/function: PF00106 adh_short [H]
EC number: =1.1.1.100 [H]
Molecular weight: Translated: 26693; Mature: 26693
Theoretical pI: Translated: 5.13; Mature: 5.13
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
1.2 %Cys (Translated Protein) 4.0 %Met (Translated Protein) 5.2 %Cys+Met (Translated Protein) 1.2 %Cys (Mature Protein) 4.0 %Met (Mature Protein) 5.2 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MNRLQDKVAIITGAGSGFGLGMARRFAAEGARVVLADVNVKRVEDGLADISSNGISIQAD CCCCCCEEEEEEECCCCCCHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHCCCCEEEEEC VSRKDDMERVARTAFEEFGRIDIMVNNAGFTHRNMPLTDVDEHNFDLIVAVNMKALYYST CCCCHHHHHHHHHHHHHCCEEEEEECCCCCEECCCCCCCCCCCCCEEEEEEEEEEEEEEE QLVVPIMEHQGGGVIINTASATGLHPRKGLTWYCASKSWVVSATKAMALELAERNIRVNC EEEEEEEECCCCEEEEECCCCCCCCCCCCEEEEECCCCEEEEHHHHHHHHHHHCCEEEEE LCPAESDGEGLKMFLAEDTPEARAALKSTIPLGRFSTPKDVAEAALWLASDDASMVTGVA EECCCCCCCCEEEEEECCCCHHHHHHHHCCCCCCCCCHHHHHHHEEEEECCCCCEEEEEE LGIDGGYSI EECCCCCCC >Mature Secondary Structure MNRLQDKVAIITGAGSGFGLGMARRFAAEGARVVLADVNVKRVEDGLADISSNGISIQAD CCCCCCEEEEEEECCCCCCHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHCCCCEEEEEC VSRKDDMERVARTAFEEFGRIDIMVNNAGFTHRNMPLTDVDEHNFDLIVAVNMKALYYST CCCCHHHHHHHHHHHHHCCEEEEEECCCCCEECCCCCCCCCCCCCEEEEEEEEEEEEEEE QLVVPIMEHQGGGVIINTASATGLHPRKGLTWYCASKSWVVSATKAMALELAERNIRVNC EEEEEEEECCCCEEEEECCCCCCCCCCCCEEEEECCCCEEEEHHHHHHHHHHHCCEEEEE LCPAESDGEGLKMFLAEDTPEARAALKSTIPLGRFSTPKDVAEAALWLASDDASMVTGVA EECCCCCCCCEEEEEECCCCHHHHHHHHCCCCCCCCCHHHHHHHEEEEECCCCCEEEEEE LGIDGGYSI EECCCCCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 10.0
TargetDB status: NA
Availability: NA
References: 10360571 [H]