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The map label for this gene is gcvT [H]

Identifier: 225686498

GI number: 225686498

Start: 691173

End: 692276

Strand: Reverse

Name: gcvT [H]

Synonym: BMEA_B0703

Alternate gene names: 225686498

Gene position: 692276-691173 (Counterclockwise)

Preceding gene: 225686500

Following gene: 225686497

Centisome position: 58.39

GC content: 61.5

Gene sequence:

>1104_bases
ATGGGCGATACCGCACATTTGAATACCCTGCCGTTGCAGGATCTGCATGAAAAGGCTGGCGCGCGCTTCGGCGGCTTTGC
CGGCTGGAACATGCCAACCACCTATCCGCTGGGTGTGATGAAGGAACATCTTCATACGCGCGACCATGCGGGCCTCTTCG
ACATTTCCCACATGAAGCTGGTGGAAGTTTCCGGCGCGGATGCCGCCGCGCTTCTCGCCGAGACCTGCCCGCTCGATCCG
ACGATCCTGAAGACGGGCCAGTCGAAATATACGTTCTTCCTCAATGATAATGGCGGCGTGCTGGATGATCTCATCGTCAC
GCGCCTTGGCGAAGACCGTTTCATGGTTGTTGCCAATGCGGGCAATGCCGATGCCGACATCGAGCATCTCAATGAAGCCG
CGTCGGGCAAGGCCGTAAAGGTTAATCCGCTCGACCGTGTTTTCCTTGCTTTGCAGGGGCCGGAAGCAGAAGCTGTCATC
ACCGATGCCGGTCTGCCGGGCGCCGATCTTGCCTTCATGAGCGGTTTCGAGCCGAAACAGAGCTGGTTCATGACCCGTTC
GGGCTATACCGGCGAAGACGGTTTCGAGATTGGCCTGCCTGCCGATGAAGCCCGTGCGCTGGCCGAAAAGCTTCTTGCCG
ATGAACGTGTCGAATGGATCGGCCTTGCCGCCCGCGATTCCTTACGCCTCGAAGCGGGCCTCTGCCTGCACGGTCAGGAC
ATCACGCCGGAAACCGATCCGGTTTCGGCTGGCCTCACCTGGGCGATCACCAAGGCTGTGCGCGAAAAAGCCGCCTTCAA
CGGCGCGAAAGCCGTTCTCGACGCCATTGCCAAAGGCGCCAGCGCCAAGCGCGTCGGCCTCAAGCCGGAAGGCCGCCAGC
CGGTGCGCGCCGGGGCCGACCTTTTCGACGAAAGTGGCCGCCAGATCGGCACCGTCACCTCGGGCGGCTTTGGCCCTTCC
GCCGGTTTCCCGGTCGCCATGGGCTATGTCGAGGCAAGCCTCGCCACCCCCGGCACCCGTGTTTTTGCAGATGTTCGCGG
CAACAAGGTTCCCGTTGACGTCCACGCACTTCCCTTCACACCGCATCGCTATCGCAAAGGATGA

Upstream 100 bases:

>100_bases
ATGGCTTTATATATAGCCATGCGAGTCTCTCAGGCCTGAGACAGAGGGGCACGAACCAACCGCATTTTGCGGAAGGCATA
CGTGCGTCTCTGGAGTTGTT

Downstream 100 bases:

>100_bases
TTTCCATGGCCAATATCCTGTTCACCGAAGATCATGAGTGGATCAACGTCGAAAACGGCGTTGCCACGGTTGGCATCACG
ATCCACGCACAGGAACAGCT

Product: glycine cleavage system aminomethyltransferase T

Products: NA

Alternate protein names: Glycine cleavage system T protein [H]

Number of amino acids: Translated: 367; Mature: 366

Protein sequence:

>367_residues
MGDTAHLNTLPLQDLHEKAGARFGGFAGWNMPTTYPLGVMKEHLHTRDHAGLFDISHMKLVEVSGADAAALLAETCPLDP
TILKTGQSKYTFFLNDNGGVLDDLIVTRLGEDRFMVVANAGNADADIEHLNEAASGKAVKVNPLDRVFLALQGPEAEAVI
TDAGLPGADLAFMSGFEPKQSWFMTRSGYTGEDGFEIGLPADEARALAEKLLADERVEWIGLAARDSLRLEAGLCLHGQD
ITPETDPVSAGLTWAITKAVREKAAFNGAKAVLDAIAKGASAKRVGLKPEGRQPVRAGADLFDESGRQIGTVTSGGFGPS
AGFPVAMGYVEASLATPGTRVFADVRGNKVPVDVHALPFTPHRYRKG

Sequences:

>Translated_367_residues
MGDTAHLNTLPLQDLHEKAGARFGGFAGWNMPTTYPLGVMKEHLHTRDHAGLFDISHMKLVEVSGADAAALLAETCPLDP
TILKTGQSKYTFFLNDNGGVLDDLIVTRLGEDRFMVVANAGNADADIEHLNEAASGKAVKVNPLDRVFLALQGPEAEAVI
TDAGLPGADLAFMSGFEPKQSWFMTRSGYTGEDGFEIGLPADEARALAEKLLADERVEWIGLAARDSLRLEAGLCLHGQD
ITPETDPVSAGLTWAITKAVREKAAFNGAKAVLDAIAKGASAKRVGLKPEGRQPVRAGADLFDESGRQIGTVTSGGFGPS
AGFPVAMGYVEASLATPGTRVFADVRGNKVPVDVHALPFTPHRYRKG
>Mature_366_residues
GDTAHLNTLPLQDLHEKAGARFGGFAGWNMPTTYPLGVMKEHLHTRDHAGLFDISHMKLVEVSGADAAALLAETCPLDPT
ILKTGQSKYTFFLNDNGGVLDDLIVTRLGEDRFMVVANAGNADADIEHLNEAASGKAVKVNPLDRVFLALQGPEAEAVIT
DAGLPGADLAFMSGFEPKQSWFMTRSGYTGEDGFEIGLPADEARALAEKLLADERVEWIGLAARDSLRLEAGLCLHGQDI
TPETDPVSAGLTWAITKAVREKAAFNGAKAVLDAIAKGASAKRVGLKPEGRQPVRAGADLFDESGRQIGTVTSGGFGPSA
GFPVAMGYVEASLATPGTRVFADVRGNKVPVDVHALPFTPHRYRKG

Specific function: The glycine cleavage system catalyzes the degradation of glycine [H]

COG id: COG0404

COG function: function code E; Glycine cleavage system T protein (aminomethyltransferase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvT family [H]

Homologues:

Organism=Homo sapiens, GI44662838, Length=370, Percent_Identity=40.2702702702703, Blast_Score=246, Evalue=3e-65,
Organism=Homo sapiens, GI257796258, Length=351, Percent_Identity=40.4558404558405, Blast_Score=233, Evalue=2e-61,
Organism=Homo sapiens, GI257796254, Length=365, Percent_Identity=37.2602739726027, Blast_Score=201, Evalue=7e-52,
Organism=Homo sapiens, GI257796256, Length=315, Percent_Identity=39.6825396825397, Blast_Score=194, Evalue=7e-50,
Organism=Homo sapiens, GI24797151, Length=350, Percent_Identity=24.8571428571429, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI197927446, Length=323, Percent_Identity=23.5294117647059, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI21361378, Length=323, Percent_Identity=23.5294117647059, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI1789272, Length=355, Percent_Identity=33.2394366197183, Blast_Score=156, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI17560118, Length=375, Percent_Identity=38.9333333333333, Blast_Score=223, Evalue=1e-58,
Organism=Caenorhabditis elegans, GI32563613, Length=314, Percent_Identity=26.7515923566879, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI71994052, Length=373, Percent_Identity=23.3243967828418, Blast_Score=68, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI71994045, Length=373, Percent_Identity=23.3243967828418, Blast_Score=68, Evalue=9e-12,
Organism=Saccharomyces cerevisiae, GI6320222, Length=386, Percent_Identity=35.4922279792746, Blast_Score=206, Evalue=3e-54,
Organism=Drosophila melanogaster, GI20129441, Length=371, Percent_Identity=39.3530997304582, Blast_Score=244, Evalue=6e-65,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013977
- InterPro:   IPR006222
- InterPro:   IPR006223
- InterPro:   IPR022903 [H]

Pfam domain/function: PF01571 GCV_T; PF08669 GCV_T_C [H]

EC number: =2.1.2.10 [H]

Molecular weight: Translated: 38914; Mature: 38783

Theoretical pI: Translated: 5.26; Mature: 5.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGDTAHLNTLPLQDLHEKAGARFGGFAGWNMPTTYPLGVMKEHLHTRDHAGLFDISHMKL
CCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCEEEECCEEE
VEVSGADAAALLAETCPLDPTILKTGQSKYTFFLNDNGGVLDDLIVTRLGEDRFMVVANA
EEECCCCHHHHHHHHCCCCHHHEECCCCEEEEEECCCCCHHHHHHHHHCCCCEEEEEEEC
GNADADIEHLNEAASGKAVKVNPLDRVFLALQGPEAEAVITDAGLPGADLAFMSGFEPKQ
CCCCCHHHHHHHHHCCCEEEECCCCEEEEEEECCCCCEEEEECCCCCCCHHHHCCCCCHH
SWFMTRSGYTGEDGFEIGLPADEARALAEKLLADERVEWIGLAARDSLRLEAGLCLHGQD
HEEEEECCCCCCCCEEECCCHHHHHHHHHHHHHHCCCCEEEEECCCCEEEECCEEEECCC
ITPETDPVSAGLTWAITKAVREKAAFNGAKAVLDAIAKGASAKRVGLKPEGRQPVRAGAD
CCCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHH
LFDESGRQIGTVTSGGFGPSAGFPVAMGYVEASLATPGTRVFADVRGNKVPVDVHALPFT
HHHHCCCEEEEEECCCCCCCCCCCEEEHEEEHHCCCCCCEEEEECCCCCCEEEEEECCCC
PHRYRKG
CHHCCCC
>Mature Secondary Structure 
GDTAHLNTLPLQDLHEKAGARFGGFAGWNMPTTYPLGVMKEHLHTRDHAGLFDISHMKL
CCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCEEEECCEEE
VEVSGADAAALLAETCPLDPTILKTGQSKYTFFLNDNGGVLDDLIVTRLGEDRFMVVANA
EEECCCCHHHHHHHHCCCCHHHEECCCCEEEEEECCCCCHHHHHHHHHCCCCEEEEEEEC
GNADADIEHLNEAASGKAVKVNPLDRVFLALQGPEAEAVITDAGLPGADLAFMSGFEPKQ
CCCCCHHHHHHHHHCCCEEEECCCCEEEEEEECCCCCEEEEECCCCCCCHHHHCCCCCHH
SWFMTRSGYTGEDGFEIGLPADEARALAEKLLADERVEWIGLAARDSLRLEAGLCLHGQD
HEEEEECCCCCCCCEEECCCHHHHHHHHHHHHHHCCCCEEEEECCCCEEEECCEEEECCC
ITPETDPVSAGLTWAITKAVREKAAFNGAKAVLDAIAKGASAKRVGLKPEGRQPVRAGAD
CCCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHH
LFDESGRQIGTVTSGGFGPSAGFPVAMGYVEASLATPGTRVFADVRGNKVPVDVHALPFT
HHHHCCCEEEEEECCCCCCCCCCCEEEHEEEHHCCCCCCEEEEECCCCCCEEEEEECCCC
PHRYRKG
CHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA