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The map label for this gene is ubiH [C]

Identifier: 225686358

GI number: 225686358

Start: 531611

End: 532969

Strand: Direct

Name: ubiH [C]

Synonym: BMEA_B0546

Alternate gene names: 225686358

Gene position: 531611-532969 (Clockwise)

Preceding gene: 225686353

Following gene: 225686359

Centisome position: 44.84

GC content: 61.96

Gene sequence:

>1359_bases
TTGATCGCAATTTGGTTTAAGTGCGGCGGAAACGCATCTGGCAAGAATCGCTTTTGCTGCCAGTATCAAGAGCGGCGGCT
TCACCCGAAACCGCCATGGCCGAGGATGAGCGCGATGAATGACGTGGTTGTAAACAAGCCCCTCACCGACATTGTTATCA
GTGGCGGCGGCCCGGCCGGCATGATGGCGGCGCTGGCGCTTGGGGTCCGCGGCTACCATACCGTGCTGCTCGGCCCCGAA
ACCGACAAGACCGACCGGCGCACCACCGCACTGATGATGCCCGCGATCCGTTTTCTGGAGCAGATCGGCGTCTGGGCTGC
GATCGAGCCGGAAGCGGCTCCCTTGCAATCCATGCGCATCGTGGATGCAACCAGGCGCCTTATCCGCAGCCCTGCGGTCA
TGTTCCGTGCGAGCGAGATTGATGAGATTGCCTTCGGCTACAACATCCCCAACGCCGTGCTGAATGCAAAGCTTGCCGAA
GCGGTCGCGGCCAGTCGCAATATCCGGCGCATCACTGTCCCGGCCATCGAATATCGCCCCAATGGCGACCATGTCACCGT
GACGCTCAAGGGGGGCGATACGCTGCACACACGCCTGTTGGTCGCCGCCGACGGGCGCAATTCCGGTGCGCGCGACGCCG
CTGGCATCCGCACCCGCCGCTGGAGCTATCCGCAAACGGCCGTGGTTCTTTCCTTTTCCCATATGATTGACCACGAGAAT
ATTTCGACCGAATTTCACACCGAAGAAGGCCCGTTTACACAAGTGCCGCTCAAGGGGCGGCGATCAAGCCTCGTCTGGGT
GGTTAATCCGGCGCGCGCCGAAAAGCTGCTTTCAATGAGCGATGAGGCTCTTGCGGTCCATATCGAGGAGATGATGCAAT
CCATGCTGGGCAAGATCACGCTGGAGGTGCGCCCGCAAGCCTGGCCGCTTTCCGGCCTCGTGCCCCATGTCTTTGCAGCA
AAGCGCACCATCCTGATCGGCGAAGCTGCCCATGTCTTTCCGCCCATCGGCGCGCAAGGGCTGAACCTTGGCACACGCGA
CGTGGAAACACTGGTAAAGGCCATTGAGAGCGATTCGGTCGATCCCGGTTCCGAGCGTGTCATGCGCGCTTATGACCGCG
CGCGGCGTCCCGATATTTTCGCGCGTACCGGCTCGGTCGATGCGCTCAACCGCTCGCTGCTTTCCTCCATGCTGCCTGCG
CAGATCCTGCGCGGTGTAGGGCTGGAAATGCTTCGCTCCTTTGCGCCGCTGCGCGCGTTCTTCATGCGCGAGGGCCTTCG
CCCCGGCAGCGGTTTTTCGCACCTTCTGCCCCGGCTCCCGCGTCTGCCCGGCAAAGCTGACGACGCCGCAAGACAATAG

Upstream 100 bases:

>100_bases
TCTAAAAAGCCGCAATGTTCCATCAGCTTTCACCGAATAAGGCCAAAAGAGCAAGTAAGCCATAGGGTATTAAGCCGTCA
TTCCACGGAAGATTGGCCTT

Downstream 100 bases:

>100_bases
ATCTCTCACCCTGACAGTTTTCCTGCCTGCCGACGACTTTAATTCGCCGTACAATGAACTACATTAATTCCCATGGGTAT
GGCACAGATAAAACACGCAA

Product: 2-octaprenyl-6-methoxyphenyl hydroxylase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 452; Mature: 452

Protein sequence:

>452_residues
MIAIWFKCGGNASGKNRFCCQYQERRLHPKPPWPRMSAMNDVVVNKPLTDIVISGGGPAGMMAALALGVRGYHTVLLGPE
TDKTDRRTTALMMPAIRFLEQIGVWAAIEPEAAPLQSMRIVDATRRLIRSPAVMFRASEIDEIAFGYNIPNAVLNAKLAE
AVAASRNIRRITVPAIEYRPNGDHVTVTLKGGDTLHTRLLVAADGRNSGARDAAGIRTRRWSYPQTAVVLSFSHMIDHEN
ISTEFHTEEGPFTQVPLKGRRSSLVWVVNPARAEKLLSMSDEALAVHIEEMMQSMLGKITLEVRPQAWPLSGLVPHVFAA
KRTILIGEAAHVFPPIGAQGLNLGTRDVETLVKAIESDSVDPGSERVMRAYDRARRPDIFARTGSVDALNRSLLSSMLPA
QILRGVGLEMLRSFAPLRAFFMREGLRPGSGFSHLLPRLPRLPGKADDAARQ

Sequences:

>Translated_452_residues
MIAIWFKCGGNASGKNRFCCQYQERRLHPKPPWPRMSAMNDVVVNKPLTDIVISGGGPAGMMAALALGVRGYHTVLLGPE
TDKTDRRTTALMMPAIRFLEQIGVWAAIEPEAAPLQSMRIVDATRRLIRSPAVMFRASEIDEIAFGYNIPNAVLNAKLAE
AVAASRNIRRITVPAIEYRPNGDHVTVTLKGGDTLHTRLLVAADGRNSGARDAAGIRTRRWSYPQTAVVLSFSHMIDHEN
ISTEFHTEEGPFTQVPLKGRRSSLVWVVNPARAEKLLSMSDEALAVHIEEMMQSMLGKITLEVRPQAWPLSGLVPHVFAA
KRTILIGEAAHVFPPIGAQGLNLGTRDVETLVKAIESDSVDPGSERVMRAYDRARRPDIFARTGSVDALNRSLLSSMLPA
QILRGVGLEMLRSFAPLRAFFMREGLRPGSGFSHLLPRLPRLPGKADDAARQ
>Mature_452_residues
MIAIWFKCGGNASGKNRFCCQYQERRLHPKPPWPRMSAMNDVVVNKPLTDIVISGGGPAGMMAALALGVRGYHTVLLGPE
TDKTDRRTTALMMPAIRFLEQIGVWAAIEPEAAPLQSMRIVDATRRLIRSPAVMFRASEIDEIAFGYNIPNAVLNAKLAE
AVAASRNIRRITVPAIEYRPNGDHVTVTLKGGDTLHTRLLVAADGRNSGARDAAGIRTRRWSYPQTAVVLSFSHMIDHEN
ISTEFHTEEGPFTQVPLKGRRSSLVWVVNPARAEKLLSMSDEALAVHIEEMMQSMLGKITLEVRPQAWPLSGLVPHVFAA
KRTILIGEAAHVFPPIGAQGLNLGTRDVETLVKAIESDSVDPGSERVMRAYDRARRPDIFARTGSVDALNRSLLSSMLPA
QILRGVGLEMLRSFAPLRAFFMREGLRPGSGFSHLLPRLPRLPGKADDAARQ

Specific function: Oxygenase That Introduces The Hydroxyl Group At Carbon Four Of 2-Octaprenyl-6-Methoxyphenol Resulting In The Formation Of 2-Octaprenyl-6-Methoxy-1,4-Benzoquinone. [C]

COG id: COG0654

COG function: function code HC; 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ubiH/COQ6 family [H]

Homologues:

Organism=Homo sapiens, GI32967305, Length=425, Percent_Identity=26.1176470588235, Blast_Score=112, Evalue=5e-25,
Organism=Homo sapiens, GI32967307, Length=340, Percent_Identity=28.2352941176471, Blast_Score=110, Evalue=3e-24,
Organism=Escherichia coli, GI1789274, Length=387, Percent_Identity=31.266149870801, Blast_Score=142, Evalue=3e-35,
Organism=Escherichia coli, GI1786883, Length=381, Percent_Identity=29.9212598425197, Blast_Score=142, Evalue=4e-35,
Organism=Escherichia coli, GI1789273, Length=397, Percent_Identity=25.4408060453401, Blast_Score=123, Evalue=2e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002938
- InterPro:   IPR003042
- InterPro:   IPR018168
- InterPro:   IPR010971 [H]

