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The map label for this gene is pepQ [H]

Identifier: 225630671

GI number: 225630671

Start: 1029724

End: 1031391

Strand: Reverse

Name: pepQ [H]

Synonym: WRi_009590

Alternate gene names: 225630671

Gene position: 1031391-1029724 (Counterclockwise)

Preceding gene: 225630672

Following gene: 225630670

Centisome position: 71.33

GC content: 34.89

Gene sequence:

>1668_bases
ATGTCAAAAATCGAAGAATTTCGTTCTTTTATGCACGAGATAAACGTTGATGCATTTATGTTGCATACTAAAGATGAATA
TTTAAATGAGTATTCAGAGGAGCTAACAAAGCTGTGTGGCTTTACAGGAACAAATGGGCTACTTATCGTTACAAAAGACA
ACAAGTGCCCATTTTTTACGGATGGACGCTATATCACACAAGCTCGCAATCAGCTCGATCGGGGCAATTTTCAAGTATAT
AATATACAAGAAGAGGATCCACGCGAATGGATAAAAGCAAACTTAACATCGACTGCCTCACTAGGTTATTATTTGCAATA
TTTTACCATAGAAGATATAAGAAAGTATGAGAATATCTGTAAATTAATACCCTGTTTAGCTGGAAAAAAAAGTGACTATC
GAAAACAAGCAGTGGTTTTACATTCTATTGAACATGCTGGTGAAAGTAGTAAGGACAAATGTGAAAAAGTCGCTAAAAGT
ATAGATAAAGAAGCTGAAGCAGTGCTTTTAACTGATCCAAATTCAATTTCATGGTTATTAAATTTAAGAAACGAAAATGC
TAAATATACTCCATGTATATTGGGTCGTGCTATATTGTATAAAAGCGGTAATGTTGATTTGTTTATTCAAGATAAAGAAC
ATTCAACTATAGAAGCAAATTTAGGCAATCATATAAATATTTTTGATATTAGTGAGCTAGAAAATTCGCTGCACAAGCTA
AATTCAATAGTCATGGATCCAAGCACAACTCCAATGAGTATCATGGCTGTAATAAAAGATAAACAGGTAGCTGAGAGAGA
AGATCCTTGTCTAATTTATAAAGCAGCAAAAAACCAAACTGAAATAGCTGGGGCTATAAATGCGCATATCAGAGATGGAG
TGGCAGTTACAAATTTTCTATATTGGCTTGAAAATAATGTTGGTACAGAACTTGAAGCTGAAGAAAAGATTTTAGAATAC
AGAAAAGAGCAGAATTTGTTTAAGCAACTAAGTTTTCCAACAATTTCAGCATTTAATGAGAATGGAGCAATAATTCACTA
TCGTGCAAGCAGTAAGACGAATAAAGTAATTCAGAAAGATGGACTGTATTTGATTGACTCTGGTGGCCAGTACCTTGACG
GCACAACTGATGTGACAAAAACTGTAGCAATTGGCAATCCAACTGATGAACAAATAACCCACTATACAATAGTACTCAAA
GCTCACATTGCTATAGCAAGTGTCATCTTTCCTCCTGGCACTACTGGTGGAGAATTGGATATATTAGCACGTACGCATTT
ATGGAAATTTGGAATGGACTATATGCATGGTACAGGGCATGGAGTAGGAAGTTACCTATCAGTACACGAAGGACCACAAG
CAATATCAAAGGGAAATAAAGTGAAACTCACGCCAGGCATGATACTATCCAACGAACCTGGCTATTACATTCCGGGAGAG
TATGGAATAAGGATTGAAAATCTGATGTATGTTGATAAACATAAAAATGGTTTCTTGGGATTTAAACAACTAACCTCTAT
TCCATATGATAGAAGGCTAATAAGTGTGCAAATGCTTACTAAGGATGAAATTGAATGGATAAATGGCTACCATCAATTTG
TCTATAAAAACTTAGAAAATAGCGTCAAAGATAAGGAGTGGTTAAAGAAAGTATGTGACCCTTTATAA

Upstream 100 bases:

>100_bases
AGCAAATACAAGGCATCACTCCCGCAGCGATAGTGAGCATATTAGTGTATTTGAGAAACAGGAAAACGAAAGTGGCTGCT
AATTTTGTATGAGGTGTTCT

Downstream 100 bases:

>100_bases
GCAAAGGAGCATTTTTTATTATTTAAAAAGTATTAATGCAATTGTGACAGGTATTTTGTATTGTTTTTAATTTTAAAATA
ATATATAATAAAGGACACGT

Product: aminopeptidase P

Products: NA

Alternate protein names: X-Pro dipeptidase; Imidodipeptidase; Proline dipeptidase; Prolidase [H]

Number of amino acids: Translated: 555; Mature: 554

Protein sequence:

>555_residues
MSKIEEFRSFMHEINVDAFMLHTKDEYLNEYSEELTKLCGFTGTNGLLIVTKDNKCPFFTDGRYITQARNQLDRGNFQVY
NIQEEDPREWIKANLTSTASLGYYLQYFTIEDIRKYENICKLIPCLAGKKSDYRKQAVVLHSIEHAGESSKDKCEKVAKS
IDKEAEAVLLTDPNSISWLLNLRNENAKYTPCILGRAILYKSGNVDLFIQDKEHSTIEANLGNHINIFDISELENSLHKL
NSIVMDPSTTPMSIMAVIKDKQVAEREDPCLIYKAAKNQTEIAGAINAHIRDGVAVTNFLYWLENNVGTELEAEEKILEY
RKEQNLFKQLSFPTISAFNENGAIIHYRASSKTNKVIQKDGLYLIDSGGQYLDGTTDVTKTVAIGNPTDEQITHYTIVLK
AHIAIASVIFPPGTTGGELDILARTHLWKFGMDYMHGTGHGVGSYLSVHEGPQAISKGNKVKLTPGMILSNEPGYYIPGE
YGIRIENLMYVDKHKNGFLGFKQLTSIPYDRRLISVQMLTKDEIEWINGYHQFVYKNLENSVKDKEWLKKVCDPL

Sequences:

>Translated_555_residues
MSKIEEFRSFMHEINVDAFMLHTKDEYLNEYSEELTKLCGFTGTNGLLIVTKDNKCPFFTDGRYITQARNQLDRGNFQVY
NIQEEDPREWIKANLTSTASLGYYLQYFTIEDIRKYENICKLIPCLAGKKSDYRKQAVVLHSIEHAGESSKDKCEKVAKS
IDKEAEAVLLTDPNSISWLLNLRNENAKYTPCILGRAILYKSGNVDLFIQDKEHSTIEANLGNHINIFDISELENSLHKL
NSIVMDPSTTPMSIMAVIKDKQVAEREDPCLIYKAAKNQTEIAGAINAHIRDGVAVTNFLYWLENNVGTELEAEEKILEY
RKEQNLFKQLSFPTISAFNENGAIIHYRASSKTNKVIQKDGLYLIDSGGQYLDGTTDVTKTVAIGNPTDEQITHYTIVLK
AHIAIASVIFPPGTTGGELDILARTHLWKFGMDYMHGTGHGVGSYLSVHEGPQAISKGNKVKLTPGMILSNEPGYYIPGE
YGIRIENLMYVDKHKNGFLGFKQLTSIPYDRRLISVQMLTKDEIEWINGYHQFVYKNLENSVKDKEWLKKVCDPL
>Mature_554_residues
SKIEEFRSFMHEINVDAFMLHTKDEYLNEYSEELTKLCGFTGTNGLLIVTKDNKCPFFTDGRYITQARNQLDRGNFQVYN
IQEEDPREWIKANLTSTASLGYYLQYFTIEDIRKYENICKLIPCLAGKKSDYRKQAVVLHSIEHAGESSKDKCEKVAKSI
DKEAEAVLLTDPNSISWLLNLRNENAKYTPCILGRAILYKSGNVDLFIQDKEHSTIEANLGNHINIFDISELENSLHKLN
SIVMDPSTTPMSIMAVIKDKQVAEREDPCLIYKAAKNQTEIAGAINAHIRDGVAVTNFLYWLENNVGTELEAEEKILEYR
KEQNLFKQLSFPTISAFNENGAIIHYRASSKTNKVIQKDGLYLIDSGGQYLDGTTDVTKTVAIGNPTDEQITHYTIVLKA
HIAIASVIFPPGTTGGELDILARTHLWKFGMDYMHGTGHGVGSYLSVHEGPQAISKGNKVKLTPGMILSNEPGYYIPGEY
GIRIENLMYVDKHKNGFLGFKQLTSIPYDRRLISVQMLTKDEIEWINGYHQFVYKNLENSVKDKEWLKKVCDPL

Specific function: Splits dipeptides with a prolyl in the C-terminal position and a nonpolar amino acid at the N-terminal position [H]

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family. Archaeal-type prolidase subfamily [H]

Homologues:

Organism=Homo sapiens, GI264681563, Length=597, Percent_Identity=32.998324958124, Blast_Score=290, Evalue=2e-78,
Organism=Homo sapiens, GI93141226, Length=602, Percent_Identity=31.063122923588, Blast_Score=280, Evalue=2e-75,
Organism=Homo sapiens, GI264681565, Length=597, Percent_Identity=31.1557788944724, Blast_Score=255, Evalue=6e-68,
Organism=Escherichia coli, GI1788728, Length=189, Percent_Identity=34.9206349206349, Blast_Score=89, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17509539, Length=619, Percent_Identity=31.3408723747981, Blast_Score=270, Evalue=2e-72,
Organism=Caenorhabditis elegans, GI25149105, Length=602, Percent_Identity=26.4119601328904, Blast_Score=183, Evalue=2e-46,
Organism=Saccharomyces cerevisiae, GI6322999, Length=419, Percent_Identity=35.5608591885441, Blast_Score=243, Evalue=7e-65,
Organism=Drosophila melanogaster, GI17137632, Length=595, Percent_Identity=31.0924369747899, Blast_Score=271, Evalue=1e-72,
Organism=Drosophila melanogaster, GI161078230, Length=599, Percent_Identity=28.0467445742905, Blast_Score=209, Evalue=4e-54,
Organism=Drosophila melanogaster, GI21357287, Length=599, Percent_Identity=28.0467445742905, Blast_Score=209, Evalue=4e-54,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000587
- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR001131 [H]

Pfam domain/function: PF01321 Creatinase_N; PF00557 Peptidase_M24 [H]

EC number: =3.4.13.9 [H]

Molecular weight: Translated: 62945; Mature: 62814

Theoretical pI: Translated: 6.28; Mature: 6.28

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKIEEFRSFMHEINVDAFMLHTKDEYLNEYSEELTKLCGFTGTNGLLIVTKDNKCPFFT
CCHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCEEE
DGRYITQARNQLDRGNFQVYNIQEEDPREWIKANLTSTASLGYYLQYFTIEDIRKYENIC
CCCHHHHHHHHCCCCCEEEEECCCCCHHHHHHHCCCCCCCCCEEEEEEEHHHHHHHHHHH
KLIPCLAGKKSDYRKQAVVLHSIEHAGESSKDKCEKVAKSIDKEAEAVLLTDPNSISWLL
HHHHHHCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCEEEEECCCCEEEEE
NLRNENAKYTPCILGRAILYKSGNVDLFIQDKEHSTIEANLGNHINIFDISELENSLHKL
EECCCCCCCCHHHHCCEEEEECCCEEEEEECCCCCEEEECCCCEEEEEEHHHHHHHHHHH
NSIVMDPSTTPMSIMAVIKDKQVAEREDPCLIYKAAKNQTEIAGAINAHIRDGVAVTNFL
HHEEECCCCCCHHHHEEHHCCHHHCCCCCEEEEEECCCCCHHHHHHHHHHCCCHHHHHHH
YWLENNVGTELEAEEKILEYRKEQNLFKQLSFPTISAFNENGAIIHYRASSKTNKVIQKD
HHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCEEEEECCCCCCHHHHHC
GLYLIDSGGQYLDGTTDVTKTVAIGNPTDEQITHYTIVLKAHIAIASVIFPPGTTGGELD
CEEEEECCCCCCCCCCCCEEEEEECCCCCCCCEEEEEEEEEHEEEEEEEECCCCCCCCEE
ILARTHLWKFGMDYMHGTGHGVGSYLSVHEGPQAISKGNKVKLTPGMILSNEPGYYIPGE
EEEHHHHHHHCCHHHCCCCCCCCCEEECCCCHHHHCCCCEEEECCCEEEECCCCEEECCC
YGIRIENLMYVDKHKNGFLGFKQLTSIPYDRRLISVQMLTKDEIEWINGYHQFVYKNLEN
CCEEEEEEEEEECCCCCCCCHHHHHCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHH
SVKDKEWLKKVCDPL
HCCHHHHHHHHCCCC
>Mature Secondary Structure 
SKIEEFRSFMHEINVDAFMLHTKDEYLNEYSEELTKLCGFTGTNGLLIVTKDNKCPFFT
CHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCEEE
DGRYITQARNQLDRGNFQVYNIQEEDPREWIKANLTSTASLGYYLQYFTIEDIRKYENIC
CCCHHHHHHHHCCCCCEEEEECCCCCHHHHHHHCCCCCCCCCEEEEEEEHHHHHHHHHHH
KLIPCLAGKKSDYRKQAVVLHSIEHAGESSKDKCEKVAKSIDKEAEAVLLTDPNSISWLL
HHHHHHCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCEEEEECCCCEEEEE
NLRNENAKYTPCILGRAILYKSGNVDLFIQDKEHSTIEANLGNHINIFDISELENSLHKL
EECCCCCCCCHHHHCCEEEEECCCEEEEEECCCCCEEEECCCCEEEEEEHHHHHHHHHHH
NSIVMDPSTTPMSIMAVIKDKQVAEREDPCLIYKAAKNQTEIAGAINAHIRDGVAVTNFL
HHEEECCCCCCHHHHEEHHCCHHHCCCCCEEEEEECCCCCHHHHHHHHHHCCCHHHHHHH
YWLENNVGTELEAEEKILEYRKEQNLFKQLSFPTISAFNENGAIIHYRASSKTNKVIQKD
HHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCEEEEECCCCCCHHHHHC
GLYLIDSGGQYLDGTTDVTKTVAIGNPTDEQITHYTIVLKAHIAIASVIFPPGTTGGELD
CEEEEECCCCCCCCCCCCEEEEEECCCCCCCCEEEEEEEEEHEEEEEEEECCCCCCCCEE
ILARTHLWKFGMDYMHGTGHGVGSYLSVHEGPQAISKGNKVKLTPGMILSNEPGYYIPGE
EEEHHHHHHHCCHHHCCCCCCCCCEEECCCCHHHHCCCCEEEECCCEEEECCCCEEECCC
YGIRIENLMYVDKHKNGFLGFKQLTSIPYDRRLISVQMLTKDEIEWINGYHQFVYKNLEN
CCEEEEEEEEEECCCCCCCCHHHHHCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHH
SVKDKEWLKKVCDPL
HCCHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9679194 [H]