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The map label for this gene is ispA [C]

Identifier: 225630859

GI number: 225630859

Start: 1256005

End: 1256796

Strand: Reverse

Name: ispA [C]

Synonym: WRi_011650

Alternate gene names: 225630859

Gene position: 1256796-1256005 (Counterclockwise)

Preceding gene: 225630866

Following gene: 225630858

Centisome position: 86.92

GC content: 37.37

Gene sequence:

>792_bases
ATGCTAGACGAAACAACAAAAAATTTGCTTATTGTAGAAGTAAATAAACTCTTACCCGAAAATAGCGAGAATAAGCTTAT
ATCAGCTATGCGTTATATACTCCTTGCTCCTGCAAAACATATACGCTCCTTTTTAGTCGTAGCTTCATCGCGAGTGTTTA
ACGCGGAAGCTAAAAAAGTAATATCAGTTGCTGCAGCAATTGAATTTGTTCATGCTTACTCTCTAATTCACGATGATTTA
CCGTGCATGGACAACAGTGATACTCGCAGAAGCCAGCTAAGCTGCCATAAAAAATTTGATGAAGCAACAGCAGTGCTTGC
CGGAGATGCACTACTTACTCTGGCTTTTGAGGTATTATCTTCGTTAAATGAGAAACGCTGTGAGATCATAAAAGTGCTCT
CTCAAGCAATAGGAATTAGGGGAATGGTGGGAGGACAGGCTTTAGATATTGACACAGATTTTAACAAAATAAAAGAAATT
CATTTGATGAAAACCGCAAAACTATTTGCAGCTTCATGTGAAATAGGTGCTATAATAGGGGGTGCTACAGATGAACAACG
GAGAGCGTTATATAACTTCGGGATAAACCTAGGGCTTATCTTTCAAGCTAAGGATGATATTGAAGACTACGAACAAGATA
AAACAAATAACCTAATGTCTGTGCTTGGTAAAAGTGAAGTAGAGGACTATATAGACGGCCTCTTTAAACAAGGCTTGGAT
AATTTGAGTGCGCTTTCAGGGGATACTAATTATTTATATGATTTATTGAATCAAGTAAAGAAAGATGGTTAG

Upstream 100 bases:

>100_bases
TTTTATGTTTGCAATATCTTTTATAACTGGTAAACTACAGTAAAGTTTTCTACTGCCCTAGCTGGCTAGCGTTACGTGCT
AAACAATTAACAATTCAAAA

Downstream 100 bases:

>100_bases
AAAAATTATATTACAAATGCTTATTTCCGTAGTAATGATTCTCACTTTAACTTCTGCTTTTGTGTTTACTATTGTCTATA
TAAACAAAGGTAAACCGGAA

Product: Geranylgeranyl pyrophosphate synthase

Products: NA

Alternate protein names: FPP synthase; (2E,6E)-farnesyl diphosphate synthase; Geranyltranstransferase [H]

Number of amino acids: Translated: 263; Mature: 263

Protein sequence:

>263_residues
MLDETTKNLLIVEVNKLLPENSENKLISAMRYILLAPAKHIRSFLVVASSRVFNAEAKKVISVAAAIEFVHAYSLIHDDL
PCMDNSDTRRSQLSCHKKFDEATAVLAGDALLTLAFEVLSSLNEKRCEIIKVLSQAIGIRGMVGGQALDIDTDFNKIKEI
HLMKTAKLFAASCEIGAIIGGATDEQRRALYNFGINLGLIFQAKDDIEDYEQDKTNNLMSVLGKSEVEDYIDGLFKQGLD
NLSALSGDTNYLYDLLNQVKKDG

Sequences:

>Translated_263_residues
MLDETTKNLLIVEVNKLLPENSENKLISAMRYILLAPAKHIRSFLVVASSRVFNAEAKKVISVAAAIEFVHAYSLIHDDL
PCMDNSDTRRSQLSCHKKFDEATAVLAGDALLTLAFEVLSSLNEKRCEIIKVLSQAIGIRGMVGGQALDIDTDFNKIKEI
HLMKTAKLFAASCEIGAIIGGATDEQRRALYNFGINLGLIFQAKDDIEDYEQDKTNNLMSVLGKSEVEDYIDGLFKQGLD
NLSALSGDTNYLYDLLNQVKKDG
>Mature_263_residues
MLDETTKNLLIVEVNKLLPENSENKLISAMRYILLAPAKHIRSFLVVASSRVFNAEAKKVISVAAAIEFVHAYSLIHDDL
PCMDNSDTRRSQLSCHKKFDEATAVLAGDALLTLAFEVLSSLNEKRCEIIKVLSQAIGIRGMVGGQALDIDTDFNKIKEI
HLMKTAKLFAASCEIGAIIGGATDEQRRALYNFGINLGLIFQAKDDIEDYEQDKTNNLMSVLGKSEVEDYIDGLFKQGLD
NLSALSGDTNYLYDLLNQVKKDG

Specific function: Unknown

COG id: COG0142

COG function: function code H; Geranylgeranyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FPP/GGPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI50659086, Length=208, Percent_Identity=29.8076923076923, Blast_Score=71, Evalue=1e-12,
Organism=Escherichia coli, GI1786623, Length=220, Percent_Identity=41.3636363636364, Blast_Score=130, Evalue=6e-32,
Organism=Escherichia coli, GI1789578, Length=220, Percent_Identity=32.2727272727273, Blast_Score=110, Evalue=8e-26,
Organism=Caenorhabditis elegans, GI17505681, Length=153, Percent_Identity=31.3725490196078, Blast_Score=71, Evalue=6e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000092
- InterPro:   IPR017446
- InterPro:   IPR008949 [H]

Pfam domain/function: PF00348 polyprenyl_synt [H]

EC number: =2.5.1.10 [H]

Molecular weight: Translated: 29049; Mature: 29049

Theoretical pI: Translated: 4.92; Mature: 4.92

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDETTKNLLIVEVNKLLPENSENKLISAMRYILLAPAKHIRSFLVVASSRVFNAEAKKV
CCCCCCCCEEEEEEHHHCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
ISVAAAIEFVHAYSLIHDDLPCMDNSDTRRSQLSCHKKFDEATAVLAGDALLTLAFEVLS
HHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SLNEKRCEIIKVLSQAIGIRGMVGGQALDIDTDFNKIKEIHLMKTAKLFAASCEIGAIIG
HHCHHHHHHHHHHHHHHCCCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHCCHHHEEC
GATDEQRRALYNFGINLGLIFQAKDDIEDYEQDKTNNLMSVLGKSEVEDYIDGLFKQGLD
CCCCHHHHHHHHCCCCEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHH
NLSALSGDTNYLYDLLNQVKKDG
HHHHCCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure
MLDETTKNLLIVEVNKLLPENSENKLISAMRYILLAPAKHIRSFLVVASSRVFNAEAKKV
CCCCCCCCEEEEEEHHHCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
ISVAAAIEFVHAYSLIHDDLPCMDNSDTRRSQLSCHKKFDEATAVLAGDALLTLAFEVLS
HHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SLNEKRCEIIKVLSQAIGIRGMVGGQALDIDTDFNKIKEIHLMKTAKLFAASCEIGAIIG
HHCHHHHHHHHHHHHHHCCCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHCCHHHEEC
GATDEQRRALYNFGINLGLIFQAKDDIEDYEQDKTNNLMSVLGKSEVEDYIDGLFKQGLD
CCCCHHHHHHHHCCCCEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHH
NLSALSGDTNYLYDLLNQVKKDG
HHHHCCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8486607; 7918490 [H]