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The map label for this gene is adiC [H]

Identifier: 225630625

GI number: 225630625

Start: 972641

End: 973915

Strand: Reverse

Name: adiC [H]

Synonym: WRi_008970

Alternate gene names: 225630625

Gene position: 973915-972641 (Counterclockwise)

Preceding gene: 225630630

Following gene: 225630623

Centisome position: 67.36

GC content: 37.57

Gene sequence:

>1275_bases
GTGTCAAATAAAATAGATTTTTGGGCTATTTTTGCCTTAGTGATTAGCAGCCAAATTGGCTCTGGAATTTTTATGCTTCC
AATTAGCCTTGCTCCATATGGCATGTATAGCCTTATAAGCTGGATAATATCAGGGCTTGGTGCTATATCTCTTGCTTTAG
TTTTTGCCTCACTCTGCGCAAAATTTCCGGAAACGGGTGGCCCTCACGTCTATGTAAAGCATGCTTTTGGCCCTGCTGCA
GCTTTTTTTGTTGGTTGGACGTATTGGGTGATCTCATGGGTTAGCACAACAGCCGTAATAGTTGTGGGTGTTGGTTATCT
TACACCATTTTTCCATGAAGATATTCAAAACGTACATCTGTTTTTAGAGATGTTATTACTTACAATTATTACACTAATAA
ATTTTAGAGGAGTAGCTACTGCTGGACGTGTTGAGTTTTTATTGACGGTGATAAAAATTTCTGTATTGCTTGTAATACCT
ATAGCAGCATTGTTTTTTTTTGATAGAAATAACTTCATCATAAGTGAAGAAATATCAAATCTTACAACATCGCAGATTCT
TGCCCGTTCTACACTTATTACTCTATGGGGTTTTATTGGAGTTGAATTGGCAACAGCACCTGCAGGGTCAGTTGATAATC
CAGCTAGAACAATACCAAGAGCAGTGGTACTTGGAACAATCTCTGTTGCTGTTGTGTATTTTATCAACAATCTTGCAATT
ATGGGATTAATAAATGGCAATGATTTAGCAAGTTCAAGAGCACCATATGTTGACGCAATAAAAATTATGGCCTCTGGCAA
TTGGCACTTGATTATTTCTATAACTGCGTTCATTTTTTGTGTTGGTACTTTAAACGCTTGGGTACTAGCTAGTGGACAAG
TGGCCCTTGGCCTTGCAAAAGATAAACTGATGCCACAGTTTTTTGCTCAAAGAAACAAGCACGGTTCTCCTTTCTGGGGC
ATAACAACTAGCTCAGTTGGAACTGCAACTTTACTAATCCTCACTTCAAGCAACAATTTTGCTAAGCAGATCACATCAAT
TATCGACTTTTCTGTAGTTTCATTTTTATTTGTTTACCTTGCATGCAGTCTTGCTTTTCTCAAAGTTATTGTGCAAGAAA
AGAGTTGTTACAAATTTTTAATTGGCAGTATAGCAACAACCTTTTGCTGCTGGGTAATATTTGAAACTTCTGTGAATACC
TTGCTGATCGCAAGCTTATTCACTGCAAGTGGCGTACCTCTTTATTTATTTTGGTATCGCAGAGTTTCTGTATAG

Upstream 100 bases:

>100_bases
TTAGGAATAAATTGAAAAAAATGCAAGTTTTTATGTTAAAAGATCAATTGAAATTTCTGAGTTTAGGGTATATTGTTAAT
CTATTTAGATAAGAATTATT

Downstream 100 bases:

>100_bases
CAAATGTTATGTATCTGTTCAGCAGAGTGGCAAAATAAGGTAGACGAGAAAAGACAACTATAGGAAGAAATGGGTGTCAT
GCCAGTGCGTGACACTGGCA

Product: Amino acid permease family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 424; Mature: 423

Protein sequence:

>424_residues
MSNKIDFWAIFALVISSQIGSGIFMLPISLAPYGMYSLISWIISGLGAISLALVFASLCAKFPETGGPHVYVKHAFGPAA
AFFVGWTYWVISWVSTTAVIVVGVGYLTPFFHEDIQNVHLFLEMLLLTIITLINFRGVATAGRVEFLLTVIKISVLLVIP
IAALFFFDRNNFIISEEISNLTTSQILARSTLITLWGFIGVELATAPAGSVDNPARTIPRAVVLGTISVAVVYFINNLAI
MGLINGNDLASSRAPYVDAIKIMASGNWHLIISITAFIFCVGTLNAWVLASGQVALGLAKDKLMPQFFAQRNKHGSPFWG
ITTSSVGTATLLILTSSNNFAKQITSIIDFSVVSFLFVYLACSLAFLKVIVQEKSCYKFLIGSIATTFCCWVIFETSVNT
LLIASLFTASGVPLYLFWYRRVSV

Sequences:

>Translated_424_residues
MSNKIDFWAIFALVISSQIGSGIFMLPISLAPYGMYSLISWIISGLGAISLALVFASLCAKFPETGGPHVYVKHAFGPAA
AFFVGWTYWVISWVSTTAVIVVGVGYLTPFFHEDIQNVHLFLEMLLLTIITLINFRGVATAGRVEFLLTVIKISVLLVIP
IAALFFFDRNNFIISEEISNLTTSQILARSTLITLWGFIGVELATAPAGSVDNPARTIPRAVVLGTISVAVVYFINNLAI
MGLINGNDLASSRAPYVDAIKIMASGNWHLIISITAFIFCVGTLNAWVLASGQVALGLAKDKLMPQFFAQRNKHGSPFWG
ITTSSVGTATLLILTSSNNFAKQITSIIDFSVVSFLFVYLACSLAFLKVIVQEKSCYKFLIGSIATTFCCWVIFETSVNT
LLIASLFTASGVPLYLFWYRRVSV
>Mature_423_residues
SNKIDFWAIFALVISSQIGSGIFMLPISLAPYGMYSLISWIISGLGAISLALVFASLCAKFPETGGPHVYVKHAFGPAAA
FFVGWTYWVISWVSTTAVIVVGVGYLTPFFHEDIQNVHLFLEMLLLTIITLINFRGVATAGRVEFLLTVIKISVLLVIPI
AALFFFDRNNFIISEEISNLTTSQILARSTLITLWGFIGVELATAPAGSVDNPARTIPRAVVLGTISVAVVYFINNLAIM
GLINGNDLASSRAPYVDAIKIMASGNWHLIISITAFIFCVGTLNAWVLASGQVALGLAKDKLMPQFFAQRNKHGSPFWGI
TTSSVGTATLLILTSSNNFAKQITSIIDFSVVSFLFVYLACSLAFLKVIVQEKSCYKFLIGSIATTFCCWVIFETSVNTL
LIASLFTASGVPLYLFWYRRVSV

Specific function: Major component of the acid-resistance (AR) system allowing enteric pathogens to survive the acidic environment in the stomach. Exchanges extracellular arginine for its intracellular decarboxylation product agmatine (Agm) thereby expelling intracellular p

COG id: COG0531

COG function: function code E; Amino acid transporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily [H]

Homologues:

Organism=Homo sapiens, GI7657683, Length=339, Percent_Identity=24.7787610619469, Blast_Score=75, Evalue=8e-14,
Organism=Homo sapiens, GI71999149, Length=346, Percent_Identity=25.4335260115607, Blast_Score=73, Evalue=4e-13,
Organism=Homo sapiens, GI115648063, Length=310, Percent_Identity=25.4838709677419, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI115648022, Length=310, Percent_Identity=25.4838709677419, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI186910308, Length=306, Percent_Identity=25.1633986928105, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI186910306, Length=306, Percent_Identity=25.1633986928105, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI186910304, Length=306, Percent_Identity=25.1633986928105, Blast_Score=71, Evalue=1e-12,
Organism=Escherichia coli, GI2367353, Length=408, Percent_Identity=29.9019607843137, Blast_Score=183, Evalue=2e-47,
Organism=Escherichia coli, GI1786908, Length=428, Percent_Identity=28.0373831775701, Blast_Score=146, Evalue=3e-36,
Organism=Escherichia coli, GI1790575, Length=344, Percent_Identity=30.8139534883721, Blast_Score=136, Evalue=3e-33,
Organism=Escherichia coli, GI1787890, Length=445, Percent_Identity=26.0674157303371, Blast_Score=118, Evalue=6e-28,
Organism=Escherichia coli, GI87082250, Length=450, Percent_Identity=26.2222222222222, Blast_Score=106, Evalue=3e-24,
Organism=Escherichia coli, GI1790653, Length=341, Percent_Identity=24.3401759530792, Blast_Score=83, Evalue=4e-17,
Organism=Escherichia coli, GI87081708, Length=363, Percent_Identity=23.4159779614325, Blast_Score=73, Evalue=4e-14,
Organism=Escherichia coli, GI1789017, Length=375, Percent_Identity=23.2, Blast_Score=70, Evalue=4e-13,
Organism=Escherichia coli, GI48994972, Length=342, Percent_Identity=25.4385964912281, Blast_Score=66, Evalue=4e-12,
Organism=Escherichia coli, GI1786602, Length=335, Percent_Identity=22.3880597014925, Blast_Score=62, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI32566699, Length=284, Percent_Identity=25, Blast_Score=81, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17540018, Length=318, Percent_Identity=26.1006289308176, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI71993915, Length=330, Percent_Identity=22.7272727272727, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17568033, Length=325, Percent_Identity=25.5384615384615, Blast_Score=68, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6324061, Length=387, Percent_Identity=25.0645994832041, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI221331183, Length=305, Percent_Identity=27.2131147540984, Blast_Score=86, Evalue=5e-17,
Organism=Drosophila melanogaster, GI17647653, Length=305, Percent_Identity=27.2131147540984, Blast_Score=86, Evalue=5e-17,
Organism=Drosophila melanogaster, GI24664379, Length=305, Percent_Identity=27.2131147540984, Blast_Score=86, Evalue=5e-17,
Organism=Drosophila melanogaster, GI45550968, Length=354, Percent_Identity=23.4463276836158, Blast_Score=76, Evalue=5e-14,
Organism=Drosophila melanogaster, GI19921172, Length=354, Percent_Identity=23.4463276836158, Blast_Score=76, Evalue=5e-14,
Organism=Drosophila melanogaster, GI24651635, Length=306, Percent_Identity=23.8562091503268, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24651633, Length=306, Percent_Identity=23.8562091503268, Blast_Score=72, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 46189; Mature: 46058

Theoretical pI: Translated: 8.76; Mature: 8.76

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNKIDFWAIFALVISSQIGSGIFMLPISLAPYGMYSLISWIISGLGAISLALVFASLCA
CCCCHHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
KFPETGGPHVYVKHAFGPAAAFFVGWTYWVISWVSTTAVIVVGVGYLTPFFHEDIQNVHL
HCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FLEMLLLTIITLINFRGVATAGRVEFLLTVIKISVLLVIPIAALFFFDRNNFIISEEISN
HHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHH
LTTSQILARSTLITLWGFIGVELATAPAGSVDNPARTIPRAVVLGTISVAVVYFINNLAI
HHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCEEE
MGLINGNDLASSRAPYVDAIKIMASGNWHLIISITAFIFCVGTLNAWVLASGQVALGLAK
EEEECCCCCCCCCCCCHHHEEEEECCCEEEEHHHHHHHHHHHHHHHHEEECCCEEEEHHH
DKLMPQFFAQRNKHGSPFWGITTSSVGTATLLILTSSNNFAKQITSIIDFSVVSFLFVYL
HHHHHHHHHHCCCCCCCCCCEECCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHH
ACSLAFLKVIVQEKSCYKFLIGSIATTFCCWVIFETSVNTLLIASLFTASGVPLYLFWYR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCEEEEEHH
RVSV
HHCC
>Mature Secondary Structure 
SNKIDFWAIFALVISSQIGSGIFMLPISLAPYGMYSLISWIISGLGAISLALVFASLCA
CCCHHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
KFPETGGPHVYVKHAFGPAAAFFVGWTYWVISWVSTTAVIVVGVGYLTPFFHEDIQNVHL
HCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FLEMLLLTIITLINFRGVATAGRVEFLLTVIKISVLLVIPIAALFFFDRNNFIISEEISN
HHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHH
LTTSQILARSTLITLWGFIGVELATAPAGSVDNPARTIPRAVVLGTISVAVVYFINNLAI
HHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCEEE
MGLINGNDLASSRAPYVDAIKIMASGNWHLIISITAFIFCVGTLNAWVLASGQVALGLAK
EEEECCCCCCCCCCCCHHHEEEEECCCEEEEHHHHHHHHHHHHHHHHEEECCCEEEEHHH
DKLMPQFFAQRNKHGSPFWGITTSSVGTATLLILTSSNNFAKQITSIIDFSVVSFLFVYL
HHHHHHHHHHCCCCCCCCCCEECCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHH
ACSLAFLKVIVQEKSCYKFLIGSIATTFCCWVIFETSVNTLLIASLFTASGVPLYLFWYR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCEEEEEHH
RVSV
HHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]