Pfam domain/function: PF01494 FAD_binding_3 [H]

EC number: 1.14.13.-

Molecular weight: Translated: 49666; Mature: 49666

Theoretical pI: Translated: 10.50; Mature: 10.50

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIAIWFKCGGNASGKNRFCCQYQERRLHPKPPWPRMSAMNDVVVNKPLTDIVISGGGPAG
CEEEEEEECCCCCCCCCEEEEHHHCCCCCCCCCCCHHHCCHHHCCCCCHHEEEECCCCHH
MMAALALGVRGYHTVLLGPETDKTDRRTTALMMPAIRFLEQIGVWAAIEPEAAPLQSMRI
HHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHH
VDATRRLIRSPAVMFRASEIDEIAFGYNIPNAVLNAKLAEAVAASRNIRRITVPAIEYRP
HHHHHHHHHCCHHEEECCCHHHHHCCCCCCHHHHHHHHHHHHHHCCCCEEEEECEEEECC
NGDHVTVTLKGGDTLHTRLLVAADGRNSGARDAAGIRTRRWSYPQTAVVLSFSHMIDHEN
CCCEEEEEECCCCEEEEEEEEEECCCCCCCCCCCCCCCCCCCCCCCEEEEEHHHHHCCCC
ISTEFHTEEGPFTQVPLKGRRSSLVWVVNPARAEKLLSMSDEALAVHIEEMMQSMLGKIT
CCCEEECCCCCEEECCCCCCCCCEEEEECHHHHHHHHHCCCHHHHHHHHHHHHHHHCCEE
LEVRPQAWPLSGLVPHVFAAKRTILIGEAAHVFPPIGAQGLNLGTRDVETLVKAIESDSV
EEECCCCCCCCCCHHHHHHHCCEEEEECHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCC
DPGSERVMRAYDRARRPDIFARTGSVDALNRSLLSSMLPAQILRGVGLEMLRSFAPLRAF
CCCHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
FMREGLRPGSGFSHLLPRLPRLPGKADDAARQ
HHHCCCCCCCCHHHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure
MIAIWFKCGGNASGKNRFCCQYQERRLHPKPPWPRMSAMNDVVVNKPLTDIVISGGGPAG
CEEEEEEECCCCCCCCCEEEEHHHCCCCCCCCCCCHHHCCHHHCCCCCHHEEEECCCCHH
MMAALALGVRGYHTVLLGPETDKTDRRTTALMMPAIRFLEQIGVWAAIEPEAAPLQSMRI
HHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHH
VDATRRLIRSPAVMFRASEIDEIAFGYNIPNAVLNAKLAEAVAASRNIRRITVPAIEYRP
HHHHHHHHHCCHHEEECCCHHHHHCCCCCCHHHHHHHHHHHHHHCCCCEEEEECEEEECC
NGDHVTVTLKGGDTLHTRLLVAADGRNSGARDAAGIRTRRWSYPQTAVVLSFSHMIDHEN
CCCEEEEEECCCCEEEEEEEEEECCCCCCCCCCCCCCCCCCCCCCCEEEEEHHHHHCCCC
ISTEFHTEEGPFTQVPLKGRRSSLVWVVNPARAEKLLSMSDEALAVHIEEMMQSMLGKIT
CCCEEECCCCCEEECCCCCCCCCEEEEECHHHHHHHHHCCCHHHHHHHHHHHHHHHCCEE
LEVRPQAWPLSGLVPHVFAAKRTILIGEAAHVFPPIGAQGLNLGTRDVETLVKAIESDSV
EEECCCCCCCCCCHHHHHHHCCEEEEECHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCC
DPGSERVMRAYDRARRPDIFARTGSVDALNRSLLSSMLPAQILRGVGLEMLRSFAPLRAF
CCCHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
FMREGLRPGSGFSHLLPRLPRLPGKADDAARQ
HHHCCCCCCCCHHHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]