Click here to switch to the map view.

The map label for this gene is ndk [H]

Identifier: 225630850

GI number: 225630850

Start: 1247035

End: 1247454

Strand: Reverse

Name: ndk [H]

Synonym: WRi_011560

Alternate gene names: 225630850

Gene position: 1247454-1247035 (Counterclockwise)

Preceding gene: 225630854

Following gene: 225630849

Centisome position: 86.28

GC content: 35.24

Gene sequence:

>420_bases
ATGGCAATTGAGAAGACACTTTCAATATTAAAACCTGATGCAGTAAAAAATAATATTACAGGCAAGATAAATTCATATAT
TGAAAGCTCTGGACTGAAGATTATAGCACAAAAAATGATGTTACTGACAAAAAAACAAGCAGAGCTGTTTTATGAAATTC
ATAAAGATAGGCCTTTTTTTGGGGAATTGGTAGAGTTTATGACTTCTGGTTCTGTGATAGTTCAAGTTTTAGTTGGTGAA
AATGCAGTAAGTAAATACAGACAAATCATGGGAGCTACCAATCCAAAGCAGGCAGATAAAGGCACAATCAGGGGTGATTT
TGCTGATGATATTAGTGAAAATAGAGTCCACGGCTCGGATAGTCTAGAAAATGCTCGTAAGGAGATAGCTTTCTTTTTTG
CTGAATGTGAGTTGGTGTAG

Upstream 100 bases:

>100_bases
TTCATTCTTAACTATAAATAAAAAATCACTTTTATGAAATTAAAATTTATAATAAGATAAATCTATAAATATACTATTTT
ACTTAATATGAGGGAATAAT

Downstream 100 bases:

>100_bases
TTAACTCAGATTGGCGTCATCCAAGTAGCTGACAACATAGAAACGAAAAAACTTACTTGACACCCTTCGCCAGCGCCCTT
ATCATGATAGTGAAGCTATT

Product: nucleoside diphosphate kinase

Products: NA

Alternate protein names: NDK; NDP kinase; Nucleoside-2-P kinase [H]

Number of amino acids: Translated: 139; Mature: 138

Protein sequence:

>139_residues
MAIEKTLSILKPDAVKNNITGKINSYIESSGLKIIAQKMMLLTKKQAELFYEIHKDRPFFGELVEFMTSGSVIVQVLVGE
NAVSKYRQIMGATNPKQADKGTIRGDFADDISENRVHGSDSLENARKEIAFFFAECELV

Sequences:

>Translated_139_residues
MAIEKTLSILKPDAVKNNITGKINSYIESSGLKIIAQKMMLLTKKQAELFYEIHKDRPFFGELVEFMTSGSVIVQVLVGE
NAVSKYRQIMGATNPKQADKGTIRGDFADDISENRVHGSDSLENARKEIAFFFAECELV
>Mature_138_residues
AIEKTLSILKPDAVKNNITGKINSYIESSGLKIIAQKMMLLTKKQAELFYEIHKDRPFFGELVEFMTSGSVIVQVLVGEN
AVSKYRQIMGATNPKQADKGTIRGDFADDISENRVHGSDSLENARKEIAFFFAECELV

Specific function: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate [H]

COG id: COG0105

COG function: function code F; Nucleoside diphosphate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NDK family [H]

Homologues:

Organism=Homo sapiens, GI37693993, Length=138, Percent_Identity=41.304347826087, Blast_Score=120, Evalue=4e-28,
Organism=Homo sapiens, GI66392203, Length=137, Percent_Identity=40.1459854014599, Blast_Score=113, Evalue=6e-26,
Organism=Homo sapiens, GI66392227, Length=137, Percent_Identity=40.1459854014599, Blast_Score=113, Evalue=6e-26,
Organism=Homo sapiens, GI66392205, Length=137, Percent_Identity=40.1459854014599, Blast_Score=113, Evalue=6e-26,
Organism=Homo sapiens, GI4505409, Length=137, Percent_Identity=40.1459854014599, Blast_Score=113, Evalue=6e-26,
Organism=Homo sapiens, GI66392192, Length=137, Percent_Identity=40.1459854014599, Blast_Score=113, Evalue=6e-26,
Organism=Homo sapiens, GI38045913, Length=136, Percent_Identity=41.1764705882353, Blast_Score=111, Evalue=2e-25,
Organism=Homo sapiens, GI4557797, Length=136, Percent_Identity=41.1764705882353, Blast_Score=111, Evalue=2e-25,
Organism=Homo sapiens, GI4826862, Length=136, Percent_Identity=36.7647058823529, Blast_Score=105, Evalue=2e-23,
Organism=Homo sapiens, GI37574614, Length=133, Percent_Identity=36.0902255639098, Blast_Score=95, Evalue=1e-20,
Organism=Homo sapiens, GI7019465, Length=133, Percent_Identity=36.0902255639098, Blast_Score=95, Evalue=2e-20,
Organism=Homo sapiens, GI5031951, Length=138, Percent_Identity=34.7826086956522, Blast_Score=89, Evalue=2e-18,
Organism=Homo sapiens, GI4505413, Length=136, Percent_Identity=30.8823529411765, Blast_Score=76, Evalue=1e-14,
Organism=Homo sapiens, GI148839372, Length=138, Percent_Identity=30.4347826086957, Blast_Score=75, Evalue=1e-14,
Organism=Homo sapiens, GI30023828, Length=135, Percent_Identity=31.1111111111111, Blast_Score=73, Evalue=7e-14,
Organism=Escherichia coli, GI1788866, Length=139, Percent_Identity=53.9568345323741, Blast_Score=163, Evalue=5e-42,
Organism=Caenorhabditis elegans, GI17506807, Length=135, Percent_Identity=41.4814814814815, Blast_Score=118, Evalue=9e-28,
Organism=Saccharomyces cerevisiae, GI6322783, Length=136, Percent_Identity=41.1764705882353, Blast_Score=112, Evalue=2e-26,
Organism=Drosophila melanogaster, GI45549037, Length=136, Percent_Identity=44.8529411764706, Blast_Score=120, Evalue=3e-28,
Organism=Drosophila melanogaster, GI18860097, Length=136, Percent_Identity=32.3529411764706, Blast_Score=79, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001564
- InterPro:   IPR023005 [H]

Pfam domain/function: PF00334 NDK [H]

EC number: =2.7.4.6 [H]

Molecular weight: Translated: 15519; Mature: 15388

Theoretical pI: Translated: 6.53; Mature: 6.53

Prosite motif: PS00469 NDP_KINASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIEKTLSILKPDAVKNNITGKINSYIESSGLKIIAQKMMLLTKKQAELFYEIHKDRPFF
CCHHHHHHHHCCHHHCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
GELVEFMTSGSVIVQVLVGENAVSKYRQIMGATNPKQADKGTIRGDFADDISENRVHGSD
HHHHHHHCCCHHHEEEHHCCHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHCCCCCCCH
SLENARKEIAFFFAECELV
HHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
AIEKTLSILKPDAVKNNITGKINSYIESSGLKIIAQKMMLLTKKQAELFYEIHKDRPFF
CHHHHHHHHCCHHHCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
GELVEFMTSGSVIVQVLVGENAVSKYRQIMGATNPKQADKGTIRGDFADDISENRVHGSD
HHHHHHHCCCHHHEEEHHCCHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHCCCCCCCH
SLENARKEIAFFFAECELV
HHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA