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The map label for this gene is serA [H]

Identifier: 225686257

GI number: 225686257

Start: 422108

End: 423352

Strand: Direct

Name: serA [H]

Synonym: BMEA_B0432

Alternate gene names: 225686257

Gene position: 422108-423352 (Clockwise)

Preceding gene: 225686256

Following gene: 225686260

Centisome position: 35.61

GC content: 57.11

Gene sequence:

>1245_bases
ATGACCGAACGCCTCTCCCTCTCCCTCTCCCGTGATCGCATCAATGTTCTTCTTCTGGAAGGCATCAGCCAGACCGCCGT
GGAATATTTCAAATCCTCCGGCTACACCAATGTCACACATCTGCCGAAAGCATTGGACAAGGCCGATCTGATCAAGGCGA
TTTCTTCTGCGCATATCATCGGCATTCGCTCGCGTACGCAATTGACCGAGGAGATTTTCGCCGCTGCCGACCGTCTGATC
GCAGTCGGCTGCTTTTCGGTCGGCACCAATCAGGTGGAACTGAAAGCTGCCCGCAAGCGCGGTATCCCCGTCTTCAATGC
GCCATTCTCCAACACGCGCTCGGTTGCCGAACTGGTGATTGGCGAGATCATCATGCTGATGCGCCGCATTTTCCCGCGTT
CCGTTTCAGCCCATGCGGGTGGCTGGGAAAAGACAGCCATCGGAAGCTGCGAAGTGCGCGGCAAGACGCTCGGCATCGTC
GGCTACGGCAATATCGGCTCGCAGGTCGGCAATCTGGCTGAAAGCCTCGGTATGACCGTGCGTTATTACGACACGTCCGA
CAAGCTGCAATATGGCAATGTGAAGCCTGCGGCGAGCCTTGATGAACTTCTGAAAACTTCCGATGTGGTGAGTCTGCACG
TCCCGTCGAGCAAATCCACCTCGAAGCTCATCACCGAAGCCAAGCTGCGCAAGATGAAGAAGGGCGCTTTCCTCATCAAT
AATGCGCGCGGTTCCGTTGTCGATCTCGAAGCCTTGGCCAAGGTTTTGCAGGAGGGTCATCTTGCGGGCGCGGCGATCGA
TGTTTTCCCTGTGGAGCCGGCCTCCAATGGCGAGAGGTTCTCAACCCCGCTTCAGGGGCTGGAGAATGTCATTCTCACGC
CGCATATCGGCGGCTCGACCGAGGAAGCGCAGGAACGTATCGGTACGGAAGTCACCCGCAAGCTGGTCGAATATTCCGAT
GTCGGCTCCACTGTGAGCGCCGTCAATTTTCCGCAGGTGCAATTGCCGCCACGCCCGACCGGCACGCGCTTCATGCATGT
GCATGAAAACCGTCCGGGTATTCTGAACAGCCTCATGAACGTGTTTTCGCACCACCATATCAATATCGCCAGCCAGTTTC
TCCAGACGGATGGCGAGGTTGGCTATCTCGTGATGGAAGCCGATGGCGTGGGCGAAGCAAGCGATGCCGTCTTGCAGGAA
ATCCGCGAAATTCCCGGCACGATTCGCGCTCGCCTGCTATACTGA

Upstream 100 bases:

>100_bases
CGCCAGATTGGCTCGATACGAAACATAGTGTTGACGTCGGCTTTGCGTTCATTCATGTCGTAAACCGACCATCCGCCGTT
TCAGCCTGGAAACTCCCAAA

Downstream 100 bases:

>100_bases
TGAAAGACCGGAGCGGCCCGGTTCAACGGGCTGCTCCTTTCACTTCAGCATCTTATCGCTGTAGCTTCTCATAGCGCTTT
ATGAGGCGCTCCCTCCTGAG

Product: D-3-phosphoglycerate dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 414; Mature: 413

Protein sequence:

>414_residues
MTERLSLSLSRDRINVLLLEGISQTAVEYFKSSGYTNVTHLPKALDKADLIKAISSAHIIGIRSRTQLTEEIFAAADRLI
AVGCFSVGTNQVELKAARKRGIPVFNAPFSNTRSVAELVIGEIIMLMRRIFPRSVSAHAGGWEKTAIGSCEVRGKTLGIV
GYGNIGSQVGNLAESLGMTVRYYDTSDKLQYGNVKPAASLDELLKTSDVVSLHVPSSKSTSKLITEAKLRKMKKGAFLIN
NARGSVVDLEALAKVLQEGHLAGAAIDVFPVEPASNGERFSTPLQGLENVILTPHIGGSTEEAQERIGTEVTRKLVEYSD
VGSTVSAVNFPQVQLPPRPTGTRFMHVHENRPGILNSLMNVFSHHHINIASQFLQTDGEVGYLVMEADGVGEASDAVLQE
IREIPGTIRARLLY

Sequences:

>Translated_414_residues
MTERLSLSLSRDRINVLLLEGISQTAVEYFKSSGYTNVTHLPKALDKADLIKAISSAHIIGIRSRTQLTEEIFAAADRLI
AVGCFSVGTNQVELKAARKRGIPVFNAPFSNTRSVAELVIGEIIMLMRRIFPRSVSAHAGGWEKTAIGSCEVRGKTLGIV
GYGNIGSQVGNLAESLGMTVRYYDTSDKLQYGNVKPAASLDELLKTSDVVSLHVPSSKSTSKLITEAKLRKMKKGAFLIN
NARGSVVDLEALAKVLQEGHLAGAAIDVFPVEPASNGERFSTPLQGLENVILTPHIGGSTEEAQERIGTEVTRKLVEYSD
VGSTVSAVNFPQVQLPPRPTGTRFMHVHENRPGILNSLMNVFSHHHINIASQFLQTDGEVGYLVMEADGVGEASDAVLQE
IREIPGTIRARLLY
>Mature_413_residues
TERLSLSLSRDRINVLLLEGISQTAVEYFKSSGYTNVTHLPKALDKADLIKAISSAHIIGIRSRTQLTEEIFAAADRLIA
VGCFSVGTNQVELKAARKRGIPVFNAPFSNTRSVAELVIGEIIMLMRRIFPRSVSAHAGGWEKTAIGSCEVRGKTLGIVG
YGNIGSQVGNLAESLGMTVRYYDTSDKLQYGNVKPAASLDELLKTSDVVSLHVPSSKSTSKLITEAKLRKMKKGAFLINN
ARGSVVDLEALAKVLQEGHLAGAAIDVFPVEPASNGERFSTPLQGLENVILTPHIGGSTEEAQERIGTEVTRKLVEYSDV
GSTVSAVNFPQVQLPPRPTGTRFMHVHENRPGILNSLMNVFSHHHINIASQFLQTDGEVGYLVMEADGVGEASDAVLQEI
REIPGTIRARLLY

Specific function: Serine biosynthesis; first step. [C]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=287, Percent_Identity=36.9337979094077, Blast_Score=174, Evalue=1e-43,
Organism=Homo sapiens, GI145580578, Length=261, Percent_Identity=34.4827586206897, Blast_Score=129, Evalue=4e-30,
Organism=Homo sapiens, GI4557499, Length=261, Percent_Identity=34.4827586206897, Blast_Score=129, Evalue=4e-30,
Organism=Homo sapiens, GI61743967, Length=260, Percent_Identity=33.4615384615385, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI4557497, Length=260, Percent_Identity=33.4615384615385, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI145580575, Length=262, Percent_Identity=34.3511450381679, Blast_Score=126, Evalue=3e-29,
Organism=Homo sapiens, GI6912396, Length=238, Percent_Identity=28.5714285714286, Blast_Score=86, Evalue=9e-17,
Organism=Escherichia coli, GI1789279, Length=408, Percent_Identity=55.3921568627451, Blast_Score=464, Evalue=1e-132,
Organism=Escherichia coli, GI87082289, Length=248, Percent_Identity=31.8548387096774, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI1787645, Length=258, Percent_Identity=27.906976744186, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1788660, Length=268, Percent_Identity=30.9701492537313, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI87081824, Length=194, Percent_Identity=26.2886597938144, Blast_Score=69, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17532191, Length=322, Percent_Identity=34.1614906832298, Blast_Score=166, Evalue=3e-41,
Organism=Caenorhabditis elegans, GI25147481, Length=236, Percent_Identity=32.2033898305085, Blast_Score=109, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6322116, Length=419, Percent_Identity=44.6300715990453, Blast_Score=366, Evalue=1e-102,
Organism=Saccharomyces cerevisiae, GI6320925, Length=419, Percent_Identity=43.9140811455847, Blast_Score=363, Evalue=1e-101,
Organism=Saccharomyces cerevisiae, GI6324055, Length=256, Percent_Identity=27.734375, Blast_Score=97, Evalue=6e-21,
Organism=Saccharomyces cerevisiae, GI6324964, Length=253, Percent_Identity=30.4347826086957, Blast_Score=95, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6325144, Length=156, Percent_Identity=30.1282051282051, Blast_Score=74, Evalue=6e-14,
Organism=Saccharomyces cerevisiae, GI6324980, Length=127, Percent_Identity=31.496062992126, Blast_Score=68, Evalue=3e-12,
Organism=Drosophila melanogaster, GI19921140, Length=306, Percent_Identity=31.0457516339869, Blast_Score=144, Evalue=1e-34,
Organism=Drosophila melanogaster, GI24646446, Length=260, Percent_Identity=35, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI24646448, Length=260, Percent_Identity=35, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI24646452, Length=260, Percent_Identity=35, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI24646450, Length=260, Percent_Identity=35, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI62472511, Length=260, Percent_Identity=35, Blast_Score=124, Evalue=2e-28,
Organism=Drosophila melanogaster, GI28574286, Length=268, Percent_Identity=28.7313432835821, Blast_Score=109, Evalue=3e-24,
Organism=Drosophila melanogaster, GI28571528, Length=308, Percent_Identity=25.6493506493506, Blast_Score=106, Evalue=3e-23,
Organism=Drosophila melanogaster, GI45551003, Length=248, Percent_Identity=27.4193548387097, Blast_Score=99, Evalue=6e-21,
Organism=Drosophila melanogaster, GI45552429, Length=248, Percent_Identity=27.4193548387097, Blast_Score=99, Evalue=6e-21,
Organism=Drosophila melanogaster, GI24585514, Length=248, Percent_Identity=27.4193548387097, Blast_Score=99, Evalue=6e-21,
Organism=Drosophila melanogaster, GI28574282, Length=248, Percent_Identity=27.4193548387097, Blast_Score=99, Evalue=6e-21,
Organism=Drosophila melanogaster, GI28574284, Length=248, Percent_Identity=27.4193548387097, Blast_Score=99, Evalue=6e-21,
Organism=Drosophila melanogaster, GI24585516, Length=240, Percent_Identity=25.8333333333333, Blast_Score=83, Evalue=3e-16,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR010771
- InterPro:   IPR016040
- ProDom:   PD147088 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 44843; Mature: 44712

Theoretical pI: Translated: 8.24; Mature: 8.24

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1 ; PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTERLSLSLSRDRINVLLLEGISQTAVEYFKSSGYTNVTHLPKALDKADLIKAISSAHII
CCCCEEEEECCCCEEEEEECCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCEEE
GIRSRTQLTEEIFAAADRLIAVGCFSVGTNQVELKAARKRGIPVFNAPFSNTRSVAELVI
EECHHHHHHHHHHHHHHHHHEEEEHHCCCCCEEEHHHHHCCCCEEECCCCCHHHHHHHHH
GEIIMLMRRIFPRSVSAHAGGWEKTAIGSCEVRGKTLGIVGYGNIGSQVGNLAESLGMTV
HHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEECCCEEEEEEECCHHHHHHHHHHHHCCEE
RYYDTSDKLQYGNVKPAASLDELLKTSDVVSLHVPSSKSTSKLITEAKLRKMKKGAFLIN
EEECCCCCEECCCCCCCHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHHCCCEEEE
NARGSVVDLEALAKVLQEGHLAGAAIDVFPVEPASNGERFSTPLQGLENVILTPHIGGST
CCCCCEEEHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCCHHHHHHCEEECCCCCCCH
EEAQERIGTEVTRKLVEYSDVGSTVSAVNFPQVQLPPRPTGTRFMHVHENRPGILNSLMN
HHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCEEECCCCCCCCEEEEEECCCCHHHHHHHH
VFSHHHINIASQFLQTDGEVGYLVMEADGVGEASDAVLQEIREIPGTIRARLLY
HHHCCCHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHHHHHCCHHHHHEECC
>Mature Secondary Structure 
TERLSLSLSRDRINVLLLEGISQTAVEYFKSSGYTNVTHLPKALDKADLIKAISSAHII
CCCEEEEECCCCEEEEEECCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCEEE
GIRSRTQLTEEIFAAADRLIAVGCFSVGTNQVELKAARKRGIPVFNAPFSNTRSVAELVI
EECHHHHHHHHHHHHHHHHHEEEEHHCCCCCEEEHHHHHCCCCEEECCCCCHHHHHHHHH
GEIIMLMRRIFPRSVSAHAGGWEKTAIGSCEVRGKTLGIVGYGNIGSQVGNLAESLGMTV
HHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEECCCEEEEEEECCHHHHHHHHHHHHCCEE
RYYDTSDKLQYGNVKPAASLDELLKTSDVVSLHVPSSKSTSKLITEAKLRKMKKGAFLIN
EEECCCCCEECCCCCCCHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHHCCCEEEE
NARGSVVDLEALAKVLQEGHLAGAAIDVFPVEPASNGERFSTPLQGLENVILTPHIGGST
CCCCCEEEHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCCHHHHHHCEEECCCCCCCH
EEAQERIGTEVTRKLVEYSDVGSTVSAVNFPQVQLPPRPTGTRFMHVHENRPGILNSLMN
HHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCEEECCCCCCCCEEEEEECCCCHHHHHHHH
VFSHHHINIASQFLQTDGEVGYLVMEADGVGEASDAVLQEIREIPGTIRARLLY
HHHCCCHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHHHHHCCHHHHHEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]