Click here to switch to the map view.

The map label for this gene is tmk [H]

Identifier: 225630910

GI number: 225630910

Start: 1317062

End: 1317700

Strand: Direct

Name: tmk [H]

Synonym: WRi_012260

Alternate gene names: 225630910

Gene position: 1317062-1317700 (Clockwise)

Preceding gene: 225630907

Following gene: 225630915

Centisome position: 91.09

GC content: 31.77

Gene sequence:

>639_bases
ATGTATACTGTTTGCATATTCTTTTTTAGTATTATAATTATAAAACTTATGTTCATAACTTTCGAAGGAATAGACGGCTC
TGGTAAAACAACACAATCTAAGCTACTTGCAAATCATTTTAAGCAAATTCACGGCGAAAATAATGTGGTATTGACTCGAG
AACCAGGTGGCACTAACTTTGCAGAAAAGATAAGAGGAGTGTTGTTAACGAATAATATTGATCCTATTTCTGAACTCTTG
CTACTTATTTCGATGAGGCGCGAACATATGAAAAAATTAATATTACCAGCTCTTGCAGAAGGAAAAATAGTGATTTGTGA
TCGGTTTATTGATTCAACTATTGCATACCAAGGATATGGGCTTAGTGTTGATTTAGGGCTAATAAGGGACTTACATAAGT
TAGTAGAAATTAAATGTCCAGATATTACATTTATTCTAGATATTGATGTTAAAGTTGGGTTAAATAGAGCAAAAGACAAG
AATAAATATGAAGAAATGGATGTTAATTTTTACAATAAGGTCAGAAAAGGATTTCAGGAAATAGCCATAAAAGAGCCCGT
TAGGTGCAGTGTTATCACTGGAATTGAAACAAAAAATGATAATCACGTACACAATGAAATTATTGATAAAATCACCTAG

Upstream 100 bases:

>100_bases
TAAAACTAAAATCGACTTTAGGAGTATTCAGAGCAACCATAGACTATTATTATACCACATGTAATTTACGGTCTTATTAT
TTAAATGTCAAACGGTTTCT

Downstream 100 bases:

>100_bases
CTTGTGATAGAAAATTATCAATTTCAGGTAACATTATTTCATATGAATAACTTTTTGTTTGAGTAGCTAAAAAATCCTGT
ATTTTGTCTGGATCTTCTTC

Product: thymidylate kinase

Products: NA

Alternate protein names: dTMP kinase [H]

Number of amino acids: Translated: 212; Mature: 212

Protein sequence:

>212_residues
MYTVCIFFFSIIIIKLMFITFEGIDGSGKTTQSKLLANHFKQIHGENNVVLTREPGGTNFAEKIRGVLLTNNIDPISELL
LLISMRREHMKKLILPALAEGKIVICDRFIDSTIAYQGYGLSVDLGLIRDLHKLVEIKCPDITFILDIDVKVGLNRAKDK
NKYEEMDVNFYNKVRKGFQEIAIKEPVRCSVITGIETKNDNHVHNEIIDKIT

Sequences:

>Translated_212_residues
MYTVCIFFFSIIIIKLMFITFEGIDGSGKTTQSKLLANHFKQIHGENNVVLTREPGGTNFAEKIRGVLLTNNIDPISELL
LLISMRREHMKKLILPALAEGKIVICDRFIDSTIAYQGYGLSVDLGLIRDLHKLVEIKCPDITFILDIDVKVGLNRAKDK
NKYEEMDVNFYNKVRKGFQEIAIKEPVRCSVITGIETKNDNHVHNEIIDKIT
>Mature_212_residues
MYTVCIFFFSIIIIKLMFITFEGIDGSGKTTQSKLLANHFKQIHGENNVVLTREPGGTNFAEKIRGVLLTNNIDPISELL
LLISMRREHMKKLILPALAEGKIVICDRFIDSTIAYQGYGLSVDLGLIRDLHKLVEIKCPDITFILDIDVKVGLNRAKDK
NKYEEMDVNFYNKVRKGFQEIAIKEPVRCSVITGIETKNDNHVHNEIIDKIT

Specific function: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis [H]

COG id: COG0125

COG function: function code F; Thymidylate kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidylate kinase family [H]

Homologues:

Organism=Escherichia coli, GI1787340, Length=179, Percent_Identity=35.195530726257, Blast_Score=103, Evalue=9e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018095
- InterPro:   IPR018094 [H]

Pfam domain/function: PF02223 Thymidylate_kin [H]

EC number: =2.7.4.9 [H]

Molecular weight: Translated: 24110; Mature: 24110

Theoretical pI: Translated: 7.98; Mature: 7.98

Prosite motif: PS01331 THYMIDYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYTVCIFFFSIIIIKLMFITFEGIDGSGKTTQSKLLANHFKQIHGENNVVLTREPGGTNF
CCHHHHHHHHHHHHHHHHHHEECCCCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCCH
AEKIRGVLLTNNIDPISELLLLISMRREHMKKLILPALAEGKIVICDRFIDSTIAYQGYG
HHHHCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHCCCCC
LSVDLGLIRDLHKLVEIKCPDITFILDIDVKVGLNRAKDKNKYEEMDVNFYNKVRKGFQE
CEEHHHHHHHHHHHHHCCCCCEEEEEEEEEEECCCCCCCCCHHHHHCHHHHHHHHHHHHH
IAIKEPVRCSVITGIETKNDNHVHNEIIDKIT
HHHCCCCEEEEEECCCCCCCCHHHHHHHHHCC
>Mature Secondary Structure
MYTVCIFFFSIIIIKLMFITFEGIDGSGKTTQSKLLANHFKQIHGENNVVLTREPGGTNF
CCHHHHHHHHHHHHHHHHHHEECCCCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCCH
AEKIRGVLLTNNIDPISELLLLISMRREHMKKLILPALAEGKIVICDRFIDSTIAYQGYG
HHHHCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHCCCCC
LSVDLGLIRDLHKLVEIKCPDITFILDIDVKVGLNRAKDKNKYEEMDVNFYNKVRKGFQE
CEEHHHHHHHHHHHHHCCCCCEEEEEEEEEEECCCCCCCCCHHHHHCHHHHHHHHHHHHH
IAIKEPVRCSVITGIETKNDNHVHNEIIDKIT
HHHCCCCEEEEEECCCCCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA