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The map label for this gene is hemL [H]

Identifier: 225686241

GI number: 225686241

Start: 401125

End: 402486

Strand: Direct

Name: hemL [H]

Synonym: BMEA_B0412

Alternate gene names: 225686241

Gene position: 401125-402486 (Clockwise)

Preceding gene: 225686239

Following gene: 225686242

Centisome position: 33.84

GC content: 58.66

Gene sequence:

>1362_bases
ATGAACCTTTTCACATCGCAGTTTCGCAATTCGCAATTGCTGGCCAGCAAGGCCCATGCGCTCATTCCCGGCGGGTGCCA
TACCTATGCCAAGGGAGACGATCAGTATCCGGTGCTTGCGCCGGGTTTCATCCAGCGCGGCTCAGGCGCCCATGTCTTCG
ACGTGGATGGCCACGAATATATCGAATATGGGATGGGAAACCGCGCCGTCGGCCTCGGCCATGCCTATCCGCCGGTGGTG
CGAGCCGTACGCGAGGCCTTGCAGGATGGCTGCAATTTTACCCGGCCAAGTGCTATCGAACTCGACTGCGCGGAAAGCTT
TCTCGAACTGATTGAGGGGGCGGAAATGGTCAAATTCTGCAAGGACGGCTCGGATGCGACTTCCGGCGCGCTTCGCCTTG
CCCGCGCCTATACAGGGCGTGACATGGTGGCCTGCTGCGCCGACCATCCCTTCTTTTCGACCGACGACTGGTTCATTGGC
ACCACGAAGATGAGCGCAGGCATTCCCGCGTCGGTTTCTGCGCTCACCGCGACGTTTCGCTATAATGATATTGCCAGTGT
CGAGGCGCTTTTCGAGGACTATCCGGGGTGCATCGCCGCCATCATCATGGAGCCGGCGCGCGCAGACGAGCCGCAAGACA
ATTTTCTCCATGAAGCCATGCGCATTGCCCATGAAAACGGTGCACTTTTCATTCTGGATGAAATGATTACCGGCTTTCGC
TGGCATATGCGCGGCGCGCAGAAGCTTTATGGTATCGTGCCGGACCTTTCCTGTTTCGGAAAGGCGCTCGGCAATGGCTT
TGCCATTTCTGCGCTCGCGGGCAAGGCCGAATATATGCGGCTTGGCGGGCTTCACCATACGGATTTCCCCCGCGTCTTTC
TGCTTTCCACGACGCATGGGGCGGAAACCCATGCCATGGCCGCGGCGATTGCCACTATGGCGATCTATCGCGATGAGCCG
GTGATCGAGCGTCTTTATGAACAAGGTGCGAAGCTTGCCGCAGGCATAAACGAGGCTATTGCCGGTCATCGGCTTCAGGA
TCATGTGCGCCTATCGGGGCGGCCTTGTTGCCTCACCTATTCCACGCTGGATGGAAACGGAATGCCTTCGCAGGCATTTC
GCACCCTTTTCCTTCAGGAAACAATCCGGCGCGGCGTGCTGATGCCCTCGCTGGTTGTGAGCTACACGCATAGCGATGCC
GATATTGCCCGCACCATCGATGCGGTTCACGGTGCGCTCGGCATCTATGTGCGGGCGCTCAATGACGGCGTGGAGTCCTG
TCTGGTCGGGCGGCCGTCGCAGGTTGTCTATCGCCGTTTCAACGAAGATCCGGCTTCCTCATGCCCACCGCCAAGATTGT
AA

Upstream 100 bases:

>100_bases
CCGGTCAAGAACTGGCTGCGCCGCGTGCGGGAGCGCGTGCACACGGTATGGTCGACGGCCTGAGCGGCCGCTCTCGAAAA
AGCGTTTGAAGGATTTTGTT

Downstream 100 bases:

>100_bases
GAGGCATAGCCCTTTTTCTTCTGGCTTTTGCCATGACGGGCGGGGCGCGCGCAATTGCGGCCGATACGCAATTTCCGCTT
CAGGTGAGCGGGGATCGGCA

Product: glutamate-1-semialdehyde 2,1-aminomutase

Products: NA

Alternate protein names: GSA; Glutamate-1-semialdehyde aminotransferase; GSA-AT [H]

Number of amino acids: Translated: 453; Mature: 453

Protein sequence:

>453_residues
MNLFTSQFRNSQLLASKAHALIPGGCHTYAKGDDQYPVLAPGFIQRGSGAHVFDVDGHEYIEYGMGNRAVGLGHAYPPVV
RAVREALQDGCNFTRPSAIELDCAESFLELIEGAEMVKFCKDGSDATSGALRLARAYTGRDMVACCADHPFFSTDDWFIG
TTKMSAGIPASVSALTATFRYNDIASVEALFEDYPGCIAAIIMEPARADEPQDNFLHEAMRIAHENGALFILDEMITGFR
WHMRGAQKLYGIVPDLSCFGKALGNGFAISALAGKAEYMRLGGLHHTDFPRVFLLSTTHGAETHAMAAAIATMAIYRDEP
VIERLYEQGAKLAAGINEAIAGHRLQDHVRLSGRPCCLTYSTLDGNGMPSQAFRTLFLQETIRRGVLMPSLVVSYTHSDA
DIARTIDAVHGALGIYVRALNDGVESCLVGRPSQVVYRRFNEDPASSCPPPRL

Sequences:

>Translated_453_residues
MNLFTSQFRNSQLLASKAHALIPGGCHTYAKGDDQYPVLAPGFIQRGSGAHVFDVDGHEYIEYGMGNRAVGLGHAYPPVV
RAVREALQDGCNFTRPSAIELDCAESFLELIEGAEMVKFCKDGSDATSGALRLARAYTGRDMVACCADHPFFSTDDWFIG
TTKMSAGIPASVSALTATFRYNDIASVEALFEDYPGCIAAIIMEPARADEPQDNFLHEAMRIAHENGALFILDEMITGFR
WHMRGAQKLYGIVPDLSCFGKALGNGFAISALAGKAEYMRLGGLHHTDFPRVFLLSTTHGAETHAMAAAIATMAIYRDEP
VIERLYEQGAKLAAGINEAIAGHRLQDHVRLSGRPCCLTYSTLDGNGMPSQAFRTLFLQETIRRGVLMPSLVVSYTHSDA
DIARTIDAVHGALGIYVRALNDGVESCLVGRPSQVVYRRFNEDPASSCPPPRL
>Mature_453_residues
MNLFTSQFRNSQLLASKAHALIPGGCHTYAKGDDQYPVLAPGFIQRGSGAHVFDVDGHEYIEYGMGNRAVGLGHAYPPVV
RAVREALQDGCNFTRPSAIELDCAESFLELIEGAEMVKFCKDGSDATSGALRLARAYTGRDMVACCADHPFFSTDDWFIG
TTKMSAGIPASVSALTATFRYNDIASVEALFEDYPGCIAAIIMEPARADEPQDNFLHEAMRIAHENGALFILDEMITGFR
WHMRGAQKLYGIVPDLSCFGKALGNGFAISALAGKAEYMRLGGLHHTDFPRVFLLSTTHGAETHAMAAAIATMAIYRDEP
VIERLYEQGAKLAAGINEAIAGHRLQDHVRLSGRPCCLTYSTLDGNGMPSQAFRTLFLQETIRRGVLMPSLVVSYTHSDA
DIARTIDAVHGALGIYVRALNDGVESCLVGRPSQVVYRRFNEDPASSCPPPRL

Specific function: Porphyrin biosynthesis by the C5 pathway; second step. [C]

COG id: COG0001

COG function: function code H; Glutamate-1-semialdehyde aminotransferase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786349, Length=349, Percent_Identity=36.9627507163324, Blast_Score=179, Evalue=4e-46,
Organism=Escherichia coli, GI1788044, Length=276, Percent_Identity=32.9710144927536, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1787560, Length=383, Percent_Identity=26.8929503916449, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI145693181, Length=315, Percent_Identity=26.984126984127, Blast_Score=76, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004639
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =5.4.3.8 [H]

Molecular weight: Translated: 49235; Mature: 49235

Theoretical pI: Translated: 6.16; Mature: 6.16

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLFTSQFRNSQLLASKAHALIPGGCHTYAKGDDQYPVLAPGFIQRGSGAHVFDVDGHEY
CCCCHHHHCCCHHHHHHCCEECCCCCCCCCCCCCCCCEECCHHHCCCCCCEEEECCCHHH
IEYGMGNRAVGLGHAYPPVVRAVREALQDGCNFTRPSAIELDCAESFLELIEGAEMVKFC
HHHCCCCCEEECCCCCHHHHHHHHHHHHCCCCCCCCCCEEHHHHHHHHHHHCCHHHHHHH
KDGSDATSGALRLARAYTGRDMVACCADHPFFSTDDWFIGTTKMSAGIPASVSALTATFR
CCCCCCHHHHHHHHHHHCCCCHHHECCCCCCCCCCCCEEEEECCCCCCCCHHHHHEEEHC
YNDIASVEALFEDYPGCIAAIIMEPARADEPQDNFLHEAMRIAHENGALFILDEMITGFR
CCCHHHHHHHHHHCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCEEEEHHHHHHHH
WHMRGAQKLYGIVPDLSCFGKALGNGFAISALAGKAEYMRLGGLHHTDFPRVFLLSTTHG
HHHHHHHHHHHCCCCHHHHHHHHCCCEEEEHHHCCHHHHHHCCCCCCCCCEEEEEECCCC
AETHAMAAAIATMAIYRDEPVIERLYEQGAKLAAGINEAIAGHRLQDHVRLSGRPCCLTY
CHHHHHHHHHHHHHHHCCCHHHHHHHHCCHHHHHHHHHHHHCCHHHHHHEECCCCEEEEE
STLDGNGMPSQAFRTLFLQETIRRGVLMPSLVVSYTHSDADIARTIDAVHGALGIYVRAL
EECCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHEECCCCHHHHHHHHHHHHHHHHHHHHH
NDGVESCLVGRPSQVVYRRFNEDPASSCPPPRL
HHHHHHHHCCCCHHHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure
MNLFTSQFRNSQLLASKAHALIPGGCHTYAKGDDQYPVLAPGFIQRGSGAHVFDVDGHEY
CCCCHHHHCCCHHHHHHCCEECCCCCCCCCCCCCCCCEECCHHHCCCCCCEEEECCCHHH
IEYGMGNRAVGLGHAYPPVVRAVREALQDGCNFTRPSAIELDCAESFLELIEGAEMVKFC
HHHCCCCCEEECCCCCHHHHHHHHHHHHCCCCCCCCCCEEHHHHHHHHHHHCCHHHHHHH
KDGSDATSGALRLARAYTGRDMVACCADHPFFSTDDWFIGTTKMSAGIPASVSALTATFR
CCCCCCHHHHHHHHHHHCCCCHHHECCCCCCCCCCCCEEEEECCCCCCCCHHHHHEEEHC
YNDIASVEALFEDYPGCIAAIIMEPARADEPQDNFLHEAMRIAHENGALFILDEMITGFR
CCCHHHHHHHHHHCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCEEEEHHHHHHHH
WHMRGAQKLYGIVPDLSCFGKALGNGFAISALAGKAEYMRLGGLHHTDFPRVFLLSTTHG
HHHHHHHHHHHCCCCHHHHHHHHCCCEEEEHHHCCHHHHHHCCCCCCCCCEEEEEECCCC
AETHAMAAAIATMAIYRDEPVIERLYEQGAKLAAGINEAIAGHRLQDHVRLSGRPCCLTY
CHHHHHHHHHHHHHHHCCCHHHHHHHHCCHHHHHHHHHHHHCCHHHHHHEECCCCEEEEE
STLDGNGMPSQAFRTLFLQETIRRGVLMPSLVVSYTHSDADIARTIDAVHGALGIYVRAL
EECCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHEECCCCHHHHHHHHHHHHHHHHHHHHH
NDGVESCLVGRPSQVVYRRFNEDPASSCPPPRL
HHHHHHHHCCCCHHHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA