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The map label for this gene is zitB [H]

Identifier: 225630776

GI number: 225630776

Start: 1168279

End: 1169175

Strand: Direct

Name: zitB [H]

Synonym: WRi_010760

Alternate gene names: 225630776

Gene position: 1168279-1169175 (Clockwise)

Preceding gene: 225630775

Following gene: 225630777

Centisome position: 80.8

GC content: 35.01

Gene sequence:

>897_bases
ATGACAGCAGTGCACAACGGCAAACACTCAGCGGCGCAGTCCAAGCGCTTAATCTATTCCATAATAATAGTTGCGATAAC
AATGTTTATGGAAATAGTAGGTGGAATAATTTCACATTCGCTTGCTCTATTGTCAGATGCAGGGCATATGCTTACTGACC
TCTTTGCCTTGGTTTTAAGCTGGTTAGCACATAGGTTTTCAGCTAAGAAATCCGATTTGCAGAGATCATACGGATATCAT
CGGTTGCAGATAATTGCAGCATTTGTTAATGGTTTAACTCTATTCCTCATTGCAGTAATCATTATAATTGAGTCAATAAA
GAGGTTTATTTTTCCAGTCAATGTTGAGTGGAAAGTAATGTTAATAATTGCTACACTCGGTCTTGTCTCTAACATAATAG
TCTTTTTTATATTACATAGTAAATGCGAGAGCAATATAAACATAAAAAGTGCTGTACTACACGTTATAGGAGATATTTTA
GGTTCTGTAGCTGCTATACTTGCATCTATAATTATCATGCTTACTGGATGGCAAATAGTAGATCCAATCTTATCAGTATT
TGTTAGTGTGATAATTCTAAATAGCGGCTATAAAATTCTCAAAAATTCTTGCCATATACTCCTTGAAGGTACGCCTGAGG
GTATATCTGCTGAAGAGATAAAAAGTAAGATCACATCAGAATTACCTGAAGTGATAGATGTGCACCACATACATACATGG
TCGCTGTCTGATAATTATTTTATAATTACCATGCATGCTAAAATAAAGCAAAATGTGCAGCACACCAATGTTTTATATGA
AATAAAAAAAATATTGCTAGATAAGTTCGAGATAGCACACTCTACAGTCGAGATCGAATACGATGAGTGTGCGGATAATA
AGATACTTAAACATTGA

Upstream 100 bases:

>100_bases
TGGGTAATTAGCTCAGTTGGTAGAGCACTTGCTTGACGTGCAAGCGGTCGCTGGTTCGAACCCAGTGTTACCCACGTTTT
TGTTCATGAAAAGATTTTAT

Downstream 100 bases:

>100_bases
CGTTTTAAATTATTATGCTATTACTAGAGTGTAATGATGTTGAAGGTAAGCTATGATAGGTATTTCTCAAATACAATTTC
CTTCAAAGGATTCTAGTAAG

Product: cation efflux family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 298; Mature: 297

Protein sequence:

>298_residues
MTAVHNGKHSAAQSKRLIYSIIIVAITMFMEIVGGIISHSLALLSDAGHMLTDLFALVLSWLAHRFSAKKSDLQRSYGYH
RLQIIAAFVNGLTLFLIAVIIIIESIKRFIFPVNVEWKVMLIIATLGLVSNIIVFFILHSKCESNINIKSAVLHVIGDIL
GSVAAILASIIIMLTGWQIVDPILSVFVSVIILNSGYKILKNSCHILLEGTPEGISAEEIKSKITSELPEVIDVHHIHTW
SLSDNYFIITMHAKIKQNVQHTNVLYEIKKILLDKFEIAHSTVEIEYDECADNKILKH

Sequences:

>Translated_298_residues
MTAVHNGKHSAAQSKRLIYSIIIVAITMFMEIVGGIISHSLALLSDAGHMLTDLFALVLSWLAHRFSAKKSDLQRSYGYH
RLQIIAAFVNGLTLFLIAVIIIIESIKRFIFPVNVEWKVMLIIATLGLVSNIIVFFILHSKCESNINIKSAVLHVIGDIL
GSVAAILASIIIMLTGWQIVDPILSVFVSVIILNSGYKILKNSCHILLEGTPEGISAEEIKSKITSELPEVIDVHHIHTW
SLSDNYFIITMHAKIKQNVQHTNVLYEIKKILLDKFEIAHSTVEIEYDECADNKILKH
>Mature_297_residues
TAVHNGKHSAAQSKRLIYSIIIVAITMFMEIVGGIISHSLALLSDAGHMLTDLFALVLSWLAHRFSAKKSDLQRSYGYHR
LQIIAAFVNGLTLFLIAVIIIIESIKRFIFPVNVEWKVMLIIATLGLVSNIIVFFILHSKCESNINIKSAVLHVIGDILG
SVAAILASIIIMLTGWQIVDPILSVFVSVIILNSGYKILKNSCHILLEGTPEGISAEEIKSKITSELPEVIDVHHIHTWS
LSDNYFIITMHAKIKQNVQHTNVLYEIKKILLDKFEIAHSTVEIEYDECADNKILKH

Specific function: Involved in zinc efflux across the cytoplasmic membrane, thus reducing zinc accumulation in the cytoplasm and rendering bacteria more resistant to zinc. It may contribute to zinc homeostasis at low concentrations of zinc [H]

COG id: COG1230

COG function: function code P; Co/Zn/Cd efflux system component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily [H]

Homologues:

Organism=Homo sapiens, GI289803013, Length=292, Percent_Identity=28.4246575342466, Blast_Score=134, Evalue=1e-31,
Organism=Homo sapiens, GI289803009, Length=292, Percent_Identity=28.4246575342466, Blast_Score=134, Evalue=1e-31,
Organism=Homo sapiens, GI289803007, Length=292, Percent_Identity=28.4246575342466, Blast_Score=134, Evalue=1e-31,
Organism=Homo sapiens, GI289803003, Length=292, Percent_Identity=28.4246575342466, Blast_Score=134, Evalue=1e-31,
Organism=Homo sapiens, GI64762489, Length=293, Percent_Identity=28.3276450511945, Blast_Score=133, Evalue=2e-31,
Organism=Homo sapiens, GI21361112, Length=300, Percent_Identity=25.6666666666667, Blast_Score=131, Evalue=6e-31,
Organism=Homo sapiens, GI52352805, Length=298, Percent_Identity=27.8523489932886, Blast_Score=130, Evalue=1e-30,
Organism=Homo sapiens, GI20070323, Length=315, Percent_Identity=26.6666666666667, Blast_Score=124, Evalue=8e-29,
Organism=Homo sapiens, GI21359890, Length=300, Percent_Identity=26.6666666666667, Blast_Score=123, Evalue=3e-28,
Organism=Homo sapiens, GI14210520, Length=222, Percent_Identity=26.5765765765766, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI52351208, Length=136, Percent_Identity=33.8235294117647, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI222080086, Length=129, Percent_Identity=33.3333333333333, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI40255009, Length=129, Percent_Identity=33.3333333333333, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI52352803, Length=126, Percent_Identity=32.5396825396825, Blast_Score=65, Evalue=7e-11,
Organism=Escherichia coli, GI1786966, Length=279, Percent_Identity=42.6523297491039, Blast_Score=217, Evalue=8e-58,
Organism=Caenorhabditis elegans, GI193210990, Length=299, Percent_Identity=26.7558528428094, Blast_Score=140, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI17555796, Length=307, Percent_Identity=27.0358306188925, Blast_Score=138, Evalue=4e-33,
Organism=Caenorhabditis elegans, GI17555794, Length=311, Percent_Identity=27.3311897106109, Blast_Score=137, Evalue=5e-33,
Organism=Caenorhabditis elegans, GI32564488, Length=308, Percent_Identity=27.2727272727273, Blast_Score=108, Evalue=3e-24,
Organism=Saccharomyces cerevisiae, GI6320411, Length=179, Percent_Identity=32.9608938547486, Blast_Score=84, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6324892, Length=127, Percent_Identity=34.6456692913386, Blast_Score=79, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6323899, Length=126, Percent_Identity=30.952380952381, Blast_Score=77, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24583858, Length=315, Percent_Identity=27.3015873015873, Blast_Score=120, Evalue=8e-28,
Organism=Drosophila melanogaster, GI24585900, Length=139, Percent_Identity=28.0575539568345, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24585898, Length=139, Percent_Identity=28.0575539568345, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24585896, Length=139, Percent_Identity=28.0575539568345, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI19921672, Length=139, Percent_Identity=28.0575539568345, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24584409, Length=143, Percent_Identity=30.0699300699301, Blast_Score=75, Evalue=5e-14,
Organism=Drosophila melanogaster, GI28574430, Length=143, Percent_Identity=30.0699300699301, Blast_Score=75, Evalue=8e-14,
Organism=Drosophila melanogaster, GI24645863, Length=105, Percent_Identity=36.1904761904762, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24656728, Length=130, Percent_Identity=33.8461538461538, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24656724, Length=130, Percent_Identity=33.8461538461538, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24656720, Length=130, Percent_Identity=33.8461538461538, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24656715, Length=130, Percent_Identity=33.8461538461538, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI21357035, Length=130, Percent_Identity=33.8461538461538, Blast_Score=73, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002524 [H]

Pfam domain/function: PF01545 Cation_efflux [H]

EC number: NA

Molecular weight: Translated: 33282; Mature: 33151

Theoretical pI: Translated: 7.52; Mature: 7.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAVHNGKHSAAQSKRLIYSIIIVAITMFMEIVGGIISHSLALLSDAGHMLTDLFALVLS
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHH
WLAHRFSAKKSDLQRSYGYHRLQIIAAFVNGLTLFLIAVIIIIESIKRFIFPVNVEWKVM
HHHHHHHCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHH
LIIATLGLVSNIIVFFILHSKCESNINIKSAVLHVIGDILGSVAAILASIIIMLTGWQIV
HHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHH
DPILSVFVSVIILNSGYKILKNSCHILLEGTPEGISAEEIKSKITSELPEVIDVHHIHTW
HHHHHHHHHHHHHCCCHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHEEEE
SLSDNYFIITMHAKIKQNVQHTNVLYEIKKILLDKFEIAHSTVEIEYDECADNKILKH
EECCCEEEEEEEHHHHHCHHHHHHHHHHHHHHHHHHHHHHHEEEEEHHHCCCCCCCCC
>Mature Secondary Structure 
TAVHNGKHSAAQSKRLIYSIIIVAITMFMEIVGGIISHSLALLSDAGHMLTDLFALVLS
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHH
WLAHRFSAKKSDLQRSYGYHRLQIIAAFVNGLTLFLIAVIIIIESIKRFIFPVNVEWKVM
HHHHHHHCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHH
LIIATLGLVSNIIVFFILHSKCESNINIKSAVLHVIGDILGSVAAILASIIIMLTGWQIV
HHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHH
DPILSVFVSVIILNSGYKILKNSCHILLEGTPEGISAEEIKSKITSELPEVIDVHHIHTW
HHHHHHHHHHHHHCCCHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHEEEE
SLSDNYFIITMHAKIKQNVQHTNVLYEIKKILLDKFEIAHSTVEIEYDECADNKILKH
EECCCEEEEEEEHHHHHCHHHHHHHHHHHHHHHHHHHHHHHEEEEEHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]